Changes in aerobic capacity and visceral fat but not myocyte lipid levels predict increased insulin action after exercise in overweight and obese men

Diabetes Care

Volumn 26, Issue 6, 2003, Pages 1706-1713

  Gan, Seng Khee ^a   Kriketos, Adamandia D ^a   Ellis, Bronwyn A ^a   Thompson, Campbell H ^b   Kraegen, Edward W ^a   Chisholm, Donald J ^a  

^a GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b FLINDERS MEDICAL CENTRE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A; GLUCOSE; INSULIN; LONG CHAIN ACYL COENZYME A; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADULT; AEROBIC CAPACITY; ARTICLE; BODY FAT; CELL LEVEL; CLINICAL ARTICLE; DUAL ENERGY X RAY ABSORPTIOMETRY; EXERCISE; FATTY ACID OXIDATION; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TRANSPORT; HORMONE ACTION; HUMAN; INSULIN SENSITIVITY; LIPID BLOOD LEVEL; MALE; MUSCLE BIOPSY; MUSCLE CELL; OBESITY; PHYSICAL ACTIVITY; PREDICTION; PROTON NUCLEAR MAGNETIC RESONANCE; SITTING; SOLEUS MUSCLE; TIBIALIS ANTERIOR MUSCLE; VASTUS LATERALIS MUSCLE;

ABDOMEN; ACYL COENZYME A; ADIPOSE TISSUE; ADULT; BLOOD GLUCOSE; BODY COMPOSITION; EXERCISE; GLUCOSE CLAMP TECHNIQUE; HUMANS; LIPID METABOLISM; LIPIDS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MUSCLE CELLS; MUSCLE, SKELETAL; OBESITY; OXIDATION-REDUCTION; OXYGEN CONSUMPTION; QUESTIONNAIRES; REGRESSION ANALYSIS; TRIGLYCERIDES;

EID: 0042670073     PISSN: 01495992     EISSN: None     Source Type: Journal    
DOI: 10.2337/diacare.26.6.1706     Document Type: Article

References (55)

1. Goodpaster BH, Thaete FL, Simoneau J-A, Kelley DE: Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat. Diabetes 46:1579-1585, 1997
2. Carey DG, Jenkins AB, Campbell LV, Freund J, Chisholm DJ: Abdominal fat and insulin resistance in normal and overweight women: direct measurements reveal a strong relationship in subjects at both low and high risk of NIDDM. Diabetes 45:633-638, 1996
3. Ellis BA, Poynten A, Lowy AJ, Furler SM, Chisholm DJ, Kraegen EW, Cooney GJ: Long-chain acyl-CoA esters as indicators of lipid metabolism and insulin sensitivity in rat and human muscle. Am J Physiol Endocrinol Metab 279:E554-E560, 2000
4. Kraegen EW, Clark PW, Jenkins AB, Daley EA, Chisholm DJ, Storlien LH: Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats. Diabetes 40:1397-1403, 1991
5. Oakes ND, Cooney GJ, Camilleri S, Chisholm DJ, Kraegen EW: Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding. Diabetes 46:1768-1774, 1997
6. Forouhi NG, Jenkinson G, Thomas EL, Mullick S, Mierisova S, Bhonsle U, McKeigue PM, Bell JD: Relation of triglyceride stores in skeletal muscle cells to central obesity and insulin sensitivity in European and South Asian men. Diabetologia 42:932-935, 1999
7. Furler SM, Poynten AM, Kriketos AD, Lowy AJ, Ellis BA, Maclean EL, Courtenay BG, Kraegen EW, Campbell LV, Chisholm DJ: Independent influences of central fat and skeletal muscle lipids on insulin sensitivity. Obes Res 9:535-543, 2001
8. Jacob S, Machann J, Rett K, Brechtel K, Volk A, Renn W, Maerker E, Matthaei S, Schick F, Claussen CD, Haring HU: Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects. Diabetes 48:1113-1119, 1999
9. Krssak M, Falk Petersen K, Dresner A, DiPietro L, Vogel SM, Rothman DL, Roden M, Shulman GI: Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study. Diabetologia 42:113-116, 1999
10. Levin K, Daa Schroeder H, Alford FP, Beck-Nielsen H: Morphometric documentation of abnormal intramyocellular fat storage and reduced glycogen in obese patients with type II diabetes. Diabetologia 44:824-833, 2001
11. Pan DA, Lillioja S, Kriketos AD, Milner MR, Baur LA, Bogardus C, Jenkins AB, Storlien LH: Skeletal muscle triglyceride levels are inversely related to insulin action. Diabetes 46:983-988, 1997
12. Perseghin G, Scifo P, De Cobelli F, Pagliato E, Battezzati A, Arcelloni C, Vanzulli A, Testolin G, Pozza G, Del Maschio A, Luzi L: Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents. Diabetes 48:1600-1606, 1999
13. Phillips DI, Caddy S, Ilic V, Fielding BA, Frayn KN, Borthwick AC, Taylor R: Intramuscular triglyceride and muscle insulin sensitivity: evidence for a relationship in nondiabetic subjects. Metabolism 45:947-950, 1996
14. Richelsen B, Pedersen SB, Moller-Pedersen T, Bak JF: Regional differences in triglyceride breakdown in human adipose tissue: effects of catecholamines, insulin, and prostaglandin E2. Metabolism 40:990-996, 1991
15. Kraegen EW, Cooney GJ, Ye JM, Thompson AL, Furler SM: The role of lipids in the pathogenesis of muscle insulin resistance and beta cell failure in type II diabetes and obesity. Exp Clin Endocrinol Diabetes 109: S189-S201, 2001
16. Wendling PS, Peters SJ, Heigenhauser GJ, Spriet LL: Variability of triacylglycerol content in human skeletal muscle biopsy samples. J Appl Physiol 81:1150-1155, 1996
17. Kiens B, Essen-Gustavsson B, Christensen NJ, Saltin B: Skeletal muscle substrate utilization during submaximal exercise in man: effect of endurance training. J Physiol 469:459-478, 1993
18. Morgan TE, Short FA, Cobb LA: Effect of long-term exercise on skeletal muscle lipid composition. Am J Physiol 216:82-86, 1969
19. Malenfant P, Tremblay A, Doucet E, Imbeault P, Simoneau JA, Joanisse DR: Elevated intramyocellular lipid concentration in obese subjects is not reduced after diet and exercise training. Am J Physiol Endocrinol Metab 280:E632-E639, 2001
20. Hurley BF, Nemeth PM, Martin WH 3rd, Hagberg JM, Dalsky GP, Holloszy JO: Muscle triglyceride utilization during exercise: effect of training. J Appl Physiol 60:562-567, 1986
21. Suter E, Hoppeler H, Claassen H, Billeter R, Aebi U, Horber F, Jaeger P, Marti B: Ultrastructural modification of human skeletal muscle tissue with 6-month moderate-intensity exercise training. Int J Sports Med 16:160-166, 1995
22. Bergman BC, Butterfield GE, Wolfel EE, Casazza GA, Lopaschuk GD, Brooks GA: Evaluation of exercise and training on muscle lipid metabolism. Am J Physiol 276:E106-E117, 1999
23. Goodpaster BH, He J, Watkins S, Kelley DE: Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes. J Clin Endocrinol Metab 86:5755-5761, 2001
24. Lapsys NM, Kriketos AD, Lim-Fraser M, Poynten AM, Lowy A, Furler SM, Chisholm DJ, Cooney GJ: Expression of genes involved in lipid metabolism correlate with peroxisome proliferator-activated receptor gamma expression in human skeletal muscle. J Clin Endocrinol Metab 85:4293-4297, 2000
25. Boesch C, Slotboom J, Hoppeler H, Kreis R: In vivo determination of intra-myocellular lipids in human muscle by means of localized 1H-MR-spectroscopy. Magnetic Resonance in Medicine 37:484-493, 1997
26. Szczepaniak LS, Babcock EE, Schick F, Dobbins RL, Garg A, Burns DK, McGarry JD, Stein DT: Measurement of intracellular triglyceride stores by H spectroscopy: validation in vivo. Am J Physiol 276:E977-E989, 1999
27. Expert Committee on the Diagnosis and Classification of Diabetes Mellitus: Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 20:1183-1197, 1997
28. Kannel WB, Sorlie P: Some health benefits of physical activity: the Framingham Study. Arch Intern Med 139:857-861, 1979
29. American College of Sports Medicine: Guidelines for Exercise Testing and Prescription. Kenney WL, Ed. Baltimore, MD, Williams & Wilkins, 1995
30. Frayn KN: Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol 55:628-634, 1983
31. Rico-Sanz J, Hajnal JV, Thomas EL, Mierisova S, Ala-Korpela M, Bell JD: Intracellular and extracellular skeletal muscle triglyceride metabolism during alternating intensity exercise in humans. J Physiol (Lond) 510:615-622, 1998
32. Kiens B, Richter EA: Utilization of skeletal muscle triacylglycerol during postexercise recovery in humans. Am J Physiol 275: E332-E337, 1998
33. Segal KR, Edano A, Abalos A, Albu J, Blando L, Tomas MB, Pi-Sunyer FX: Effect of exercise training on insulin sensitivity and glucose metabolism in lean, obese, and diabetic men. J Appl Physiol 71:2402-2411, 1991
34. King DS, Baldus PJ, Sharp RL, Kesl LD, Feltmeyer TL, Riddle MS: Time course for exercise-induced alterations in insulin action and glucose tolerance in middle-aged people. J Appl Physiol 78:17-22, 1995
35. King DS, Dalsky GP, Clutter WE, Young DA, Staten MA, Cryer PE, Holloszy JO: Effects of lack of exercise on insulin secretion and action in trained subjects. Am J Physiol 254:E537-E542, 1988
36. Burstein R, Polychronakos C, Toews CJ, MacDougall JD, Guyda HJ, Posner BI: Acute reversal of the enhanced insulin action in trained athletes: association with insulin receptor changes. Diabetes 34:756-760, 1985
37. Mikines KJ, Sonne B, Tronier B, Galbo H: Effects of acute exercise and detraining on insulin action in trained men. J Appl Physiol 66:704-711, 1989
38. Romijn JA, Coyle EF, Sidossis LS, Gastaldelli A, Horowitz JF, Endert E, Wolfe RR: Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration. Am J Physiol 265:E380-E391, 1993
39. Kang J, Robertson RJ, Hagberg JM, Kelley DE, Goss FL, DaSilva SG, Suminski RR, Utter AC: Effect of exercise intensity on glucose and insulin metabolism in obese individuals and obese NIDDM patients. Diabetes Care 19:341-349, 1996
40. Goodpaster BH, Kelley DE, Wing RR, Meier A, Thaete FL: Effects of weight loss on regional fat distribution and insulin sensitivity in obesity. Diabetes 48:839-847, 1999
41. Markovic TP, Campbell LV, Balasubramanian S, Jenkins AB, Fleury AC, Simons LA, Chisholm DJ: Beneficial effect on average lipid levels from energy restriction and fat loss in obese individuals with or without type 2 diabetes. Diabetes Care 21:695-700, 1998
42. Ross R, Rissanen J: Mobilization of visceral and subcutaneous adipose tissue in response to energy restriction and exercise. Am J Clin Nutr 60:695-703, 1994
43. Zamboni M, Armellini F, Turcato E, Todesco T, Bissoli L, Bergamo-Andreis IA, Bosello O: Effect of weight loss on regional body fat distribution in premenopausal women. Am J Clin Nutr 58:29-34, 1993
44. Smith SR, Zachwieja JJ: Visceral adipose tissue: a critical review of intervention strategies. Int J Obes Relat Metab Disord 23:329-335, 1999
45. Ross R, Janssen I: Is abdominal fat preferentially reduced in response to exercise-induced weight loss? Med Sci Sports Exerc 31:S568-S572, 1999
46. Rice B, Janssen I, Hudson R, Ross R: Effects of aerobic or resistance exercise and/or diet on glucose tolerance and plasma insulin levels in obese men. Diabetes Care 22:684-691, 1999
47. Montague CT, O'Rahilly S: The perils of portliness: causes and consequences of visceral adiposity. Diabetes 49:883-888, 2000
48. Wojtaszewski JF, Hansen BF, Kiens B, Richter EA: Insulin signaling in human skeletal muscle: time course and effect of exercise. Diabetes 46:1775-1781, 1997
49. Wojtazsewski JF, Nielsen P, Kiens B, Richter EA: Regulation of glycogen synthase kinase-3 in human skeletal muscle: effects of food intake and bicycle exercise. Diabetes 50:265-269, 2001
50. Winder WW: Energy-sensing and signaling by AMP-activated protein kinase in skeletal muscle. J Appl Physiol 91:1017-1028, 2001
51. Thorell A, Hirshman MF, Nygren J, Jorfeldt L, Wojtaszewski JF, Dufresne SD, Horton ES, Ljungqvist O, Goodyear LJ: Exercise and insulin cause GLUT-4 translocation in human skeletal muscle. Am J Physiol 277:E733-E741, 1999
52. Richter EA, Derave W, Wojtaszewski JF: Glucose, exercise and insulin: emerging concepts. J Physiol 535:313-322, 2001
53. Krssak M, Petersen KF, Bergeron R, Price T, Laurent D, Rothman DL, Roden M, Shulman GI: Intramuscular glycogen and intramyocellular lipid utilization during prolonged exercise and recovery in man: a 13C and 1H nuclear magnetic resonance spectroscopy study. J Clin Endocrinol Metab 85:748-751, 2000
54. Rico-Sanz J, Moosavi M, Thomas EL, McCarthy J, Coutts GA, Saeed N, Bell JD: In vivo evaluation of the effects of continuous exercise on skeletal muscle triglycerides in trained humans. Lipids 35:1313-1318, 2000
55. Brechtel K, Niess AM, Machann J, Rett K, Schick F, Claussen CD, Dickhuth HH, Haering HU, Jacob S: Utilisation of intramyocellular lipids (IMCLs) during exercise as assessed by proton magnetic resonance spectroscopy (1H-MRS). Horm Metab Res 33:63-66, 2001