Homocysteine and folate deficiency sensitize oligodendrocytes to the cell death-promoting effects of a presenilin-1 mutation and amyloid β-peptide

NeuroMolecular Medicine

Volumn 3, Issue 2, 2003, Pages 119-127

  Pak, Kirk J ^a   Chan, Sic L ^a   Mattson, Mark P ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Alzheimer's disease; Apoptosis; Folic acid; P53 tumor suppressor; PARP; Stroke; White matter

Indexed keywords

AMYLOID BETA PROTEIN; FOLIC ACID; HOMOCYSTEINE; MUTANT PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PRESENILIN 1; PROTEIN P53; ENZYME INHIBITOR; MEMBRANE PROTEIN;

ALZHEIMER DISEASE; AMINO ACID DEFICIENCY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DEGENERATIVE DISEASE; DNA DAMAGE; FOLIC ACID DEFICIENCY; HOMOCYSTEINE DEFICIENCY; IN VIVO STUDY; MOUSE; NERVE CELL NECROSIS; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; WHITE MATTER; WILD TYPE; ANIMAL; BRAIN; CELL CULTURE; CELL DEATH; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; METABOLISM; MOUSE MUTANT; MUTATION; MYELINATED NERVE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; UPREGULATION;

ANIMALIA;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; BRAIN; CELL DEATH; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DNA DAMAGE; ENZYME INHIBITORS; FOLIC ACID DEFICIENCY; HOMOCYSTEINE; MEMBRANE PROTEINS; MICE; MICE, MUTANT STRAINS; MUTATION; NERVE FIBERS, MYELINATED; OLIGODENDROGLIA; POLY(ADP-RIBOSE) POLYMERASES; PRESENILIN-1; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 0042697665     PISSN: 15351084     EISSN: None     Source Type: Journal    
DOI: 10.1385/NMM:3:2:119     Document Type: Article

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