The 5-HT(1A) antagonist WAY 100635 can block the low-dose locomotor stimulant effects of cocaine

Brain Research

Volumn 862, Issue 1-2, 2000, Pages 242-246

  Carey, Robert ^a   Damianopoulos, Ernest ^a   Depalma, Gail ^a  

^a SYRACUSE VA MEDICAL CENTER   (United States)

Author keywords

5 HT(1A) receptors; Cocaine; Dopamine; Drugs of abuse: cocaine; Locomotion; Neural basis of behavior; WAY 100635

Indexed keywords

COCAINE; DOPAMINE TRANSPORTER; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; SEROTONIN 1A RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DOPAMINERGIC TRANSMISSION; DOSE RESPONSE; DRUG EFFECT; LOCOMOTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REWARD;

3,4-DIHYDROXYPHENYLACETIC ACID; ANIMALS; BEHAVIOR, ANIMAL; BRAIN CHEMISTRY; COCAINE; DOPAMINE; DOPAMINE UPTAKE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; LIMBIC SYSTEM; LOCOMOTION; MALE; PIPERAZINES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN ANTAGONISTS;

EID: 0034678534     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)02084-9     Document Type: Article

References (20)

1. Bardo M.T. Neuropharmacological mechanisms of drug reward: beyond dopamine in the nucleus accumbens. Crit. Rev. Neurobiol. 12:1998;37-67.
2. Carey R.J., Damianopoulos E.N. Activation of an apomorphine behavior pattern by cocaine: A new behavioral test for drug substitution. J. Neurosci. Methods. 46:1993;1-10.
3. Carey R.J., DePalma G. A simple, rapid HPLC method for the concurrent measurement of cocaine and catecholamines in brain tissue samples. J. Neurosci. Methods. 58:1995;25-28.
4. Cunningham K.A., Lakoski J.M. The interaction of cocaine with serotonin dorsal raphe neurons. Single-unit extracellular recording studies. Neuropsychopharmacology. 3:1990;41-50.
5. Cunningham K.A., Paris J.M., Goeders N.E. Chronic cocaine enhances serotonin autoregulation and serotonin uptake binding. Synapse. 11:1992;112-123.
6. 1A receptor antagonist. Behav. Brain Res. 73:1996;337-353.
7. Herges S., Taylor D.A. Involvement of serotonin in the modulation of cocaine-induced locomotor activity in the rat. Pharmacol. Biochem. Behav. 59:1998;595-611.
8. Koob G.F. Drugs of abuse: anatomy, pharmacology and function of reward pathways [Review]. Trends Pharmacol. Sci. 13:1992;177-184.
9. A.T. McLellan, A.R. Childress, R. Ehrman, R., C.P. O'Brien, Opiate and cocaine related stimuli elicit craving and physiological responses in drug-abuse patients, Presented at the meeting of Society for Stimulus Properties of Drugs, at Cape Cod, MA (1988) June 28.
10. Morency M.A., Beninger R.J. Dopaminergic substrates of cocaine-induced place conditioning. Brain Res. 399:1987;33-41.
11. Newlin D.B. A comparison of drug conditioning and craving for alcohol and cocaine. Galanter M. Recent Developments in Alcoholism. Vol. 10. Alcohol and Cocaine: Similarities and Differences:1992;147-164 Plenum, New York.
12. Newman A.H., Allen A.C., Izenwasser S., Katz J.L. Novel 3α-(diphenylmethoxy)tropane analogs: potent dopamine uptake inhibitors without cocaine-like behavioral profiles. J. Med. Chem. 37:1994;2258-2261.
13. Pettit H.O., Ettenberg A., Bloom F.E., Koob G.F. Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats. Psychopharmacology (Berlin). 84:1984;167-173.
14. Ritz M.C., Cone E.J., Kuhar M.J. Cocaine inhibition of ligand binding at dopamine, norepinephrine and serotonin transporters: a structure-activity study. Life Sci. 46:1990;635-645.
15. Robledo P., Maldonado-Lopez R., Koob G.F. Role of dopamine receptors in the nucleus accumbens in the rewarding properties of cocaine. Ann. NY Acad. Sci. 654:1992;509-512.
16. Rocha B.A., Fumagalli F., Gainetdinov R.R., Jones S.R., Ator R., Giros B., Miller G.W., Caron M.G. Cocaine self-administration in dopamine-transporter knockout mice. Nature Neurosci. 1:1998;132-137.
17. Rothman R.B., Grieg N., Kim A., deCosta B.R., Rice K.C., Carroll F.I., Pert A. Cocaine and GBR 12909 produce equivalent motoric responses at different occupancy of the dopamine transporter. Pharmacol. Biochem. Behav. 43:1992;1135-1142.
18. Spyraki C., Fibiger H.C., Phillips A.G. Cocaine-induced place preference conditioning: lack of effects of neuroleptics and 6-hydroxydopamine lesions. Brain Res. 253:1982;195-203.
19. Woolverton W.L., Johnson K.M. Neurobiology of cocaine abuse [Review]. Trends Pharmacol. Sci. 13:1992;193-200.
20. Woolverton W.L., Kleven M.S. Multiple dopamine receptors and the behavioral effects of cocaine. NIDA Res. Monogr. Series. 88:1988;160-184.