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Volumn 119, Issue 6, 1996, Pages 1117-1124

Inhibition by pentoxifylline of extracellular signal-regulated kinase activation by platelet-derived growth factor in hepatic stellate cells

Author keywords

Cyclic AMP; Extracellular signal regulated kinase (ERK); Hepatic fibrosis; Hepatic stellate cells (HSCs); Intracellular calcium; Mitogen activated protein kinase (MAPK); Pentoxifylline; Phosphatidylinositol 3 kinase (PI 3 K); Platelet derived growth factor (PDGF)

Indexed keywords

ANTITHROMBOCYTIC AGENT; CALCIUM ION; COLLAGEN; CYCLIC AMP; MESSENGER RNA; PENTOXIFYLLINE; PHOSPHATIDYLINOSITOL KINASE; PHOSPHOTRANSFERASE; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN C FOS;

EID: 0029958518     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb16012.x     Document Type: Article
Times cited : (58)

References (41)
  • 1
    • 0024514942 scopus 로고
    • Pentoxifylline inhibits normal human dermal fibroblasts in vitro proliferation, collagen, glycosaminoglycan, and fibronectin production, and increases collagenase activity
    • BERMAN, B., MATTHEW, R. & DUNCAN, R. (1989). Pentoxifylline inhibits normal human dermal fibroblasts in vitro proliferation, collagen, glycosaminoglycan, and fibronectin production, and increases collagenase activity. J. Invest. Dermatol., 92, 605-610.
    • (1989) J. Invest. Dermatol. , vol.92 , pp. 605-610
    • Berman, B.1    Matthew, R.2    Duncan, R.3
  • 2
    • 0001188857 scopus 로고
    • Antifibrotic effect of pentoxifylline in rat biliary fibrosis due to bile duct obstruction
    • Abstract
    • BOIGK, G., RAETSCH, C., STROETER, L., WALDSCHMIDT, J., HERBST, H., RIECKEN, E.O. & SCHUPPAN, D. (1995). Antifibrotic effect of pentoxifylline in rat biliary fibrosis due to bile duct obstruction. J. Hepatol., 23, 142 (Abstract).
    • (1995) J. Hepatol. , vol.23 , pp. 142
    • Boigk, G.1    Raetsch, C.2    Stroeter, L.3    Waldschmidt, J.4    Herbst, H.5    Riecken, E.O.6    Schuppan, D.7
  • 3
    • 0027501802 scopus 로고
    • ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor
    • ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor. EMBO J., 11, 4211-4220.
    • (1993) EMBO J. , vol.11 , pp. 4211-4220
    • Burgering, B.M.T.1    Pronk, G.J.2    Van Weeren, P.C.3    Chardin, P.4    Bos, J.L.5
  • 5
    • 0027486489 scopus 로고
    • Pentoxifylline inhibits the proliferation and glycosaminoglycan synthesis of cultured fibroblasts derived from patients with Graves' ophthalmopathy and pretibial myxoedema
    • CHANG, C.C., CHANG, T.C., KAO, S.C.S., KUO, Y.F. & CHIEN, L.F. (1993). Pentoxifylline inhibits the proliferation and glycosaminoglycan synthesis of cultured fibroblasts derived from patients with Graves' ophthalmopathy and pretibial myxoedema. Acta Endocrinol., 129, 322-327.
    • (1993) Acta Endocrinol. , vol.129 , pp. 322-327
    • Chang, C.C.1    Chang, T.C.2    Kao, S.C.S.3    Kuo, Y.F.4    Chien, L.F.5
  • 6
    • 0026757051 scopus 로고
    • Activation of MAP kinases by calcium-dependent and calcium-independent pathways. Stimulation by thapsigargin and epidermal growth factor
    • CHAO, T-S.O., BYRON, K.L., LEE, K-M., VILLEREAL, M. & ROSNER, M.R. (1992). Activation of MAP kinases by calcium-dependent and calcium-independent pathways. Stimulation by thapsigargin and epidermal growth factor. J. Biol. Chem., 267, 19876-19883.
    • (1992) J. Biol. Chem. , vol.267 , pp. 19876-19883
    • Chao, T.-S.O.1    Byron, K.L.2    Lee, K.-M.3    Villereal, M.4    Rosner, M.R.5
  • 7
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • CHOMCZYNSKI, P. & SACCHI, N. (1987). Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162, 156-159.
    • (1987) Anal. Biochem. , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 8
    • 0028589148 scopus 로고
    • Platelet-derived receptor signals
    • CLAESSON-WELSH, L. (1994). Platelet-derived receptor signals. J. Biol. Chem., 269, 32023-32026.
    • (1994) J. Biol. Chem. , vol.269 , pp. 32023-32026
    • Claesson-Welsh, L.1
  • 9
    • 0028895654 scopus 로고
    • Molecular binding domain in signal transduction proteins
    • COHEN, G.B., REN, R. & BALTIMORE, D. (1995). Molecular binding domain in signal transduction proteins. Cell, 80, 237-248.
    • (1995) Cell , vol.80 , pp. 237-248
    • Cohen, G.B.1    Ren, R.2    Baltimore, D.3
  • 10
    • 0027716596 scopus 로고
    • Inhibition by cAMP of Ras-dependent activation of Raf
    • COOK, S.J. & MCCORMICK, F. (1993). Inhibition by cAMP of Ras-dependent activation of Raf. Science, 262, 1069-1072.
    • (1993) Science , vol.262 , pp. 1069-1072
    • Cook, S.J.1    Mccormick, F.2
  • 11
    • 0028949133 scopus 로고
    • Adenylyl cyclases and the interaction between calcium and cAMP signalling
    • COOPER, D.M., MONS, N. & KARPEN, J.W. (1995). Adenylyl cyclases and the interaction between calcium and cAMP signalling. Nature, 374, 421-424.
    • (1995) Nature , vol.374 , pp. 421-424
    • Cooper, D.M.1    Mons, N.2    Karpen, J.W.3
  • 12
    • 0028801716 scopus 로고
    • Pentoxifylline, pentifylline, and interferons decrease type I and type III procollagen mRNA levels in dermal fibroblasts: Evidence for mediation by nuclear factor 1 down-regulation
    • DUNCAN, M.R., HASAN, A. & BERMAN, B. (1995). Pentoxifylline, pentifylline, and interferons decrease type I and type III procollagen mRNA levels in dermal fibroblasts: evidence for mediation by nuclear factor 1 down-regulation. J. Invest. Dermatol., 104, 282-286.
    • (1995) J. Invest. Dermatol. , vol.104 , pp. 282-286
    • Duncan, M.R.1    Hasan, A.2    Berman, B.3
  • 14
    • 33746521801 scopus 로고
    • The cellular basis of hepatic fibrosis: Mechanisms and treatment strategies
    • FRIEDMAN, S.L. (1993). The cellular basis of hepatic fibrosis: Mechanisms and treatment strategies. N. Engl. J. Med., 328, 1828-1835.
    • (1993) N. Engl. J. Med. , vol.328 , pp. 1828-1835
    • Friedman, S.L.1
  • 15
    • 0023916830 scopus 로고
    • 2+ pump by cyclic nucleotides in cultured vascular smooth muscle cells
    • 2+ pump by cyclic nucleotides in cultured vascular smooth muscle cells. J. Biol. Chem., 263, 8058-8065.
    • (1988) J. Biol. Chem. , vol.263 , pp. 8058-8065
    • Furukawa, K.1    Tawada, Y.2    Shigekawa, M.3
  • 16
    • 0025741580 scopus 로고
    • A mutational analysis of phosphatidylinositol-3-kinase activation by human colony-stimulating factor-1 receptor
    • GHOSH CHOUDHURY, G., WANG, L.-M., PIERCE, J., HARVEY, S.A., & SAKAGUCHi, A.Y. (1991). A mutational analysis of phosphatidylinositol-3-kinase activation by human colony-stimulating factor-1 receptor. J. Biol. Chem., 266, 8068-8072.
    • (1991) J. Biol. Chem. , vol.266 , pp. 8068-8072
    • Ghosh Choudhury, G.1    Wang, L.-M.2    Pierce, J.3    Harvey, S.A.4    Sakaguchi, A.Y.5
  • 17
    • 0027374550 scopus 로고
    • Protein kinase A antagonizes platelet-derived growth factor-induced signalling by mitogen-activated protein kinase in human arterial smooth muscle cells
    • GRAVES, L.M., BORNFELDT, K.E., RAINES, E.W., POTTS, B.C., MACDONALD, S.G., ROSS, R. & KREBS, E.G. (1993). Protein kinase A antagonizes platelet-derived growth factor-induced signalling by mitogen-activated protein kinase in human arterial smooth muscle cells. Proc. Natl. Acad. Sci. U.S.A., 90, 10300-10304.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 10300-10304
    • Graves, L.M.1    Bornfeldt, K.E.2    Raines, E.W.3    Potts, B.C.4    Macdonald, S.G.5    Ross, R.6    Krebs, E.G.7
  • 18
    • 0028278181 scopus 로고
    • Signal transduction and gene regulation: The nuclear response to cAMP
    • LALLI, E. & SASSONE-CORSI, P. (1994). Signal transduction and gene regulation: the nuclear response to cAMP. J. Biol. Chem., 269, 17359-17362.
    • (1994) J. Biol. Chem. , vol.269 , pp. 17359-17362
    • Lalli, E.1    Sassone-Corsi, P.2
  • 19
    • 0023772719 scopus 로고
    • Lipocytes and transitional cells in alcoholic liver disease: A morphometric study
    • MAK, K.M. & LIEBER, C.S. (1988). Lipocytes and transitional cells in alcoholic liver disease: a morphometric study. Hepatology, 8, 1027-1033.
    • (1988) Hepatology , vol.8 , pp. 1027-1033
    • Mak, K.M.1    Lieber, C.S.2
  • 20
    • 0028882512 scopus 로고
    • Involvement of phosphatidylinositol 3-kinase in the activation of extracellular signal-regulated kinase by PDGF in hepatic stellate cells
    • MARRA, F., PINZANI, M., DEFRANCO, R., LAFFI, G. & GENTILINI, P. (1995a). Involvement of phosphatidylinositol 3-kinase in the activation of extracellular signal-regulated kinase by PDGF in hepatic stellate cells. FEBS Lett., 376, 141-145.
    • (1995) FEBS Lett. , vol.376 , pp. 141-145
    • Marra, F.1    Pinzani, M.2    Defranco, R.3    Laffi, G.4    Gentilini, P.5
  • 21
    • 10544244253 scopus 로고
    • Phosphatidylinositol 3-kinase mediates PDGF mitogenic signalling in hepatic stellate cells
    • Abstract
    • MARRA, F., PINZANI, M., LAFFI, G. & GENTILINI P. (1995b). Phosphatidylinositol 3-kinase mediates PDGF mitogenic signalling in hepatic stellate cells. J. Hepatol., 23(Suppl. 1), 132 (Abstract).
    • (1995) J. Hepatol. , vol.23 , Issue.1 SUPPL. , pp. 132
    • Marra, F.1    Pinzani, M.2    Laffi, G.3    Gentilini, P.4
  • 22
    • 0027360267 scopus 로고
    • Cultured human liver fat-storing cells produce monocyte chemotactic protein-1. Regulation by proinflammatory cytokines
    • MARRA, F., VALENTE, A.J., PINZANI, M. & ABBOUD, H.E. (1993). Cultured human liver fat-storing cells produce monocyte chemotactic protein-1. Regulation by proinflammatory cytokines. J. Clin. Invest., 92, 1674-1680.
    • (1993) J. Clin. Invest. , vol.92 , pp. 1674-1680
    • Marra, F.1    Valente, A.J.2    Pinzani, M.3    Abboud, H.E.4
  • 23
    • 0028872649 scopus 로고
    • Specificity of receptor tyrosine signalling: Transient versus sustained extracellular signal-regulated kinase activation
    • MARSHALL, C.J. (1995). Specificity of receptor tyrosine signalling: transient versus sustained extracellular signal-regulated kinase activation. Cell, 80, 179-185.
    • (1995) Cell , vol.80 , pp. 179-185
    • Marshall, C.J.1
  • 25
    • 0026941991 scopus 로고
    • Phosphatidylinositol 3-kinase: A novel effector
    • PARKER, P.J. & WATERFIELD, M.D. (1992). Phosphatidylinositol 3-kinase: a novel effector. Cell Growth Differ., 3, 747-752.
    • (1992) Cell Growth Differ. , vol.3 , pp. 747-752
    • Parker, P.J.1    Waterfield, M.D.2
  • 26
    • 0028859279 scopus 로고
    • Protein modules and signalling networks
    • PAWSON, T. (1995). Protein modules and signalling networks. Nature, 373, 573-580.
    • (1995) Nature , vol.373 , pp. 573-580
    • Pawson, T.1
  • 27
    • 0027415060 scopus 로고
    • Pentoxifylline prevents fibrosis in an animal model and inhibits platelet-derived growth factor-driven proliferation of fibroblasts
    • PETERSON, T. (1993). Pentoxifylline prevents fibrosis in an animal model and inhibits platelet-derived growth factor-driven proliferation of fibroblasts. Hepatology, 17, 486-493.
    • (1993) Hepatology , vol.17 , pp. 486-493
    • Peterson, T.1
  • 28
    • 0029001211 scopus 로고
    • Novel insight into the biology and physiology of the Ito cell
    • PINZANI, M. (1995). Novel insight into the biology and physiology of the Ito cell. Pharmac. Ther., 66, 387-412.
    • (1995) Pharmac. Ther. , vol.66 , pp. 387-412
    • Pinzani, M.1
  • 29
    • 0026534092 scopus 로고
    • Regulation of macrophage-colony stimulating factor in liver fat-storing cells by peptide growth factors
    • PINZANI, M., ABBOUD, H.E., GESUALDO, L & ABBOUD, S.L. (1992a). Regulation of macrophage-colony stimulating factor in liver fat-storing cells by peptide growth factors. Am. J. Physiol. Cell Physiol., 262, C876-C881.
    • (1992) Am. J. Physiol. Cell Physiol. , vol.262
    • Pinzani, M.1    Abboud, H.E.2    Gesualdo, L.3    Abboud, S.L.4
  • 30
    • 0026775513 scopus 로고
    • Fat-storing cells as liver-specific pericytes. Spatial dynamics of agonist-stimulated intracellular calcium transients
    • PINZANI, M., FAILLI, P., RUOCCO, C., CASINI, A., MILANI, S., BALDI, E., GIOTTI, A. & GENTILINI, P. (1992b). Fat-storing cells as liver-specific pericytes. Spatial dynamics of agonist-stimulated intracellular calcium transients. J. Clin. Invest., 90, 642-646.
    • (1992) J. Clin. Invest. , vol.90 , pp. 642-646
    • Pinzani, M.1    Failli, P.2    Ruocco, C.3    Casini, A.4    Milani, S.5    Baldi, E.6    Giotti, A.7    Gentilini, P.8
  • 31
    • 0028980141 scopus 로고
    • Transforming growth factor-β1 regulates platelet-derived growth factor β subunit in human liver fat-storing cells
    • PINZANI, M., GENTILINI, A., CALIGIURI, A., DEFRANCO, R., PELLEGRINI, G., MILANI, S., MARRA, F. & GENTILINI, P. (1995). Transforming growth factor-β1 regulates platelet-derived growth factor β subunit in human liver fat-storing cells. Hepatology, 21, 232-239.
    • (1995) Hepatology , vol.21 , pp. 232-239
    • Pinzani, M.1    Gentilini, A.2    Caligiuri, A.3    Defranco, R.4    Pellegrini, G.5    Milani, S.6    Marra, F.7    Gentilini, P.8
  • 32
    • 0024840085 scopus 로고
    • Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells
    • PINZANI, M., GESUALDO, L., SABBAH, G.M. & ABBOUD, H.E. (1989). Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells. J. Clin. Invest., 84, 1786-1793.
    • (1989) J. Clin. Invest. , vol.84 , pp. 1786-1793
    • Pinzani, M.1    Gesualdo, L.2    Sabbah, G.M.3    Abboud, H.E.4
  • 36
    • 0028923502 scopus 로고
    • The cAMP response element binding protein synergizes with other transcription factors to mediate cAMP responsiveness
    • ROESLER, W.J., GRAHAM, J.G., KOLEN, R., KLEMM, D.J. & MCFIE, P.J. (1995). The cAMP response element binding protein synergizes with other transcription factors to mediate cAMP responsiveness. J. Biol. Chem., 270, 8225-8232.
    • (1995) J. Biol. Chem. , vol.270 , pp. 8225-8232
    • Roesler, W.J.1    Graham, J.G.2    Kolen, R.3    Klemm, D.J.4    Mcfie, P.J.5
  • 37
    • 0016173816 scopus 로고
    • Inhibition of various cyclic AMP phosphodiesterase by pentoxifylline and theophylline
    • STEFANOVICH, V., VON POLMITZ, M. & REISER, M. (1974). Inhibition of various cyclic AMP phosphodiesterase by pentoxifylline and theophylline. Drugs, 24, 1747-1751.
    • (1974) Drugs , vol.24 , pp. 1747-1751
    • Stefanovich, V.1    Von Polmitz, M.2    Reiser, M.3
  • 38
    • 0027211693 scopus 로고
    • Phospholipase C-gamma and phosphatidylinositol 3-kinase are the downstream mediators of the PDGF receptor's mitogenic signal
    • VALIUS, M. & KAZLAUKAS, A. (1993). Phospholipase C-gamma and phosphatidylinositol 3-kinase are the downstream mediators of the PDGF receptor's mitogenic signal. Cell, 73, 321-324.
    • (1993) Cell , vol.73 , pp. 321-324
    • Valius, M.1    Kazlaukas, A.2
  • 39
    • 0028525824 scopus 로고
    • Endothelin stimulates mitogen-activated protein-kinase activity in mesangial cells through ET(A)
    • WANG, Y.Z., POUYSSEGUR, J. & DUNN, M.J. (1994). Endothelin stimulates mitogen-activated protein-kinase activity in mesangial cells through ET(A). J. Am. Soc. Nephrol., 5, 1074-1080.
    • (1994) J. Am. Soc. Nephrol. , vol.5 , pp. 1074-1080
    • Wang, Y.Z.1    Pouyssegur, J.2    Dunn, M.J.3
  • 40
    • 0023189396 scopus 로고
    • Pentoxifylline. A review of its pharmacodynamic and pharmacokinetic properties and its therapeutic effects
    • WARD, A. & CLISSOLD, S.P. (1987). Pentoxifylline. A review of its pharmacodynamic and pharmacokinetic properties and its therapeutic effects. Drugs, 34, 50-97.
    • (1987) Drugs , vol.34 , pp. 50-97
    • Ward, A.1    Clissold, S.P.2
  • 41
    • 0027772672 scopus 로고
    • Inhibition of the EGF-activated MAP kinase signalling pathway by adenosine 3′,5′-monophosphate
    • WU, J., DENT, P., JELINEK, T., WOLFMAN, A., WEBER, M.J. & STURGILL, T.W. (1993). Inhibition of the EGF-activated MAP kinase signalling pathway by adenosine 3′,5′-monophosphate. Science, 262, 1065-1069.
    • (1993) Science , vol.262 , pp. 1065-1069
    • Wu, J.1    Dent, P.2    Jelinek, T.3    Wolfman, A.4    Weber, M.J.5    Sturgill, T.W.6


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