Demethylation of radiolabelled dextromethorphan in rat microsomes and intact hepatocytes: Kinetics and sensitivity to cytochrome P450 2D inhibitors

European Journal of Biochemistry

Volumn 270, Issue 18, 2003, Pages 3768-3777

  Di Marco, Annalise ^a   Yao, Dan ^b   Laufer, Ralph ^a,c  

^a Merck Research Laboratories   (Italy)

^b MERCK RESEARCH LABORATORIES   (United States)

^c IRBM   (Italy)

Author keywords

CYP2D; Cytochrome P450; Hepatocytes; Microsomes

Indexed keywords

CYTOCHROME P450 2D; DEXTROMETHORPHAN; KETOCONAZOLE; MEPYRAMINE; PROPAFENONE; QUINIDINE; QUININE; TERFENADINE; VERAPAMIL;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASSAY; CELL TRANSPORT; CONTROLLED STUDY; DEMETHYLATION; ENZYME SUBSTRATE; EXTRACELLULAR SPACE; IC 50; INHIBITION KINETICS; INTERMETHOD COMPARISON; INTRACELLULAR SPACE; ISOTOPE LABELING; LIVER CELL; LIVER MICROSOME; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BENZOFLAVONES; CARBON RADIOISOTOPES; CYTOCHROME P-450 ENZYME SYSTEM; DEXTROMETHORPHAN; ENZYME INHIBITORS; HEPATOCYTES; INHIBITORY CONCENTRATION 50; KINETICS; MALE; METHYLATION; MICROSOMES, LIVER; OXIDOREDUCTASES, O-DEMETHYLATING; PROTEIN BINDING; QUINIDINE; QUININE; RATS; RATS, SPRAGUE-DAWLEY; SULFAPHENAZOLE; TROLEANDOMYCIN;

ANIMALIA; CINCHONA PUBESCENS;

EID: 0141782243     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1033.2003.03763.x     Document Type: Article

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