Nicotine induces a long QT phenotype in Kcnq1-deficient mouse hearts

Journal of Pharmacology and Experimental Therapeutics

Volumn 306, Issue 3, 2003, Pages 980-987

  Tosaka, Toshimasa ^a   Casimiro, Mathew C ^b   Rong, Qi ^a   Tella, Srihari ^c   Oh, Michelle ^a   Katchman, Alexander N ^a   Pezzullo, John C ^a   Pfeifer, Karl ^b   Ebert, Steven N ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c Drug Enforcement Administration   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; GENE PRODUCT; ISOPRENALINE; NICOTINE; PROTEIN KCNQ1; UNCLASSIFIED DRUG;

ADRENERGIC STIMULATION; ANIMAL TISSUE; ARTICLE; CARDIOTOXICITY; CONTROLLED STUDY; ELECTROCARDIOGRAM; GENE DISRUPTION; GENE TARGETING; HEART RATE; IN VIVO STUDY; ISOLATED HEART; LONG QT SYNDROME; MOUSE; NEUROTRANSMISSION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SYMPATHETIC TONE; TELEMETRY; WILD TYPE;

ANIMALS; ARRHYTHMIA; ELECTROCARDIOGRAPHY; HEART; KCNQ POTASSIUM CHANNELS; KCNQ1 POTASSIUM CHANNEL; LONG QT SYNDROME; MICE; MICE, MUTANT STRAINS; NICOTINE; NICOTINIC AGONISTS; PERFUSION; PHENOTYPE; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED;

EID: 0042934080     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.053017     Document Type: Article

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