Fusin - A place for HIV-1 and T4 cells to meet

Nature Medicine

Volumn 2, Issue 6, 1996, Pages 640-641

  Dimitrov, Dimiter S ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CYTOKINE RECEPTOR; FUSIDATE SODIUM; MEMBRANE PROTEIN;

CELL FUSION; DRUG RESISTANCE; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOTHERAPY; NOTE; PRIORITY JOURNAL; VIRUS ENVELOPE; VIRUS TRANSMISSION;

ANTIGENS, CD4; CD4-POSITIVE T-LYMPHOCYTES; CELL MEMBRANE; DRUG DESIGN; HIV ENVELOPE PROTEIN GP41; HIV-1; HUMANS; MEMBRANE PROTEINS; RECEPTORS, CXCR4;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0029945407     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0696-640     Document Type: Note

References (8)

1. Maddon, P.J. et al. The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell 47, 333-348 (1986).
2. Feng, Y., Broder, C.C., Kennedy, P.E. & Berger, E.A. HIV-1 entry cofactor: Functional cDNA cloning of a seven-transmembrane, G proteincoupled receptor. Science 272, 872-876 (1996).
3. Murphy, P.M. The molecular biology of leukocyte chemoattractant receptors. Ann. Rev. Immunol. 12, 593-633 (1994).
4. Blumenthal, R. & Dimitrov, D.S. Membrane fusion, in Handbook of Physiology (eds. Huffman, J.F. & Jamieson, J.C.) Vol. 1, eh. 14 (Oxford University Press, New York, 1996).
5. Capon, D.J. et al. Designing CD4 immunoadhesins for AIDS therapy. Nature 337, 525-531 (1989).
6. Wild, CT., Shugars, D.C., Greemvell, T.K., McDanal, C.B. & Matthews, T.J. Peptides corresponding to a predictive alpha-helical domain of human immunodeficiency virus type 1 gp41 are potent inhibitors of virus infection. Proc. Natl. Acad. Sci. USA 91, 9770-9774 (1994).
7. Burkly, L., Mulrey, N., Blumenthal, R. & Dimitrov, D.S. Synergistic inhibition of human immunodeficiency virus type 1 envelope glycoprotein-mediated cell fusion and infection by an antibody to CD4 domain 2 in combination with anti-gp120 antibodies. J. Virology 69, 4267-4273 (1995).
8. Reimann, K.A. et al. In vivo administration to rhesus monkeys of a CD4-specific monoclonal antibody capable of blocking AIDS virus replication. AIDS Res. Hum. Retroviruses 9, 199-207 (1993).