Failure of ritanserin to block cocaine cue reactivity in humans

Drug and Alcohol Dependence

Volumn 42, Issue 3, 1996, Pages 167-174

  Ehrman, Ronald N ^a   Robbins, Steven J ^a   Cornish, James W ^a   Childress, Anna Rose ^a   O'Brien, Charles P ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Cocaine; Psychosis; Ritanserin

Indexed keywords

COCAINE; RITANSERIN;

ADULT; ARTICLE; ASSOCIATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DEPENDENCE; DRUG EFFECT; DRUG USE; HEART RATE; HUMAN; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; SKIN CONDUCTANCE; SKIN TEMPERATURE; TREATMENT FAILURE; WITHDRAWAL SYNDROME;

EID: 0030561364     PISSN: 03768716     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0376-8716(96)01278-1     Document Type: Article

References (36)

1. Adam, K. and Oswald, I. (1989) Effects of repeated ritanserin on middle-aged poor sleepers. Psychopharmacology 99, 219-221.
2. Alim, T.N., Rosse, R.B., Vocci, F.J. and Deutsch, S.I. (1994) Open-label, dose run-up study of diethylpropion in initial cocaine abstinence. Clin. Neuropharmacol. 17, 175-187.
3. Alim, T.N., Rosse, R.B., Vocci, F.J., Lindquist, T. and Deutsch, S.I. (1995) Diethylpropion pharmacotherapeutic adjuvant therapy for inpatient treatment of cocaine dependence: A test of the cocaine-agonist hypothesis. Clin. Neuropharmacol. 18, 183-195.
4. Aronson, S.C., Black, J.E., McDougle, C.J., Scanley, B.E., Jatlow, P., Kosten, T.R., Heninger, G.R. and Price, L.H. (1995) Serotonergic mechanisms of cocaine effects in humans. Psychopharmacology 119, 179-185.
5. Baker, T.B., Morse, E. and Sherman, J.E. (1987). The motivation to use drugs. A psychobiological analysis of urges. In: The Nebraska Symposium on Motivation. Alcohol Use and Abuse (Rivers, C., ed.), University of Nebraska Press, Lincoln, pp. 257-323
6. Berger, S.P., Hall, S., Mickalian, J.D., Reid, M.S., Crawford, C.A., Delucchi, K., Carr, K. and Hall, S. (1996) Haloperidol antagonism of cue-elicited cocaine craving. Lancet 347, 504-508.
7. 2 receptor antagonism in dysthymic disorder: a double-blind placebo-controlled study with ritanserin. Acta Psychiatr. Scand. 83, 244-248.
8. Childress, A.R., Ehrman. R., McLellan, A.T., MacRae, J., Natale, M. and O'Brien, C.P. (1994) Can induced moods trigger drug-related responses in opiate abuse patients? J. Sub. Abuse Treat. 11, 17-23.
9. Childress, A.R., Ehrman, R.N., McLellan, A.T. and O'Brien, C.P. (1988) Conditioned craving and arousal in cocaine addiction: A preliminary report. NIDA Res, Monograph 81, 74-80.
10. Ehrman, R.N., Robbins, S.J., Childress, A.R. and O'Brien, C.P. (1992) Conditioned responses to cocaine-related stimuli in cocaine abuse patients. Psychopharmacology 107, 523-529.
11. Gold, M.S., Miller, N.S. and Jonas, J.M. (1992) Cocaine (and crack): Neurobiology. In: Substance Abuse: A Comprehensive Textbook (Lowinson, J.H., Ruiz, P. and Millman, R.B., eds.), 2nd edn. Williams and Wilkins, Philadelphia, pp. 222-235).
12. Hensman, R., Guimaraes, F.S., Wang, M. and Deakin, J.F.W. (1991) Effects of ritanserin on aversive classical conditioning in humans. Psychopharmacology 104, 220-224.
13. Howell, L.L. and Byrd, L.D. (1995) Serotonergic modulation of the behavioral effects of cocaine in the squirrel monkey. J. Pharmacol. Exp. Ther. 275, 1551-1559.
14. Kamali, F., Stansfield, S.C., Ashton, C.H., Hammond, G.L., Emanuel, M.B. and Rawlins, M.D. (1992) Absence of withdrawal effects of ritanserin following chronic dosing in healthy volunteers. Psychopharmacology 108, 213-217.
15. Kosten, T.R. (1992) Can cocaine craving be a medication development outcome? Am. J. Addict. 1, 230-239.
16. Kranzler, H.R. and Bauer, L.O. (1992) Bromocriptine and cocaine cue reactivity in cocaine-dependent patients. Br. J. Addict. 87, 1537-1548.
17. Lacosta, S. and Roberts, D.C.S. (1993) MDL 72222, ketanserin, and methysergide pretreatments fail to alter breaking points on a progressive ratio schedule reinforced by intravenous cocaine. Pharmacol. Biochem. Behav. 44, 161-165.
18. 2 receptor blocker, as add-on treatment in narcolepsy. Sleep 14, 130-132.
19. Levy, A.D., Li, Q., Kerr, J.E., Rittenhouse, P.A., Milonas, G., Cabrera, T.M., Battaglia, G., Avarez Sanz, M.C. and Van de Kar, L.D. (1991) Cocaine-induced elevations of plasma adrenocorticotropin hormone and corticosterone is mediated by serotonergic neurons. J. Pharmacol. Exp. Ther. 259, 495-500.
20. Margolin, A., Avants, K. and Kosten, T.R. (1994) Cue-elicited cocaine craving and autogenic relaxation: Association with treatment outcome. J. Sub. Abuse Treat. 11, 549-552.
21. McLellan, A.T., Luborsky, L., Woody, G.E. and O'Brien, C.P. (1980). An improved diagnostic evaluation instrument for substance abuse patients: The Addiction Severity Index. J. Nerv. Ment. Dis. 168, 26-33.
22. 2 antagonist attenuates craving for cocaine by rats. Pharmacol. Biochem. Behav. 46, 125-129.
23. McNair, D., Lorr, M. and Droppleman, L. (1971) Manual: Profile of Mood States. Educational and industrial Testing Service, San Diego.
24. Meert, T.F., Awouters, Fl, Niemegeers, C.J. and Schellekens, K.H. (1991) Ritanserin reduces abuse of alcohol, cocaine, and fentanyl in rats. Pharmacopsychiatry 24, 159-162.
25. Meert, T.F. and Janssen, P.A.J. (1992) Ritanserin, a new therapeutic approach for drug abuse. Part 2: Effects on cocaine. Drug Dev. Res. 25, 39-53.
26. Monti, J.M., Alterwain, P., Estevez, F., Alvarino, F., Giusti, M.,Olivera, S. and Labraga, P. (1993) The effects of ritanserin on mood and sleep in abstinent alcoholic patients. Sleep 16, 647-654.
27. Negrete, J.C. and Emil, S. (1992) Cue-evoked arousal in cocaine users: a study of variance and predictive value. Drug Alcohol Depend. 30, 187-192.
28. Nomidos, G.G. and Spyraki, C. (1988) Effects of ritanserin on the rewarding properties of d-amphetamine, morphine and diazepam revealed by conditioned place preference in rats. Pharmacol. Biochem. Behav. 30, 853-858.
29. Paiva, T., Arriaga, F., Wauquier, A., Lara, E., Largo, R. and Leitao, J. N. (1988) Effects of ritanserin on sleep disturbances of dysthmic patients. Psychopharmacology 96, 395-399.
30. Peltier, R.L., Emmett-Oglesby, M.W., Thomas, W.H. and Schenk, S. (1994) Failure of ritanserin to block the discriminative or reinforcing stimulus effects of cocaine. Pharmacol. Biochem. Behav. 48, 473-478.
31. Robbins, S.J., Ehrman, R.N., Childress, A.R. and O'Brien, C.P. (1992) Using cue reactivity to screen medications for cocaine abuse: a test of amantadine hydrochloride. Addict. Behav. 17, 491-499.
32. Robbins, S.J., Ehrman, R.N., Childress, A.R. and O'Brien, C.P. (1996) Relationships among physiological and self-report responses produced by cocaine-related cues. Addict, Behav. 22, 1-11.
33. Rosse, R.B., Alim, T.N., Fay-McCarthy, M., Collins, J.P., Vocci, F.J., Lindquist, T., Jentgen, C., Hess, A.L. and Deutsch, S.I. (1994) Nimodipine pharmacotherapeutic adjuvant therapy for inpatient treatment of cocaine dependence. Clin. Neuropharmacol. 17, 348-358.
34. Rosse, R.B., Alim, T.N., Johri, S.K., Hess, A.L. and Deutsch, S.I. (1995) Anxiety and pupil reactivity in cocaine dependent subjects endorsing cocaine-induced paranoia: preliminary report. Addiction 90, 981-984.
35. Satel, S.L., Krystal, J.H., Delgado, P.L., Kosten, T.R. and Charney, D.S. (1995) Tryptophan depletion and attenuation of cue-induced craving for cocaine. Am. J. Psychiatry 152, 778-783.
36. Witkin, J.M. (1994) Pharmacotherapy of cocaine abuse: Preclinical development. Neurosci. Biobehav. Rev. 18, 121-142.