Protection of mouse islet isografts from nonspecific inflammatory damage by recipient treatment with nicotinamide and 15-deoxyspergualin

Cell Transplantation

Volumn 5, Issue 1, 1996, Pages 41-47

  Kenmochi, T ^a   Miyamoto, M ^a   Mullen, Y ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

15 Deoxyspergualin; Mouse islet isograft; Nicotinamide; Nonspecific inflammation

Indexed keywords

15 DEOXYSPERGUALIN; GLUCOSE; NICOTINAMIDE; SODIUM CHLORIDE; STREPTOZOCIN;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; GLUCOSURIA; GRAFT REJECTION; HISTOLOGY; INFLAMMATION; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; INTRAVENOUS GLUCOSE TOLERANCE TEST; MOUSE; NEWBORN; NONHUMAN; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; STREPTOZOCIN DIABETES;

EID: 0029981458     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.1016/0963-6897(95)02013-6     Document Type: Article

References (29)

1. H. Amemiya S. Suzuki K. Ota A novel rescue drug, 15-deoxyspergualin First clinical trials for recurrent graft rejection in renal recipients 2nd ed. Transplantation 49 1990 337 343
2. L. Bergmann K.D. Kröncke D. Suschek H. Kolb V. Kolb-Bachofern Cytotoxication of IL-ß against pancreatic islets is mediated via nitric oxide formation and is inhibited by NG-monomethyl-L-arginine FEBS. Lett. 299 1992 103 106
3. J.A. Corbett J.R. Lancaster Jr M.A. Sweetland L. McDaniel Interleukin-lß-induced formation of EPRdetectable iron-nitrosyl complexes in islets of Langerhans: Role of nitric oxide in interleukin-1ß-induced inhibition of insulin secretion J. Biol. Chem. 266 1991 21351 21354
4. G. Dickneite H.U. Schorlemmer H.H. Sedlacek W. Falk K. Ulrichs W. Müller-Ruchholtz Suppression of macrophage function and prolongation of graft survival by the new guanidine-like structure, 15-deoxyspergualin 2nd ed. Transplant. Proc. 19 1987 1301 1304
5. R.B. Elliott H.P. Chase Prevention or delay of type 1 (insulin-dependent) diabetes mellitus in children using nicotinamide Diabetologia 34 1991 362 365
6. P.J. Gores J.S. Najarian E. Stephanian J.J. Lloveras S.L. Kelly D.E.R. Sutherland Insulin independence in type I diabetes after transplantation of unpurified islets from single donor with 15-deoxyspergualin Lancet 341 1993 19 21
7. M. Gotoh J. Porter T. Kanai A.P. Monaco T. Maki Multiple donor allotransplantation: A new approach to pancreatic islet transplantation Transplantation 45 1988 1008 1012
8. D.W.R. Gray R. Sutton P. McShane M. Peters P.J. Morris Exocrine contamination impairs implantation of pancreatic islets transplanted beneath the kidney J. Surg. Res. 45 1988 432 442
9. H. Iwata T. Takagi H. Amemiya Marked prolongation of islet xenograft survival (hamster to mouse) by microencapsulation and administration of 15-deoxyspergualin 2nd ed. Transplant. Proc. 24 1992 1517 1518
10. + cells, and CD4 and CD8 T lymphocytes in primary nonfunction and classic rejection of islet allografts J. Exp. Med. 172 1990 291 302
11. D.B. Kaufman P.F. Gores M.J. Field A.C. Farney S.A. Gruber E. Stephanian D.E.R. Sutherland Effect of 15-deoxyspergualin on immediate function and long-term survival of transplanted islets in murine recipients of a marginal islet mass Diabetes 43 1994 778 783
12. T. Kenmochi Y. Mullen M. Miyamoto E. Stein Protection of mouse islet isografts from early transplantation damage by nicotinamide treatment of recipients 2nd ed. Transplant. Proc. 26 1994 693
13. Kenmochi, T.; Miyamoto, M.; Mullen, Y. unpublished data.
14. O. Korsgren L. Jansson S. Sandler A. Andersson Hyperglycemia-induced B-cell toxicity: The fate of pancreatic islets transplanted into diabetic mice is dependent on their genetic background J. Clin. Invest. 86 1990 2161 2168
15. K.D. Krönke J. Funda B. Berschick H. Kolb V. KolbBachofen Macrophage cytotoxicity towards isolated islet cells: Neither lysis nor its protection by nicotinamide are beta-cell specific Diabetologia 34 1991 232 238
16. K.D. Kröncke V. Kolb-Bachofen B. Berschick V. Burkart H. Kolb Activated macrophages kill pancreatic islet cells via arginine-dependent nitric oxide generation Biochem. Biophys. Res. Commun. 175 1991 752 758
17. S.S. Lazarus S.H. Shapiro Influence of nicotinamide and pyridine nucleotides on streptozotocin and alloxan-induced pancreatic B cell cytotoxicity Diabetes 22 1973 499 506
18. T. Mandrup-Poulsen G.A. Spinas S.J. Prowse Islet cytotoxicity of interleukin 1: Influence of culture conditions and islet donor characteristics Diabetes 36 1987 641 647
19. J. Mendola J.R. Wright P.E. Lacy Oxygen free-radical scavengers and immune destruction of murine islets in allograft rejection and multiple low-dose streptozotocininduced insulitis Diabetes 38 1989 379 385
20. M. Nagata Y. Mullen S. Matsuo M. Herrera M. ClareSalzler Destruction of islet isografts by severe nonspecific inflammation 2nd ed. Transplant. Proc. 22 1990 855 856
21. Y. Nakajima H. Yabuuchi H. Kanehiro T. Wada M. Hisanaga H. Nakano Prolongation of pancreatic islet xenografi survival and thymus alteration by 15-deoxyspergualin Transplantation 48 1989 351 352
22. H. Okamoto Regulation of proinsulin synthesis in pancreatic islets and a new aspect to insulin-dependent diabetes Mol. Cell. Biochem. 37 1981 43 61
23. H. Okamoto The role of poly (ADP-ribose) synthetase in the development of insulin-dependent diabetes and islet ß-cell regeneration Biomed. Biochim. Acta. 44 1985 15 20
24. T. Otonkoski G.M. Beattie M.I. Mally C. Ricordi A. Hayek Nicotinamide is a potent inducer of endocrine differentiation in cultured human fetal pancreatic cells J. Clin. Invest. 92 1993 1459 1466
25. R.B. Stevens J.D. Ansite D.E.R. Sutherland M. Tepper C.D. Mills 15-deoxyspergualin (DSG) inhibits nitric oxide (NO) production in the BB/W rat: Mechanism for inhibition of islet cell dysfunction in diabetes (DM) and transplantation (Tx) Cell Transplantation 3 1994 226
26. T. Takeuchi H. Inum S. Kunimoto A new antibiotic, spergualin: Isolation and antitumor activity J. Antibiot. 34 1981 1619 1621
27. + T-cells in the destruction of islet grafts by spontaneously diabetic mice 2nd ed. Proc. Natl. Acad. Sci. USA 88 1991 527 531
28. K. Yamada K. Nonaka T. Hanafusa A. Miyazaki H. Toyoshima S. Tarui Preventive and therapeutic effects of large-dose nicotinamide injections on diabetes associated with insulitis: An observation in nonobese diabetic (NOD) mice Diabetes 31 1982 749 753
29. K. Yamada E. Ryu K. Nonaka Protective effect of nicotinamide and 3-aminobenzamide on islet cell damage induced by gamma-interferon and tumor necrosis factor Diabetes Res. 13 1990 85 87