Caspase-dependent and -independent panc-1 cell death due to actinomycin D and MK 886 are additive but increase clonogenic survival

Experimental Biology and Medicine

Volumn 228, Issue 8, 2003, Pages 915-925

  Anderson, Kenning M ^a   Alrefai, Waddah ^a   Bonomi, Philip ^a   Seed, Thomas M ^b   Dudeja, Pradeep ^c   Hu, Yunming ^a   Harris, Jules E ^a  

^a RUSH MEDICAL COLLEGE   (United States)

^b ARMED FORCES RADIOBIOLOGY RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Actinomycin D; MK 886; Panc 1; Pancreatic cancer; Programmed cell death type 1 and type 2

Indexed keywords

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; CASPASE; DACTINOMYCIN; LIPOXYGENASE INHIBITOR;

ARTICLE; CANCER CELL CULTURE; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CLONOGENIC ASSAY; CONTROLLED STUDY; ENZYME ASSAY; HUMAN; HUMAN CELL; PANCREAS CANCER;

EID: 0141513738     PISSN: 15353702     EISSN: None     Source Type: Journal    
DOI: 10.1177/153537020322800807     Document Type: Article

References (49)

1. Zakeri Z, Bursch W, Tenniswood M, Lockshin RA. Cell death: programmed, apoptosis, necrosis or other? Cell Death Differ 2:87-96, 1995.
2. Bortner CD, Oldenburg NBE, Cidlowski JA. The role of DNA fragmentation in apoptosis. Trends Cell Biol 5:21-26, 1995.
3. Huschtscha LI, Bartier WA, Malmstrom A, Tattersall MHN. Cell death by apoptosis following anticancer drug treatment in vitro. Int J Oncol 6:585-593, 1995.
4. Scaffidi C, Fulda S, Srinivasan A, Friesen C, Li F, Tomaselli KJ, Debetin K-M, Krammer PH, Peter ME. Two CD95 (APO-1? Fas) signaling pathways. EMBO J 7:1675-1687, 1998.
5. Kroemer G, Reed JC. Mitochondrial control of cell death. Nat Med 6:513-519, 2000.
6. Kaufmann SH, Earnshaw WC. Induction of apoptosis by cancer chemotherapy. Exp Cell Res 256:42-49, 2000.
7. Ungerfogen H, Voss M, Jansen M, Roeder C, Henne-Bruns D, Kremer R, Kalthoff H. Human pancreatic adenocarcinoma express FAS and Fas ligand yet are resistant to Fas-mediated apoptosis. Can Res 68:1741-1749, 1998.
8. Susin SA, Zamzami N, Kroemer G. Mitochondria as regulators of apoptosis: doubt no more. Biochim Biophys Acta 1366:151-165, 1998.
9. Stahnke K, Fulda S, Friesen C, Straub G, Debatin K-M. Activation of apoptosis pathways in peripheral blood lymphocytes by in vivo chemotherapy. Blood 98:3066-3073, 2001.
10. Schimmer AD, Hedley DW, Penn LZ, Minden MD. Receptor- and mitochondrial-mediated apoptosis in acute leukemia: a translational view. Blood 98:3541-3553, 2001.
11. Park I-C, Park M-J, Hwang C-S, Rhee C-H, Whang D-Y, Jang J-J, Choe T-B, Hong S-I, Lee S-H. Mitomycin C induces apoptosis in a caspase-dependent and Fas/CD95-independent manner in human gastric adenocarcinoma cells. Can Lett 158:125-132, 2000.
12. Jacobson MD, Burne JF, King MP, Miyashira T, Reed JC, Raff MC. Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA. Nature 361:365-369, 1993.
13. Marchetti P, Susin SA, Ecaudin D, Gamen S, Castedo M, Hirsch T, Zamzani N, Naval J, Senik A, Kroemer G. Apoptosis-associated derangement of mitochondrial function in cells lacking mitochondrial DNA. Can Res 56:2033-2038, 1996.
14. Costantini P, Jacotot E, Decaudin D, Kroemer G. Mitochondria as a novel target of anti cancer chemotherapy. J Nat Can Inst 92:1042-1053, 2000.
15. Anderson KM, Seed T, Wilson DE, Harris JE. 5, 8, 11, 14-Eicosatetraenoic acid-induced destruction of mitochondria in human prostate cells (PC3). In Vitro Cell Dev Biol 28A:410-414, 1992.
16. Anderson KM, Harris JE. Is induction of type 2 programmed cell death in cancer cells from solid tumors directly related to mitochondrial mass? Med Hypo 57:87-90, 2001.
17. Egushi Y, Shimizu S, Tsujimoto Y. Intracellular ATP levels determine cell fate by necrosis or apoptosis. Can Res 57:1835-1840, 1997.
18. Gjersten BT, Cressey LI, Ruchaud S, Houge G, Lanotte M, Doskeland SO. Multiple apoptotic death types triggered through activation of separate pathways by cAMP and inhibitors of protein phosphatases in one (IPC) leukemia) cell line. J Cell Sci 107:3363-3377, 1994.
19. Asher E, Payne CM, Bernstein C. Evaluation of cell death in EBV-transformed lymphocytes using agarose gel electrophoresis, light microscopy and electron microscopy II. Induction of non-classic apoptosis ("para-aptosis") by tritiated thyymidine. Leukocyte Lymph 19:107-119, 1995.
20. Sperandio S, de Belle I, Bredesen DE. An alternative, nonapoptotic form of programmed cell death. Proc Natl Acad Sci U S A 97:14376-14381, 2000.
21. Bursch W. The autophagosomal-lysosomal compartment in programmed cell death. Cell Death Differ 8:569-581, 2001.
22. Zang Y, Beard RL, Chandraratna RAS, Kang JX. Evidence of a lysosomal pathway for apoptosis induced by the synthetic retinoid CD437 in human leukemia HL-60 cells. Cell Death Differ 8:477-485, 2001.
23. Orlowski RZ. The role of the ubiquitin-proteosome pathway in apoptosis. Cell Death Differ 6:303-313, 1999.
24. Nakagawa T, Zhu H, Morishoma N, Li E, Xu J, Yankee BA, Yuan J. Caspase-12 mediates endoplasmic reticulum-specific apoptosis and cytotoxicity by amyloid-β. Nature 403:98-103, 2000.
25. Saeki K, Yuo A, Okuma E, Yazaki Y, Susin SA, Kroemer G. Takaku F. Bcl-2 down-regulation causes autophagy in a caspase-independent manner in human leukemic HL60 Cells. Cell Death Differ 7:1263-1269, 2000.
26. Amarante-Mendes GP, Finucane DM, Martin SJ, Cotter TG, Salvesen GS, Green DR. Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death. Cell Death Differ 5:298-306, 1998.
27. Susin SA, Daugas E, Ravagnan L, Samejima K, Zamzami N, Loeffler M, Costantini P, Ferri KF, Irinopoulou T, Prevost M-C, Brothers G, Mak TW, Penninger J, Ernshaw WC, Kroemer G. Two distinct pathways leading to nuclear apoptosis. J Exp Med 192:571-579, 2000.
28. Chi S, Kitanaka C, Noguchi K, Mochizuki T, Nagashima Y, Shirouzu M, Fujita H, Yoshida M, Chen W, Asai A, Himeno M, Yokoyama S, Kuchino Y. Oncogenic ras triggers cell suicide through activation of a caspase-independent cell death program in human cancer cells. Oncogene 18:2281-2290, 1999.
29. Henkels KM, Turchi JJ. Cisplatin-induced apoptosis proceeds by caspase-3-dependent and -independent pathways in cisplatin-resistant and -sensitive human ovarian cancer cell lines. Can Res 59:3077-3083, 1999.
30. Kleeff J, Kornmann M, Sawhney H, Korc M. Actinomycin D induces apoptosis and inhibits growth of pancreatic cancer cells. Int J Can 86:399-407, 2000.
31. Datta K, Biswal SS, Kehrer JP. The 5-lipoxygenase-activating protein (FLAP) inhibitor, MK 886, induces apoptosis independently of FLAP. Biochem J 340:371-375, 1999.
32. Anderson KM, Alrefai WA, Anderson CA, Bonomi P, Harris JW. MK 886 functions as a radiomimetic agent: genomic responses related to oxidative stress, the cell cycle, proliferation and programmed cell death in Panc-1 cells. In: Honn KV, Marnett LJ, Nigam S, Dennis E, Serhan C, Eds. Eicosanoids and other Bioactive Lipids in Cancer, Inflammation and Related Diseases. New York and London, Kluwer Academic/Plenum Publishers, 2002, pp451-456.
33. Avis I, Hong SH, Martinez, A Moody T, Choi YH, Trepel J, Das R, Jett M, Mulshine JL. 5-Lipoxygenase inhibitors can mediate apoptosis in human breast cancer cell lines through complex eicosanoid interactions. FASEB J 15:2007-2009, 2001.
34. Anderson KM, Seed T, Meng J, Ou D, Alrefai WA, Harris JE. 5-Lipoxygenase inhibitors reduce panc-1 survival: the mode of cell death and synergism of MK 886 with γ linolenic acid. Antican Res 18:791-800, 1998.
35. Yin DX, Schimke RT. BCL-2 expression delays drug-induced apoptosis but does not increase clonogenic survival after drug treatment in HeLa cells. Can Res 55:4922-4928, 1995.
36. Lock RB, Stribinskiene L. Dual modes of death induced by ectoposide in human epithelial tumor cells allow Bcl-2 to inhibit apoptosis without affecting clonogenic survival. Can Res 56:4006-4012, 1996.
37. Ou D, Anderson KM, Leslie W, Bonomi P, Harris JE. Does maximizing programmed cell death necessarily yield an optimum clinical advantage? Med Hypo 52:235-238, 1999.
38. Tannock IF, Lee C. Evidence against apoptosis as a major mechanism for reproductive cell death following treatment of cell lines with anticancer drugs. Br J Can 84:100-105, 2001.
39. Lai PBS, Ross JA, Fearon KCH, Anderson JD, Carter DC. Cell cycle arrest and induction of apoptosis in pancreatic cancer cells exposed to eicosapentaenoic acid in vitro. Br J Can 74:1375-1383, 1996.
40. Hawkins RA, Sangster K, Arends MJ. Apoptotic death of pancreatic cancer cells induced by polyunsaturated fatty acids varies with double bond number and involves an oxidative mechanism. J Pathol 185:61-70, 1998.
41. Grossman J, Walther K, Artinger M, Kiessling S Scholmerich J. Apoptotic signaling during initiation of detachment-induced apoptosis ("anoikis" ) of primary human intestinal epithelial cells. Cell Growth Differ 12:147-155, 2001.
42. Collins RJ, Harmon BV, Gobe GC, Kerr JFR. Internucleosomal DNA cleavage should not be the sole criterion for identifying apoptosis. Int J Rad 61:451-453, 1992.
43. Schwartz LM, Smith SW, Jones MEE, Osborne BA. Do all programmed cell deaths occur via apoptosis? Proc Natl Acad Sci U S A 90:980-984, 1993.
44. Enari M, Sakahira H, Yokoyama H, Okawa K, Iwamatsu A, Nagata S. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 391:43-50, 1998.
45. Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM, Mangion J, Jacotot E, Costantini P, Loeffler M, Larochette N, Goodlett DR, Abersold R, Siderovski DP, Penninger JM, Kroemer G. Molecular characteristics of mitochondrial apoptosis-inducing factor. Nature 397:441-446, 1999.
46. Dumont JE, Pecasse F, Maenhaut C. Crosstalk and specificity in signaling: Are we cross-talking ourselves into general confusion? Cell Signal 13:457-464, 2001.
47. Choi Y-J, Park J-W, Woo J-H, Kim Y-H, Lee S-H, Lee J-M, Kwon TK. Failure to activate caspase 3 in phorbol ester-resistant leukemia cells is associated with resistance to apoptotic cell death. Can Lett 182:183-191, 2002.
48. Anderson KM, Seed T, Plate JMD, Jajeh A, Meng J, Harris JE. Selective inhibitors of 5-lipoxygenase reduce CML blast cell proliferation and induce limited differentiation and apoptosis. Leukocyte Res 19:789-801, 1995.
49. Anderson KM, Alrefai WA, Anderson CA, Bonomi P, Harris JE. Widespread countervailing genomic responses induced by chemotherapy or radiation as a cause of therapeutic failure. Med Hypo 54:1000-1002, 2000.