-
1
-
-
85039647590
-
-
Cancer facts and figures [online]. Available from URL: [Accessed Aug 30]
-
Cancer facts and figures [online]. Available from URL: http://www.cancer.org [Accessed 2002 Aug 30]
-
(2002)
-
-
-
2
-
-
0000374496
-
Non-small cell lung cancer
-
DeVita Jr V, Hellman S, Rosenberg S, editors. 6th ed. Philadelphia (PA): Lippincott Williams & Wilkins
-
Ginsberg R, Vokes E, Rosenzweig K. Non-small cell lung cancer. In: DeVita Jr V, Hellman S, Rosenberg S, editors. Cancer: principles and practice of oncology. 6th ed. Philadelphia (PA): Lippincott Williams & Wilkins, 2001: 925-82
-
(2001)
Cancer: Principles and Practice of Oncology
, pp. 925-982
-
-
Ginsberg, R.1
Vokes, E.2
Rosenzweig, K.3
-
3
-
-
0035145583
-
Angiogenesis during implantation, and placental and early embryonic development
-
Sherer D, Abulafia O. Angiogenesis during implantation, and placental and early embryonic development. Placenta 2001; 22: 1-13
-
(2001)
Placenta
, vol.22
, pp. 1-13
-
-
Sherer, D.1
Abulafia, O.2
-
4
-
-
0002137518
-
Angiogenesis in female reproductive organs
-
Alexander N, d'Arcangues C, editors. Washington, DC: AAAS Press
-
Folkman J. Angiogenesis in female reproductive organs. In: Alexander N, d'Arcangues C, editors. Steroid hormones and uterine bleeding. Washington, DC: AAAS Press, 1992: 143-58
-
(1992)
Steroid Hormones and Uterine Bleeding
, pp. 143-158
-
-
Folkman, J.1
-
7
-
-
0028223727
-
Aberrant production of interleukin-8 and thrombospondin-1 by psoriatic keratinocytes mediates angiogenesis
-
Nickoloff B, Mitra R, Varani J, et al. Aberrant production of interleukin-8 and thrombospondin-1 by psoriatic keratinocytes mediates angiogenesis. Am J Pathol 1994; 144: 820-8
-
(1994)
Am. J. Pathol.
, vol.144
, pp. 820-828
-
-
Nickoloff, B.1
Mitra, R.2
Varani, J.3
-
8
-
-
0035173448
-
Novel mechanism for age-related macular degeneration: An equilibrium shift between the angiogenesis factors VEGF and PEDF
-
Ohno-Matsui K, Morita I, Tombran-Tink J, et al. Novel mechanism for age-related macular degeneration: an equilibrium shift between the angiogenesis factors VEGF and PEDF. J Cell Physiol 2001; 189: 323-33
-
(2001)
J. Cell Physiol.
, vol.189
, pp. 323-333
-
-
Ohno-Matsui, K.1
Morita, I.2
Tombran-Tink, J.3
-
9
-
-
0028929803
-
Angiogenesis in cancer, vascular, rheumatoid and other disease
-
Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1995; 1: 27-31
-
(1995)
Nat. Med.
, vol.1
, pp. 27-31
-
-
Folkman, J.1
-
10
-
-
0030576517
-
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
-
Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996; 86: 353-64
-
(1996)
Cell
, vol.86
, pp. 353-364
-
-
Hanahan, D.1
Folkman, J.2
-
11
-
-
0021239705
-
Endothelial proliferation in tumours and normal tissues: Continous labelling studies
-
Hobson B, Denekamp J. Endothelial proliferation in tumours and normal tissues: continous labelling studies. Br J Cancer 1984; 49: 405-13
-
(1984)
Br. J. Cancer
, vol.49
, pp. 405-413
-
-
Hobson, B.1
Denekamp, J.2
-
12
-
-
0030020131
-
Tumor angiogenesis and tissue factor
-
Folkman J. Tumor angiogenesis and tissue factor. Nat Med 1996; 2: 167-8
-
(1996)
Nat. Med.
, vol.2
, pp. 167-168
-
-
Folkman, J.1
-
13
-
-
0030484797
-
Reciprocal paracrine interactions between tumour cells and endothelial cells: The 'angiogenic progression' hypothesis
-
Rak J, Filmus J, Kerbel R. Reciprocal paracrine interactions between tumour cells and endothelial cells: the 'angiogenic progression' hypothesis. Eur J Cancer 1996; 32A: 2438-50
-
(1996)
Eur. J. Cancer
, vol.32 A
, pp. 2438-2450
-
-
Rak, J.1
Filmus, J.2
Kerbel, R.3
-
14
-
-
0030484702
-
Role of integrins in angiogenesis
-
Brooks P. Role of integrins in angiogenesis. Eur J Cancer 1996; 32A: 2423-9
-
(1996)
Eur. J. Cancer
, vol.32 A
, pp. 2423-2429
-
-
Brooks, P.1
-
15
-
-
0028362876
-
Requirement of vascular integrin alpha v beta 3 for angiogenesis
-
Brooks P, Clark R, Cheresh D. Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science 1994; 264: 569-71
-
(1994)
Science
, vol.264
, pp. 569-571
-
-
Brooks, P.1
Clark, R.2
Cheresh, D.3
-
17
-
-
0029127230
-
Angiogenesis mediated by soluble forms of E-selectin and vascular cell adhesion molecule-1
-
Koch A, Halloran M, Haskell C, et al. Angiogenesis mediated by soluble forms of E-selectin and vascular cell adhesion molecule-1. Nature 1995; 376: 517-9
-
(1995)
Nature
, vol.376
, pp. 517-519
-
-
Koch, A.1
Halloran, M.2
Haskell, C.3
-
18
-
-
0030932552
-
In vitro inhibition of endothelial cell growth by the antiangiogenic drug AGM-1470 (TNP-470) and the anti-endoglin antibody TEC-11
-
Maier J, Delia D, Thorpe P, et al. In vitro inhibition of endothelial cell growth by the antiangiogenic drug AGM-1470 (TNP-470) and the anti-endoglin antibody TEC-11. Anticancer Drugs 1997; 8: 238-44
-
(1997)
Anticancer Drugs
, vol.8
, pp. 238-244
-
-
Maier, J.1
Delia, D.2
Thorpe, P.3
-
19
-
-
0033052090
-
The plasmin cascade and matrix metalloproteinases in non-small cell lung cancer
-
Cox G, Steward W, O'Byrne K. The plasmin cascade and matrix metalloproteinases in non-small cell lung cancer. Thorax 1999; 54: 169-79
-
(1999)
Thorax
, vol.54
, pp. 169-179
-
-
Cox, G.1
Steward, W.2
O'Byrne, K.3
-
20
-
-
0024234532
-
Urokinase-dependent adhesion loss and shape change afer cyclic adenosine monophosphate elevation in cultured rat mesangial cells
-
Glass W, Radnik R, Garoni J, et al. Urokinase-dependent adhesion loss and shape change afer cyclic adenosine monophosphate elevation in cultured rat mesangial cells. J Clin Invest 1988; 82: 1992-2000
-
(1988)
J. Clin. Invest.
, vol.82
, pp. 1992-2000
-
-
Glass, W.1
Radnik, R.2
Garoni, J.3
-
21
-
-
0030788411
-
The urokinase-type plasminogen activator system in cancer metastasis: A review
-
Andreasen P, Kjoller L, Christensen L, et al. The urokinase-type plasminogen activator system in cancer metastasis: a review. Int J Cancer 1997; 72: 1-22
-
(1997)
Int. J. Cancer
, vol.72
, pp. 1-22
-
-
Andreasen, P.1
Kjoller, L.2
Christensen, L.3
-
22
-
-
0028325321
-
Plasminogen activators and their inhibitors in non-small cell lung cancer: Low content of type 2 plasminogen activator inhibitor associated with tumor dissemination
-
Nagayama M, Sato A, Hayakawa H, et al. Plasminogen activators and their inhibitors in non-small cell lung cancer: low content of type 2 plasminogen activator inhibitor associated with tumor dissemination. Cancer 1994; 73: 1398-405
-
(1994)
Cancer
, vol.73
, pp. 1398-1405
-
-
Nagayama, M.1
Sato, A.2
Hayakawa, H.3
-
23
-
-
0032784649
-
Expression of plasminogen activator inhibitors 1 and 2 in lung cancer and their role in tumor progression
-
Robert C, Bolen I, Gazzeri S, et al. Expression of plasminogen activator inhibitors 1 and 2 in lung cancer and their role in tumor progression. Clin Cancer Res 1999; 5: 2094-102
-
(1999)
Clin. Cancer Res.
, vol.5
, pp. 2094-2102
-
-
Robert, C.1
Bolen, I.2
Gazzeri, S.3
-
24
-
-
0031733174
-
Multifunctional potential of the plasminogen activation system in tumor invasion and metastasis
-
Reuning U, Magdolen V, Wilhelm O, et al. Multifunctional potential of the plasminogen activation system in tumor invasion and metastasis. Int J Oncol 1998; 13: 893-906
-
(1998)
Int. J. Oncol.
, vol.13
, pp. 893-906
-
-
Reuning, U.1
Magdolen, V.2
Wilhelm, O.3
-
25
-
-
0028070859
-
Prognostic impact of urokinase, urokinase receptor and type-1 plasminogen activator inhibitor in squamous and large cell lung cancer tissue
-
Pedersen H, Brunner N, Francis D, et al. Prognostic impact of urokinase, urokinase receptor and type-1 plasminogen activator inhibitor in squamous and large cell lung cancer tissue. Cancer Res 1994; 54: 4671-5
-
(1994)
Cancer Res.
, vol.54
, pp. 4671-4675
-
-
Pedersen, H.1
Brunner, N.2
Francis, D.3
-
26
-
-
0035408087
-
Interference with the urokinase plasminogen activator system: A promising therapy concept for solid tumours
-
Muchlenweg B, Sperl S, Madolen V, et al. Interference with the urokinase plasminogen activator system: a promising therapy concept for solid tumours. Expert Opin Biol Ther 2001; 1: 683-91
-
(2001)
Expert Opin. Biol. Ther.
, vol.1
, pp. 683-691
-
-
Muchlenweg, B.1
Sperl, S.2
Madolen, V.3
-
27
-
-
0033999308
-
Matrix metalloproteinases: Biologic activity and clinical implications
-
Nelson A, Fingleton B, Rothenberg M, et al. Matrix metalloproteinases: biologic activity and clinical implications. J Clin Oncol 2000; 18: 1135-49
-
(2000)
J. Clin. Oncol.
, vol.18
, pp. 1135-1149
-
-
Nelson, A.1
Fingleton, B.2
Rothenberg, M.3
-
28
-
-
0035819527
-
Development of matrix metalloproteinase inhibitors in cancer therapy
-
Hidalgo M, Eckhardt S. Development of matrix metalloproteinase inhibitors in cancer therapy. J Natl Cancer Inst 2001; 93: 178-93
-
(2001)
J. Natl. Cancer Inst.
, vol.93
, pp. 178-193
-
-
Hidalgo, M.1
Eckhardt, S.2
-
29
-
-
0030939074
-
Expression of urokinase-type plasminogen activator, stromelysin 1, stromelysin 3, and matrilysin genes in lung carcinomas
-
Bolon I, Devouasoux M, Moro R, et al. Expression of urokinase-type plasminogen activator, stromelysin 1, stromelysin 3, and matrilysin genes in lung carcinomas. Am J Pathol 1997; 150: 1619-29
-
(1997)
Am. J. Pathol.
, vol.150
, pp. 1619-1629
-
-
Bolon, I.1
Devouasoux, M.2
Moro, R.3
-
30
-
-
0027469921
-
Association between expression of activated 72-kilodalton gelatinase and tumor spread in non-small-cell lung carcinoma
-
Brown P, Bloxidge R, Stuart N, et al. Association between expression of activated 72-kilodalton gelatinase and tumor spread in non-small-cell lung carcinoma. J Natl Cancer Inst 1993; 85: 574-8
-
(1993)
J. Natl. Cancer Inst.
, vol.85
, pp. 574-578
-
-
Brown, P.1
Bloxidge, R.2
Stuart, N.3
-
31
-
-
0030785679
-
Expression of matrix metalloproteinases and their inhibitors in human bronchopulmonary carcinomas: Quantificative and morphological analyses
-
Nawrocki B, Polette M, Marchand V, et al. Expression of matrix metalloproteinases and their inhibitors in human bronchopulmonary carcinomas: quantificative and morphological analyses. Int J Cancer 1997; 72: 556-64
-
(1997)
Int. J. Cancer
, vol.72
, pp. 556-564
-
-
Nawrocki, B.1
Polette, M.2
Marchand, V.3
-
32
-
-
0028838487
-
Activation of the precursor of gelatinase A/72 kDa type IV collagenase/MMP-2 in lung carcinomas correlates with the expression of membrane-type matrix metalloproteinase (MT-MMP) and with lymph node metastasis
-
Tokuraku M, Sato H, Murakami S, et al. Activation of the precursor of gelatinase A/72 kDa type IV collagenase/MMP-2 in lung carcinomas correlates with the expression of membrane-type matrix metalloproteinase (MT-MMP) and with lymph node metastasis. Int J Cancer 1995; 64: 355-9
-
(1995)
Int. J. Cancer
, vol.64
, pp. 355-359
-
-
Tokuraku, M.1
Sato, H.2
Murakami, S.3
-
33
-
-
0015008620
-
Isolation of a tumor factor responsible for angiogenesis
-
Folkman J, Merler E, Abernathy C, et al. Isolation of a tumor factor responsible for angiogenesis. J Exp Med 1971; 133: 275-88
-
(1971)
J. Exp. Med.
, vol.133
, pp. 275-288
-
-
Folkman, J.1
Merler, E.2
Abernathy, C.3
-
34
-
-
0021359304
-
Heparin affinity: Purification of a tumor-derived capillary endothelial cell growth factor
-
Shing Y, Folkman J, Sullivan R, et al. Heparin affinity: purification of a tumor-derived capillary endothelial cell growth factor. Science 1984; 223: 1296-9
-
(1984)
Science
, vol.223
, pp. 1296-1299
-
-
Shing, Y.1
Folkman, J.2
Sullivan, R.3
-
35
-
-
0022397812
-
Primary structure of bovine brain acidic fibroblast growth factor
-
Esch F, Ueno N, Baird A, et al. Primary structure of bovine brain acidic fibroblast growth factor. Biochem Biophys Res Commun 1985; 133: 554-62
-
(1985)
Biochem. Biophys. Res. Commun.
, vol.133
, pp. 554-562
-
-
Esch, F.1
Ueno, N.2
Baird, A.3
-
36
-
-
0022399773
-
Isolation and characterization of angiogenin, an angiogenic protein from human carcinoma cells
-
Fett J, Strydom D, Lobb R, et al. Isolation and characterization of angiogenin, an angiogenic protein from human carcinoma cells. Biochemistry 1985; 24: 5480-6
-
(1985)
Biochemistry
, vol.24
, pp. 5480-5486
-
-
Fett, J.1
Strydom, D.2
Lobb, R.3
-
37
-
-
0022501030
-
Transforming growth factor-alpha: A more potent angiogenic mediator than epidermal growth factor
-
Schreiber A, Winkler M, Derynck R. Transforming growth factor-alpha: a more potent angiogenic mediator than epidermal growth factor. Science 1986; 232: 1250-3
-
(1986)
Science
, vol.232
, pp. 1250-1253
-
-
Schreiber, A.1
Winkler, M.2
Derynck, R.3
-
38
-
-
0022471924
-
Transforming growth factor type beta: Rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro
-
Roberts A, Sporn M, Assoian R, et al. Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci U S A 1986; 83: 4167-71
-
(1986)
Proc. Natl. Acad. Sci. U. S. A.
, vol.83
, pp. 4167-4171
-
-
Roberts, A.1
Sporn, M.2
Assoian, R.3
-
39
-
-
0013624595
-
Tumor necrosis factor type alpha, a potent inhibitor of endothelial cell growth in vitro, is angiogenic in vivo
-
Frater-Schroder M, Risau W, Hallmann R, et al. Tumor necrosis factor type alpha, a potent inhibitor of endothelial cell growth in vitro, is angiogenic in vivo. Proc Natl Acad Sci U S A 1987; 84: 5277-88
-
(1987)
Proc. Natl. Acad. Sci. U. S. A.
, vol.84
, pp. 5277-5288
-
-
Frater-Schroder, M.1
Risau, W.2
Hallmann, R.3
-
40
-
-
0021111648
-
Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
-
Senger D, Galli S, Dvorak A, et al. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 1983; 219: 983-5
-
(1983)
Science
, vol.219
, pp. 983-985
-
-
Senger, D.1
Galli, S.2
Dvorak, A.3
-
41
-
-
0024818355
-
Vascular endothelial growth factor is a secreted angiogenic mitogen
-
Leung D, Cachianes G, Kuang W, et al. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989; 246: 1306-9
-
(1989)
Science
, vol.246
, pp. 1306-1309
-
-
Leung, D.1
Cachianes, G.2
Kuang, W.3
-
42
-
-
0024531796
-
Granulocyte- and granulocyte-macrophage-colony stimulating factors induce human endothelial cells to migrate and proliferate
-
Bussolino F, Wang J, Defilippi P, et al. Granulocyte- and granulocyte-macrophage-colony stimulating factors induce human endothelial cells to migrate and proliferate. Nature 1989; 337: 471-3
-
(1989)
Nature
, vol.337
, pp. 471-473
-
-
Bussolino, F.1
Wang, J.2
Defilippi, P.3
-
43
-
-
0024563134
-
Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor
-
Ishikawa F, Miyazono K, Hellman U, et al. Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor. Nature 1989; 338: 557-62
-
(1989)
Nature
, vol.338
, pp. 557-562
-
-
Ishikawa, F.1
Miyazono, K.2
Hellman, U.3
-
44
-
-
0026052391
-
Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor
-
Maglione D, Guerriero V, Viglietto G, et al. Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor. Proc Natl Acad Sci U S A 1991; 88: 9267-71
-
(1991)
Proc. Natl. Acad. Sci. U. S. A.
, vol.88
, pp. 9267-9271
-
-
Maglione, D.1
Guerriero, V.2
Viglietto, G.3
-
45
-
-
0027097806
-
Interleukin-8 as a macrophage-derived mediator of angiogenesis
-
Koch A, Polverini P, Kunkel S, et al. Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science 1992; 258: 1798-801
-
(1992)
Science
, vol.258
, pp. 1798-1801
-
-
Koch, A.1
Polverini, P.2
Kunkel, S.3
-
46
-
-
0027076643
-
Pleiotrophin stimulates fibroblasts and endothelial and epithelial cells and is expressed in human cancer
-
Fang W, Hartmann N, Chow D, et al. Pleiotrophin stimulates fibroblasts and endothelial and epithelial cells and is expressed in human cancer. J Biol Chem 1992; 267: 25889-97
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 25889-25897
-
-
Fang, W.1
Hartmann, N.2
Chow, D.3
-
47
-
-
0027792295
-
Scatter factor (hepatocyte growth factor) is a potent angiogenesis factor in vivo
-
Rosen E, Grant D, Kleinman H, et al. Scatter factor (hepatocyte growth factor) is a potent angiogenesis factor in vivo. Symp Soc Exp Biol 1993; 47: 227-34
-
(1993)
Symp. Soc. Exp. Biol.
, vol.47
, pp. 227-234
-
-
Rosen, E.1
Grant, D.2
Kleinman, H.3
-
48
-
-
0028618340
-
Stimulation and inhibition of angiogenesis by placental proliferin and proliferin-related protein
-
Jackson D, Volpert O, Bouck N, et al. Stimulation and inhibition of angiogenesis by placental proliferin and proliferin-related protein. Science 1994; 266: 1581-4
-
(1994)
Science
, vol.266
, pp. 1581-1584
-
-
Jackson, D.1
Volpert, O.2
Bouck, N.3
-
49
-
-
0030480322
-
Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
-
Suri C, Jones P, Patan S, et al. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell 1996; 87: 1171-80
-
(1996)
Cell
, vol.87
, pp. 1171-1180
-
-
Suri, C.1
Jones, P.2
Patan, S.3
-
50
-
-
0031049187
-
The activin-binding protein follistatin regulates autocrine endothelial cell activity and induces angiogenesis
-
Kozian D, Ziche M, Augustin H. The activin-binding protein follistatin regulates autocrine endothelial cell activity and induces angiogenesis. Lab Invest 1997; 76: 267-76
-
(1997)
Lab. Invest.
, vol.76
, pp. 267-276
-
-
Kozian, D.1
Ziche, M.2
Augustin, H.3
-
51
-
-
0032508682
-
Biological action of leptin as an angiogenic factor
-
Sierra-Honigmann M, Nath A, Murakami C, et al. Biological action of leptin as an angiogenic factor. Science 1998; 281: 1683-6
-
(1998)
Science
, vol.281
, pp. 1683-1686
-
-
Sierra-Honigmann, M.1
Nath, A.2
Murakami, C.3
-
52
-
-
0029004025
-
Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis
-
Dvorak H, Brown L, Detmar M, et al. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol 1995; 146: 1029-39
-
(1995)
Am. J. Pathol.
, vol.146
, pp. 1029-1039
-
-
Dvorak, H.1
Brown, L.2
Detmar, M.3
-
53
-
-
0032963472
-
Vascular endothelial growth factor (VEGF)-mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl-2 expression
-
Nor J, Christensen J, Mooney D, et al. Vascular endothelial growth factor (VEGF)-mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl-2 expression. Am J Pathol 1999; 154: 375-84
-
(1999)
Am. J. Pathol.
, vol.154
, pp. 375-384
-
-
Nor, J.1
Christensen, J.2
Mooney, D.3
-
54
-
-
0026446859
-
Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells
-
Unemori E, Ferrara N, Bauer E, et al. Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells. J Cell Physiol 1992; 153: 557-62
-
(1992)
J. Cell Physiol.
, vol.153
, pp. 557-562
-
-
Unemori, E.1
Ferrara, N.2
Bauer, E.3
-
55
-
-
0028968307
-
Vascular endothelial growth factor increases urokinase receptor expression in vascular endothelial cells
-
Mandriota S, Seghezzi G, Vassalli J, et al. Vascular endothelial growth factor increases urokinase receptor expression in vascular endothelial cells. J Biol Chem 1995; 270: 9709-16
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 9709-9716
-
-
Mandriota, S.1
Seghezzi, G.2
Vassalli, J.3
-
56
-
-
0026321129
-
Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor type 1 in microvascular endothelial cells
-
Pepper M, Ferrera N, Orci L, et al. Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor type 1 in microvascular endothelial cells. Biochem Biophys Res Commun 1991; 181: 902-6
-
(1991)
Biochem. Biophys. Res. Commun.
, vol.181
, pp. 902-906
-
-
Pepper, M.1
Ferrera, N.2
Orci, L.3
-
57
-
-
0026485002
-
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
-
Shweiki D, Itin A, Soffer D, et al. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 1992; 359: 843-5
-
(1992)
Nature
, vol.359
, pp. 843-845
-
-
Shweiki, D.1
Itin, A.2
Soffer, D.3
-
58
-
-
0032907687
-
Vascular endothelial growth factor (VEGF) and its receptors
-
Neufeld G, Cohen T, Gengrinovitch S, et al. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J 1999; 13: 9-22
-
(1999)
FASEB J.
, vol.13
, pp. 9-22
-
-
Neufeld, G.1
Cohen, T.2
Gengrinovitch, S.3
-
59
-
-
0028822834
-
Mutant ras oncogenes upregulate VEGF/VPF expression: Implications for induction and inhibition of tumor angiogenesis
-
Rak J, Mitsuhashi Y, Bayko L, et al. Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis. Cancer Res 1995; 55: 4575-80
-
(1995)
Cancer Res.
, vol.55
, pp. 4575-4580
-
-
Rak, J.1
Mitsuhashi, Y.2
Bayko, L.3
-
60
-
-
0027958348
-
Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression
-
Kieser A, Welch H, Brandner G, et al. Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression. Oncogene 1994; 9: 963-9
-
(1994)
Oncogene
, vol.9
, pp. 963-969
-
-
Kieser, A.1
Welch, H.2
Brandner, G.3
-
61
-
-
0027359953
-
Vascular permeability factor (VPF, VEGF) in tumor biology
-
Senger D, Van de Water L, Brown L, et al. Vascular permeability factor (VPF, VEGF) in tumor biology. Cancer Metastasis Rev 1993; 12: 303-24
-
(1993)
Cancer Metastasis Rev.
, vol.12
, pp. 303-324
-
-
Senger, D.1
Van de Water, L.2
Brown, L.3
-
62
-
-
0035863288
-
Vascular endothelial growth factor 189 mRNA isoform expression specifically correlates with tumor angiogenesis, patient survival, and postoperative relapse in non-small-cell lung cancer
-
Yuan A, Yu C, Kuo S, et al. Vascular endothelial growth factor 189 mRNA isoform expression specifically correlates with tumor angiogenesis, patient survival, and postoperative relapse in non-small-cell lung cancer. J Clin Oncol 2001; 19: 432-41
-
(2001)
J. Clin. Oncol.
, vol.19
, pp. 432-441
-
-
Yuan, A.1
Yu, C.2
Kuo, S.3
-
63
-
-
0029777325
-
Structure and distribution of modules in extracellular proteins
-
Bork P, Downing K, Kieffer B, et al. Structure and distribution of modules in extracellular proteins. Q Rev Biophysics 1996; 29: 119-67
-
(1996)
Q. Rev. Biophysics
, vol.29
, pp. 119-167
-
-
Bork, P.1
Downing, K.2
Kieffer, B.3
-
64
-
-
0026572345
-
The fms-like tyrosine, kinase, a receptor for vascular endothelial growth factor
-
de Vries C, Escobedo J, Ueno H, et al. The fms-like tyrosine, kinase, a receptor for vascular endothelial growth factor. Science 1992; 255: 989-91
-
(1992)
Science
, vol.255
, pp. 989-991
-
-
de Vries, C.1
Escobedo, J.2
Ueno, H.3
-
65
-
-
0026702970
-
Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor
-
Terman B, Dougher-Vermazen M, Carrion M, et al. Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. Biochem Biophys Res Commun 1992; 187: 1579-86
-
(1992)
Biochem. Biophys. Res. Commun.
, vol.187
, pp. 1579-1586
-
-
Terman, B.1
Dougher-Vermazen, M.2
Carrion, M.3
-
66
-
-
85013312416
-
Tumor angiogenesis: Therapeutic implications
-
Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971; 285: 1182-6
-
(1971)
N. Engl. J. Med.
, vol.285
, pp. 1182-1186
-
-
Folkman, J.1
-
67
-
-
0026525407
-
Interferon alfa-2a therapy for life-threatening hemangiomas of infancy
-
Ezekowitz R, Mulliken J, Folkman J. Interferon alfa-2a therapy for life-threatening hemangiomas of infancy. N Engl J Med 1992; 326: 1456-63
-
(1992)
N. Engl. J. Med.
, vol.326
, pp. 1456-1463
-
-
Ezekowitz, R.1
Mulliken, J.2
Folkman, J.3
-
68
-
-
85039633548
-
-
The Angiogenesis Foundation [online]. Available from URL: [Accessed Aug 30]
-
The Angiogenesis Foundation [online]. Available from URL: http://www.angio.org [Accessed 2002 Aug 30]
-
(2002)
-
-
-
69
-
-
0023160237
-
Inhibition of angiogenesis by interferons: Effects on tumor- and lymphocyte-induced vascular responses
-
Sidky Y, Borden E. Inhibition of angiogenesis by interferons: effects on tumor- and lymphocyte-induced vascular responses. Cancer Res 1987; 47: 5155-61
-
(1987)
Cancer Res.
, vol.47
, pp. 5155-5161
-
-
Sidky, Y.1
Borden, E.2
-
70
-
-
0023118633
-
Inhibition of endothelial cell proliferation by gamma-interferon
-
Friesel R, Komoriya A, Maciag T. Inhibition of endothelial cell proliferation by gamma-interferon. J Cell Biol 1987; 104: 689-96
-
(1987)
J. Cell Biol.
, vol.104
, pp. 689-696
-
-
Friesel, R.1
Komoriya, A.2
Maciag, T.3
-
71
-
-
0022382006
-
Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity
-
Docherty A, Lyons A, Smith B, et al. Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity. Nature 1985; 318: 66-8
-
(1985)
Nature
, vol.318
, pp. 66-68
-
-
Docherty, A.1
Lyons, A.2
Smith, B.3
-
73
-
-
0028125576
-
Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) and mapping of the TIMP3 gene to chromosome 22
-
Apte S, Mattei M, Olsen B. Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) and mapping of the TIMP3 gene to chromosome 22. Genomics 1994; 19: 86-90
-
(1994)
Genomics
, vol.19
, pp. 86-90
-
-
Apte, S.1
Mattei, M.2
Olsen, B.3
-
74
-
-
0032126344
-
Cloning of the human tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and TIMP4 genes to human chromosome 3p25 and mouse chromosome 6, respectively
-
Olson T, Hirohata S, Ye J, et al. Cloning of the human tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and TIMP4 genes to human chromosome 3p25 and mouse chromosome 6, respectively. Genomics 1998; 51: 148-51
-
(1998)
Genomics
, vol.51
, pp. 148-151
-
-
Olson, T.1
Hirohata, S.2
Ye, J.3
-
75
-
-
0025109549
-
Platelet factor 4 blocks the binding of basic fibroblast growth factor to the receptor and inhibits the spontaneous migration of vascular endothelial cells
-
Sato Y, Abe M, Takaki R. Platelet factor 4 blocks the binding of basic fibroblast growth factor to the receptor and inhibits the spontaneous migration of vascular endothelial cells. Biochem Biophys Res Commun 1990; 172: 595-600
-
(1990)
Biochem. Biophys. Res. Commun.
, vol.172
, pp. 595-600
-
-
Sato, Y.1
Abe, M.2
Takaki, R.3
-
76
-
-
0025853349
-
Thrombospondin exerts an antiangiogenic effect on cord formation by endothelial cells in vitro
-
Iruela-Arispe M. Thrombospondin exerts an antiangiogenic effect on cord formation by endothelial cells in vitro. Proc Natl Acad Sci U S A 1991; 88: 5026-30
-
(1991)
Proc. Natl. Acad. Sci. U. S. A.
, vol.88
, pp. 5026-5030
-
-
Iruela-Arispe, M.1
-
77
-
-
0025949596
-
The 16K fragment of prolactin specifically inhibits basal or fibroblast growth factor stimulated growth of capillary endothelial cells
-
Ferrara N, Clapp C, Weiner R. The 16K fragment of prolactin specifically inhibits basal or fibroblast growth factor stimulated growth of capillary endothelial cells. Endocrinology 1991; 129: 896-900
-
(1991)
Endocrinology
, vol.129
, pp. 896-900
-
-
Ferrara, N.1
Clapp, C.2
Weiner, R.3
-
78
-
-
0027970092
-
Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma
-
O'Reilly M, Holmgren L, Shing Y, et al. Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 1994; 79: 315-28
-
(1994)
Cell
, vol.79
, pp. 315-328
-
-
O'Reilly, M.1
Holmgren, L.2
Shing, Y.3
-
79
-
-
0028897739
-
Inhibition of angiogenesis in vivo by interleukin 12
-
Voest E, Kenyon B, O'Reilly M, et al. Inhibition of angiogenesis in vivo by interleukin 12. J Natl Cancer Inst 1995; 87: 581-6
-
(1995)
J. Natl. Cancer Inst.
, vol.87
, pp. 581-586
-
-
Voest, E.1
Kenyon, B.2
O'Reilly, M.3
-
80
-
-
0031454617
-
Endostatin: An endogenous inhibitor of angiogenesis and tumor growth
-
O'Reilly M, Boehm T, Shing Y, et al. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell 1997; 88: 277-85
-
(1997)
Cell
, vol.88
, pp. 277-285
-
-
O'Reilly, M.1
Boehm, T.2
Shing, Y.3
-
81
-
-
15144358851
-
Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
-
Maisonpierre P, Suri C, Jones P, et al. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 1997; 277: 55-60
-
(1997)
Science
, vol.277
, pp. 55-60
-
-
Maisonpierre, P.1
Suri, C.2
Jones, P.3
-
82
-
-
0032445492
-
Vasostatin, a calreticulin fragment, inhibits angiogenesis and suppresses tumor growth
-
Pike S, Yao L, Jones K, et al. Vasostatin, a calreticulin fragment, inhibits angiogenesis and suppresses tumor growth. J Exp Med 1998; 188: 2349-56
-
(1998)
J. Exp. Med.
, vol.188
, pp. 2349-2356
-
-
Pike, S.1
Yao, L.2
Jones, K.3
-
83
-
-
0038757017
-
METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity
-
Vazquez F, Hastings G, Ortega M, et al. METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity. J Biol Chem 1999; 274: 23349-57
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 23349-23357
-
-
Vazquez, F.1
Hastings, G.2
Ortega, M.3
-
84
-
-
0033538517
-
Pigment epithelium-derived factor: A potent inhibitor of angiogenesis
-
Dawson D, Volpert O, Gillis P, et al. Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. Science 1999; 285: 245-8
-
(1999)
Science
, vol.285
, pp. 245-248
-
-
Dawson, D.1
Volpert, O.2
Gillis, P.3
-
85
-
-
0033530257
-
Antiangiogenic activity of prostate-specific antigen
-
Fortier A, Nelson B, Grella D, et al. Antiangiogenic activity of prostate-specific antigen. J Natl Cancer Inst 1999; 91: 1635-40
-
(1999)
J. Natl. Cancer Inst.
, vol.91
, pp. 1635-1640
-
-
Fortier, A.1
Nelson, B.2
Grella, D.3
-
86
-
-
0033578910
-
Antiangiogenic activity of the cleaved conformation of the serpin antithrombin
-
O'Reilly M, Pirie-Shepherd S, Lane W, et al. Antiangiogenic activity of the cleaved conformation of the serpin antithrombin. Science 1999; 285: 1926-8
-
(1999)
Science
, vol.285
, pp. 1926-1928
-
-
O'Reilly, M.1
Pirie-Shepherd, S.2
Lane, W.3
-
87
-
-
13044311402
-
Troponin I is present in human cartilage and inhibits angiogenesis
-
Moses M, Wiederschain D, Wu I, et al. Troponin I is present in human cartilage and inhibits angiogenesis. Proc Natl Acad Sci U S A 1999; 96: 2645-50
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 2645-2650
-
-
Moses, M.1
Wiederschain, D.2
Wu, I.3
-
88
-
-
0033593014
-
Thrombospondin-2: A potent endogenous inhibitor of tumor growth and angiogenesis
-
Streit M, Riccardi L, Velasco P, et al. Thrombospondin-2: a potent endogenous inhibitor of tumor growth and angiogenesis. Proc Natl Acad Sci U S A 1999; 96: 14888-593
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 14888-15593
-
-
Streit, M.1
Riccardi, L.2
Velasco, P.3
-
89
-
-
0032906102
-
VEGI, a novel cytokine of the tumor necrosis factor family, is an angiogenesis inhibitor that suppresses the growth of colon carcinomas in vivo
-
Zhai Y, Ni J, Jiang G, et al. VEGI, a novel cytokine of the tumor necrosis factor family, is an angiogenesis inhibitor that suppresses the growth of colon carcinomas in vivo. FASEB J 1999; 13: 181-9
-
(1999)
FASEB J.
, vol.13
, pp. 181-189
-
-
Zhai, Y.1
Ni, J.2
Jiang, G.3
-
90
-
-
0033979905
-
Canstatin, a novel matrix-derived inhibitor of angiogenesis and tumor growth
-
Kamphaus G, Colorado P, Panka D, et al. Canstatin, a novel matrix-derived inhibitor of angiogenesis and tumor growth. J Biol Chem 2000; 275: 1209-15
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 1209-1215
-
-
Kamphaus, G.1
Colorado, P.2
Panka, D.3
-
91
-
-
0035114425
-
Metastatin: A hyaluronan-binding complex from cartilage that inhibits tumor growth
-
Liu N, Lapcevich R, Underhill C, et al. Metastatin: a hyaluronan-binding complex from cartilage that inhibits tumor growth. Cancer Res 2001; 61: 1022-8
-
(2001)
Cancer Res.
, vol.61
, pp. 1022-1028
-
-
Liu, N.1
Lapcevich, R.2
Underhill, C.3
-
92
-
-
0029944122
-
Angiostatin induces and sustains dormancy of human primary tumors in mice
-
O'Reilly M, Holmgren L, Chen C, et al. Angiostatin induces and sustains dormancy of human primary tumors in mice. Nat Med 1996; 2: 689-92
-
(1996)
Nat. Med.
, vol.2
, pp. 689-692
-
-
O'Reilly, M.1
Holmgren, L.2
Chen, C.3
-
93
-
-
0033870356
-
Angiostatin expression in non-small cell lung cancer
-
Volm M, Mattern J, Koomagi R. Angiostatin expression in non-small cell lung cancer. Clin Cancer Res 2000; 6 (8): 3236-40
-
(2000)
Clin. Cancer Res.
, vol.6
, Issue.8
, pp. 3236-3240
-
-
Volm, M.1
Mattern, J.2
Koomagi, R.3
-
94
-
-
0000829627
-
Recombinant human angiostatin: A phase I clinical trial assessing safety, pharmacokinetics and pharmacodynamics
-
[abstract no. 10]
-
DeMoraes E, Fogler W, Grant D, et al. Recombinant human angiostatin: a phase I clinical trial assessing safety, pharmacokinetics and pharmacodynamics [abstract no. 10]. Proc Am Soc Clin Oncol 2001; 20: 3a
-
(2001)
Proc. Am. Soc. Clin. Oncol.
, vol.20
-
-
DeMoraes, E.1
Fogler, W.2
Grant, D.3
-
95
-
-
0031469819
-
Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
-
Boehm T, Folkman J, Browder T, et al. Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance. Nature 1997; 390: 404-7
-
(1997)
Nature
, vol.390
, pp. 404-407
-
-
Boehm, T.1
Folkman, J.2
Browder, T.3
-
97
-
-
0025204095
-
Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumor growth
-
Ingber D, Fujita T, Kishimoto S, et al. Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumor growth. Nature 1990; 348: 555-7
-
(1990)
Nature
, vol.348
, pp. 555-557
-
-
Ingber, D.1
Fujita, T.2
Kishimoto, S.3
-
98
-
-
0041896640
-
TNP-470: Preclinical and clinical development
-
Voest E, D'Amore P, editors. New York: Marcel Dekker, Inc
-
Milkowski D, Weiss R. TNP-470: preclinical and clinical development. In: Voest E, D'Amore P, editors. Tumor angiogenesis and microcirculation. New York: Marcel Dekker, Inc., 2001: 431-47
-
(2001)
Tumor Angiogenesis and Microcirculation
, pp. 431-447
-
-
Milkowski, D.1
Weiss, R.2
-
99
-
-
0031839534
-
Combined effects of TNP-470 and taxol in human non-small cell lung cancer cell lines
-
Satoh H, Ishikawa H, Fujimoto M, et al. Combined effects of TNP-470 and taxol in human non-small cell lung cancer cell lines. Anticancer Res 1998; 18: 1027-30
-
(1998)
Anticancer Res.
, vol.18
, pp. 1027-1030
-
-
Satoh, H.1
Ishikawa, H.2
Fujimoto, M.3
-
100
-
-
0001504902
-
Phase I study of the angiogenesis inhibitor TNP-470 in combination of paclitaxel in patients with solid tumors
-
[abstract no. 707]
-
Herbst R, Tran H, Madden T, et al. Phase I study of the angiogenesis inhibitor TNP-470 in combination of paclitaxel in patients with solid tumors [abstract no. 707]. Proc Am Soc Clin Oncol 2000; 19: 182a
-
(2000)
Proc. Am. Soc. Clin. Oncol.
, vol.19
-
-
Herbst, R.1
Tran, H.2
Madden, T.3
-
101
-
-
85039642611
-
Phase I study of the angiogenesis inhibitor TNP-470 in combination with paclitaxel and carboplatin in patients with solid tumors
-
[abstract no. 394]
-
Tran H, Blumenschein JGL, Madden T, et al. Phase I study of the angiogenesis inhibitor TNP-470 in combination with paclitaxel and carboplatin in patients with solid tumors [abstract no. 394]. Proc Am Soc Clin Oncol 2001; 20: 99a
-
(2001)
Proc. Am. Soc. Clin. Oncol.
, vol.20
-
-
Tran, H.1
Blumenschein, J.G.L.2
Madden, T.3
-
102
-
-
0023696675
-
Inhibition by human recombinant tissue inhibitor of metalloproteinases of human amnion invasion and lung colonization by murine B16-F10 melanoma cells
-
Schultz R, Silberman S, Persky B, et al. Inhibition by human recombinant tissue inhibitor of metalloproteinases of human amnion invasion and lung colonization by murine B16-F10 melanoma cells. Cancer Res 1988; 48: 5539-45
-
(1988)
Cancer Res.
, vol.48
, pp. 5539-5545
-
-
Schultz, R.1
Silberman, S.2
Persky, B.3
-
103
-
-
0025238632
-
Inhibition of collagenolytic activity and metastasis of tumor cells by a recombinant human tissue inhibitor of metalloproteinases
-
Alvarez O, Carmichael D, DeClerck Y. Inhibition of collagenolytic activity and metastasis of tumor cells by a recombinant human tissue inhibitor of metalloproteinases. J Natl Cancer Inst 1990; 82: 589-95
-
(1990)
J. Natl. Cancer Inst.
, vol.82
, pp. 589-595
-
-
Alvarez, O.1
Carmichael, D.2
DeClerck, Y.3
-
104
-
-
0032837016
-
Tissue inhibitors of matrix metalloproteinases in cancer
-
Blavier L, Henriet P, Imren S, et al. Tissue inhibitors of matrix metalloproteinases in cancer. Ann N Y Acad Sci 1999; 878: 108-19
-
(1999)
Ann. N. Y. Acad. Sci.
, vol.878
, pp. 108-119
-
-
Blavier, L.1
Henriet, P.2
Imren, S.3
-
105
-
-
0031776982
-
Phase I trial of marimastat, a novel matrix metalloproteinase inhibitor, administered orally to patients with advanced lung cancer
-
Wojtowicz-Praga S, Torri J, Johnson M, et al. Phase I trial of marimastat, a novel matrix metalloproteinase inhibitor, administered orally to patients with advanced lung cancer. J Clin Oncol 1998; 16: 2150-6
-
(1998)
J. Clin. Oncol.
, vol.16
, pp. 2150-2156
-
-
Wojtowicz-Praga, S.1
Torri, J.2
Johnson, M.3
-
106
-
-
0001834442
-
Randomized double-blind placebo-controlled trial of marimastat in patients with small cell lung cancer following response to first-line chemotherapy: An NCIC-CTG and EORTC study
-
[abstract no. 11]
-
Shepherd F, Giaccone G, Debruyne C, et al. Randomized double-blind placebo-controlled trial of marimastat in patients with small cell lung cancer following response to first-line chemotherapy: an NCIC-CTG and EORTC study [abstract no. 11]. Proc Am Soc Clin Oncol 2001; 20: 4a
-
(2001)
Proc. Am. Soc. Clin. Oncol.
, vol.20
-
-
Shepherd, F.1
Giaccone, G.2
Debruyne, C.3
-
107
-
-
0000203704
-
Pilot pharmacokinetic study of marimastat in combination with carboplatin/paclitaxel in patients with metastatic or locally advanced inoperable non-small cell lung cancer
-
[abstract 719]
-
Anderson I, Supko J, Eder J. Pilot pharmacokinetic study of marimastat in combination with carboplatin/paclitaxel in patients with metastatic or locally advanced inoperable non-small cell lung cancer [abstract 719]. Proc Am Soc Clin Oncol 1999; 18: 187a
-
(1999)
Proc. Am. Soc. Clin. Oncol.
, vol.18
-
-
Anderson, I.1
Supko, J.2
Eder, J.3
-
108
-
-
0035060804
-
Matrix proteinase inhibition by AE-941, a multifunctional anti-angiogenic compound
-
Gingras D, Renaud A, Mousseau N, et al. Matrix proteinase inhibition by AE-941, a multifunctional anti-angiogenic compound. Anticancer Res 2001; 21: 145-55
-
(2001)
Anticancer Res.
, vol.21
, pp. 145-155
-
-
Gingras, D.1
Renaud, A.2
Mousseau, N.3
-
109
-
-
0035207897
-
Neovastat, a naturally occurring multifunctional antiangiogenic drug, in phase III clinical trials
-
Falardeau P, Champagne P, Poyet P, et al. Neovastat, a naturally occurring multifunctional antiangiogenic drug, in phase III clinical trials. Semin Oncol 2001; 28: 620-5
-
(2001)
Semin. Oncol.
, vol.28
, pp. 620-625
-
-
Falardeau, P.1
Champagne, P.2
Poyet, P.3
-
110
-
-
0000909547
-
A phase I trial of BMS-275291: A novel, non-hydroxamate, sheddase-sparing matrix metalloproteinase inhibitor with no dose-limiting arthritis
-
[abstract no. 387]
-
Hurwitz H, Humphrey J, Williams K, et al. A phase I trial of BMS-275291: a novel, non-hydroxamate, sheddase-sparing matrix metalloproteinase inhibitor with no dose-limiting arthritis [abstract no. 387]. Proc Am Soc Clin Oncol 2001; 20: 98a
-
(2001)
Proc. Am. Soc. Clin. Oncol.
, vol.20
-
-
Hurwitz, H.1
Humphrey, J.2
Williams, K.3
-
111
-
-
0001185393
-
Phase III study of the matrix metalloprotease (MMP) inhibitor prinomastat in patients having advanced non-small cell lung cancer (NSCLC)
-
[abstract no. 1226]
-
Smylie M, Mercier R, Aboulafia D, et al. Phase III study of the matrix metalloprotease (MMP) inhibitor prinomastat in patients having advanced non-small cell lung cancer (NSCLC) [abstract no. 1226]. Proc Am Soc Clin Oncol 2001; 20: 307a
-
(2001)
Proc. Am. Soc. Clin. Oncol.
, vol.20
-
-
Smylie, M.1
Mercier, R.2
Aboulafia, D.3
-
112
-
-
0033986165
-
Phase I and pharmacologic study of the specific matrix metalloproteinase inhibitor BAY 12-9566 on a protracted oral daily dosing schedule in patients with solid malignancies
-
Rowinsky E, Humphrey R, Hammond L, et al. Phase I and pharmacologic study of the specific matrix metalloproteinase inhibitor BAY 12-9566 on a protracted oral daily dosing schedule in patients with solid malignancies. J Clin Oncol 2000; 18: 178-86
-
(2000)
J. Clin. Oncol.
, vol.18
, pp. 178-186
-
-
Rowinsky, E.1
Humphrey, R.2
Hammond, L.3
-
113
-
-
0034772722
-
Phase I and pharmacological study of the oral matrix metalloproteinase inhibitor, MMI270 (CGS27023A), in patients with advanced solid cancer
-
Levitt N, Eskens F, O'Byrne K, et al. Phase I and pharmacological study of the oral matrix metalloproteinase inhibitor, MMI270 (CGS27023A), in patients with advanced solid cancer. Clin Cancer Res 2001; 7: 1912-22
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 1912-1922
-
-
Levitt, N.1
Eskens, F.2
O'Byrne, K.3
-
114
-
-
0033043733
-
Wide spectrum of antitumor activity of a neutralizing monoclonal antibody to human vascular endothelial growth factor
-
Asano M, Yukita A, Suzuki H. Wide spectrum of antitumor activity of a neutralizing monoclonal antibody to human vascular endothelial growth factor. Jpn J Cancer Res 1999; 90: 93-100
-
(1999)
Jpn. J. Cancer Res.
, vol.90
, pp. 93-100
-
-
Asano, M.1
Yukita, A.2
Suzuki, H.3
-
115
-
-
0030856731
-
Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders
-
Presta L, Chen H, O'Connor S, et al. Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res 1997; 57: 4593-9
-
(1997)
Cancer Res.
, vol.57
, pp. 4593-4599
-
-
Presta, L.1
Chen, H.2
O'Connor, S.3
-
116
-
-
0035253739
-
Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer
-
Gordon M, Margolin M, Talpaz M, et al. Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer. J Clin Oncol 2001; 19: 843-50
-
(2001)
J. Clin. Oncol.
, vol.19
, pp. 843-850
-
-
Gordon, M.1
Margolin, M.2
Talpaz, M.3
-
117
-
-
0000397265
-
A randomized phase II trial comparing Rhumab VEGF plus carboplatin/paclitaxel (CP) to CP alone in patients with stage IIIb/IV NSCLC
-
[abstract no. 1896]
-
DeVore R, Fehrenbacher L, Herbst R, et al. A randomized phase II trial comparing Rhumab VEGF plus carboplatin/paclitaxel (CP) to CP alone in patients with stage IIIb/IV NSCLC [abstract no. 1896]. Proc Am Soc Clin Oncol 2000; 19: 485a
-
(2000)
Proc. Am. Soc. Clin. Oncol.
, vol.19
-
-
DeVore, R.1
Fehrenbacher, L.2
Herbst, R.3
-
119
-
-
0033883776
-
SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors
-
Laird A, Vajkoczy P, Shawver L, et al. SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors. Cancer Res 2000; 60: 4152-60
-
(2000)
Cancer Res.
, vol.60
, pp. 4152-4160
-
-
Laird, A.1
Vajkoczy, P.2
Shawver, L.3
-
120
-
-
0036145292
-
The antiangiogenic agents SU5416 and SU6668 increase the antitumor effects of fractionated irradiation
-
Ning S, Laird D, Cherrington J, et al. The antiangiogenic agents SU5416 and SU6668 increase the antitumor effects of fractionated irradiation. Radiat Res 2002; 157: 45-51
-
(2002)
Radiat. Res.
, vol.157
, pp. 45-51
-
-
Ning, S.1
Laird, D.2
Cherrington, J.3
-
121
-
-
0000103504
-
Phase I experience with SU6668, a novel multiple receptor tyrosine kinase inhibibitor in patients with advanced malignancies
-
[abstract no. 383]
-
Rosen L, Rosen P, Kabbinavar F, et al. Phase I experience with SU6668, a novel multiple receptor tyrosine kinase inhibibitor in patients with advanced malignancies [abstract no. 383]. Proc Am Soc Clin Oncol 2001; 20: 97a
-
(2001)
Proc. Am. Soc. Clin. Oncol.
, vol.20
-
-
Rosen, L.1
Rosen, P.2
Kabbinavar, F.3
-
122
-
-
0003302112
-
Development of a preclinical pharmacokinetic/pharmacodynamic relationship for the angiogenesis inhibitor SU11248, a selective inhibitor of VEGF and PDGF receptor tyrosine kinases in clinical development
-
[abstract 94]
-
Mendel DB, Laird AD, Xin X, et al. Development of a preclinical pharmacokinetic/pharmacodynamic relationship for the angiogenesis inhibitor SU11248, a selective inhibitor of VEGF and PDGF receptor tyrosine kinases in clinical development [abstract 94]. Proc Am Soc Clin Oncol 2002; 21: 24a
-
(2002)
Proc. Am. Soc. Clin. Oncol.
, vol.21
-
-
Mendel, D.B.1
Laird, A.D.2
Xin, X.3
-
123
-
-
85039633808
-
-
Sugen [online]. Available from URL: [Accessed Aug 30]
-
Sugen [online]. Available from URL: http:\\www.sugen.com [Accessed 2002 Aug 30]
-
(2002)
-
-
-
124
-
-
0028216334
-
Thalidomide is an inhibitor of angiogenesis
-
D'Amato R. Thalidomide is an inhibitor of angiogenesis. Proc Natl Acad Sci USA 1994; 91: 4082-5
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 4082-4085
-
-
D'Amato, R.1
-
125
-
-
0003202346
-
Pilot and safety trial of carboplatin, paclitaxel and thalidomide in advanced non-small cell lung cancer
-
[abstract no. 2130]
-
Merchant J, Hammes L, Larson M, et al. Pilot and safety trial of carboplatin, paclitaxel and thalidomide in advanced non-small cell lung cancer [abstract no. 2130]. Proc Am Soc Clin Oncol 2000; 19: 541a
-
(2000)
Proc. Am. Soc. Clin. Oncol.
, vol.19
-
-
Merchant, J.1
Hammes, L.2
Larson, M.3
-
126
-
-
0035409208
-
Immunotherapeutic and antitumour potential of thalidomide analogues
-
Marriott J, Muller G, Stirling D, et al. Immunotherapeutic and antitumour potential of thalidomide analogues. Expert Opin Biol Ther 2001; 1: 675-82
-
(2001)
Expert Opin. Biol. Ther.
, vol.1
, pp. 675-682
-
-
Marriott, J.1
Muller, G.2
Stirling, D.3
-
127
-
-
0033376890
-
Potentiation of platinum antitumor effects in human lung tumor xenografts by the angiogenesis inhibitor squalamine: Effects on tumor neovascularization
-
Schiller J, Bittner G. Potentiation of platinum antitumor effects in human lung tumor xenografts by the angiogenesis inhibitor squalamine: effects on tumor neovascularization. Clin Cancer Res 1999; 5: 4287-94
-
(1999)
Clin. Cancer Res.
, vol.5
, pp. 4287-4294
-
-
Schiller, J.1
Bittner, G.2
-
128
-
-
0034906455
-
Squalamine treatment of human tumors in nu/nu mice enhances platinum-based chemotherapies
-
Williams J, Weitman S, Gonzalez C, et al. Squalamine treatment of human tumors in nu/nu mice enhances platinum-based chemotherapies. Clin Cancer Res 2001; 7: 724-33
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 724-733
-
-
Williams, J.1
Weitman, S.2
Gonzalez, C.3
-
129
-
-
0038752347
-
A phase I and pharmacokinetic study of the angiogenesis inhibitor, squalamine lactate (MSI-1256F)
-
[Abstract no. 698]
-
Kalidas M, Hammond L, Patnaik A, et al. A phase I and pharmacokinetic study of the angiogenesis inhibitor, squalamine lactate (MSI-1256F) [Abstract no. 698]. Proc Am Soc Clin Oncol 2000; 19: 180a
-
(2000)
Proc. Am. Soc. Clin. Oncol.
, vol.19
-
-
Kalidas, M.1
Hammond, L.2
Patnaik, A.3
-
130
-
-
0003297860
-
Phase 2A trial of squalamine for treatment of advanced non-small cell lung cancer
-
[abstract 1353]
-
Schiller J, Hammond L, Carbone D, et al. Phase 2A trial of squalamine for treatment of advanced non-small cell lung cancer [abstract 1353]. Proc Am Soc Clin Oncol 2001; 20: 339a
-
(2001)
Proc. Am. Soc. Clin. Oncol.
, vol.20
-
-
Schiller, J.1
Hammond, L.2
Carbone, D.3
-
131
-
-
0028205812
-
Structure function analysis of signal and growth inhibition by carboxyamido-triazole, CAI
-
Kohn E, Felder C, Jacobs W, et al. Structure function analysis of signal and growth inhibition by carboxyamido-triazole, CAI. Cancer Res 1994; 54: 935-42
-
(1994)
Cancer Res.
, vol.54
, pp. 935-942
-
-
Kohn, E.1
Felder, C.2
Jacobs, W.3
-
133
-
-
9044229717
-
Clinical investigation of a cytostatic calcium influx inhibitor in patients with refractory cancers
-
Kohn E, Reed E, Sarosy G, et al. Clinical investigation of a cytostatic calcium influx inhibitor in patients with refractory cancers. Cancer Res 1996; 56: 569-73
-
(1996)
Cancer Res.
, vol.56
, pp. 569-573
-
-
Kohn, E.1
Reed, E.2
Sarosy, G.3
-
134
-
-
0034901273
-
A phase 1 trial of carboxyamido-triazole and paclitaxel for relapsed solid tumors: Potential efficacy of the combination and demonstration of pharmacokinetic interaction
-
Kohn E, Reed E, Sarosy G, et al. A phase 1 trial of carboxyamido-triazole and paclitaxel for relapsed solid tumors: potential efficacy of the combination and demonstration of pharmacokinetic interaction. Clin Cancer Res 2001; 7: 1600-9
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 1600-1609
-
-
Kohn, E.1
Reed, E.2
Sarosy, G.3
-
135
-
-
0026083903
-
Tumor angiogenesis and metastasis: Correlation in invasive breast carcinoma
-
Weidner N, Semple J, Welch W, et al. Tumor angiogenesis and metastasis: correlation in invasive breast carcinoma. N Engl J Med 1991; 324: 1-8
-
(1991)
N. Engl. J. Med.
, vol.324
, pp. 1-8
-
-
Weidner, N.1
Semple, J.2
Welch, W.3
-
136
-
-
0001909442
-
Prognostic significance of tumor vascularity
-
Teicher B, editor. Totowa: Humana Press
-
Gasparini G, Harris A. Prognostic significance of tumor vascularity. In: Teicher B, editor. Antiangiogenic agents in cancer therapy. Totowa: Humana Press, 1999: 317-40
-
(1999)
Antiangiogenic Agents in Cancer Therapy
, pp. 317-340
-
-
Gasparini, G.1
Harris, A.2
-
137
-
-
0030512898
-
Quantification of angiogenesis in solid human tumours: An international consensus on the methodology and criteria of evaluation
-
Vermeulen P, Gasparini G, Fox S, et al. Quantification of angiogenesis in solid human tumours: an international consensus on the methodology and criteria of evaluation. Eur J Cancer 1996; 32A: 2474-84
-
(1996)
Eur. J. Cancer
, vol.32 A
, pp. 2474-2484
-
-
Vermeulen, P.1
Gasparini, G.2
Fox, S.3
-
138
-
-
0026636356
-
Relation of neovascularization to metastasis of non-small-cell lung cancer
-
Macchiarini P, Fontanini G, Hardin J, et al. Relation of neovascularization to metastasis of non-small-cell lung cancer. Lancet 1992; 340: 145-6
-
(1992)
Lancet
, vol.340
, pp. 145-146
-
-
Macchiarini, P.1
Fontanini, G.2
Hardin, J.3
-
139
-
-
17444442088
-
Immunocytochemical markers in stage I lung cancer: Relevance to prognosis
-
Pastorino U, Andreola S, Taglibue E, et al. Immunocytochemical markers in stage I lung cancer: relevance to prognosis. J Clin Oncol 1997; 15: 2858-65
-
(1997)
J. Clin. Oncol.
, vol.15
, pp. 2858-2865
-
-
Pastorino, U.1
Andreola, S.2
Taglibue, E.3
-
140
-
-
0029980088
-
Prognostic value of angiogenesis in operable non-small cell lung cancer
-
Giatromanolaki A, Koukourakis A, O'Byrne K, et al. Prognostic value of angiogenesis in operable non-small cell lung cancer. J Pathol 1996; 179: 80-8
-
(1996)
J. Pathol.
, vol.179
, pp. 80-88
-
-
Giatromanolaki, A.1
Koukourakis, A.2
O'Byrne, K.3
-
141
-
-
0030940210
-
Prognostic value of the expression of p53, bcl-2, and bax oncoproteins, and neovascularization in patients with radically resected non-small-cell lung cancer
-
Apolinario R, van der Valk P, de Jong J, et al. Prognostic value of the expression of p53, bcl-2, and bax oncoproteins, and neovascularization in patients with radically resected non-small-cell lung cancer. J Clin Oncol 1997; 15: 2456-66
-
(1997)
J. Clin. Oncol.
, vol.15
, pp. 2456-2466
-
-
Apolinario, R.1
van der Valk, P.2
de Jong, J.3
-
142
-
-
0030996171
-
Angiogenesis as a prognostic indicator of survival in non-small-cell lung carcinoma: A prospective study
-
Fontanini G, Lucchi M, Vignati S, et al. Angiogenesis as a prognostic indicator of survival in non-small-cell lung carcinoma: a prospective study. J Natl Cancer Inst 1997; 89: 881-6
-
(1997)
J. Natl. Cancer Inst.
, vol.89
, pp. 881-886
-
-
Fontanini, G.1
Lucchi, M.2
Vignati, S.3
-
143
-
-
0029942156
-
Prognostic significance of tumoral angiogenesis in completely resected late stage lung carcinoma (stage IIIA-N2). Impact of adjuvant therapies in a subset of patients at high risk of recurrence
-
Angeletti C, Lucchi M, Fontanini G, et al. Prognostic significance of tumoral angiogenesis in completely resected late stage lung carcinoma (stage IIIA-N2). Impact of adjuvant therapies in a subset of patients at high risk of recurrence. Cancer 1996; 78: 409-15
-
(1996)
Cancer
, vol.78
, pp. 409-415
-
-
Angeletti, C.1
Lucchi, M.2
Fontanini, G.3
-
144
-
-
0035179614
-
Evaluation of angiogenesis in non-small cell lung cancer: Comparison between anti-CD34 antibody and anti-CD105 antibody
-
Tanaka F, Otake Y, Yanagihara K, et al. Evaluation of angiogenesis in non-small cell lung cancer: comparison between anti-CD34 antibody and anti-CD105 antibody. Clin Cancer Res 2001; 7: 3410-5
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 3410-3415
-
-
Tanaka, F.1
Otake, Y.2
Yanagihara, K.3
-
145
-
-
0028822945
-
Quantification and prognostic value of breast cancer angiogenesis: Comparison of microvessel density, Chaulkley count and computer image analysis
-
Fox S, Leek R, Weekes M. Quantification and prognostic value of breast cancer angiogenesis: comparison of microvessel density, Chaulkley count and computer image analysis. J Pathol 1995; 177: 275-83
-
(1995)
J. Pathol.
, vol.177
, pp. 275-283
-
-
Fox, S.1
Leek, R.2
Weekes, M.3
-
146
-
-
0035914261
-
Measuring changes in human tumour vasculature in response to therapy using functional imaging techniques
-
Anderson H, Price P, Blomley M, et al. Measuring changes in human tumour vasculature in response to therapy using functional imaging techniques. Br J Cancer 2001; 85: 1085-93
-
(2001)
Br. J. Cancer
, vol.85
, pp. 1085-1093
-
-
Anderson, H.1
Price, P.2
Blomley, M.3
-
147
-
-
0035163875
-
Challenges for imaging angiogenesis
-
Padhani A, Neeman M. Challenges for imaging angiogenesis. Br J Radiol 2001; 74: 886-90
-
(2001)
Br. J. Radiol.
, vol.74
, pp. 886-890
-
-
Padhani, A.1
Neeman, M.2
-
148
-
-
0034125666
-
Quantitative assessment of angiogenesis and tumor vessel architecture by computer-assisted digital image analysis: Effects of VEGF-toxin conjugate on tumor microvessel density
-
Wild R, Ramakrishnan S, Sedgewick J, et al. Quantitative assessment of angiogenesis and tumor vessel architecture by computer-assisted digital image analysis: effects of VEGF-toxin conjugate on tumor microvessel density. Microvasc Res 2000; 59: 368-76
-
(2000)
Microvasc. Res.
, vol.59
, pp. 368-376
-
-
Wild, R.1
Ramakrishnan, S.2
Sedgewick, J.3
-
149
-
-
0035715329
-
Quantitative analysis of angiogenesis using confocal lase scanning microscopy
-
Guo L, Burke P, Lo S, et al. Quantitative analysis of angiogenesis using confocal lase scanning microscopy. Angiogenesis 2001; 4: 187-91
-
(2001)
Angiogenesis
, vol.4
, pp. 187-191
-
-
Guo, L.1
Burke, P.2
Lo, S.3
-
150
-
-
0032926187
-
Elevated levels of circulating plasma matrix metalloproteinase 9 in non-small cell lung cancer patients
-
Iizasa T, Fujisawa T, Suzuki M, et al. Elevated levels of circulating plasma matrix metalloproteinase 9 in non-small cell lung cancer patients. Clin Cancer Res 1999; 5: 149-53
-
(1999)
Clin. Cancer Res.
, vol.5
, pp. 149-153
-
-
Iizasa, T.1
Fujisawa, T.2
Suzuki, M.3
-
151
-
-
0028328983
-
Elevated levels of an angiogenic peptide, basic fibroblast growth factor, in the urine of patients with a wide spectrum of cancers
-
Nguyen M, Watanabe H, Budson A, et al. Elevated levels of an angiogenic peptide, basic fibroblast growth factor, in the urine of patients with a wide spectrum of cancers. J Natl Cancer Inst 1994; 86: 356-61
-
(1994)
J. Natl. Cancer Inst.
, vol.86
, pp. 356-361
-
-
Nguyen, M.1
Watanabe, H.2
Budson, A.3
-
152
-
-
0031803176
-
Elevated vascular endothelial growth factor levels in sera of patients with lung cancer
-
Takigawa N, Segawa Y, Fujimoto N, et al. Elevated vascular endothelial growth factor levels in sera of patients with lung cancer. Anticancer Res 1998; 18: 1251-4
-
(1998)
Anticancer Res.
, vol.18
, pp. 1251-1254
-
-
Takigawa, N.1
Segawa, Y.2
Fujimoto, N.3
-
153
-
-
0035144946
-
Increased serum levels of basic fibroblast growth factor in lung cancer patients: Relevance to response of therapy and prognosis
-
Ueno K, Inoue Y, Kawaguchi T, et al. Increased serum levels of basic fibroblast growth factor in lung cancer patients: relevance to response of therapy and prognosis. Lung Cancer 2001; 31: 213-9
-
(2001)
Lung Cancer
, vol.31
, pp. 213-219
-
-
Ueno, K.1
Inoue, Y.2
Kawaguchi, T.3
-
154
-
-
0035865450
-
Clinical implications of circulating angiogenic factors in cancer patients
-
Poon R, Fan S, Wong J. Clinical implications of circulating angiogenic factors in cancer patients. J Clin Oncol 2001; 19: 1207-25
-
(2001)
J. Clin. Oncol.
, vol.19
, pp. 1207-1225
-
-
Poon, R.1
Fan, S.2
Wong, J.3
-
155
-
-
0034111270
-
Development of target-based antineoplastic agents
-
Stadler W, Ratain M. Development of target-based antineoplastic agents. Invest New Drugs 2000; 18: 7-16
-
(2000)
Invest. New Drugs
, vol.18
, pp. 7-16
-
-
Stadler, W.1
Ratain, M.2
-
156
-
-
0031882946
-
Results of single and repeat dose studies of the oral matrix metalloproteinase inhibitor marimastat in healthy male volunteers
-
Millar A, Brown P, Moore J, et al. Results of single and repeat dose studies of the oral matrix metalloproteinase inhibitor marimastat in healthy male volunteers. Br J Clin Pharmacol 1998; 45: 21-6
-
(1998)
Br. J. Clin. Pharmacol.
, vol.45
, pp. 21-26
-
-
Millar, A.1
Brown, P.2
Moore, J.3
-
157
-
-
0016801215
-
A clinical trial design avoiding undue placebo treatment
-
Amery W, Dony J. A clinical trial design avoiding undue placebo treatment. J Clin Pharmacol 1975; 15: 674-9
-
(1975)
J. Clin. Pharmacol.
, vol.15
, pp. 674-679
-
-
Amery, W.1
Dony, J.2
|