Selective enhancement of gene transfer by steroid-mediated gene delivery

Nature Biotechnology

Volumn 19, Issue 12, 2001, Pages 1155-1161

  Rebuffat, Alexandre ^a   Bernasconi, Alessio ^a   Ceppi, Maurizio ^b   Wehrli, Hans ^a   Verca, Stefano Brenz ^b   Ibrahim, Merdol ^c   Frey, Brigitte M ^a   Frey, Felix J ^a   Rusconi, Sandro ^b  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF FRIBOURG   (Switzerland)

^c Institute of Histology and General Embryology   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; BONE; CELL CULTURE; CROSSLINKING; DNA;

GENE DELIVERY TECHNOLOGIES;

GENE TRANSFER;

DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; PSORALEN; STEROID;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA CROSS LINKING; DNA TRANSFECTION; GENE TARGETING; GENE TRANSFER; GENE TRANSLOCATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN BINDING; TRANSACTIVATION; TRANSGENE;

ACTIVE TRANSPORT, CELL NUCLEUS; ADENOVIRIDAE; ANIMALS; BETA-GALACTOSIDASE; CELL DIVISION; CELL NUCLEUS; CROSS-LINKING REAGENTS; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; FICUSIN; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENES, REPORTER; GENETIC VECTORS; HELA CELLS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; LIGANDS; MICROSCOPY, CONFOCAL; MODELS, BIOLOGICAL; PLASMIDS; PROTEIN BINDING; RECEPTORS, GLUCOCORTICOID; STEROIDS; TRANSFECTION; TRANSGENES;

ANIMALIA;

EID: 0035204259     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/nbt1201-1155     Document Type: Article

References (43)

1. Cellular and molecular barriers to gene transfer by a cationic lipid
2. High efficiency transformation by direct microinjection of DNA into cultured mammalian cells
3. Lipofection: A highly efficient, lipid-mediated DNA-transfection procedure
4. Efficacy of a peptide-based gene delivery system depends on mitotic activity
5. On the mechanism of DNA transfection: Efficient gene transfer without viruses
6. Metabolic instability of plasmid DNA in the cytosol: A potential barrier to gene transfer
7. Nuclear import and export of viruses and virus genomes
8. Vectors for gene delivery
9. DNA vector chemistry: The covalent attachment of signal peptides to plasmid DNA
10. Gene delivery: A single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus
11. A peptide nucleic acid-nuclear localization signal fusion that mediates nuclear transport of DNA
12. The nuclear receptor superfamily: The second decade
13. Different regions of the immunophilin FKBP52 determine its association with the glucocorticoid receptor, hsp 90, and cytoplasmic dynein
14. Cytoplasmic 8 S glucocorticoid receptor binds to actin filaments through the 90-kDa heat shock protein moiety
15. Hsp90-binding immunophilins in plants: The protein movers
16. Structure and function of the glucocorticoid receptor
17. Determinants of subcellular distribution of the glucocorticoid receptor
18. Functional domains of the human glucocorticoid receptor
19. Genetic complementation of a glucocorticoid receptor deficiency by expression of cloned receptor cDNA
20. Downregulation and phosphorylation of glucocorticoid receptors in cultured cells. Investigations with a monospecific antiserum against a bacterially expressed receptor fragment
21. Effects of inhaled corticosteroid therapy on expression and DNA-binding activity of nuclear factor kappaB in asthma
22. Transcriptional potencies of inhaled glucocorticoids
23. Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family
24. Antiandrogens in prostate cancer
25. Prostate cancer schemes for androgen escape
26. Expression levels of estrogen receptor-alpha, estrogen receptor-beta, coactivators, and corepressors in breast cancer
27. Increased expression of estrogen receptor beta mRNA in tamoxifen-resistant breast cancer patients
28. Nuclear import of DNA in digitonin-permeabilized cells
29. HIV- 1 genome nuclear import is mediated by a central DNA flap
30. Gene chemistry: Functionally and conformationally intact fluorescent plasmid DNA
31. Improved green fluorescence
32. A transcriptional repressor obtained by alternative translation of a trinucleotide repeat
33. Serine/threonine protein phosphatase (PP5) participates in the regulation of glucocorticoid receptor nucleocytoplasmic shuttling
34. Efficient generation of recombinant adenovirus vectors by homologous recombination in Escherichia coli
35. Comparison of lipid-mediated and adenoviral gene transfer in human monocyte-derived macrophages and COS- 7 cells
36. Manipulation of adenovirus vectors
37. Growth, purification and titration of adenoviruses
38. R Functional dissection of the hormone and DNA binding activities of the glucocorticoid receptor
39. Characterization of a monoclonal antibody to the rat liver glucocorticoid receptor
40. Psoralen photochemistry