High-throughput techniques for compound characterization and purification

Current Opinion in Drug Discovery and Development

Volumn 4, Issue 6, 2001, Pages 719-728

  Kyranos, J N ^a   Cai, H ^a   Zhang, B ^a   Goetzinger, W K ^a  

^a ARQULE INC   (United States)

Author keywords

Characterization; Combinatorial chemistry; High throughput; HPLC; Mass spectrometry; Purification

Indexed keywords

DEXTROMETHORPHAN;

AUTOMATION; COMBINATORIAL CHEMISTRY; FLOW INJECTION ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INFRARED SPECTROSCOPY; LIQUID LIQUID EXTRACTION; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; PURIFICATION; REVERSED PHASE LIQUID CHROMATOGRAPHY; REVIEW; SOLID PHASE EXTRACTION; SUPERCRITICAL FLUID CHROMATOGRAPHY; SYNTHESIS;

CHROMATOGRAPHY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG EVALUATION, PRECLINICAL; FLOW INJECTION ANALYSIS; PHARMACEUTICAL PREPARATIONS;

EID: 0035165945     PISSN: 13676733     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (60)

1. Analytical methods in combinatorial chemistry
2. Techniques for analysis and purification in high-throughput chemistry
3. Mass spectrometry in combinatorial chemistry
4. Infrared spectrometry in solid-phase synthesis
5. FT-infrared spectroscopy and IR-microscopy on-bead analysis of solid-phase synthesis
6. FTIR imaging for chemically sensitive, high-throughput analysis of combinatorial libraries
7. Near-infrared spectrometric determination of di- and tripeptides synthesized by a combinatorial solid-phase method
8. Multispectral imaging microscope with millisecond time resolution
9. High resolution MAS-NMR in combinatorial chemistry
10. Single-bead structure elucidation. Requirements for analysis of combinatorial solid-phase libraries by Nanoprobe MAS-NMR spectroscopy
11. Improved high-resolution diffusion filtered 1H MAS NMR
12. Mass spectrometry and combinatorial chemistry: New approaches for direct support-bound compound identification
13. Mass spectrometry screening of combinatorial mixtures, correlation of measured and predicted electrospray ionization spectra
14. Single bead and hard tag decoding using accurate isotopic difference target analysis-encoded combinatorial libraries
15. Single bead characterization using analytical constructs: Application to quality control of libraries
16. Analysis of libraries encoded with GC tags: Compound elution, tag decode analysis, and statistical sampling analysis
17. Automated high-throughput infusion ESI-MS with direct coupling to a microtiter plate
18. Development of multichannel devices with an array of electrospray tips for high-throughput mass spectrometry
19. A fully integrated monolithic microchip electrospray device for mass spectrometry
20. Techniques for increasing the throughput of flow injection mass spectrometry
21. FTICR-mass spectrometry for high-resolution analysis in combinatorial chemistry
22. Assessment of purity and screening of peptide libraries by nested ion mobility-TOFMS: Identification of RNase S-protein binders
23. Direct-injection NMR (DINMR): A flow NMR technique for the analysis of combinatorial chemistry libraries
24. Small volume flow probe for automated direct-injection NMR analysis: Design and performance
25. 1H-nuclear magnetic resonance spectroscopy and time-of-flight mass spectrometry
26. A novel approach to high-throughput quality control of parallel synthesis libraries
27. Atmospheric pressure photoionization: An ionization method for liquid chromatography-mass spectrometry
28. Advancing hyphenated chromatographic systems
29. Directly coupled HPLC-NMR and HPLC-NMR-MS in pharmaceutical research and development
30. A protocol for high-throughput drug mixture quantitation: Fast LC-MS or flow injection analysis-MS?
31. Fast gradient RP-HPLC for high-throughput quality control analysis of spatially addressable combinatorial libraries
32. Expediting the method development and quality control of reversed-phase liquid chromatography electrospray ionization mass spectrometry for pharmaceutical analysis by using an LC/MS performance test mix
33. Evaluation of evaporative light-scattering detector for combinatorial library quantitation by reversed phase HPLC
34. Automated high-throughput quantification of combinatorial arrays
35. Efficient characterization of combinatorial libraries using mass spectrometry and chemiluminescent nitrogen detection
36. Supercritical fluid and unified chromatography
37. High speed screening of combinatorial libraries by gradient packed column supercritical fluid chromatography
38. Increasing bioanalytical throughput using pcSFC-MS/MS: 10 Minutes per 96-well plate
39. Enantioseparations in super- and subcritical fluid chromatography
40. SFC of drug enantiomers
41. Modifier effects on column efficiency in packed-column supercritical fluid chromatography
42. Tuning of mobile and stationary phase polarity for the separation of polar compound by SFC
43. Mixed-mode anioncation exchange/hydrophilic interaction liquid chromatography-electrospray mass spectrometry as an alternative to reversed phase for small molecule drug discovery
44. Analysis of combinatorial chemistry samples by micellar electrokinetic chromatography
45. Using parallel LC-MS and LC-MS-MS to increase sample throughput
46. Novel approaches to high-throughput quantitative LC-MS/MS in a regulated environment
47. A four-column parallel chromatography system for isocratic or gradient LC/MS analyses
48. Combinatorial chemistry and mass spectrometry in the 21st century drug discovery laboratory
49. High-throughput purification of compound libraries
50. High-throughput high-performance liquid chromatography/mass spectrometry for modern drug discovery
51. Automated high-throughput liquid-liquid extraction for initial purification of combinatorial libraries
52. New designs and formats in solid-phase extraction sample preparation
53. Solid-phase extraction methods developed in a modular 96-well plate format
54. Chemoselective high-throughput purification mediated by solid-supported reagents: Its application to the first 6, 9-disubstituted purine library synthesis
55. Convenient synthesis of 2,9-disubstituted guanines mediated by solid-supported reagents
56. High-throughput parallel flash purification using an automated, multichannel UV flash chromatography system
57. Automated normal-phase preparative high-performance liquid chromatography as a substitute for flash chromatography in the synthetic research laboratory
58. The development of a semi-preparatory scale supercritical-fluid chromatograph for high-throughput purification of 'combi-chem' libraries
59. Practical advantages of packed column supercritical fluid chromatography in supporting combinatorial chemistry
60. TM: A novel high-throughput SFC prep technique