Effect of DL-α-lipoic acid on neural antioxidants in aged rats

Pharmacological Research

Volumn 42, Issue 3, 2000, Pages 219-222

  Arivazhagan, P ^a   Panneerselvam, C ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Antioxidants; Lipid peroxide and aged rats; Lipoic acid

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; GLUTATHIONE; MALONALDEHYDE; THIOCTIC ACID;

AGING; ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN PROTECTION; CONTROLLED STUDY; DEGENERATIVE DISEASE; DRUG EFFICACY; DRUG MECHANISM; HUMAN; LIPID PEROXIDATION; MALE; PRIORITY JOURNAL; RAT;

EID: 0033824498     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.2000.0679     Document Type: Article

References (32)

1. Ageing-associated changes in human brain
2. Oxidative processes and antioxidative defense mechanisms in the ageing brain
3. Age and peroxidative stress-related modifications of the cerebral enzymatic activities linked to mitochondria and the glutathione system
4. Alzheimer's and Parkinson's disease. Brain levels of glutathione, glutathione disulfide, and vitamin E
5. Vitamin E prevents oxidative modification of brain and lymphocyte band 3 proteins during ageing
6. Alpha-lipoic acid: Antioxidant potency against lipid peroxidation of neural tissues in vitro and implications for diabetic neuropathy
7. α-lipoic acid protects against reperfusion injury following cerebral ischemia in rats
8. Age-associated decline in ascorbic acid concentration, recycling, and biosynthesis in rat hepatocytes - Reversal with α-lipoic acid supplementation
9. Effect of DL-α-lipoic acid on the status of lipid peroxidation and antioxidants in aged rats
10. Levels of glutathione reductase, glutathione-S-transferase activities in rat lung and liver
11. Selected methods for the determination of ascorbic acid in animal cells, tissues and fluids
12. Vitamin E analysis method for animal tissues
13. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
14. Free radical-lipid interactions and their pathological consequences
15. Dynamics of lipid peroxidation and its inhibition by antioxidants
16. Low glutathione levels in brain regions of aged rats
17. Oxidative stress and mitochondrial DNA mutations in human aging
18. + in Drosophila-melanogaster
19. Antioxidants in human health and disease
20. Thioctic acid and dihydrolipoic acid are novel antioxidants which interact with reactive oxygen species
21. Thioctic (lipoic) acid: A therapeutic metal-chelating antioxidant?
22. Cellular defenses against damage from reactive oxygen species
23. The effect of ageing on glutathione and cysteine levels in different regions of the mouse brain
24. Influence of oxidative stress on the age linked alterations of the cerebral glutathione system
25. Dihydrolipoic acid activates oligomycin - Sensitive thiol groups and increases ATP synthesis in mitochondria
26. Lipoic acid increases de novo synthesis of cellular glutathione by improving cysteine utilization
27. Unequivocal evidence in support of the non-enzymatic redox coupling between glutathione/glutathione disulfide and ascorbic acid/dehydroascorbic acid
28. Effect of ascorbic acid supplementation on phagocytic function in rats during ageing
29. Neurochemical, neurophysiological and neuropathological studies in vitamin E deficiency
30. Effect of age on vitamin E concentrations in various regions of the brain and a few selected peripheral tissues of the rat, and on the uptake of radioactive vitamin E by various regions of rat brain
31. Neuroprotection by the metabolic antioxidant α-lipoic acid
32. Dihydrolipoic acid - A universal antioxidant both in the membrane and in the aqueous phase. Reduction in peroxyl, ascorbyl and chromanoxyl radicals