Immunocytochemical detection of the serotonin transporter in rat brain

Neuroscience

Volumn 73, Issue 1, 1996, Pages 217-231

  Sur, C ^a   Betz, H ^a   Schloss, P ^a  

^a MAX PLANCK INSTITUTE FOR BRAIN RESEARCH   (Germany)

Author keywords

antidepressants; indoleamine; light microscopy; neurotransmitters; uptake; varicosity

Indexed keywords

COMPLEMENTARY DNA; NEUROTRANSMITTER; SEROTONIN; SEROTONIN RECEPTOR; SEROTONIN TRANSPORTER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTICLE; CONTROLLED STUDY; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; MICROSCOPY; NEUROANATOMY; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONINERGIC SYSTEM; TISSUE DISTRIBUTION;

EID: 0029904206     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/0306-4522(96)00030-9     Document Type: Article

References (65)

1. Amara S. G. and Kuhar M. J. (1993) Neurotransmitter transporters: recent progress. A. Rev. Neurosci. 16, 73-93.
2. Austin M. C., Bradley C. C., Mann J. J. and Blakely R. D. (1994) Expression of serotonin transporter messenger RNA in the human brain. J. Neurochem. 62, 2362-2367.
3. Barker E. L., Kimmel H. L. and Blakely R. D. (1994) Chimeric human and rat serotonin transporters reveal domains involved in recognition of transporter ligands. Molec. Pharmac. 46, 799-807.
4. Beaudet A. and Sotelo C. (1981) Synaptic remodeling of serotonin axon terminals in rat agranular cerebellum. Brain Res. 206, 305-329.
5. Blakely R. D., Berson H. E., Fremeau Jr R. T., Caron M. G., Peek M. M., Prince H. K. and Bradley C. C. (1991) Cloning and expression of a functional serotonin transporter from rat brain. Nature 354, 66-70.
6. Blier P. and de Montigny C. (1994) Current advances and trends in treatment of depression. Trends Pharmac. Sci. 15, 220-226.
7. Bliss T. V. P., Goddard G. V. and Riives M. (1983) Reduction of long term potentiation in the dendate gyrus of the rat following selective depletion of monoamines. J. Physiol., Lond. 334, 475-491.
8. Briley M. S., Langer S. Z., Raisman R., Sechter D. and Zarifian E. (1980) Tritiated imipramine binding sites are decreased in platelets of untreated depressed patients. Science 209, 303-305.
9. Bruns D., Engert F. and Lux H.-D. (1993) A fast activating presynaptic reuptake current during serotoninergic transmission in identified neurons of Hirudo. Neuron 10, 559-572.
10. Burnet P. W. J., Michelson D., Smith M. A., Gold P. W. and Sternberg E. M. (1994) The effect of chronic imipramine administration on the densities of 5-HT1A and 5-HT2 receptors and the abundancies of 5-HT receptor and transporter mRNA in the cortex, hippocampus and dorsal raphe of three strains of rat. Brain Res. 638, 311-324.
11. 3H]citalopram. Neuroscience 54, 691-699.
12. 3H]imipramine. J. Pharmac. exp. Ther. 242, 364-371.
13. Datiche F., Luppi P.-H. and Cattarelli M. (1995) Serotoninergic and non-serotoninergic projections from the raphe nuclei to the piriform cortex in the rat: a cholera toxin B subunit (CTb) and 5-HT immunohistochemical study. Brain Res. 671, 27-37.
14. +-dependent, fluoxetine-sensitive serotonin uptake by astrocytes tissue-printed from rat cerebral cortex. J. Neurosci. 14, 4972-4986.
15. 3H]imipramine binding sites: association and serotoninergic neurons. Brain Res. Bull. 11, 325-334.
16. 3H]paroxetine binding is altered in the hippocampus but not the frontal cortex or caudate nucleus from subjects with schizophrenia. J. Neurochem. 64, 1197-1202.
17. Fujita M., Shimada S., Maeno H., Nishimura T. and Tohyama M. (1993) Cellular localization of serotonin transporter mRNA in the rat brain. Neurosci. Lett. 162, 59-62.
18. Fuxe K. and Jonsson G. (1967) A modification of the histochemical fluorescence method for the improved localization of 5-HT. Histochemie 11, 161-166.
19. 3H]imipramine binding sites in the brain of the rat: relationship to ascending 5-hydroxytryptamine neuron system. Proc. natn. Acad. Sci. U.S.A. 80, 3836-3840.
20. Gerson S. C. and Baldessarini R. J. (1980) Motor effects of serotonin in the central nervous system. Life Sci. 27, 1435-1451.
21. Hartig P. R. (1989) Molecular biology of 5-HT receptors. Trends pharmac. Sci. 10, 64-69.
22. Hoffman B. J., Mezey E. and Brownstein M. J. (1991) Cloning of a serotonin transporter affected by antidepressants. Science 254, 579-580.
23. 3H]imipramine binding in rat brain. Eur. J. Pharmac. 102, 481-488.
24. 3H]imipramine localization and relationship to serotonin transporter. J. Pharmac. exp. Ther. 252, 410-418.
25. Iversen L. L. (1973) Catecholamine uptake processes. Br. med. Bull. 29, 130-135.
26. Kilty J. E., Lorang D. and Amara S. G. (1991) Cloning and expression of a cocaine-sensitive rat dopamine transporter. Science 254, 578-579.
27. 3H]cyanoimipramine. Brain Res. 454, 78-88.
28. Laemmli U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
29. 3H]imipramine binding in rat hypothalamus: association with uptake of serotonin but not of norepinephrine. Science 210, 1133-1135.
30. Lidov H. G. W., Grzanna R. and Molliver M. E. (1980) The serotonin innervation of the cerebral cortex in the rat - an immunohistochemical analysis. Neuroscience 5, 207-227.
31. Lorang D., Amara S. G. and Simerly R. B. (1994) Cell-type-specific expression of catecholamine transporters in the rat brain. J. Neurosci. 14, 4903-4914.
32. Mayeux R., Stern Y., Cote L. and Williams J. B. W. (1984) Altered serotonin metabolism in depressed patients with Parkinson's disease. Neurology 34, 642-646.
33. Mayser W., Betz H. and Schloss P. (1991) Isolation of cDNAs encoding a novel member of the neurotransmitter transporter gene family. Fedn Eur. biochem. Socs. Lett. 295, 203-206.
34. Meltzer H. Y. and Lowry M. T. (1987) The serotonin hypothesis of depression. In Psychopharmacology, the Third Generation of Progress, 3rd edn (ed. Meltzer H. Y.), pp. 513-526. Raven Press, New York.
35. Mengod G., Nguyen H., Le H., Waeber C., Lübbert H. and Palacios J. M. (1990) The distribution and cellular localization of the serotonin 1c receptor mRNA in the rodent rat brain examined by in situ hybridization histochemistry. Comparison with receptor binding distribution. Neuroscience 35, 577-591.
36. 3H]imipramine in rat hippocampus. J. Neurochem. 47, 1609-1613.
37. Noda M., Takahashi H., Tanabe T., Toyosato T., Furutami Y., Hirose T., Asai M., Inayama T. and Numa S. (1982) Primary structure of a α-subunit of Torpedo californica acetylcholine receptor deduced from cDNA sequence. Nature 299, 793-797.
38. O'Hearn E., Battaglia G., De Souza E. B., Kuhar M. J. and Molliver M. E. (1988) Methylenedioxyamphetamine (MDA) and methylenedioxymetamphetamine (MDMA) cause selective ablation of serotoninergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity. J. Neurosci. 8, 2788-2803.
39. Oleskevich S. and Descarries L. (1990) Quantified distribution of the serotonin innervation in adult rat hippocampus. Neuroscience 34, 19-33.
40. Pacholczyk T., Blakely R. D. and Amara S. G. (1991) Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter. Nature 350, 350-353.
41. 3H]5-hydroxytryptamine. Neuroscience 6, 115-138.
42. Paxinos G. and Watson C. (1986) The Rat Brain in Stereotaxic Coordinates. Academic Press, San Diego.
43. Pompeiano M., Palacio J. M. and Mengod G. (1992) Distribution and cellular localization of mRNA coding for 5-HT1A receptor in the rat brain: correlation with receptor binding. J. Neurosci. 12, 440-453.
44. Qian Y., Melikian H. E., Rye D. B., Levey A. I. and Blakely R. D. (1995) Identification and characterization of antidepressant-sensitive serotonin transporter proteins using site-specific antibodies. J. Neurosci. 15, 1261-1274.
45. 3H-paroxetine binding sites in putamen. Neurology 36, 556-560.
46. Ramamoorthy S., Bauman A. L., Moore K. L., Han H., Yang Feng T., Chang A. S., Ganapathy V. and Blakely R. D. (1993) Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization. Proc. natn. Acad. Sci. U.S.A. 90, 2542-2546.
47. Ropert N. (1988) Inhibitory action of serotonin in CA1 hippocampal neurons in vitro. Neuroscience 26, 69-81.
48. Rudnick G. and Wall S. C. (1992) The molecular mechanism of "ecstasy" [3,4-methylenedioxymetamphetamine (MDMA)]: Serotonin transporters are targets for MDMA-induced serotonin release. Proc. natn. Acad. Sci. U.S.A. 89, 1817-1821.
49. 3H]indalpine binding sites in the rat brain - II. Regional distribution. J. Neurochem. 45, 521-526.
50. Scatton B., Javoy-Agid F., Rouquier L., Dubois B. and Agid Y. (1983) Reduction of cortical dopamine, noradrenaline, serotonin and their metabolites in Parkinson's disease. Brain Res. 275, 321-328.
51. 3H]citalopram binding. Biochemistry 34, 12,590-12,595.
52. 125I-α-bungarotoxin to Drosophila head membranes identifies a 42 kDa toxin binding polypeptide. Neurosci. Lett. 145, 63-66.
53. Schloss P., Püschel A. W. and Betz H. (1994) Neurotransmitter transporters: new members of known families. Curr. Opin. Cell Biol. 6, 595-599.
54. Shimada S., Kitayama S., Lin C.-L., Patel A., Nanthakumar E., Gregor P., Kuhar M. and Uhl G. (1991) Cloning and expression of a cocaine-sensitive dopamine transporter complementary DNA. Science 254, 576-578.
55. Steinbusch H. W. M. (1981) Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. Neuroscience 6, 557-618.
56. Thompson S. and Gähwiler B. H. (1992) Effects of the GABA uptake inhibitor tiagabine on inhibitory synaptic potentials in rat hippocampal slice cultures. J. Neurophysiol. 67, 1698-1701.
57. Traub R. D., Miles R. and Wong R. K. S. (1989) Model of the origin of rhythmic population oscillations in the hippocampal slice. Science 243, 1319-1325.
58. Vanderwolf C. H. (1989) A general role for serotonin in the control of behavior: studies with intracerebral 5,7-dihydroxytryptamine. Brain Res. 504, 192-198.
59. Vertes R. P. (1991) A PHA-L analysis of ascending projections of the dorsal raphe nucleus in the rat. J. comp. Neurol. 313, 643-668.
60. Watanabe Y., Sakai R. R., McEwens B. S. and Mendelson S. (1993) Stress and antidepressant effects on hippocampal and cortical 5-HT1A and 5-HT2 receptors and transport sites for serotonin. Brain Res. 615, 87-94.
61. 3H]Imipramine labels sites on brain astroglial cells not related to serotonin uptake. J. Neurochem. 41, 1319-1323.
62. Worrall D. M. and Williams D. C. (1994) Sodium ion-dependent transporters for neurotransmitters: a review of recent developments. Biochem. J. 297, 425-436.
63. Wright D. E., Seroogy K. B., Lundgren K. H., Davis B. M. and Jennes L. (1995) Comparative localization of serotonin 1A, 1C and 2 receptor subtype mRNAs in rat brain. J. comp. Neurol. 351, 357-373.
64. Yamamoto T. and Hirano A. (1985) Nucleus raphe dorsalis in Alzheimer's disease: neurofibrillary tangles and loss of large neurons. Ann. Neurol. 17, 573-577.
65. Yau J. L. W., Kelly P. A. T., Sharkey J. and Seckl J. R. (1994) Chronic 3,4-methylenedioxymetamphetamine administration decreases glucocorticoid and mineralocorticoid receptor, but increases 5-hydroxytryptamine 1C receptor gene expression in the rat hippocampus. Neuroscience 61, 31-40.