α-lipoic acid protects the retina against ischemia-reperfusion

Neuropharmacology

Volumn 43, Issue 6, 2002, Pages 1015-1025

  Chidlow, G ^a   Schmidt, K G ^a   Wood, J P M ^a   Melena, J ^b   Osborne, N N ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

Author keywords

lipoic acid; Antioxidant; Ischemia reperfusion; Neuroprotection; Retina

Indexed keywords

ASCORBIC ACID; BASIC FIBROBLAST GROWTH FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR; CALCIUM CHANNEL; CILIARY NEUROTROPHIC FACTOR; DEFEROXAMINE; DILTIAZEM; DIZOCILPINE; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTATHIONE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MELATONIN; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID; NEUROFILAMENT PROTEIN; NIFEDIPINE; NITRIC OXIDE SYNTHASE; RHODOPSIN; SODIUM CHANNEL; TETRODOTOXIN; THIOCTIC ACID; THY 1 ANTIGEN; VERATRIDINE;

A WAVE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANOXIA; ARTICLE; B WAVE; CONTROLLED STUDY; DRUG EFFECT; ELECTRORETINOGRAM; EYE PROTECTION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INTRAOCULAR PRESSURE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; RETINA GANGLION CELL; RETINA ISCHEMIA; RETINA NERVE CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYSTOLIC BLOOD PRESSURE;

ANESTHETICS, LOCAL; ANIMALS; ANTIGENS, THY-1; ANTIOXIDANTS; BINDING, COMPETITIVE; BRAIN-DERIVED NEUROTROPHIC FACTOR; CALCIUM; CALCIUM CHANNEL BLOCKERS; CELLS, CULTURED; CILIARY NEUROTROPHIC FACTOR; DILTIAZEM; DIZOCILPINE MALEATE; DNA PRIMERS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ELECTRORETINOGRAPHY; FIBROBLAST GROWTH FACTORS; GLIAL FIBRILLARY ACIDIC PROTEIN; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; N-METHYLASPARTATE; NIFEDIPINE; RATS; REPERFUSION INJURY; RETINAL DISEASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHODOPSIN; RNA, MESSENGER; SODIUM; TETRODOTOXIN; THIOCTIC ACID; VERATRIDINE;

EID: 0036849110     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(02)00129-6     Document Type: Article

References (43)

1. Aguirre N., Barrionuevo M., Ramirez M.J., Del Rio J., Lasheras B. Alpha-lipoic acid prevents 3,4-methylenedioxy-methamphetamine (MDMA)-induced neurotoxicity. Neuroreport. 10:1999;3675-3680.
2. Biewenga G.P., Haenen G.R., Bast A. The pharmacology of the antioxidant lipoic acid. General Pharmacology. 29:1997;315-331.
3. Block F., Schwarz M. Effects of antioxidants on ischemic retinal dysfunction. Experimental Eye Research. 64:1997;559-564.
4. Block F., Schwarz M. The b-wave of the electroretinogram as an index of retinal ischemia. General Pharmacology. 30:1998;281-287.
5. Bonne C., Muller A., Villain M. Free radicals in retinal ischemia. General Pharmacology. 30:1998;275-280.
6. Chidlow G., Melena J., Osborne N.N. Betaxolol, a beta(1)-adrenoceptor antagonist, reduces Na(+) influx into cortical synaptosomes by direct interaction with Na(+) channels: comparison with other beta-adrenoceptor antagonists. British Journal of Pharmacology. 130:2000;759-766.
7. Chun M.H., Ju W.K., Kim K.Y., Lee M.Y., Hofmann H.D., Kirsch M., Oh S.J. Upregulation of ciliary neurotrophic factor in reactive Muller cells in the rat retina following optic nerve transection. Brain Research. 868:2000;358-362.
8. Coleman K., Fitzgerald D., Eustace P., Bouchier Hayes D. Electroretinography, retinal ischaemia and carotid artery disease. European Journal of Vascular Surgery. 4:1990;569-573.
9. Freisleben H.J. Lipoic acid reduces ischemia-reperfusion injury in animal models. Toxicology. 148:2000;159-171.
10. Gilgun Sherki Y., Melamed E., Offen D. Oxidative stress induced-neurodegenerative diseases: the need for antioxidants that penetrate the blood brain barrier. Neuropharmacology. 40:2001;959-975.
11. Greenamyre J.T., Garcia Osuna M., Greene J.G. The endogenous cofactors, thioctic acid and dihydrolipoic acid, are neuroprotective against NMDA and malonic acid lesions of striatum. Neuroscience Letters. 171:1994;17-20.
12. Han D., Sen C.K., Roy S., Kobayashi M.S., Tritschler H.J., Packer L. Protection against glutamate-induced cytotoxicity in C6 glial cells by thiol antioxidants. American Journal of Physiology. 273:1997;R1771-1778.
13. Hayreh S.S. The blood supply of the optic nerve head and the evaluation of it - myth and reality. Progress in Retinal and Eye Research. 20:2001;563-593.
14. Honjo M., Tanihara H., Kido N., Inatani M., Okazaki K., Honda Y. Expression of ciliary neurotrophic factor activated by retinal Muller cells in eyes with NMDA - and kainic acid-induced neuronal death. Investigative Ophthalmology and Visual Science. 41:2000;552-560.
15. Ju W.K., Kim K.Y., Park S.J., Park D.K., Park C.B., Oh S.J., Chung J.W., Chun M.H. Nitric oxide is involved in sustained and delayed cell death of rat retina following transient ischemia. Brain Research. 881:2000;231-236.
16. Ju W.K., Lee M.Y., Hofmann H.D., Kirsch M., Chun M.H. Expression of CNTF in Muller cells of the rat retina after pressure-induced ischemia. Neuroreport. 10:1999;419-422.
17. Kowluru R.A., Kennedy A. Therapeutic potential of anti-oxidants and diabetic retinopathy. Expert Opinion on Investigational Drugs. 10:2001;1665-1676.
18. Love S. Oxidative stress in brain ischemia. Brain Pathology. 9:1999;119-131.
19. Martinez Vila E., Sieira P.I. Current status and perspectives of neuroprotection in ischemic stroke treatment. Cerebrovascular Diseases. 11:(1):2001;60-70.
20. Melena J., Osborne N.N. Voltage-dependent calcium channels in the rat retina: involvement in NMDA-stimulated influx of calcium. Experimental Eye Research. 72:2001;393-401.
21. 2+ channels. European Journal of Pharmacology. 378:1999;317-322.
22. Mitsui Y., Schmelzer J.D., Zollman P.J., Mitsui M., Tritschler H.J., Low P.A. Alpha-lipoic acid provides neuroprotection from ischemia-reperfusion injury of peripheral nerve. Journal of Neurological Sciences. 163:1999;11-16.
23. Muller U., Krieglstein J. Prolonged pretreatment with alpha-lipoic acid protects cultured neurons against hypoxic, glutamate-, or iron-induced injury. Journal of Cerebral Blood Flow and Metabolism. 15:1995;624-630.
24. Narahashi T., Huang C.S., Song J.H., Yeh J.Z. Ion channels as targets for neuroprotective agents. Annals of the New York Academy of Sciences. 825:1997;380-388.
25. Nash M.S., Osborne N.N. Assessment of Thy-1 mRNA levels as an index of retinal ganglion cell damage. Investigative Ophthalmology and Visual Science. 40:1999;1293-1298.
26. Nash M.S., Wood J.P., Melena J., Osborne N.N. Flupirtine ameliorates ischaemic-like death of rat retinal ganglion cells by preventing calcium influx. Brain Research. 856:2000;236-239.
27. Obrosova I.G., Fathallah L., Greene D.A. Early changes in lipid peroxidation and antioxidative defense in diabetic rat retina: effect of DL-alpha-lipoic acid. European Journal of Pharmacology. 398:2000;139-146.
28. Obrosova I.G., Stevens M.J., Lang H.J. Diabetes-induced changes in retinal NAD-redox status: pharmacological modulation and implications for pathogenesis of diabetic retinopathy. Pharmacology. 62:2001;172-180.
29. Organisciak D.T., Darrow R.M., Jiang Y.I., Marak G.E., Blanks J.C. Protection by dimethylthiourea against retinal light damage in rats. Investigative Ophthalmology and Visual Science. 33:1992;1599-1609.
30. Osborne N.N., Larsen A.K. Antigens associated with specific retinal cells are affected by ischaemia caused by raised intraocular pressure: effect of glutamate antagonists. Neurochemistry International. 29:1996;263-270.
31. Osborne N.N., Melena J., Chidlow G., Wood J.P. A hypothesis to explain ganglion cell death caused by vascular insults at the optic nerve head: possible implication for the treatment of glaucoma. British Journal of Ophthalmology. 85:2001;1252-1259.
32. Osborne N.N., Chidlow G., Wood J.P., Schmidt K.G., Casson R., Melena J. Expectations in the treatment of retinal diseases: neuroprotection. Current Eye Research. 22:2001;321-332.
33. Osborne N.N., Ugarte M., Chao M., Chidlow G., Bae J.H., Wood J.P., Nash M.S. Neuroprotection in relation to retinal ischemia and relevance to glaucoma. Survey of Ophthalmology. 43:(1):1999;S102-S128.
34. Packer L., Tritschler H.J., Wessel K. Neuroprotection by the metabolic antioxidant alpha-lipoic acid. Free Radical Biology and Medicine. 22:1997;359-378.
35. Packer L., Witt E.H., Tritschler H.J. Alpha-lipoic acid as a biological antioxidant. Free Radical Biology and Medicine. 19:1995;227-250.
36. Schonheit K., Gille L., Nohl H. Effect of alpha-lipoic acid and dihydrolipoic acid on ischemia/reperfusion injury of the heart and heart mitochondria. Biochimica et Biophysica Acta. 1271:1995;335-342.
37. 2+ exchanger. Journal of Neuroscience. 12:1992;430-439.
38. Tirosh O., Sen C.K., Roy S., Kobayashi M.S., Packer L. Neuroprotective effects of alpha-lipoic acid and its positively charged amide analogue. Free Radical Biology and Medicine. 26:1999;1418-1426.
39. Unoki K., LaVail M.M. Protection of the rat retina from ischemic injury by brain-derived neurotrophic factor, ciliary neurotrophic factor, and basic fibroblast growth factor. Investigative Ophthalmology and Visual Science. 35:1994;907-915.
40. Vorwerk C.K., Gorla M.S.R., Dreyer E.B. An experimental basis for implicating excitotoxicity in glaucomatous optic neuropathy. Survey of Ophthalmology. 43:1999;S142-S150.
41. Wen R., Cheng T., Song Y., Matthes M.T., Yasumura D., LaVail M.M., Steinberg R.H. Continuous exposure to bright light upregulates bFGF and CNTF expression in the rat retina. Current Eye Research. 17:1998;494-500.
42. Wen R., Song Y., Cheng T., Matthes M.T., Yasumura D., LaVail M.M., Steinberg R.H. Injury-induced upregulation of bFGF and CNTF mRNAS in the rat retina. Journal of Neuroscience. 15:1995;7377-7385.
43. Wood J.P., DeSantis L., Chao H.M., Osborne N.N. Topically applied betaxolol attenuates ischaemia-induced effects to the rat retina and stimulates BDNF mRNA. Experimental Eye Research. 72:2001;79-86.