The oral immunogenicity of BioProtein, a bacterial single-cell protein, is affected by its particulate nature

British Journal of Nutrition

Volumn 90, Issue 1, 2003, Pages 169-178

  Christensen, Hanne R ^a   Larsen, Linea C ^a   Frøkiær, Hanne ^a  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

BioProtein; Oral immunogenicity; Particulate food antigen; Single cell protein

Indexed keywords

ANTIBODY; BACTERIAL PROTEIN; FOOD ANTIGEN; IMMUNOGLOBULIN; IMMUNOGLOBULIN A; NUCLEIC ACID; BACTERIUM ANTIBODY; BIOPROTEIN, BACTERIA;

ANIMAL EXPERIMENT; ANIMAL FOOD; ANTIBODY DETECTION; ANTIBODY PRODUCTION; ANTIGEN ANTIBODY REACTION; ARTICLE; CONTROLLED STUDY; CROSS REACTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FERMENTATION; FOOD ANALYSIS; FOOD COMPOSITION; FOOD INTAKE; FOOD QUALITY; FOOD SAFETY; HOMOGENATE; IMMUNE RESPONSE; IMMUNOGENICITY; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOGLOBULIN PRODUCTION; METHANOTROPHIC BACTERIUM; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; PARTICULATE MATTER; PROTEIN INTAKE; SALIVA ANALYSIS; SALIVA LEVEL; ANIMAL; BAGG ALBINO MOUSE; BLOOD; CELL DIVISION; COMPARATIVE STUDY; CYTOLOGY; FOOD; IMMUNOLOGY; METHODOLOGY; ORAL DRUG ADMINISTRATION; RANDOMIZATION; SALIVA; SPLEEN;

ANIMALIA; BACTERIA (MICROORGANISMS);

ADMINISTRATION, ORAL; ANIMALS; ANTIBODIES, BACTERIAL; BACTERIAL PROTEINS; CELL DIVISION; CROSS REACTIONS; DIETARY PROTEINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FOOD; IMMUNITY, MUCOSAL; IMMUNOGLOBULIN A; MICE; MICE, INBRED BALB C; NUCLEIC ACIDS; RANDOM ALLOCATION; SALIVA; SPLEEN;

EID: 0042871291     PISSN: 00071145     EISSN: None     Source Type: Journal    
DOI: 10.1079/BJN2003863     Document Type: Article

References (36)

1. Ahmed T, Sumazaki R, Nagai Y, Shibasaki M & Takita H (1997) Immune response to food antigens: Kinetics of food-specific antibodies in the normal population. Acta Paediatr Jpn 39, 322-328.
2. Anupama & Ravindra P (2000) Value-added food: Single cell protein. Biotechnol Adv 18, 459-479.
3. Barkholt V & Jensen AL (1997) Amino-acid analysis - Determination of cystein plus half-cystein in proteins after hydrochloric-acid hydrolysis with a disulfide compound as additive. Anal Biochem 177, 318-322.
4. Barnes RMR, Johnson PM, Harvey MM, Blears J & Finn R (1988) Human-serum antibodies reactive with dietary proteins - IgG subclass distribution. Int Arch Allergy Appl Immunol 87, 184-188.
5. Brandtzaeg P (1998) Development and basic mechanisms of human gut immunity. Nutr Rev 56, S5-S18.
6. Coombs RRA, Kieffer M, Fraser DR & Frazier PJ (1983) Naturally developing antibodies to wheat gliadin fractions and to other cereal antigens in rabbits, rats and guinea-pigs on normal laboratory diets. Int Arch Allergy Appl Immunol 70, 200-204.
7. Dahlgren UIH, Wold AE, Hanson LA & Midtvedt T (1991) Expression of a dietary-protein in Echerichia coli renders it strongly antigenic to gut lymphoid-tissue. Immunology 73, 394-397.
8. Dannaeus A (1993) Age-related antibody response to food antigens. Pediatr Allergy Immunol 4, Suppl. 3, 21-24.
9. Ermak TH & Giannasca PJ (1998) Microparticle targeting to M cells. Adv Drug Deliv Rev 34, 261-283.
10. Fjellbirkeland A, Kleivdal H, Joergensen C, Thestrup H & Jensen HB (1997) Outer membrane proteins of Methylcoccus capsulatus (Bath). Arch Microbiol 168, 128-135.
11. Fujihashi K, Kweon MN, Kiyono H, VanCott JL, VanGinkel FW, Yamamoto M & McGhee JR (1997) A T cell/B cell epithelial cell internet for mucosal inflammation and immunity. Springer Semin Immunopathol 18, 477-494.
12. Goding JW (1996) The Antibody Response, 3rd ed. London: Academic Press
13. Haman L, El-Samalouti V, Ulmer AJ, Flad H-D & Rietschel ET (1998) Components of gut bacteria as immunomodulators. Int J Microbiol 41, 141-154.
14. Husby S, Oxelius VA, Teisner B, Jensenius JC & Svehag SE (1985) Humoral immunity to dietary antigens in healthy adults - Occurrence, isotype and IgG subclass distribution of serum antibodies to protein antigens. Int Arch Allergy Appl Immunol 77, 416-422.
15. Jenkins PG, Howard KA, Blackhall NW, Thomas NW, Davis SS & O'Hagan DT (1994) Microparticulate absorption from the rat intestine. J Control Release 29, 339-350.
16. Kerr MA & Loomes LM (1994) Properties of immunoglobulins. In Immunochemistry Labfax, pp. 23-42 [MA Kerr and R Thorpe, editors]. Oxford: Bios Scientific Publishers
17. Khoury SJ, Lider O, Alsabbagh A & Weiner HL (1990) Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic-protein. 3. Synergistic effect of lipopolysaccharide. Cell Immunol 131, 302-310.
18. Kim SM, Enomoto A, Hachimura S, Yamauchi K & Kaminogawa S (1993) Serum antibody-response elicited by a casein diet is directed to only limited determinants of alpha-s1-casein. Int Arch Allergy Immunol 101, 260-265.
19. Kuhad RC, Singh A, Tripathi KK, Saxena RK & Eriksson KEL. (1997) Microorganisms as an alternative source of protein. Nutr Rev 55, 65-75.
20. Larsen J & Joergensen L (1996) Reduction of RNA and DNA in Methylococcus capsulatus by endogenous nucleases. Appl Microbiol Biotechnol 45, 137-140.
21. Macpherson AJ, Hunziker L, McCoy K & Lamarre A (2001) IgA responses in the intestinal mucosa against pathogenic and non-pathogenic microorganisms. Microbes Infect 3, 1021-1035.
22. Matsunaga Y, Wakatsuki Y, Tabata Y, Kawasaki H, Usui T, Yoshida M, Itoh T, Habu S & Kita T (2000) Oral immunization with size-purified microsphere beads as a vehicle selectively induces systemic tolerance and sensitization. Vaccine 19, 579-588.
23. Medzhitov R & Janeway C (2000) Innate immune recognition: Mechanisms and pathways. Immunol Rev 173, 89-97.
24. Moeremans M, Daneels G & Demey J (1985) Sensitive colloidal metal (gold or silver) staining of protein blots on nitrocellulose membranes. Anal Biochem 145, 315-321.
25. Mølck A-M, Poulsen M, Christensen HR, Lauridsen TS & Madsen C (2002) Immunotoxicity of nucleic acid reduced BioProtein - A bacterial derived single cell protein - In Wistar rats. Toxicology 174, 183-200.
26. Nakase H, Okazaki K, Tabata Y, et al. (2001) Rectal immunization with antigen-containing microspheres induces stronger Th2 responses than oral immunization: A new method for vaccination. Vaccine 20, 377-384.
27. O'Hagan DT, Palin K, Davis SS, Artursson P & Sjoholm I (1989) Microparticles as potentially orally active immunological adjuvants. Vaccine 7, 421-424.
28. Pulendran B, Kumar P, Cutler CW, Mohamadzadeh M, Van Dyke T & Banchereau J (2001) Lipopolysaccharides from distinct pathogens induce different classes of immune responses in vivo. J Immunol 167, 5067-5076.
29. Rumbo M, Chirdo FG, Anon MC & Fossati CA (1998) Detection and characterization of antibodies specific to food antigens (gliadin, ovalbumin and beta-lactoglobulin) in human serum, saliva, colostrum and milk. Clin Exp Immunol 112, 453-458.
30. Schagger H & VonJagow G (1987) Tricine sodium dodecylsulfate polyacrylamide-gel electrophoresis for the separation of proteins in the range from 1-KDa to 100-kDa. Anal Biochem 166, 368-379.
31. Scrimshaw NS & Murray EB (1995) Nutritional value and safety of single cell protein. In Enzymes, Biomass and Feed, pp. 221-237 [G Reed and TW Nagodawithana, editors]. Weinham: VCH.
32. Strobel S & Mowat AM (1998) Immune responses to dietary antigens: Oral tolerance. Immunol Today 19, 173-181.
33. Strober W & Coffman RL (1997) Tolerance and immunity in the mucosal immune system - Introduction. Res Immunol 148, 489-490.
34. Tabata Y, Inoue Y & Ikada Y (1996) Size effect on systemic and mucosal immune responses induced by oral administration of biodegradable microspheres. Vaccine 14, 1677-1685.
35. Whittenbury R & Krieg NR (1984) Methylococcaceae. In Bergey's Manual of Systemic Bacteriology, pp. 256-261 [NR Krieg and JG Holt, editors]. Baltimore, MD: Williams and Wilkins.
36. Wold AE, Dahlgren UIH, Hanson LA, Mattsbybaltzer I & Midvetdt T (1989) Difference between bacterial and food antigens in mucosal immunogenicity. Infect Immun 57, 2666-2673.