Pentoxifylline inhibits platelet-derived growth factor-stimulated cyclin D1 expression in mesangial cells by blocking Akt membrane translocation

Molecular Pharmacology

Volumn 64, Issue 4, 2003, Pages 811-822

  Lin, Shuei Liong ^a,b   Chen, Ruey Hwa ^b   Chen, Yung Ming ^a,b   Chiang, Wen Chih ^a,b   Tsai, Tun Jun ^a,b   Hsieh, Bor Shen ^a,b  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

BUCLADESINE; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; FORSKOLIN; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PENTOXIFYLLINE; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR; THY 1 ANTIGEN;

ANIMAL CELL; ARTICLE; CELL CYCLE G1 PHASE; CELL FUNCTION; CELL STIMULATION; CHRONIC KIDNEY DISEASE; DIABETIC NEPHROPATHY; DRUG EFFECT; DRUG INHIBITION; EFFECTOR CELL; MESANGIUM CELL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROLIFERATIVE GLOMERULONEPHRITIS; PROTEIN EXPRESSION; PROTEINURIA; RAT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BIOLOGICAL TRANSPORT; CYCLIN D1; ENZYME INHIBITORS; G1 PHASE; GENE EXPRESSION; GLOMERULAR MESANGIUM; PENTOXIFYLLINE; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS;

EID: 0141457722     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.64.4.811     Document Type: Article

References (40)

1. Alessi DR, Deak M, Casamayor A, Caudwell FB, Morrice N, Norman DG, Gaffney P, Reese CB, MacDaugall CB, Harbison D, et al. (1997) Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase. Curr Biol 7:776-789.
2. Bourbon NA, Sandirasegarane L, and Kester M (2002) Ceramide-induced inhibition of Akt is mediated through protein kinase Czeta: implications for growth arrest. J Biol Chem 277:3286-3292.
3. Chen RH, Chang MC, Su YH, Tsai YT, and Kuo ML (1999a) Interleukin-6 inhibits transforming growth factor-β-induced apoptosis through the phosphatidylinositol 3-kinase/Akt and signal transducers and activators of transcription 3 pathways. J Biol Chem 274:23013-23019.
4. Chen RH, Su YH, Chuang RLC, and Chang TY (1998) Suppression of transforming growth factor-β-induced apoptosis through a phosphatidylinositol 3-kinase/Akt-dependent pathway. Oncogene 17:1959-1968.
5. Chen YM, Chien CT, Hu-Tsai MI, Wu KD, Tsai CC, Wu MS, and Tsai TJ (1999b) Pentoxifylline attenuates experimental mesangial proliferative glomerulonephritis. Kidney Int 56:932-943.
6. Chen YM, Lin SL, Chen CW, Chiang WC, Tsai TJ, and Hsieh BS (2003) Tumor necrosis factor-α stimulates fractalkine production by mesangial cells and regulates monocytes transmigration: down-regulation by cAMP. Kidney Int 63:474-486.
7. Chen YM, Wu KD, Tsai TJ, and Hsieh BS (1999c) Pentoxifylline inhibits PDGF-induced proliferation of and TGF-beta-stimulated collagen synthesis by vascular smooth muscle cells. J Mol Cell Cardiol 3:773-783.
8. Kip1 regulated by mitogen- activated protein kinase kinase (MEK1). Proc Natl Acad Sci USA 95:1091-1096.
9. Chini EN, Choi E, Grande JP, Burnett JC, and Dousa TP (1995) Adrenomedullin suppresses mitogenesis in rat mesangial cells via cAMP pathway. Biochem Biophys Res Commun 215:868-873.
10. Kip1 gene expression. J Biol Chem 276:35636-35643.
11. Choudhury GG, Karamitsos C, Hernandez J, Gentilini A, Bardgette J and Abboud HE (1997) PI-3-kinase and MAPK regulate mesangial cell proliferation and migration in response to PDGF. Am J Physiol 273:F931-F938.
12. Ciullo I, Diez-Roux G, Di Domenico M, Migliaccio A, and Avvedimento EV (2001) cAMP signaling selectively influences Ras effector pathways. Oncogene 20:1186-1192.
13. Diehl JA, Cheng M, Roussel MF, and Sherr CJ (1998) Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subeellular localization. Genes Dev 12:3499-3511.
14. Duclous D, Bresson-Vautrin C, and Chalopin JM (2001) Use of pentoxifylline in membranous nephropathy. Lancet 357:1672-1673.
15. Floege J, Ostendorf T, Janssen U, Gurg M, Radeke HH, Vargeese C, Gill SC, Green LS, and Janjic N (1999) Novel approach to specific growth factor inhibition in vivo: antagonism of platelet-derived growth factor in glomerulonephritis by aptamers. Am J Pathol 154:169-179.
16. Gilbert RE, Kelly DJ, Mckay T, Chadban S, Hill PA, Cooper ME, Atkins RC, and Nikolic-Paterson DJ (2001) PDGF signal transduction inhibition ameliorates experimental mesangial proliferative glomerulonephritis. Kidney Int 59:1324-1332.
17. Hutchinson J, Jin J, Cardiff RD, Woodgett JR, and Muller WJ (2001) Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression. Mol Cell Biol 21:2203-2212.
18. Johnson RJ, Raines EW, Floege J, Yoshimura A, Pritzl P, Alpers C, and Ross R (1992) Inhibition of mesangial cell proliferation and matrix expansion in glomerulonephritis in the rat by antibody to platelet-derived growth factor. J Exp Med 175:1413-1416.
19. Jones SM and Kazlauskas A (2001) Growth-factor-dependent mitogenesis requires two distinct phases of signaling. Nat Cell Biol 3:165-172.
20. Jones SM, Klinghoffer R, Prestwich GD, Toker A, and Kazlauskas A (1999) PDGF induces an early and a late wave of PI3K activity and only the late wave is required for progression through G1. Curr Biol 9:512-521.
21. Kitagawa M, Higashi H, Jung HK, Suzuki-Takahashi I, Ikeda M, Tamai K, Kato J, Segawa K, Yoshida E, Nishimura S, et al. (1996) The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. EMBO (Eur Mol Biol Organ) J 15:7060-7069.
22. Klahr S, Schreiner G, and Ichikawa I (1988) The progression of renal disease. N Engl J Med 318:1657-1666.
23. Kohno M, Yasunari K, Minami M, Kano H, Maeda K, Mandal AK, Inoki K, Haneda M, and Yoshikawa J (1999) Regulation of rat mesangial cell migration by platelet-derived growth factor, angiotensin II and adrenomedullin. J Am Soc Nephrol 10:2495-2502.
24. Lang S, Hartner A, Sterzel RB, and Schocklmann HO (2000) Requirement of cyclin Di in mesangial cell mitogenesis. J Am Soc Nephrol 11:1398-1408.
25. Lin SL, Chen YM, Chien CT, Chiang WC, Tsai CC, and Tsai TJ (2002) Pentoxifylline attenuated the renal disease progression in rats with remnant kidney. J Am Soc Nephrol 13:2916-2929.
26. Mei FC, Qiao J, Tsygankova OM, Meinkoth JL, Quilliam LA, and Cheng X (2002) Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation. J Biol Chem 277:11497-11504.
27. Navarro JF, Mora C, Rivero A, Gallego E, Chahin J, Macia M, Mendez ML, and Garcia J (1999) Urinary protein excretion and serum tumor necrosis factor in diabetic patients with advanced renal failure: effects of pentoxifylline administration. Am J Kidney Dis 33:458-463.
28. Ostendorf T, Kunter U, Grone HJ, Bahlmann F, Kawachi H, Shimizu F, Koch KM, Janjic N, and Floege J (2001) Specific antagonism of PDGF prevents renal scarring in experimental glomerulonephritis. J Am Soc Nephrol 12:909-918.
29. Peterson TC, Peterson MR, Robertson HA, During M, and Dragunow M (2002) Selective down-regulation of c-jun gene expression by pentoxifylline and c-jun antisense interrupts platelet-derived growth factor signaling: pentoxifylline inhibits phosphorylation of c-Jun on serine 73. Mol Pharmacol 61:1476-1488.
30. Pinzani M, Marra F, Caligirui A, DeFranco R, Gentilini A, Failli P, and Gentilini P (1996) Inhibition by pentoxifylline of extracellular signal-regulated kinase activation by platelet-derived growth factor in hepatic stellate cells. Br J Pharmacol 119:1117-1124.
31. Scheid MP and Woodgett JR (2001) PKB/AKT: functional insights from genetic models. Nat Rev Mol Cell Bio 2:760-768.
32. Schindler T, Bornmann W, Pellicena P, Miller WT, Clarkson B, and Kuriyan J (2000) Structural mechanism for STI-571 inhibition of Abelson tyrosine kinase. Science (Wash DC) 289:1938-1942.
33. Shankland SJ, Hugo C, Coats SR, Nangaku M, Pichler RH, Gordon KL, Pippin J, Roberts JM, Couser WG, and Johnson RJ (1996) Changes in cell-cycle protein expression during experimental mesangial proliferative glomerulonephritis. Kidney Int 50:1230-1239.
34. Kip1. Kidney Int 51:1088-1099.
35. Stratford S, DeWald DB, and Summers SA (2001) Ceramide dissociates 3′-phosphoinositide production from pleckstrin homology domain translocation. Biochem J 354:359-368.
36. Tamura K, Kanaoka Y, Jinno S, Nagata A, Ogiso Y, Shimizu K, Hayakawa T, Nojima H, and Okayama H (1993) Cyclin G: a new mammalian cyclin with homology to fission yeast Cig1. Oncogene 8:2113-2118.
37. Terada Y, Inoshita S, Nakashima O, Yamada T, Tamamori M, Ito H, Sasaki S, and Marumo F (1998) Cyclin D1, p16 and retinoblastoma gene regulate mitogenic signaling of endothelin in rat mesangial cells. Kidney Int 53:76-83.
38. Tsai TJ, Lin RH, Chang CC, Chen YM, Chen CF, Ko FN, and Teng CM (1995) Vasodilator agents modulate rat glomerular mesangial cell growth and collagen synthesis. Nephron 70:91-100.
39. Vanhaesebroeck B, Leevers SJ, Panayotou G, and Waterfield MD (1997) Phosphoinositide 3-kinases: a conserved family of signal transducers. Trends Biochem Sci 22:267-272.
40. Wang L, Liu F, and Adamo ML (2001) Cylic AMP inhibits extracellular signal-regulated kinase and phosphatidylinositol 3-kinase/Akt pathways by inhibiting Rap1. J Biol Chem 276:37242-37249.