Acute stroke therapy at the millennium: Consummating the marriage between the laboratory and bedside: The Feinberg lecture

Stroke

Volumn 30, Issue 8, 1999, Pages 1722-1728

  Grotta, James C ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

American Heart Association; Clinical trials; Neuroprotection; Research; rtPA; Thrombolysis

Indexed keywords

ADENOSINE; ALCOHOL; ALTEPLASE; APTIGANEL; CAFFEINE; CALPAIN; DIASPIRIN CROSSLINKED HEMOGLOBIN; DIZOCILPINE; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; LUBELUZOLE; MAGNESIUM SULFATE; N TERT BUTYL ALPHA PHENYLNITRONE; NEUROPROTECTIVE AGENT; TACROLIMUS;

APOPTOSIS; BLOOD CLOT LYSIS; BRAIN BLOOD FLOW; CELL DEATH; CLINICAL TRIAL; CONFERENCE PAPER; EARLY DIAGNOSIS; HUMAN; INTRAARTERIAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REPERFUSION; SCORING SYSTEM; STROKE; TREATMENT OUTCOME;

EID: 0032776135     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.30.8.1722     Document Type: Conference Paper

References (24)

1. Ackerman RH, Correia JA, Alpen NM, Baron J, Gouliamos A, Grotta JC, Brownell GL, Taveras JM. Positron imaging in ischemic stroke disease using compounds labeled with oxygen 15. Arch Neurol. 1981;38: 537-543.
2. Hypervolemic hemodilution treatment of acute stroke: results of a randomized multicenter trial using pentastarch: the Hemodilution in Stroke Study Group. Stroke. 1989;20:317-323.
3. NINDS rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med. 1995;333:1581-1587.
4. Pulsinelli WA, Briefly JB, Plum F. Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann Neurol. 1982;11: 491-498.
5. Petito CK, Feldmann E, Pulsinelli WA, Plum F. Delayed hippocampal damage in humans following cardiorespiratory arrest. Neurology. 1987; 37:1281-1286.
6. Picone CM, Grotta JC, Earls R, Strong R, Dedman J. Immunohistochemical determination of calcium-calmodulin binding predicts neuronal damage after global ischemia. J Cereb Blood Flow Metab. 1989;9: 1325-1331.
7. Grotta JC, Pettigrew LC, Reid C, Rosenbaum D, McCandless D, Rhoades H. Studies on the efficacy and mechanism of action of a calcium blocker after global cerebral ischemia. Stroke. 1988;19:447-454.
8. Rosenbaum DM, D'Amore J, Llena J, Rybak S, Balkany A, Kessler JA. Pretreatment with intraventricular aurintricarboxylic acid decreases infarct size by inhibiting apoptosis following transient global ischemia in gerbils. Ann Neurol. 1998;43:654-660.
9. 2+/calmodulin-dependent protein kinase II: potential role in neuronal damage. J Neurochem. 1992;58:1743-1753.
10. Rosenbaum D, Grotta J, Yatsu F, Picone C, Pettigrew LC, Bratina P, Zabramski J, Spetzler R, Lopez L, Marier J, Ellis D. Pilot study of nicardipine for acute ischemic stroke. Angiology. 1990;41:1017-1022.
11. Grotta JC. Current medical and surgical therapies for cerebrovascular disease. N Engl J Med. 1987;317:1505-1516.
12. Choi DW, Maulucci-Gedde M, Kriegstein AR. Glutamate neurotoxicity in cortical cell culture. J Neurosci. 1987;7:357-368.
13. Grotta JC, Picone CM, Ostrow PT, Strong RA, Earls RM, Yao LP, Rhoades HM, Dedman JR. CGS 19755, a competitive NMDA receptor antagonist, reduces calcium-calmodulin binding and improves outcome after global cerebral ischemia. Ann Neurol. 1990;27:612-619.
14. Grotta J, Clark W, Coull B, Pettigrew LC, Mackay B, Goldstein LB, Meissner I, Murphy D, LaRue L. Safety and tolerability of the glutamate antagonist CGS 19755 (Selfotel) in patients with acute ischemic stroke: results of a phase IIa randomized trial. Stroke. 1995;26:602-605.
15. Aronowski J, Ostrow P, Samways E, Strong R, Zivin J, Grotta J. Graded bioassay for demonstration of brain rescue from experimental acute ischemia in rats. Stroke. 1994;25:2235-2240.
16. Aronowski J, Strong R, Grotta J. Reperfusion injury: demonstration of brain damage produced by reperfusion after transient focal ischemia in rats. J Cereb Blood Flow Metab. 1997;17:1048-1056.
17. Marler JR, Tilley BC, Lu M, Brott T, Lyden P, Broderick JP, Grotta J, Levine SR, Frankel M, Horowitz S, Kwiatkowski T. Earlier treatment associated with better outcome in the NINDS tPA Stroke Study. Stroke. 1999;30:244. Abstract.
18. DeGraba T, Ostrow P, Grotta J. Threshold of calcium disturbances after focal cerebral ischemia in rats: implications of the window of therapeutic opportunity. Stroke. 1993;24:1212-1217.
19. Zhang RL, Zhang ZG, Chopp M. Increased therapeutic efficacy with rt-PA and anti-CD 18 antibody treatment of stroke in the rat. Neurology. 1999;52:273-279.
20. Grotta J. t-PA: the best current option for most patients. N Engl J Med. 1998;337:1310-1312.
21. Towne AR, Pellock JM, Ko D, DeLorenzo RJ. Determinants of mortality in status epilepticus. Epilepsia. 1994;35:27-34.
22. Morgenstern L, Frankowski R, Shedden P, Pasteur W, Grotta J. Surgical treatment for intracerebral hemorrhage. Neurology. 1999;51:1359-1363.
23. Hickenbottom S, Aronowski J, Strong R, Grotta J. Nuclear factor-kappa B activation in intracerebral hemorrhage. Neurology. 1998;50(suppl 4):A370. Abstract.
24. Bland S, Strong R, Aronowski J, Grotta J, Schallert T. Forced overuse of the contralateral forelimb increases infarct volume and impairs functional outcome following mild transient cerebral ischemia in rats. Neurology. 1999;52(suppl 2):A564. Abstract.