Differential antinociceptive effects induced by a selective cyclooxygenase-2 inhibitor (SC-236) on dorsal horn neurons and spinal withdrawal reflexes in anesthetized spinal rats

Neuroscience

Volumn 121, Issue 2, 2003, Pages 459-472

  You, H J ^a   Morch C D ^a   Chen, J ^a,b   Arendt Nielsen, L ^a  

^a AALBORG UNIVERSITY   (Denmark)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Bee venom; Cyclooxygenase; Inflammation; Nociception; Wide dynamic range neuron; Withdrawal reflex

Indexed keywords

4 [5 (4 CHLOROPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; ANTINOCICEPTIVE AGENT; BEE VENOM; CYCLOOXYGENASE 2 INHIBITOR; DIMETHYL SULFOXIDE;

AFTERDISCHARGE; ALLODYNIA; ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ELECTROSTIMULATION; FREQUENCY MODULATION; GASTROCNEMIUS MUSCLE; HYPERALGESIA; INFLAMMATION; MALE; MECHANICAL STIMULATION; MOTOR UNIT; NONHUMAN; PAIN; PRESSURE; PRIORITY JOURNAL; RAT; SENSITIZATION; SPINAL CORD DORSAL HORN; SPINAL REFLEX; WITHDRAWAL REFLEX;

EID: 0141533146     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(03)00296-3     Document Type: Article

References (45)

1. Arendt-Nielsen L., Brennum J., Sindrup S., Bak P. Electrophysiological and psychophysical quantification of temporal summation in the human nociceptive system. Eur J Appl Physiol. 68:1994;266-273.
2. Arendt-Nielsen L., Sonnenborg F.A., Andersen O.K. Facilitation of the withdrawal reflex by repeated transcutaneous electrical stimulation an experimental study on central integration in humans . Eur J Appl Physiol. 81:2000;165-173.
3. Ballou L.R., Botting R.M., Goorha S., Zhang J.Y., Vane J.R. Nociception in cyclooxygenase isozyme-deficient mice. Proc Natl Acad Sci USA. 97:2000;10272-10276.
4. Beiche F., Brune K., Geisslinger G., Goppelt-Struebe M. Expression of cyclooxygenase isoforms in the rat spinal cord and their regulation during adjuvant-induced arthritis. Inflamm Res. 47:1998;482-487.
5. Bjorkman R. Central antinociceptive effects of non-steroidal anti-inflammatory drugs and paracetamol experimental studies in the rat. Acta Anaesthesiol Scand. (Suppl 103):1995;1-44.
6. Blevins J.E., Stanley B.G., Reidelberger R.D. DMSO as a vehicle for central injections tests with feeding elicited by norepinephrine injected into the paraventricular nucleus . Pharmacol Biochem Behav. 71:2002;277-282.
7. Cashman J.N. The mechanisms of action of NSAIDs in analgesia. Drugs. 52:(Suppl. 5):1996;3-23.
8. Chapman V., Dickenson A.H. The spinal and peripheral roles of bradykinin and prostaglandins in nociceptive processing in the rat. Eur J Pharmacol. 219:1992;427-433.
9. Chen H.S., Chen J. Secondary heat, but not mechanical, hyperalgesia induced by subcutaneous injection of bee venom in the conscious rat effect of systemic MK-801, a non-competitive NMDA receptor antagonist . Eur J Pain. 4:2000;389-401.
10. Chen J., Luo C., Li H.L. The contribution of spinal neuronal changes to development of prolonged, tonic nociceptive responses of the cat induced by subcutaneous bee venom injection. Eur J Pain. 2:1998;359-376.
11. Chen J., Luo C., Li H.L., Chen H.S. Primary hyperalgesia to mechanical and heat stimuli following subcutaneous bee venom injection into the plantar surface of hind paw in the conscious rat a comparative study with the formalin test . Pain. 83:1999;67-76.
12. Dirig D.M., Konin G.P., Isakson P.C., Yaksh T.L. Effect of spinal cyclooxygenase inhibitors in rat using the formalin test and in vitro prostaglandin E2 release. Eur J Pharmacol. 23:1997;155-160.
13. Dirig D.M., Isakson P.C., Yaksh T.L. Effect of COX-1 and COX-2 inhibition on induction and maintenance of carrageenan-evoked thermal hyperalgesia in rats. J Pharmacol Exp Ther. 285:1998;1031-1038.
14. Goris R.J. Treatment of reflex sympathetic dystrophy with hydroxyl radical scavengers. Unfallchirurg. 88:1985;330-332.
15. Goris R.J., Dongen L.M., Winters H.A. Are toxic oxygen radicals involved in the pathogenesis of reflex sympathetic dystrophy? Free Radic Res Commun. 3:1987;13-18.
16. Herrero J.F., Headley P.M. Reversal by naloxone of the spinal antinociceptive actions of a systemically-administered NSAID. Br J Pharmacol. 118:1996;968-972.
17. Herrero J.F., Parrado A., Cervero F. Central and peripheral actions of the NSAID ketoprofen on spinal cord nociceptive reflexes. Neuropharmacology. 36:1997;1425-1431.
18. Herrero J.F., Laird J.M., Lopez-Garcia J.A. Wind-up of spinal cord neurones and pain sensation much ado about something? Prog Neurobiol. 61:2000;169-203.
19. Jurna I., Brune K. Central effect of the non-steroid anti-inflammatory agents, indometacin, ibuprofen, and diclofenac, determined in C fibre-evoked activity in single neurones of the rat thalamus. Pain. 41:1990;71-80.
20. Kurumbail R.G., Stevens A.N., Gierse J.K., Mcdonald J.J., Stegeman R.A., Pak J.Y., Gildehaus D., Miyashiro J.M., Penning T.D., Seibert K., Isakson P.C., Stallings W.C. Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents. Nature. 384:1996;644-648.
21. Lariviere W.R., Melzack R. The bee venom test a new tonic-pain test . Pain. 66:1996;271-277.
22. Lashbrook J.M., Ossipov M.H., Hunter J.C., Raffa R.B., Tallarida R.J., Porreca F. Synergistic antiallodynic effects of spinal morphine with ketorolac and selective COX1- and COX2-inhibitors in nerve-injured rats. Pain. 82:1999;65-72.
23. Malmberg A.B., Yaksh T.L. Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat. J Pharmacol Exp Ther. 263:1992;136-146.
24. Masferrer J.L., Koki A., Seibert K. COX-2 inhibitors a new class of antiangiogenic agents . Ann NY Acad Sci. 889:1999;84-86.
25. Mazario J., Gaitan G., Herrero J.F. Cyclooxygenase-1 vs. cyclooxygenase-2 inhibitors in the induction of antinociception in rodent withdrawal reflexes. Neuropharmacology. 40:2001;937-946.
26. Mendell L.M., Wall P.D. Responses of dorsal cord cells to peripheral cutaneous unmyelinated fibers. Nature. 206:1965;97-99.
27. Moore B.C., Simmons D.L. COX-2 inhibition, apoptosis, and chemoprevention by nonsteroidal anti-inflammatory drugs. Curr Med Chem. 7:2000;1131-1144.
28. Neugebauer V., Geisslinger G., Rumenapp P., Weiretter F., Szelenyi I., Brune K., Schaible H.G. Antinociceptive effects of R(-)- and S(+)-flurbiprofen on rat spinal dorsal horn neurons rendered hyperexcitable by an acute knee joint inflammation. J Pharmacol Exp Ther. 275:1995;618-628.
29. O'Neill G., Ford-Hutchinson A.W. Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues. FEBS Lett. 330:1993;156-160.
30. Pitcher G.M., Henry J.L. NSAID-induced cyclooxygenase inhibition differentially depresses long-lasting versus brief synaptically-elicited responses of rat spinal dorsal horn neurons in vivo. Pain. 82:1999;173-186.
31. Samad T.A., Moore K.A., Sapirstein A., Billet S., Allchorne A., Poole S., Bonventre J.V., Woolf C.J. Interleukin-1β-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity. Nature. 22:2001;471-475.
32. Santos A.R.S., Vedana E.M.A., De Freitas G.A.G. Antinociceptive effect of meloxicam, in neurogenic and inflammatory nociceptive models in mice. Inflamm Res. 47:1998;302-307.
33. Schomburg E.D., Steffens H., Mense S. Contribution of TTX-resistant C-fibres and Aδ-fibres to nociceptive flexor-reflex and non-flexor-reflex pathways in cats. Neurosci Res. 37:2000;277-287.
34. Schouenborg J., Sjölund B.H. Activity evoked by A- and C-afferent fibers in rat dorsal horn and its relation to a flexion reflex. J Neurophysiol. 50:1983;1108-1121.
35. Schouenborg J., Kalliomäki J. Functional organization of the nociceptive withdrawal reflexes I. Activation of hindlimb muscles in the rat . Exp Brain Res. 83:1990;67-78.
36. Sherrington C.S. The integrative action of the nervous system. 1906;Yale University Press, New Haven.
37. Southall M.D., Michael R.L., Vasko M.R. Intrathecal NSAIDs attenuate inflammation-induced neuropeptide release from rat spinal cord slices. Pain. 78:1998;39-48.
38. Vane J.R. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol. 231:1971;232-235.
39. Vane J.R., Mitchell J.A., Appleton I., Tomlinson A., Bishop-Bailey D., Croxtall J., Willoughby D.A. Inducible isoforms of cyclooxygense and nitric oxide synthase in inflammation. Proc Natl Acad Sci USA. 91:1994;2046-2050.
40. Willingale H.L., Gardiner N.J., Mclymont N., Giblett S., Grubb B.D. Prostanoids synthesized by cyclo-oxygenase isoforms in rat spinal cord and their contribution to the development of neuronal hyperexcitability. Br J Pharmacol. 122:1997;1593-1604.
41. Woolf C.J. Evidence for central component of post injury pain hypersensitivity. Nature. 306:1983;686-688.
42. Woolf C.J., Swett J.E. The cutaneous contribution to the hamstring flexor reflex in the rat an electrophysiological and anatomical study . Brain Res. 303:1984;299-312.
43. Yasojima K., Schwab C., McGeer E.G., McGeer P.L. Distribution of cyclooxygenase-1 and cyclooxygenase-2 mRNAs and proteins in human brain and peripheral organs. Brain Res. 830:1999;226-236.
44. You H.J., Chen J. Differential effects of subcutaneous injection of formalin and bee venom on responses of wide-dynamic-range neurons in spinal dorsal horn of the rat. Eur J Pain. 3:1999;177-180.
45. You H.J., Mørch C.D., Chen J., Arendt-Nielsen L. Simultaneous recordings of wind-up of paired spinal dorsal horn nociceptive neuron and nociceptive flexion reflex in rats. Brain Res. 960:2003;235-245.