Regulation of adenovirus alternative RNA splicing correlates with a reorganization of splicing factors in the nucleus

Experimental Cell Research

Volumn 289, Issue 1, 2003, Pages 77-85

  Gama Carvalho, Margarida ^a   Condado, Inês ^a   Carmo Fonseca, Maria ^a  

^a INSTITUTO DE MEDICINA MOLECULAR JOÃO LOBO ANTUNES   (Portugal)

Author keywords

Adenovirus; Alternative splicing; In situ hybridization; Nuclear compartmentalization; SR proteins

Indexed keywords

ADENOVIRUS; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; CORRELATION ANALYSIS; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN SITU HYBRIDIZATION; NONHUMAN; PRIORITY JOURNAL; RNA SPLICING; VIRUS GENE; VIRUS INFECTION;

ADENOVIRIDAE;

EID: 0042663831     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-4827(03)00251-9     Document Type: Article

References (32)

1. Burge, C.B., Tuschl, T.H., Sharp, P.A. Splicing of precursors to mRNAs by the spliceosomes, in: R.F. Gesteland, T.R. Cech, J.F. Atkins (Eds.), The RNA world, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1999, pp. 525-560.
2. Modrek B., Lee C. A genomic view of alternative splicing. Nat. Genet. 30:2002;13-19.
3. Smith C.W., Valcarcel J. Alternative pre-mRNA splicing: the logic of combinatorial control. Trends Biochem. Sci. 25:2000;381-388.
4. Graveley B.R. Sorting out the complexity of SR protein functions. RNA. 6:2000;1197-1211.
5. Hanamura A., Caceres J.F., Mayeda A., Franza B.R. Jr., Krainer A.R. Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors. RNA. 4:1998;430-444.
6. Kanopka A., Muhlemann O., Petersen-Mahrt S., Estmer C., Ohrmalm C., Akusjarvi G. Regulation of adenovirus alternative RNA splicing by dephosphorylation of SR proteins. Nature. 393:1998;185-187.
7. Petersen-Mahrt S.K., Estmer C., Ohrmalm C., Matthews D.A., Russell W.C., Akusjarvi G. The splicing factor-associated protein, p32, regulates RNA splicing by inhibiting ASF/SF2 RNA binding and phosphorylation. EMBO J. 18:1999;1014-1024.
8. Xiao S.H., Manley J.L. Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing. Genes Dev. 11:1997;334-344.
9. Sleeman J.E., Lamond A.I. Nuclear organization of pre-mRNA splicing factors. Curr. Opin. Cell Biol. 11:1999;372-377.
10. Jimenez-Garcia L.F., Spector D.L. In vivo evidence that transcription and splicing are coordinated by a recruiting mechanism. Cell. 73:1993;47-59.
11. Huang S., Spector D.L. Intron-dependent recruitment of pre-mRNA splicing factor in factors to sites of transcription. J. Cell Biol. 133:1996;719-732.
12. Misteli T., Caceres J.F., Spector D.L. The dynamics of a pre-mRNA splicing factor in living cells. Nature. 387:1997;523-527.
13. Misteli, T.S., D.L. Protein phosphorylation and the nuclear organization of pre-mRNA splicing. Trends Cell Biol. 7, (1997) 135-138.
14. Misteli T., Spector D.L. Serine/threonine phosphatase 1 modulates the subnuclear distribution of pre-mRNA splicing factors. Mol. Biol. Cell. 7:1996;1559-1572.
15. Colwill K., Pawson T., Andrews B., Prasad J., Manley J.L., Bell J.C., Duncan P.I. The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution. EMBO J. 15:1996;265-275. abs.html.
16. Sacco-Bubulya P., Spector D.L. Disassembly of interchromatin granule clusters alters the coordination of transcription and pre-mRNA splicing. J. Cell Biol. 156:2002;425-436.
17. Misteli T. Cell biology of transcription and pre-mRNA splicing nuclear architecture meets nuclear function. J. Cell Sci. 113:2000;1841-1849.
18. van der Houven van Oordt W., Diaz-Meco M.T., Lozano J., Krainer A.R., Moscat J., Caceres J.F. The MKK(3/6)-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation. J. Cell Biol. 149:2000;307-316.
19. Gama-Carvalho M., Carmo-Fonseca M. The rules and roles of nucleocytoplasmic shuttling proteins. FEBS Lett. 498:2001;157-163.
20. Bridge E., Xia D.X., Carmo-Fonseca M., Cardinali B., Lamond A.I., Pettersson U. Dynamic organization of splicing factors in adenovirus-infected cells. J. Virol. 69:1995;281-290.
21. Gama-Carvalho M., Carvalho M.P., Kehlenbach A., Valcarcel J., Carmo-Fonseca M. Nucleocytoplasmic shuttling of heterodimeric splicing factor U2AF. J. Biol. Chem. 276:2001;13104-13112.
22. Pombo A., Ferreira J., Bridge E., Carmo-Fonseca M. Adenovirus replication and transcription sites are spatially separated in the nucleus of infected cells. EMBO J. 13:1994;5075-5085.
23. Calado A., Kutay U., Kuhn U., Wahle E., Carmo-Fonseca M. Deciphering the cellular pathway for transport of poly(A)-binding protein II. RNA. 6:2000;245-256.
24. Hofler H. Principles of in situ hybridization. Polak J.M., McGee J.O.'D. In situ hybridization - principles and practice. 1990;Oxford Univ. Press, Oxford.
25. Puvion-Dutilleul F., Puvion E. Analysis by in situ hybridization and autoradiography of sites of replication and storage of single- and double-stranded adenovirus type 5 DNA in lytically infected HeLa cells. J. Struct. Biol. 103:1990;280-289.
26. Puvion-Dutilleul F., Puvion E. Replicating single-stranded adenovirus type 5 DNA molecules accumulate within well-delimited intranuclear areas of lytically infected HeLa cells. Eur. J. Cell. Biol. 52:1990;379-388.
27. Imperiale M.J., Akusjnarvi G., Leppard K.N. Post-transcriptional control of adenovirus gene expression. Curr. Top. Microbiol. Immunol. 199:1995;139-171.
28. Estmer Nilsson C., Petersen-Mahrt S., Durot C., Shtrichman R., Krainer A.R., Kleinberger T., Akusjarvi G. The adenovirus E4-ORF4 splicing enhancer protein interacts with a subset of phosphorylated SR proteins. EMBO J. 20:2001;864-871.
29. Bridge E., Carmo-Fonseca M., Lamond A., Pettersson U. Nuclear organization of splicing small nuclear ribonucleoproteins in adenovirus-infected cells. J. Virol. 67:1993;5792-5802.
30. Gama-Carvalho M., Krauss R.D., Chiang L., Valcarcel J., Green M.R., Carmo-Fonseca M. Targeting of U2AF65 to sites of active splicing in the nucleus. J. Cell Biol. 137:1997;975-987.
31. Besse S., Puvion-Dutilleul F. Compartmentalization of cellular and viral DNAs in adenovirus type 5 infection as revealed by ultrastructural in situ hybridization. Chromosome Res. 2:1994;123-135.
32. Himmelspach M., Cavaloc Y., Chebli K., Stevenin J., Gattoni R. Titration of serine/arginine (SR) splicing factors during adenoviral infection modulates E1A pre-mRNA alternative splicing. RNA. 1:1995;794-806.