The activin-binding protein follistatin regulates autocrine endothelial cell activity and induces angiogenesis

Laboratory Investigation

Volumn 76, Issue 2, 1997, Pages 267-276

  Kozian, Detlef H ^a   Ziche, Marina ^b   Augustin, Hellmut G ^a  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN; BASIC FIBROBLAST GROWTH FACTOR; FOLLISTATIN; RNA;

ANGIOGENESIS; ANIMAL CELL; AORTA; ARTICLE; AUTOCRINE EFFECT; CATTLE; CELL ACTIVATION; CELL GROWTH; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; CORNEA ENDOTHELIUM; ENDOTHELIUM CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; RABBIT; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

AMINO ACID SEQUENCE; ANIMALS; CATTLE; CELL DIVISION; CELL MOVEMENT; CORNEA; DOWN-REGULATION; ENDOTHELIUM; FIBROBLAST GROWTH FACTOR 2; FOLLISTATIN; GENE EXPRESSION; GLYCOPROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; NEOVASCULARIZATION, PHYSIOLOGIC; RABBITS; RNA, MESSENGER;

EID: 0031049187     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Augustin HG, Braun K, Telemenakis I, Modlich U, and Kuhn W (1995). Ovarian angiogenesis: Phenotypic characterization of endothelial cells in a physiological model of blood vessel growth and regression. Am J Pathol 147:339-351.
2. Augustin HG and Pauli BU (1992). Migrating endothelial cells are distinctly hyperglycosylated and express specific migration-associated cell surface glycoproteins. J Cell Biol 119:383-491.
3. Augustin HG, Voss AK, and Pauli BU (1993). Senescence of aortic endothelial cells in culture: Effects of basic fibroblast growth factor expression on cell phenotype, migration, and proliferation. J Cell Physiol 157:279-288.
4. Basilico C and Moscatelli D (1992). The FGF family of growth factors and oncogenes. Adv Cancer Res 59:115-165.
5. Beckner ME, Krutzsch HC, Stracke ML, Williams ST, Gallardo JA, and Liotta LA (1995). Identification of a new immunoglobulin superfamily protein expressed in blood vessels with a heparin-binding consensus sequence. Cancer Res 55:2140-2149.
6. Bell L, Luthringer DJ, Madri JA, and Warren SL (1992). Autocrine angiotensin system regulation of bovine aortic endothelial cell migration and plasminogen activator involves modulation of proto-oncogene pp 60c-src expression. J Clin Invest 89:315-320.
7. Brooks PC, Clark RAF, and Cheresh DA (1994). Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science 63:569-571.
8. Burrows FJ and Thorpe PE (1994). Vascular targeting: A new approach to the therapy of solid tumors. Pharmacol Ther 64:155-174.
9. Folkman J and Shing YJ (1992). Angiogenesis. J Biol Chem 267:10931-10934.
10. Fong GH, Rossant J, Gertsenstein M, and Breitman ML (1995). Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 376:66-70.
11. v integrins. Science 270:1500-1502.
12. Girard JP and Springer TA (1995). Cloning from purified high endothelial venule cells of hevin, a close relative of the antiadhesive extracellular matrix protein SPARC. Immunity 2:113-123.
13. Gualandris A, Rusnati M, Belleri M, Nelli EE, Bastaki M, Molinari-Tosatti MP, Bonardi F, Parolini S, Albini A, Morbidelli L, Ziche M, Corallini A, Possati L, Vacca A, Ribatti D, and Presta M (1996). Basic fibroblast growth factor overexpression in mouse endothelial cells: Autocrine model of angiogenesis and antiproliferative diseases. Cell Growth Diff 7:147-160.
14. Hemmati-Brivanlou A, Kelly OG, and Melton DA (1994). Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity. Cell 77:283-295.
15. Khachigian LM, Lindner V, Williams AJ, Collins T (1996). Egr-1-induced endothelial gene expression: A common theme in vascular injury. Science 271:1427-1431.
16. Knighton DR, Phillips GD, and Fiegel VD (1990). Wound healing angiogenesis: Indirect stimulation by basic fibroblast growth factor. J Trauma 30:5134-5144.
17. Kogure K, Omata W, Kanzaki M, Zhang Y-Q, Yasuda H, Mine T, and Kojima I (1995). A single intraportal administration of follistatin accelerates liver regeneration in partially hepatectomized rats. Gastroenterology 108:1136-1142.
18. Koyama N, Watanabe S, Tezuko M, Morisaki N, Saito Y, and Yoshida S (1994). Migratory and proliferative effect of platelet-derived growth factor in rabbit retinal endothelial cells: Evidence of an autocrine pathway of platelet-derived growth factor. J Cell Physiol 158:1-6.
19. Kozian DH and Augustin HG (1995). Rapid identification of differentially expressed endothelial cell genes by RNA-display. Biochem Biophys Res Commun 209:1068-1075.
20. Lane TF and Sage EH (1994). The biology of SPARC, a protein that modulates cell-matrix interactions. FASEB J 8:163-173.
21. Liang P and Pardee AB (1995). Recent advances in differential display. Curr Opin Immunol 7:274-280.
22. Lindner V and Collins T (1996). Expression of NF-kappa B and I kappa B-alpha by aortic endothelium in an arterial injury model. Am J Pathol 148:427-438.
23. Lindner V and Reidy MA (1993). Expression of basic fibroblast growth factor and its receptor by smooth muscle cells and endothelium in injured rat arteries: An en face study. Circ Res 73:589-595.
24. Matzuk MM, Lu N, Vogel H, Sellheyer K, Roop DR, and Bradley A (1995). Multiple defects and perinatal death in mice deficient in follistatin. Nature 374:360-363.
25. McCarthy SA and Bicknell R (1993). Inhibition of vascular endothelial growth by activin-A. J Biol Chem 268:23066-23071.
26. Michel U, Farnworth P, and Findlay JK (1993). Follistatins: More than follicle-stimulating hormone suppressing proteins. Mol Cell Endocrinol 91:1-11.
27. Mignatti R, Marimoto T, and Rifkin DB (1991). In vitro angiogenesis on the human amniotic membrane: Requirement for basic fibroblast growth factor-induced proteinases. Proc Natl Acad Sci USA 88:11007-11011.
28. Mustonen T and Alitalo K (1995). Endothelial receptor tyrosine kinases involved in angiogenesis. J Cell Biol 129:895-898.
29. Nakamura T, Takio K, Eto Y, Shibai H, Titani K, and Sugino H (1990). Activin-binding protein from rat ovary is follistatin. Science 247:836-838.
30. Nguyen M, Strubel NA, and Bischoff J (1993). A role for sialyl Lewis-X/A glycoconjugates in capillary morphogenesis. Nature 365:267-269.
31. Patthy L (1991). Modular exchange principles in proteins. Curr Opin Struct Biol 1:351-361.
32. Pili R, Chang J, Partis RA, Mueller RA, Chrest FJ, and Passaniti A (1995). The α-glucosidase 1 inhibitor castano-spermine alters endothelial cell glycolisation, prevents angiogenesis, and inhibits tumor growth. Cancer Res 55:2920-2926.
33. Pötgens AJG, Westphal HR, de Waal RMW, and Ruiter DJ (1995). The role of vascular permeability factor and basic fibroblast growth factor in tumor angiogenesis. Biol Chem Hoppe-Seyler 376:57-70.
34. Rak JW, St. Croix BD, and Kerbel RS (1995). Consequences of angiogenesis for tumor progression, metastasis and cancer therapy. Anticancer Drugs 6:3-18.
35. Rettig WJ, Garin-Chesa P, Healey JH, Su SL, Jaffe EA, and Old LJ (1992). Identification of endosialin, a cell surface glycoprotein of vascular endothelial cells in human cancer. Proc Natl Acad Sci USA 89:10832-10836.
36. Sato T N, Tozawa Y, Deutsch U, Wolburg-Buchholz K, Fujiwara Y, Gendron-Maguire M, Gridley T, Wolburg H, Risau W, and Qin Y (1995). Distinct roles of the receptor tyrosine kinases tie-1 and tie-2 in blood vessel formation. Nature 376:70-74.
37. Shalaby F, Rossant J, Yamaguchi TP, Gertsenstein M, Wu XF, Breitman ML, and Schuh AC (1995). Failure of blood-island formation and vasculogenesis in flk-1-deficient mice. Nature 376:62-66.
38. Van den Eijnden-van Raaij AJM, Feijen A, Lawson KA, and Mummery CL (1992). Differential expression of inhibin subunits and follistatin, but not of activin receptor type II, during early murine embryonic development. Dev Biol 154:356-365.
39. Wang JM, Kumar S, Pye D, van Agthoven AJ, Krupinski J, and Hunter RD (1993). A monoclonal antibody detects heterogeneity in vascular endothelium of tumours and normal tissues. Int J Cancer 54:363-370.
40. Yasuda H, Mine T, Shibata H, Eto Y, Hasegawa Y, Takeuchi T, Asano S, and Kojima I (1995). Activin A: An autocrine inhibitor of initiation of DNA synthesis in rat hepatocytes. J Clin Invest 92:1491-1496.
41. Young PE, Baumhueter S, and Lasky LA (1995). The sialomucin CD34 is expressed on hematopoietic cells and blood vessels during murine development. Blood 85:96-105.
42. Ziche M, Morbidelli L, and Donnini S (1996). Angiogenesis. Exp Nephrol 4:1-14.
43. Ziche M, Morbidelli L, Masini E, Amerini S, Granger HJ, Maggi CA, Geppetti P, and Ledda F (1994). Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P. J Clin Invest 94:2036-2044