L-(+)-swainsonine and other pyrrolidine inhibitors of naringinase: Through an enzymic looking glass from D-mannosidase to L-rhamnosidase?

Tetrahedron Letters

Volumn 37, Issue 47, 1996, Pages 8565-8568

  Davis, Benjamin ^a   Bell, Andrew A ^a   Nash, Robert J ^b   Watson, Alison A ^b   Griffiths, Rhodri C ^c   Jones, M George ^c   Smith, Colin ^d   Fleet, George W J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b ABERYSTWYTH UNIVERSITY   (United Kingdom)

^c ABERYSTWYTH UNIVERSITY   (United Kingdom)

^d GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GLUCOSIDASE; BETA GALACTOSIDASE; MANNOSIDASE; POLYGALACTURONASE; PYRROLIDINE DERIVATIVE; SUCRASE; SWAINSONINE; SWAINSONINE DERIVATIVE; TREHALASE; XYLAN ENDO 1,3 BETA XYLOSIDASE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ENANTIOMER; ENZYME INHIBITION; NONHUMAN;

ANIMALIA;

EID: 0030592842     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)01957-0     Document Type: Article

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9. 6. preceding paper
10. 7. Unless otherwise stated, all specific rotations were measured in chloroform.
11. 2O): 31.6 (C-6), 49.7 (C-5), 60.1 (C-3), 69.8, 70.2, 71.2, 71.3, 73.8 (C-2, C-1, C-7, C-8, C-8a).
12. 2O): 30.3 (t, C-6), 46.1 (t, C-5), 60.6 (t, C-3), 66.0 (d, C-8a), 67.9 (d, C-7), 68.4 (d, C-8), 69.4 (d, C-2), 70.0 (d, C-1).
13. 2O, 50MHz) 52.3,59.8 (t × 2, C-3,C-5), 64.9,69.2,69.9, 70.3 (d × 4, C-1, C-2, C-8, C-8a), 127.5,129.9 (d × 2, C-6, C-7).
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19. +,100%).
20. m 1.1 mM). Details of the other enzyme assays will be given in a full paper.
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23. 20. This work has been supported by graduate studentships from the MRC AIDS Committee, CASE EPSRC, and BBSRC.