Major lifestyle determinants of plasma total homocysteine distribution: The Hordaland Homocysteine Study

American Journal of Clinical Nutrition

Volumn 67, Issue 2, 1998, Pages 263-270

  Nygård, Ottar ^a,b   Refsum, Helga ^a   Ueland, Per M ^a   Vollset, Stein E ^a  

^a UNIVERSITY OF BERGEN   (Norway)

^b HAUKELAND UNIVERSITY HOSPITAL   (Norway)

Author keywords

Coffee consumption; Distribution; Folate intake; Hordaland Homocysteine Study; Lifestyle; Plasma total homocysteine; Reference range; Smoking; Vitamin supplements

Indexed keywords

FOLIC ACID; HOMOCYSTEINE;

ADULT; AGED; ARTICLE; COFFEE; DIETARY INTAKE; FEMALE; HUMAN; HUMAN EXPERIMENT; LIFESTYLE; MALE; NORMAL HUMAN; REFERENCE VALUE; SMOKING; VITAMIN INTAKE;

EID: 2642676850     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/67.2.263     Document Type: Article

References (34)

1. Ueland PM, Refsum H, Stabler SP, Malinow MR, Andersson A, Allen RH. Total homocysteine in plasma or serum. Methods and clinical applications. Clin Chem 1993;39:1764-79.
2. Andersson A, Brattström L, Israelsson B, Isaksson A, Hamfelt A, Hultberg B. Plasma homocysteine before and after methionine loading with regard to age, gender, and menopausal status. Eur J Clin Invest 1992;22:79-87.
3. Nygard O, Vollset SE, Refsum H, et al. Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study. JAMA 1995;274:1526-33.
4. Bostom AG, Lathrop L. Hyperhomocysteinemia in end-stage renal disease: prevalence, etiology, and potential relationship to arteriosclerotic outcomes. Kidney Int 1997;52:10-20.
5. Allen RH, Stabler SP, Savage DG, Lindenbaum J. Metabolic abnor- malities in cobalamin (vitamin-B12) and folate deficiency. FASEB J 1994;7:1344-53.
6. Kang S-S, Wong PWK, Norusis M. Homocysteinernia due to folate deficiency. Metabolism 1987;36:458-62.
7. Selhub J, Jacques PF, Wilson PWF, Rush D, Rosenberg IH. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA 1993;270:2693-8.
8. Frosst P, Blom HJ, Milos R, et al. Identification of a candidate genetic risk factor for vascular disease: a common mutation at the methylenetetrahydrofolate reductase locus. Nature Genet 1995;10:111-3.
9. Jacques PF, Bostom AG, Williams RR, et al. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 1996;93:7-9.
10. Guttormsen AB, Ueland PM, Nesthus I, et al. Determinants of vitamin responsiveness of intermediate hyperhomocysteinemia (≥ 40 mmol/L). The Hordaland Homocysteine Study. J Clin Invest 1996;98:2174-83.
11. Savage DG, Lindenbaum J, Stabler SP, Allen RH. Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies. Am J Med 1994;96:239-46.
12. Boushey CJ, Beresford SAA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: probable benefits of increasing folic acid intakes. JAMA 1995;274:1049-57.
13. Steegers-Theunissen RPM, Boers GHJ, Trijbels FJM, et al. Maternal hyperhomocysteinemia: a risk factor for neural-tube defects? Metabolism 1994;43:1475-80.
14. Mills JL, McPartlin JM, Kirke PN, et al. Homocysteine metabolism in pregnancies complicated by neural-tube defects. Lancet 1995;345:149-51.
15. Rosenquist TH, Ratashak SA, Selhub J. Homocysteine induces congenital defects of the heart and neural tube: effect of folic acid. Proc Natl Acad Sci U S A 1996;93:15227-32.
16. Smythies JR, Gottfries CG, Regland B. Disturbances of one-carbon metabolism in neuropsychiatrie disorders: a review. Biol Psychiatry 1997;41:230-3.
17. Ubbink JB, Backer PJ, Vermaak WJH, Delport R. Results of B-vitamin supplementation study used in a prediction model to define a reference range for plasma homocysteine. Clin Chem 1995;41:1033-7.
18. Joosten E, Lesaffre E, Riezler R. Are different reference intervals for methylmalonic acid and total homocysteine necessary in elderly people? Eur J Haematol 1996;57:222-6.
19. Rasmussen K, Møller J, Lyngbak M, Pedersen AMH, Dybkjær L. Age and gender-specific reference intervals for total homocysteine and methylmalonic acid in plasma before and after vitamin supplementation. Clin Chem 1996;42:630-6.
20. Nygård O, Refsum H, Ueland PM, et al. Coffee consumption and total plasma homocysteine: The Hordaland Homocysteine Study. Am J Clin Nutr 1997;65:136-43.
21. Fiskerstrand T, Refsum H, Kvalheim G, Ueland PM. Homocysteine and other thiols in plasma and urine: automated determination and sample stability. Clin Chem 1993;39:263-71.
22. Refsum H, Ueland PM, Svardal AM. Fully automated fluorescence assay for determining total homocysteine in plasma. Clin Chem 1989;35:1921-7.
23. Hastie TJ, Tibshirani RJ. Generalized additive models. London: Chapman & Hall, 1990.
24. Statistical Sciences, Inc. S-PLUS user's manual. Version 3.3 for Windows. Seattle: Statistical Sciences, Inc. 1995.
25. Dixon WJ. BMDP statistical software manual. Vols 1-2. Berkeley, CA: University of California Press, 1992.
26. Statens Livsmedelsverk. Food habits and nutrient intake in Sweden 1989. Uppsala, Sweden: Statens Livsmedelsverk, 1994.
27. Jacob RA, Mei-Miau W, Henning S, Swendseid ME. Homocysteine increases as folate decreases in plasma of healthy men during short-term dietary folate and methyl group restriction. J Nutr 1994;124:1072-80.
28. O'Keefe CA, Bailey LB, Thomas EA, et al. Controlled dietary folate affects folate status in nonpregnant women. J Nutr 1995;125:2717-25.
29. Rang S-S, Zhou J, Wong PWK, Kowalisyn J, Strokosch G. Intermediate homocysteinemia: a thermolabile variant of methylenetetrahydrofolate reductase. Am J Hum Genet 1988;43:414-21.
30. Naurath HJ, Joosten E, Riezler R, Stabler SP, Allen RH, Lindenbaum J. Effects of vitamin B12, folate, and vitamin B6 supplements in elderly people with normal serum vitamin concentrations. Lancet 1995;346:85-9.
31. Brattström L. Vitamins as homocysteine-lowering agents. J Nutr 1996;126:1276S-80S.
32. Tucker KL, Selhub J, Wilson PWF, Rosenberg IH. Dietary intake pattern relates to plasma folate and homocysteine concentrations in the Framingham Heart Study. J Nutr 1996;126:3025-31.
33. Cuskelly GJ, McNulty H, Scott JM. Effect of increasing dietary folate on red cell folate: implications for prevention of neural tube defects. Lancet 1996;347:657-9.
34. Nygård O, Nordrehaug JE, Refsum H, Farstad M, Ueland PM, Vollset SE. Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med 1997;337:230-6.