Erythromycin as a specific substrate for cytochrome P4503A isozymes and identification of a high-affinity erythromycin N-demethylase in adult female rats

Drug Metabolism and Disposition

Volumn 24, Issue 1, 1996, Pages 23-27

  Zhang, Xu Jie ^a   Thomas, Paul E ^a,b  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 14; CORN OIL; CORTICOSTERONE; CYCLOSPORIN A; CYTOCHROME P450 ISOENZYME; DEXAMETHASONE; DIGITOXIN; ERYTHROMYCIN; ETHINYLESTRADIOL; HYDROCORTISONE; MONOCLONAL ANTIBODY; N DEMETHYLASE; POLYCLONAL ANTIBODY; TESTOSTERONE; THEOPHYLLINE; TROLEANDOMYCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEMETHYLATION; ENZYME KINETICS; ENZYME SUBSTRATE; FEMALE; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER MICROSOME; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BLOTTING, WESTERN; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; ERYTHROMYCIN; FEMALE; HYDROXYLATION; ISOENZYMES; KINETICS; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; OXIDOREDUCTASES, N-DEMETHYLATING; RATS; RATS, SPRAGUE-DAWLEY; STEROID HYDROXYLASES;

ANIMALIA; ZEA MAYS;

EID: 0030029958     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. C. Dolley, ed: Erythromycin. In "Therapeutic Drugs," vol. II, pp. E45-E50. Churchill Livingstone, New York, 1991.
2. J. C.-H. Mao and P. L. Tardew: Demethylation of erythromycin by rabbit tissues in vitro. Biochem. Pharmacol 14, 1049-1056 (1965)
3. C. S. Cook, C. Hauswald, J. A. Oppermann, and G. L. Schoenhard: Involvement of cytochrome P-450 3A in metabolism of potassium canrenoate to an epoxide: mechanism of inhibition of the epoxide formation by spironolactone and its sulfur-containing metabolite. J. Pharmacol. Exp. Ther. 266, 1-7 (1993).
4. T. Nash. The colorimetric estimation of formaldehyde by means of the Hantzshe reaction. Biochem. J. 55, 416-421 (1953)
5. J. T. Wilson and C. J. van Boxtel: Pharmacokinetics of erythromycin in man. Antibiot. Chemother. 25, 181-203 (1978).
6. J. R. Halpert: Multiplicity of steroid-inducible cytochromes P450 in rat liver microsomes. Arch. Biochem. Biophys. 263, 59-68 (1988).
7. D. R. Nelson, T. Kamataki, D. J. Waxman, F. P. Guengerich, R. W. Estabrook, R. Feyereisen, F. J. Gonzalez, M. J. Coon, I. C. Gunsalus, O. Gotoh, K. Okuda, and D. W. Nebert: The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol. 12, 1-51 (1993).
8. F. J. Gonzalez, B. J. Song, and J. P. Hardwick: Pregnenolone 16α-carbonitrile-inducible P450 gene family: gene conversion and differential regulation. Mol. Cell Biol. 6, 2969-2976 (1986).
9. K. A. Hostetler, S. A. Wrighton, P. Kremers, and P. S. Guzelian: Immunochemical evidence for multiple steroid-inducible hepatic cytochromes P450 in the rat. Biochem. J. 245, 27-33 (1987).
10. T. S. Barnes, P. M. Shaw, M. D. Burhe, and W. T. Melvin: Monoclonal antibodies against human cytochromes P450 recognizing different pregnenolone 16α-carbonitrile-inducible rat cytochromes P450. Biochem. J. 248, 301-304 (1987).
11. T Prueksaritanont, M. A. Correia, A. E. Rettie, d. C. Swinney, P. E. Thomas, and L. Z. Benet: Cyclosporin metabolism by rat liver microsomes: evidence for involvement of enzyme(s) other than cytochromes P450 3A. Drug Metab. Dispos. 21, 730-737 (1993).
12. N. Sadrieh and P. E Thomas: Characterization of rat cytochrome P450 isozymes involved in the covalent binding of cyclosporin A to microsomal proteins. Toxicol. Appl. Pharmacol. 127, 222-232 (1994).