Excitatory neurotransmission in alcoholism;Exzitatorische neurotransmission bei chronischem alkoholismus

Fortschritte der Neurologie Psychiatrie

Volumn 71, Issue SUPPL. 1, 2003, Pages

  Bleich, Stefan ^a   Sperling, W ^a   Wiltfang, J ^a   Maler, J M ^a   Kornhuber, J ^a  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; CLOMETHIAZOLE; CYANOCOBALAMIN; EXCITATORY AMINO ACID; FOLIC ACID; GLUTAMIC ACID; HOMOCYSTEINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PYRIDOXINE; SULFUR AMINO ACID;

ADULT; ALCOHOLISM; AMINO ACID METABOLISM; ARTICLE; BRAIN ATROPHY; CENTRAL NERVOUS SYSTEM; CLINICAL ARTICLE; CONTROLLED STUDY; EXCITATORY POSTSYNAPTIC POTENTIAL; FEMALE; HUMAN; HYPERHOMOCYSTEINEMIA; MALE; MAMMAL; NEUROTOXICITY; NEUROTRANSMISSION; PATHOPHYSIOLOGY; RECEPTOR UPREGULATION; SYNAPSE; WITHDRAWAL SYNDROME;

ALCOHOLISM; ANIMALS; EXCITATORY AMINO ACIDS; GLUTAMIC ACID; HOMOCYSTEINE; HUMANS; NEUROTRANSMITTER AGENTS; PROGNOSIS; RECEPTORS, GLUTAMATE; SYNAPTIC TRANSMISSION;

EID: 0042657825     PISSN: 07204299     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (85)

1. Tsai G, Gastfriend DR, Coyle JT. The glutamatergic basis of human alcoholism. Am J Psychiatry 1995; 152: 332-340
2. Tsai GE, Ragan P, Chang R, Chen S, Linnoila VM, Coyle JT. Increased glutamatergic neurotransmission and oxidative stress after alcohol withdrawal. Am J Psychiatry 1998; 155: 726-732
3. Chen X, Michaelis MR, Michaelis EK. Effects of chronic ethanol treatment on the expression of calcium transport carriers and NMDA receptor proteins in brain synaptic membranes. J Neurochem 1997; 69: 1559-1569
4. Diamond I, Gordon AS. Cellular and molecular neuroscience of alcoholism. Physiol Rev 1997; 77: 1-20
5. Follesa P, Ticku MK. Chronic ethanol-mediated up-regulation of the N-methyl-D-aspartate receptor polypeptide. J Biol Chem 1996; 271: 13297-13299
6. Hu XJ, Ticku MK. Chronic ethanol treatment upregulates the NMDA receptor function and binding in mammalian cortical neurons. Mol Brain Res 1995; 30: 347-356
7. Hu XJ, Follesa P, Ticku MK. Chronic ethanol treatment produces a selective upregulation of the NMDA receptor subunit gene expression in mammalian cultured cortical neurons. Mol Brain Res 1996; 36: 211-218
8. Lovinger DM. Alcohols and neurotransmitter gated ion channels: past, present and future. Naunyn-Schmiedeberg's Arch Pharmacol 1997; 356: 267-282
9. Snell LD, Nunley KR, Lickteig RL, Browning MD, Tabakoff B, Hoffmann PL. Regional and subunit specific changes in NMDA receptor mRNA and immunoreactivity in mouse brain following chronic ethanol ingestion. Mol Brain Res 1996; 40: 71-78
10. Tabakoff B, Hoffmann PL. Alcohol addiction: an enigma among us. Neuron 1996; 16: 909-912
11. Tabakoff B, Ellevuo K, Hoffmann PL. Alcohol. In: Schuster CR, Kuhar MJ (Hrsg.). Pharmacological aspects of drug dependence, handbook of experimental pharmacology. Berlin: Springer, 1996: 374-460
12. Beal MF. Mechanisms of excitotoxicity in neurologic diseases. FASEB J 1992; 6: 3338-3344
13. Chapman AG. Glutamate and epilepsy. J Nutr Suppl 2000; 130: 1043-1045
14. Kruman II, Culmsee C, Chan SL, Kruman Y, Guo Z, Penix LR. Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. J Neurosci 2000; 20: 6920-6926
15. Lipton SA, Rosenberg PA. Mechanisms of disease: Excitatory amino acids as a final common pathway for neurologic disorders. N Eng J Med 1994; 330: 613-622
16. Meldrum BS. Glutamate as a neurotransmitter in the brain: Review of physiology and pathology. J Nutr Suppl 2000; 130: 1007-1015
17. Meldrum B, Garthwaite J. Excitatory amino acid neurotoxicity and neurodegenerative disease. TIPS 1990; 11: 379-387
18. Outinen PA, Sood SK, Liaw PCY, Sarge KD, Maeda N, Hirsh J, Ribau J, Podor TJ, Weitz JI, Austin RC. Characterization of the stress-inducing effects of homocysteine. Biochem J 1998; 332: 213-221
19. Parsons CG, Danysz W, Quack G. Glutamate in CNS disorders as a target for drug development: an update. Drug News Perspect 1998; 11: 523-569
20. Parsons RB, Waring RH, Ramsden DB, Williams AC. In vitro effect of the cysteine metabolites homocysteic acid, homocysteine and cysteic acid upon human neuronal cell lines. Neurotoxicology 1998; 19: 599-604
21. Kornhuber J, Bleich S. Memantin. In: Riederer P, Laux G, Pöldinger W (eds). Neuro-Psychopharmaka, Bd. 5, 2. Auflage. Wien: Springer Verlag, 1999: 687-704
22. Ripley TL, Little HJ. Effects of chronic ethanol withdrawal hyperexcitability of chronic treatment with a competitive N-methyl-D-aspartate receptor antagonist. J Pharmacol Exp Ther 1995; 272: 112-118
23. Grant KA, Valverius P, Hudspith M, Tabakoff B. Ethanol withdrawal seizures and the NMDA receptor complex. Eur J Pharmacol 1990a; 176: 289-296
24. Liljequist S. The competitive NMDA receptor antagonist, CGP-39 551, inhibits ethanol withdrawal seizures. Eur J Pharmacol 1991; 192: 197-198
25. Morrisett RA, Rezvani AH, Overstreet D, Janowsky DS, Wilson WA, Swartzwelder HS. MK-801 potently inhibits alcohol withdrawal seizures in rats. Eur J Pharmacol 1990; 176: 103-106
26. Rosetti ZL, Carboni S. Ethanol withdrawal is associated with increased extracellular glutamate in the rat striatum. Eur J Pharmacol 1995; 283: 177-183
27. Danysz W, Janowska E, Glazewsky S, Kostowsky W. The involvement of NMDA receptors in acute and chronic effects of ethanol. Alcohol Clin Exp Res 1992; 16: 499-504
28. Davidson M, Shanley B, Wilce PA. Increased NMDA-induced excitability during ethanol withdrawal: a behavioural and histological study. Brain Res 1995; 674: 91-96
29. Sanna E, Serra M, Cossu A, Colombo G, Follesa P, Cuccheddu T, Concas A, Biggio G. Chronic ethanol intoxication induces differential effects on GABA A and NMDA receptor function in the rat brain. Alcohol Clin Exp Res 1993; 17: 115-123
30. Carboni S, Isola R, Gessa GL, Rosetti ZL. Ethanol prevents the glutamate release induced by N-methyl-D-aspartate in the rat striatum. Neurosci Lett 1993; 152: 133-136
31. Moghaddam B, Bolinao M. Biphasic effects of ethanol on extracellular accumulation of glutamate in the hippocampus and the nucleus accumbens. Neurosci Lett 1994; 178: 99-102
32. Bustos GA, Abarca J, Forray MI, Gysling K, Bradberry CW, Roth RH. Regulation of excitatory amino acid release by N-methyl-D-aspartate receptors in rat striatum: in vivo microdialysis studies. Brain Res 1992;585:105-115
33. Morari M, O'Connor WT, Ungerstedt U, Bianchi C, Fuxe K. Functional neuroanatomy of the nigrostriatal pathways as studied with dual probe microdialysis in the awake rat. 2. Evidence for striatal N-methyl-D-aspartate receptor regulation of striatonigral GABAergic transmission and motor function. Neuroscience 1996; 72: 89-97
34. Rosetti ZL, Carboni S, Melis F, Vaccari A, Gessa GL. NMDA receptor activation mediated glutamate and aspartate release from rat striatum: prevention by MK-801. Neurochem Int 1990; 6: 63-63
35. Young AM, Bradford HF. N-methyl-D-aspartate releases excitatory amino acids in the corpus striatum in vivo. J Neurochem 1991; 56: 1677-1683
36. Gonzales R, Bungay PM, Kiianmaa K, Sansom HH, Rosetti ZL. In vivo links between neurochemistry and behavioral effects of ethanol. Alcohol Clin Exp Res 1996; 20: 203A-205A
37. Dumuis A, Sebben M, Haynes L, Pin JP, Bockaert J. NMDA receptors activate the arachidonic-acid cascade system in striatal neurons. Nature 1988; 336: 68-70
38. Pellegrini-Giampetro DE, Clerici G, Alesiani M, Carla V, Moroni F. Excitatory amino acid release from rat hippocampus slices as a consequence of free radical formation. J Neurochem 1988; 51: 1960-1963
39. Williams CH. Arachidonic acid induces a long-term activity-dependent enhancement of synaptic transmission in the hippocampus. Nature 1989; 341: 739-742
40. Volterra A, Trotti D, Gambino G, Racagni G. Convergent inhibition of glutamate uptake by arachidonic acid and oxygen free radicals: molecular mechanisms and relevance to neurodegenerative pathologies. In: Racagni G, Brunello N, Langer SL (Hrsg). Recent Advances in the treatment of neurodegenerative disorders and cognitive dysfunction. Volume 7. Basel: Karger, 1994: 129-137
41. Schuman ER, Madison DV. Nitric oxide and synaptic function. Ann Rev Neurosci 1994; 17: 153-183
42. Bogdanov MB, Wurtman RJ. Possible involvement of nitric oxide in NMDA-induced glutamate release in the rat striatum: an in vivo microdialysis study. Neurosci Lett 1997; 221: 197-201
43. Nei K, Matsuyama S, Shuntoh H, Tanaka C. NMDA receptor activation induces glutamate release through nitric oxide synthesis in guinea pig dentate gyrus. Brain Res 1996; 728: 105-110
44. Siegel S, Brose N, Janssen WG, Gasic GP, Jahn R, Heinemann SF. Regional cellular and ultrastructural distribution of N-methyl-D-aspartate receptor subunit in monkey hippocampus. Proc Natl Acad Sci USA 1994; 91: 564-568
45. Liu H, Wang H, Sheng M, Jan LY, Basbaum AI. Evidence for presynaptic N-methyl-D-aspartate receptors in the spinal cord dorsal horn. Proc Natl Acad Sci USA 1994; 91: 8383-8387
46. Collins GG, Anson J, Surtees L. Presynaptic kainate and N-methyl-D-aspartate receptors regulate excitatory amino acid release in the olfactory cortex. Brain Res 1983; 265: 157-159
47. Berretta N, Jones RS. Tonic facilitation of glutamate release by presynaptic N-methyl-D-aspartate autoreceptors in the entorhinal cortex. Neurosci 1996; 75: 339-344
48. Garcia-Munoz M, Young SJ, Groves PM. Terminal excitability of the corticostriatal pathway. II. Regulation by glutamate receptor stimulation. Brain Res 1991; 551: 207-215
49. Mayer ML, Westbrook GL. The physiology of excitatory amino acids in the vertebrate nervous system. Prog Neurobiol 1987; 28: 198-276
50. Amores-Sanchez MI, Medina MA. Methods for the determination of plasma total homocysteine: a review. Clin Chem Lab Med 2000; 38: 199-204
51. Graeme JH, Eikelboom JW. Homocysteine and vascular disease. Lancet 1999; 354: 407-413
52. Andreotti F, Burzotta F, Manzoli A, Robinson K. Homocysteine and risk of cardiovascular disease. J Thromb Thrombolysis 2000; 9: 13-21
53. Seitz HK, Maier H, Stickel F, Simanowski UA. Alkohol und Krebs. In: Seitz HK, Lieber CS, Simanowski UA (Hrsg): Alkoholbedingte Organschäden. Leipzig, Heidelberg: JA Barth-Verlag, 1995
54. Bleich S, Degner D, Javaheripour K, Kurth C, Kornhuber J. Homocysteine and alcoholism. J Neural Transm Suppl 2000; 60: 187-196
55. Bleich S, Spilker K, Kurth C, Degner D, Quintela-Schneider M, Javaheripour K, Rüther E, Kornhuber J, Wiltfang J. Oxidative stress and an altered methionine metabolism in alcoholism. Neurosci Lett 2000a; 293: 171-174
56. Bleich S, Degner D, Wiltfang J, Maler JM, Niedmann P, Cohrs S, Mangholz A, Porzig J, Sprung R, Rüther E, Kornhuber J. Elevated homocysteine levels in alcohol withdrawal. Alcohol Alcohol 2000c; 35: 351-354
57. Bleich S, Bleich K, Kropp S, Degner D, Bittermann HJ, Sperling W, Rüther E, Kornhuber J. Moderate alcohol consumption in social drinkers raises plasma homocysteine levels: a contradiction to the "French paradox"? Alcohol Alcohol 2001; 36: 189-192
58. 12 status. Nutrition 2000; 16: 296-302
59. 6 status. Am J Clin Nutr 1996; 63: 220-224
60. Hultberg B, Berglund M, Andersson A, Frank A. Elevated plasma homocysteine in alcoholics. Alcohol Clin Exp Res 1993; 17: 687-689
61. Eikelboom JW, Lonn E, Genest Jr J, Hankey G, Yusuf S. Homocyst(e)ine and cardiovascular disease: A critical review of the epidemiologic evidence. Ann Intern Med 1999; 131: 363-375
62. Nygard O, Refsum H, Ueland PM, Vollset SE. Major lifestyle determinants of plasma total homocysteine distribution: the Hordaland Homocysteine Study. Am J Clin Nutr 1998; 67: 263-270
63. Gibson JB, Carson NAJ, Neill DW. Pathological findings in homocystinuria. J Clin Pathol 1964; 17: 427-437
64. McCully KS. Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. Am J Pathol 1969; 56: 111-128
65. Watkins D, Rosenblatt DS. Functional methionine synthase deficiency (cb1E and cb1G): clinical and biochemical heterogeneity. Am J Med Genet 1989; 34: 427-434
66. Schwarz S, Zhou G-Z. N-methyl-D-aspartate receptors and CNS symptoms of homocystinuria. Lancet 1991; 337 (8751): 1226-1227
67. Lipton SA, Kim WK, Choi YB, Kumar S, Demilia DM, Rayudu PV, Arnelle DR, Stamler JS. Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor. Proc Natl Acad Sci USA 1997; 94: 5923-5928
68. Boss V, Nutt KM, Conn PJ. L-cysteinesulfinic as an endogenous agonist of a novel metabotropic receptor coupled to stimulation of phospholipase D activity. Mol Pharmacol 1994; 5: 1177-1182
69. Folbergrova J, Haugvicova R, Mares P. Behavioral and metabolic changes in immature rats during seizures induced by homocysteic acid: the protective effect of NMDA and Non-NMDA receptor antagonists. Exp Neurol 2000; 161: 336-345
70. Knöpfel T, Zeise ML, Cuenod M, Zieglgänsberger W. L-homocysteic acid but not glutamate is an endogenous N-methyl-D-aspartic acid receptor preferring agonist in rat neocortical neurons in vitro. Neurosci Lett 1987; 81: 188-192
71. Olney JW, Price MT, Salles KS, Labruyere J, Ryerson R, Mahan K, Friedrich G, Samson L. L-homocysteic acid: an endogenous excitotoxic ligand of the NMDA receptor. Brain Res Bull 1987; 19: 597-602
72. Butcher SP, Cameron D, Kendall L, Griffiths R. Homocysteine-induced alterations in extracellular amino acids in rat hippocampus. Neurochem Int 1992; 20: 75-80
73. Cuenod M, Do KQ, Grandes P, Morino P, Streit P. Localization and release of homocysteic acid, an excitatory sulfur-containing amino acid. J Histochem Cytochem 1990; 38: 713-1715
74. Kubova H, Folbergrova J, Mares P. Seizures induced by homocysteine in rats during ontogenesis. Epilepsia 1995; 36: 750-756
75. Mares P, Folbergrova J, Langmeier M, Haugvicova R, Kubova H. Convulsant action of D,L-homocysteic acid and its stereoisomers in immature rats. Epilepsia 1997; 38: 767-776
76. Bleich S, Degner D, Bandelow B, Ahsen N von, Rüther E, Kornhuber J: Homocysteine is a predictor of alcohol withdrawal seizures. NeuroReport 2000; 11: 2749-2752
77. Kurth C, Wegerer V, Degner D, Sperling W, Kornhuber J, Paulus W, Bleich S. Risk assessment of alcohol withdrawal seizures with a Kohonen Feature Map. NeuroReport 2001; 12: 45-49
78. Bleich S, Degner D, Kropp S, Rüther E, Kornhuber J. Red wine, spirits, beer and serum homocysteine. Lancet 2000; 356 (9228): 512-512
79. Barak AJ, Beckenhauer HC, Tuma DJ. Betaine, ethanol, and liver disease: A review. Alcohol 1996; 13: 395-398
80. Kenyon SH, Nicolaou A, Gibbons WA. The effect of ethanol and its metabolites upon methionine synthase activity in vitro. Alcohol 1998; 15: 305-309
81. Finkelstein JD. Methionine metabolism in mammals: The biochemical basis for homocystinuria. Metabolism 1974; 23: 387-398
82. Bleich S, Bandelow B, Javaheripour K, Müller A, Degner D, Wilhelm J, Havemann-Reinecke U, Sperling W, Rüther E, Kornhuber J. Hyperhomocysteinemia as a new risk factor for brain shrinkage in patients with alcoholism. Neurosci Lett 2003; 335: 179-182
83. Gibson JB, Carson NAJ, Neill DW. Pathological findings in homocystinuria. J Clin Pathol 1964; 17: 27-437
84. 12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 1998; 55: 1449-1455
85. Sachdev PS, Valenzuela M, Wang XL, Looi JC, Brodaty H. Relationship between plasma homocysteine levels and brain atrophy in healthy elderly individuals. Neurology 2002; 58: 1539-1541