Serotonin as an important mediator of cocaine's behavioral effects

Drugs of Today

Volumn 39, Issue 7, 2003, Pages 497-511

  Müller, Christian P ^a   Carey, Robert J ^b   Huston, Joseph P ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COCAINE; RECEPTOR SUBTYPE; SEROTONIN; SEROTONIN RECEPTOR; SEROTONIN TRANSPORTER;

BEHAVIOR; BRAIN REGION; DOPAMINERGIC SYSTEM; DRINKING; EATING; EMOTION; GROOMING; HYPERACTIVITY; LOCOMOTION; MOOD DISORDER; NONHUMAN; REVIEW;

ANIMALS; BEHAVIOR; BEHAVIOR, ANIMAL; BRAIN; COCAINE; HUMANS; RECEPTORS, SEROTONIN; SEROTONIN; SEROTONIN UPTAKE INHIBITORS;

EID: 0141620161     PISSN: 16993993     EISSN: 16994019     Source Type: Journal    
DOI: 10.1358/dot.2003.39.7.799442     Document Type: Review

References (126)

1. Koob, G.F. Drugs of abuse: Anatomy, physiology and function of reward pathways. TIPS 1992, 13: 177-84.
2. Wise, R.A. Drug-activation of brain reward pathways. Drug Alcohol Depend 1998, 51: 13-22.
3. Woolverton, W.L., Johnson, K.M. Neurobiology of cocaine abuse. TIPS 1992, 13: 193-200.
4. Newman, A.H., Allen, A.C., Izenwasser, S., Katz, J.L. Novel 3 alpha-(diphenylmethoxy)tropane analogs: Potent dopamine uptake inhibitors without cocaine-like behavioral profiles. J Med Chem 1994, 37: 2258-61.
5. Rothman, R.B., Grieg, N., Kim, A. et al. Cocaine and GBR12909 produce equivalent motoric responses at different occupancy of the dopamine transporter. Pharmacol Biochem Behav 1992, 43: 1135-42.
6. Caine, S.B. Cocaine abuse: Hard knocks for the dopamine hypothesis? Nat Neurosci 1998, 1: 90-2.
7. Uhl, G.R., Hall, F.S., Sora, I. Cocaine, reward, movement and monoamine transporters. Mol Psychiatry 2002, 7: 1-26.
8. Rocha, B.A., Fumagalli, F., Gainetdinov, R.R. et al. Cocaine self-administration in dopamine-transporter knockout mice. Nat Neurosci 1998, 1: 132-7.
9. Sora, I., Hall, F.S., Andrews, A.M. et al. Molecular mechanisms of cocaine reward: Combined dopamine and serotonin transporter knockouts eliminate cocaine place preference. Proc Natl Acad Sci USA 2001, 98: 5300-5.
10. Ritz, M.C., Cone, E.J., Kuhar, M.J. Cocaine inhibition of ligand binding at dopamine, norepinephrine and serotonin transporters: A structure-activity study. Life Sci 1990, 46: 635-45.
11. Koe, B.K. Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain. J Pharmacol Exp Therap 1976, 199: 649-61.
12. Reith, M.E., Sershen, H., Allen, D.L., Lajtha, A. A portion of [3H]cocaine binding in brain is associated with serotonergic neurons. Mol Pharmacol 1983, 23: 600-6.
13. Van Bockstaele, E.J., Pickel, V.M. Ultrastructure of serotonin-immunoreactive terminals in the core and shell of the rat nucleus accumbens: Cellular substrates for interactions with catecholamine afferents. J Comp Neurol 1993, 334: 603-17.
14. Chen, N.H., Reith, M.E. Autoregulation and monoamine interactions in the ventral tegmental area in the absence and presence of cocaine: A microdialysis study in freely moving rats. J Pharmacol Exp Therap 1994, 271: 1597-610.
15. Kelland, M.D., Freeman, A.S., Rubin, J., Chiodo, L.A. Ascending afferent regulation of rat midbrain dopamine neurons. Brain Res Bull 1993, 31: 539-46.
16. Parsons, L.H., Justice, J.B. Perfusate serotonin increases extracellular dopamine in the nucleus accumbens as measured by in vivo microdialysis. Brain Res 1993, 606: 195-9.
17. De Deurwaerdere, P., Bonhomme, N., Lucas, G., Le, M.M., Spampinato, U. Serotonin enhances striatal dopamine outflow in vivo through dopamine uptake sites. J Neurochem 1996, 66: 210-5.
18. Reith, M.E., Li, M.Y., Yan, Q.S. Extracellular dopamine, norepinephrine, and serotonin in the ventral tegmental area and nucleus accumbens of freely moving rats during intracerebral dialysis following systemic administration of cocaine and other uptake blockers. Psychopharmacol 1997, 134: 309-17.
19. Broderick, P.A., Phelix, C.F.I. Serotonin (5-HT) within dopamine reward circuits signals open-field behavior. II. Basis for 5-HT-DA interaction in cocaine dysfunctional behavior. Neurosci Biobehav Rev 1997, 21: 227-60.
20. Müller, C.P., De Souza Silva, M.A., DePalma, G., Tomaz, C., Carey, R.J., Huston, J.P. The selective serotonin(1A)-receptor antagonist WAY 100635 blocks behavioral stimulating effects of cocaine but not ventral striatal dopamine increase. Behav Brain Res 2002, 134: 337-46.
21. Müller, C.P., Carey, R.J., De Souza Silva, M.A., Jocham, G., Huston, J.P. Cocaine increases serotonergic activity in the hippocampus and nucleus accumbens in vivo: 5-HT1A-receptor antagonism blocks behavioral but potentiates serotonergic activation. Synapse 2002, 45: 67-77.
22. Jacobs, B. L., Azmitia, E.C. Structure and function of the brain serotonin system. Physiol Rev 1992, 72: 165-229.
23. Agnati, L.F., Zoli, M., Stromberg, I., Fuxe, K. Intercellular communication in the brain: Wiring versus volume transmission. Neurosci 1995, 69: 711-26.
24. Descarries, L., Umbriaco, D. Ultrastructural basis of monoamine and acetylcholine function in CNS. Sem Neurosci 1995, 7: 309-18.
25. Bunin, M.A., Wightman, R.M. Paracrine neurotransmission in the CNS: Involvement of 5-HT. TINS 1999, 22: 377-82.
26. Lucki, I. The spectrum of behaviors influenced by serotonin. Biol Psychiatry 1998, 44: 151-62.
27. Vanderwolf, C.W. A general role for serotonin in the control of behavior: Studies with intracerebral 5,7-dihydroxytryptamine. Brain Res 1989: 504, 192-198.
28. Blundell, J.E. Serotonin and appetite. Neuropharmacol 1984, 23: 1537-51.
29. Bao, J.X., Kandel, E.R., Hawkins, R.D. Involvement of presynaptic and postsynaptic mechanisms in a cellular analog of classical conditioning at aplysia sensory-motor neuron synapses in isolated cell culture. J Neurosci 1998, 18: 458-66.
30. Milner, B., Squire, L.R., Kandel, E.R. Cognitive neuroscience and the study of memory. Neuron 1998, 20: 445-68.
31. Griebel, G. 5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders: More than 30 years of research. Pharmacol Therap 1995, 65: 319-95.
32. Handley, S.L., McBlane, J.W., Critchley, M.A., Njung'e, K. Multiple serotonin mechanisms in animal models of anxiety: Environmental, emotional and cognitive factors. Behav Brain Res 1993, 58: 203-10.
33. Graeff, F.G., Guimaraes, F.S., De, A.T., Deakin, J.F. Role of 5-HT in stress, anxiety, and depression. Pharmacol Biochem Behav 1996, 54: 129-41.
34. Maes, M., Meltzer, H.Y. The serotonin hypothesis of major depression. In: Bloom, F.E. and Kupfer, D.J. (Eds.). Psychopharmacology: The fourth generation of progress. Raven Press, New York 1995, 933-44.
35. Andrews, C.M., Lucki, I. Effects of cocaine on extracellular dopamine and serotonin levels in the nucleus accumbens. Psychopharmacol 2001, 155: 221-9.
36. Bradberry, C.W., Nobiletti, J.B., Elsworth, J.D., Murphy, B., Jatlow, P., Roth, R.H. Cocaine and cocaethylene: Microdialysis comparison of brain drug levels and effects on dopamine and serotonin. J Neurochem 1993, 60: 1429-35.
37. Rutter, J.J., Baumann, M.H., Waterhouse, B.D. Systemically administered cocaine alters stimulus-evoked responses of thalamic somatosensory neurons to perithreshold vibrissae stimulation. Brain Res 1998, 798: 7-17.
38. Hadfield, M.G., Milio, C. Cocaine and regional brain monoamines in mice. Pharmacol Biochem Behav 1992, 43: 395-403.
39. Sur, C., Betz, H., Schloss, P. Immunocytochemical detection of the serotonin transporter in rat brain. Neurosci 1996, 73: 217-31.
40. Rueter, L.E., Fornal, C.A., Jacobs, B.L. A critical review of 5-HT brain microdialysis and behavior. Rev Neurosci 1997, 8: 117-37.
41. Kirby, L.G., Chou-Green, J.M., Davis, K., Lucki, I. The effects of different stressors on extracellular 5-hydroxytryptamine and 5-hydroxyindoleacetic acid. Brain Res 1997, 760: 218-30.
42. Gawin, F.H. Cocaine addiction: Psychology and neurophysiology. Science 1991, 251: 1580-6.
43. George, F.R. Cocaine produces low dose locomotor depressant effects in mice. Psychopharmacol 1989, 99: 147-50.
44. George, F.R. Cocaine produces low dose locomotor depressant effects in NBR and F344 rats. Pharmacol Biochem Behav 1990, 37: 795-8.
45. Hemby, S.E., Co, C., Reboussin, D., Davies, H.M., Dworkin, S.I., Smith, J.E. Comparison of a novel tropane analog of cocaine, 2 beta-propanoyl-3 beta-(4-tolyl) tropane with cocaine HCl in rats: Nucleus accumbens extracellular dopamine concentration and motor activity. J Pharmacol Exp Therap 1995, 273: 656-66.
46. Paulus, M.P., Callaway, C.W., Geyer, M.A. Quantitative assessment of the microstructure of rat behavior: II. Distinctive effects of dopamine releasers and uptake inhibitors. Psychopharmacol 1993, 113: 187-98.
47. Ruth, J.A., Ullman, E.A., Collins, A.C. An analysis of cocaine effects on locomotor activities and heart rate in four inbred mouse strains. Pharmacol Biochem Behav 1988, 29: 157-62.
48. Cooper, S.J., van der Hoek, G.A. Cocaine: A microstructural analysis of its effects on feeding and associated behavior in the rat. Brain Res 1993, 608: 45-51.
49. Kelly, P.H., Iversen, S.D. Selective 6OHDA-induced destruction of mesolimbic dopamine neurons: Abolition of psychostimulant-induced locomotor activity in rats. Eur J Pharmacol 1976, 40: 45-56.
50. Tatum, A.L., Seevers, M.H. Experimental cocaine addiction. J Pharm Exp Therap 1929, 36: 401-10.
51. Downs, A.W., Eddy, N.B. The effect of repeated doses of cocaine on the rat. J Pharmacol Exp Therap 1932, 46: 199-200.
52. O'Dell, L.E., Khroyan, T.V., Neisewander, J.L. Dose-dependent characterization of the rewarding and stimulant properties of cocaine following intraperitoneal and intravenous administration in rats. Psychopharmacol 1996, 123: 144-53.
53. Scheel-Krüger, J., Braestrup, C., Nielson, M., Golembiowska, K., Moglinicka, E. Cocaine: Discussion on the role of dopamine in the biochemical mechanism of action. In: Ellinwood, E.H., Kilbey, M.M. (Eds.). Cocaine and other stimulants. Plenum Press, New York 1977, 373-407.
54. Fog, R. Stereotyped and non-stereotyped behavior in rats induced by various stimulant drugs. Psychopharmacologia 1969, 14: 299-304.
55. Johanson, C.E., Fischman, M.W. The pharmacology of cocaine related to its abuse. Pharmacol Rev 1989, 41: 3-52.
56. Carey, R.J., DePalma, G., Damianopoulos, E. Cocaine and serotonin: A role for the 5-HT(1A) receptor site in the mediation of cocaine stimulanteffects. Behav Brain Res 2001, 126: 127-33.
57. Freud, S. Über Coca. In: Hirschmüller, A. (Ed.). Sigmund Freud: Schriften über Kokain. Fischer: Frankfurt/M 1999.
58. Resnick, R.B., Kestenbaum, R.S., Schwartz, L.K. Acute systemic effects of cocaine in man: A controlled study by intranasal and intravenous routes. Science 1977, 195: 696-8.
59. Bedford, J.A., Lovell, D.K., Turner, C.E., Elsohly, M.A., Wilson, M.C. The anorexic and actometric effects of cocaine and two coca extracts. Pharmacol Biochem Behav 1980, 13: 403-8.
60. Bedford, J.A., Borne, R.F., Wilson, M.C. Comparative behavioral profile of cocaine and norcocaine in rats and monkeys. Pharmacol Biochem Behav 1980, 13: 69-75.
61. Foltin, R.W., Fischman, M.W., Nautiyal, C. The effects of cocaine on food intake of baboons before, during, and after a period of repeated desipramine. Pharmacol Biochem Behav 1990, 36: 869-74.
62. van Rossum, J.M., Simons, F. Locomotor activity and anorexogenic action. Psychopharmacologia 1969, 14: 248-54.
63. Rapoza, D., Woolverton, W.L. Attenuation of the effects of cocaine on milk consumption in rats by dopamine antagonists. Pharmacol Biochem Behav 1991, 40: 133-7.
64. Javaid, J.I., Fischman, M.W., Schuster, C.R., Dekirmenjian, H., Davis, J.M. Cocaine plasma concentration: Relation to physiological and subjective effects in humans. Science 1978, 202: 227-8.
65. Rush, C.R., Baker, R.W., Wright, K. Acute physiological and behavioral effects of oral cocaine in humans: A dose-response analysis. Drug Alcohol Depend 1999, 55: 1-12.
66. Post, R.M., Kotin, J., Goodwin, F.K. The effects of cocaine on depressed patients. Am J Psychiatry 1974, 131: 511-7.
67. Costall, B., Kelly, M.E., Naylor, R.J., Onaivi, E.S. The actions of nicotine and cocaine in a mouse model of anxiety. Pharmacol Biochem Behav 1989, 33: 197-203.
68. Yang, X.M., Gorman, A.L., Dunn, A.J., Goeders, N.E. Anxiogenic effects of acute and chronic cocaine administration: Neurochemical and behavioral studies. Pharmacol Biochem Behav 1992, 41: 643-50.
69. Siegel, R.K. Cocaine hallucinations. Am J Psychiatry 1978, 135: 309-14.
70. Ellinwood, E.H.J., Petrie, W.M. Dependence on amphetamine, cocaine, and other stimulants. In: Pradhan, S.N. (Ed.). Drug abuse: Clinical and basic aspects. C.V. Mosby, St. Louis 1977, 248-62.
71. Gawin, F.H., Ellinwood, E.H.J. Cocaine and other stimulants. Actions, abuse, and treatment. N Engl J Med 1988, 318: 1173-82.
72. Bardo, M.T., Rowlett, J.K., Harris, M.J. Conditioned place preference using opiate and stimulant drugs: A meta-analysis. Neurosci Biobehav Rev 1995, 19: 39-51.
73. McBride, W.J., Murphy, J.M., Ikemoto, S. Localization of brain reinforcement mechanisms: Intracranial self-administration and intracranial place-conditioning studies. Behav Brain Res 1999, 101: 129-52.
74. Epstein, D.H., Silverman, K., Henningfield, J.E., Preston, K.L. Low-dose oral cocaine in humans: Acquisition of discrimination and time-course of effects. Behav Pharmacol 1999, 10: 531-42.
75. Oliveto, A.H., Rosen, M.I., Woods, S.W., Kosten, T.R. Discriminative stimulus, self-reported and cardiovascular effects of orally administered cocaine in humans. J Pharmacol Exp Therap 1995, 272: 231-41.
76. Walsh, S.L., Cunningham, K.A. Serotonergic mechanisms involved in the discriminative stimulus, reinforcing and subjective effects of cocaine. Psychopharmacol 1997, 130: 41-58.
77. Svingos, A.L., Hitzemann, R. 5-HT3 receptor antagonists block cocaine-induced locomotion via a PCPA-sensitive mechanism. Pharmacol Biochem Behav 1992, 43: 871-9.
78. Herges, S., Taylor, D.A. Modulatory effect of p-chlorophenylalanine microinjected into the dorsal and median raphe nuclei on cocaine-induced behavior in the rat. Eur J Pharmacol 1999, 374: 329-40.
79. Morrow, B.A., Roth, R.H. Serotonergic lesions alter cocaine-induced locomotor behavior and stress-activation of the mesocorticolimbic dopamine system. Synapse 1996, 23: 174-81.
80. Pradhan, S.N., Battacharyya, A.K., Pradhan, S. Serotoninergic manipulation of the behavioral effects of cocaine in rats. Commun Psychopharmacol 1978, 2: 481-6.
81. Molina, P.E., Ahmed, N., Gatley, J., Volkow, N.D., Abumrad, N.N. L-tryptophan attenuation of the dopaminergic and behavioral responses to cocaine. Life Sci 2001, 69: 1897-906.
82. Hjorth, S., Auerbach, S.B. 5-HT1A autoreceptors and the mode of action of selective serotonin reuptake inhibitors (SSRI). Behav Brain Res 1996, 73: 281-3.
83. Reith, M.E., Wiener, H.L., Fischette, C.T. Sertraline and cocaine-induced locomotion in mice. I. Acute studies. Psychopharmacol 1991, 103: 297-305.
84. Herges, S., Taylor, D.A. Involvement of serotonin in the modulation of cocaine-induced locomotor activity in the rat. Pharmacol Biochem Behav 1998, 59: 595-611.
85. Barnes, N.M., Sharp, T. A review of central 5-HT receptors and their function. Neuropharmacol 1999, 38: 1083-152.
86. Palacios, J.M., Waeber, C., Hoyer, D., Mengod, G. Distribution of serotonin receptors. Ann NY Acad Sci 1990, 600: 36-52.
87. Gozlan, H., El-Mestikawy, S., Pichat, L., Glowinski, J., Hamon, M. Identification of presynaptic serotonin autoreceptors using a new ligand: 3H-PAT. Nature 1983, 305: 140-2.
88. Hamon, M. The main features of central 5-HT1A receptors. In: Baumgarten, H.G., Göthert, H. (Eds.). Serotonergic neurons and 5-HT receptors in the brain: Springer, Berlin 1999, 239-268.
89. Carey, R.J., De Palma, G., Damianopoulos, E. 5-HT1A agonist/antagonist modification of cocaine stimulant effects: Implications for cocaine mechanisms. Behav Brain Res 2002, 132: 37-46.
90. De La Garza, R.D., Cunningham, K.A. The effects of the 5-hydroxytryptamine(1A) agonist 8-hydroxy-2-(di-n-propylamino)tetralin on spontaneous activity, cocaine-induced hyperactivity and behavioral sensitization: A microanalysis of locomotor activity. J Pharmacol Exp Therap 2000, 292: 610-7.
91. Müller, C.P., Carey, R.J., Salloum, J.B., Huston, J.P. Serotonin1A-receptor agonism attenuates the cocaine-induced increase in serotonin levels in the hippocampus and nucleus accumbens but potentiates hyperlocomotion: An in-vivo microdialysis study. Neuropharmacol 2003, 44: 592-603.
92. Przegalinski, E., Filip, M. Stimulation of serotonin (5-HT)1A receptors attenuates the locomotor, but not the discriminative, effects of amphetamine and cocaine in rats. Behav Pharmacol 1997, 8: 699-706.
93. Barros, M., Mello, E.L., Huston, J.P., Tomaz, C. Behavioral effects of buspirone in the marmoset employing a predator confrontation test of fear and anxiety. Pharmacol Biochem Behav 2001, 68: 255-62.
94. Carey, R., Damianopoulos, E., DePalma, G. The 5-HT(1A) antagonist WAY 100635 can block the low-dose locomotor stimulant effects of cocaine. Brain Res 2000, 862: 242-6.
95. King, G.R., Joyner, C.M., Ellinwood, E.H. Withdrawal from continuous or intermittent cocaine: Behavioral responsivity to 5-HT1 receptor agonists. Pharmacol Biochem Behav 1993, 45: 577-87.
96. Carli, M., Prontera, C., Samanin, R. Effect of 5-HT1A agonists on stress-induced deficit in open field locomotor activity of rats: Evidence that this model identifies anxiolytic-like activity. Neuropharmacol 1989, 28: 471-6.
97. Castanon, N., Scearce-Levie, K., Lucas, J.J., Rocha, B., Hen, R. Modulation of the effects of cocaine by 5-HT1B receptors: A comparison of knockouts and antagonists. Pharmacol Biochem Behav 2000, 67: 559-66.
98. Rocha, B.A., Scearce, L.K., Lucas, J.J. et al. Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor. Nature 1998, 393: 175-8.
99. Broderick, P.A., Nigro, J.P., Olabvisi, O.A. 5-HT2A antagonist attenuation of cocaine-induced serotonin (5-HT) and dopamine (DA) release in the nucleus accumbens (Nacc) during open-field behavior: In vivo microvoltametric studies using ketanserin. Soc Neurosci Abstr 2001, 27: 788.11.
100. McMahon, L.R., Cunningham, K.A. Antagonism of 5-hydroxytryptamine(2a) receptors attenuates the behavioral effects of cocaine in rats. J Pharmacol Exp Therap 2001, 297: 357-63.
101. O'Neill, M.F., Heron-Maxwell, C.L., Shaw, G. 5-HT2 receptor antagonism reduces hyperactivity induced by amphetamine, cocaine, and MK-801 but not D1 agonist C-APB. Pharmacol Biochem Behav 1999, 63: 237-43.
102. Fletcher, P., Grottick, A.J., Higgins, G. Differential effects of the 5-HT(2A) receptor antagonist M100,907 and the 5-HT(2C) receptor antagonist SB242,084 on cocaine-induced locomotor activity, cocaine self-administration and cocaine-induced reinstatement of responding. Neuropsychopharmacol 2002, 27: 576.
103. McCreary, A.C., Cunningham, K.A. Effects of the 5-HT2C/2B antagonist SB 206553 on hyperactivity induced by cocaine. Neuropsychopharmacol 1999, 20: 556-64.
104. Grottick, A.J., Fletcher, P.J., Higgins, G.A. Studies to investigate the role of 5-HT(2C) receptors on cocaine- and food-maintained behavior. J Pharmacol Exp Therap 2000, 295: 1183-91.
105. Kankaanpää, A., Meririnne, E., Seppälä T. 5-HT3 receptor antagonist MDL 72222 attenuates cocaine- and mazindol-, but not methylphenidate-induced neurochemical and behavioral effects in the rat. Psychopharmacol 2002, 159: 341-50.
106. Reith, M.E. 5-HT3 receptor antagonists attenuate cocaine-induced locomotion in mice. Eur J Pharmacol 1990, 186: 327-30.
107. Van der Hoek, G.A., Cooper, S.J. Evidence that ondansetron, a selective 5-HT3 antagonist, reduces cocaine's psychomotor stimulant effects in the rat. Psychopharmacol 1990, 101 (Suppl.): S59.
108. King, G.R., Joyner, C.M., Ellinwood, E.H. 5-HT3 receptor modulation of behavior during withdrawal from continuous or intermittent cocaine. Pharmacol Biochem Behav 1994, 47: 399-407.
109. Le, A.D., Tomkins, D., Higgins, G., Quan, B., Sellers, E.M. Effects of 5-HT3, D1 and D2 receptor antagonists on ethanol- and cocaine-induced locomotion. Pharmacol Biochem Behav 1997, 57: 325-32.
110. Ohuoha, D.C., Schindler, C.W., Rothman, R.B. Serotonin-4 receptor antagonists reverse cocaine-induced cardiac arrhythmia. Life Sci 1998, 63: 1673-8.
111. McMahon, L.R., Cunningham, K.A. Antagonism of 5-hydroxytryptamine(4) receptors attenuates hyperactivity induced by cocaine: Putative role for 5-hydroxytryptamine(4) receptors in the nucleus accumbens shell. J Pharmacol Exp Therap 1999, 291: 300-7.
112. Frantz, K.J., Hansson, K.J., Stouffer, D.G., Parsons, L.H. 5-HT(6) receptor antagonism potentiates the behavioral and neurochemical effects of amphetamine but not cocaine. Neuropharmacol 2002, 42: 170-80.
113. Herges, S., Taylor, D.A. Modulation of cocaine-induced locomotor activity, rears and head bobs by application of WAY100635 into the dorsal and median raphe nuclei of the rat. Naunyn Schmiedeberg's Arch Pharmacol 1999, 360: 129-34.
114. McMahon, L.R., Filip, M., Cunningham, K.A. Differential regulation of the mesoaccumbens circuit by serotonin 5-hydroxytryptamine (5-HT)2A and 5-HT2C receptors. J Neurosci 2001, 21: 7781-7.
115. Tzschentke, T.M. Measuring reward with the conditioned place preference paradigm: A comprehensive review of drug effects, recent progress and new issues. Prog Neurobiol 1998, 56: 613-72.
116. Biggio, G., Fadda, F., Fanni, P., Tagliamonte, A., Gessa, G.L. Rapid depletion of serum tryptophan, brain tryptophan, serotonin and 5-hydroxyindoleacetic acid by a tryptophan-free diet. Life Sci 1974, 14: 1321-9.
117. Aronson, S.C., Black, J.E., McDougle, C.J. et al. Serotonergic mechanisms of cocaine effects in humans. Psychopharmacol 1995, 119: 179-85.
118. Satel, S.L., Krystal, J.H., Delgado, P.L., Kosten, T.R., Charney, D.S. Tryptophan depletion and attenuation of cue-induced craving for cocaine. Am J Psychiatry 1995, 152: 778-83.
119. Walsh, S.L., Preston, K.L., Sullivan, J.T., Fromme, R., Bigelow, G.E. Fluoxetine alters the effects of intravenous cocaine in humans. J Clin Psychopharmacol 1994, 14: 396-407.
120. Grabowski, J., Rhoades, H., Elk, R. et al. Fluoxetine is ineffective for treatment of cocaine dependence or concurrent opiate and cocaine dependence: Two placebo-controlled double-blind trials. J Clin Psychopharmacol 1995, 15: 163-74.
121. Batki, S.L., Washburn, A.M., Delucchi, K., Jones, R.T. A controlled trial of fluoxetine in crack cocaine dependence. Drug Alcohol Depend 1996, 41: 137-42.
122. Covi, L., Hess, J.M., Kreiter, N.A., Haertzen, C.A. Effects of combined fluoxetine and counseling in the outpatient treatment of cocaine abusers. Am J Drug Alcohol Abuse 1995, 21: 327-44.
123. Chadwick, M.J., Gregory, D.L., Wendling, G. A double-blind amino acids, L-tryptophan and L-tyrosine, and placebo study with cocaine-dependent subjects in an inpatient chemical dependency treatment center. Am J Drug Alcohol Abuse 1990, 16: 275-86.
124. Ehrman, R.N., Robbins, S.J., Cornish, J.W., Childress, A.R., O'Brien, C.P. Failure of ritanserin to block cocaine cue reactivity in humans. Drug Alcohol Depend 1996, 42: 167-74.
125. Cornish, J.W., Maany, I., Fudala, P.J., Ehrman, R.N., Robbins, S.J., O'Brien, C.P. A randomized, double-blind, placebo-controlled study of ritanserin pharmacotherapy for cocaine dependence. Drug Alcohol Depend 2001, 61: 183-9.
126. Cunningham, K.A., Paris, J.M., Goeders, N.E. Chronic cocaine enhances serotonin autoregulation and serotonin uptake binding. Synapse 1992, 11: 112-23.