메뉴 건너뛰기




Volumn 24, Issue 9, 2003, Pages 508-511

Hodgkin disease immunopathogenesis: Long-standing questions, recent answers, further directions

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE; BIOAVAILABILITY; CELL MATURATION; CELL SURVIVAL; CLONAL VARIATION; DISEASE COURSE; HODGKIN DISEASE; HUMAN; IMMUNOPATHOGENESIS; NONHUMAN; PHENOTYPE; REED STERNBERG CELL; REVIEW; STEM CELL; TRANSCRIPTION REGULATION; VIRUS INFECTION;

EID: 0042380007     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4906(03)00236-9     Document Type: Review
Times cited : (6)

References (45)
  • 1
    • 0036206437 scopus 로고    scopus 로고
    • Hodgkin's lymphoma: The pathologist's viewpoint
    • Pileri S.A., et al. Hodgkin's lymphoma: the pathologist's viewpoint. J. Clin. Pathol. 55:2002;162-176.
    • (2002) J. Clin. Pathol. , vol.55 , pp. 162-176
    • Pileri, S.A.1
  • 2
    • 0028007479 scopus 로고
    • Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development
    • Küppers R., et al. Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development. Proc. Natl. Acad. Sci. U. S. A. 91:1994;10962-10966.
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 10962-10966
    • Küppers, R.1
  • 3
    • 0029952779 scopus 로고    scopus 로고
    • Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells
    • Kanzler H., et al. Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells. J. Exp. Med. 184:1996;1495-1505.
    • (1996) J. Exp. Med. , vol.184 , pp. 1495-1505
    • Kanzler, H.1
  • 4
    • 0030791751 scopus 로고    scopus 로고
    • Origin of nodular lymphocyte-predominant Hodgkin's disease from a clonal expansion of highly mutated germinal-center B cells
    • Marafioti T., et al. Origin of nodular lymphocyte-predominant Hodgkin's disease from a clonal expansion of highly mutated germinal-center B cells. N. Engl. J. Med. 337:1997;453-458.
    • (1997) N. Engl. J. Med. , vol.337 , pp. 453-458
    • Marafioti, T.1
  • 5
    • 0345391016 scopus 로고    scopus 로고
    • Identification of common germinal-center B-cell precursors in two patients with both Hodgkin's disease and non-Hodgkin's lymphoma
    • Brauninger A., et al. Identification of common germinal-center B-cell precursors in two patients with both Hodgkin's disease and non-Hodgkin's lymphoma. N. Engl. J. Med. 340:1999;1239-1247.
    • (1999) N. Engl. J. Med. , vol.340 , pp. 1239-1247
    • Brauninger, A.1
  • 6
    • 0032777040 scopus 로고    scopus 로고
    • Classical Hodgkin's disease and follicular lymphoma originating from the same germinal center B cell
    • Marafioti T., et al. Classical Hodgkin's disease and follicular lymphoma originating from the same germinal center B cell. J. Clin. Oncol. 17:1999;3804-3809.
    • (1999) J. Clin. Oncol. , vol.17 , pp. 3804-3809
    • Marafioti, T.1
  • 7
    • 0035350764 scopus 로고    scopus 로고
    • Common germinal-center B-cell origin of the malignant cells in two composite lymphomas, involving classical Hodgkin's disease and either follicular lymphoma or B-CLL
    • Küppers R., et al. Common germinal-center B-cell origin of the malignant cells in two composite lymphomas, involving classical Hodgkin's disease and either follicular lymphoma or B-CLL. Mol. Med. 7:2001;285-292.
    • (2001) Mol. Med. , vol.7 , pp. 285-292
    • Küppers, R.1
  • 8
    • 17044443197 scopus 로고    scopus 로고
    • Hodgkin and Reed-Sternberg cells represent an expansion of a single clone originating from a germinal center B-cell with functional immunoglobulin gene rearrangements but defective immunoglobulin transcription
    • Marafioti T., et al. Hodgkin and Reed-Sternberg cells represent an expansion of a single clone originating from a germinal center B-cell with functional immunoglobulin gene rearrangements but defective immunoglobulin transcription. Blood. 95:2000;1443-1450.
    • (2000) Blood , vol.95 , pp. 1443-1450
    • Marafioti, T.1
  • 9
    • 0037381009 scopus 로고    scopus 로고
    • Typing the histogenetic origin of the tumor cells of lymphocyte-rich classical Hodgkin's lymphoma in relation to tumor cells of classical and lymphocyte-predominance Hodgkin's lymphoma
    • Brauninger A., et al. Typing the histogenetic origin of the tumor cells of lymphocyte-rich classical Hodgkin's lymphoma in relation to tumor cells of classical and lymphocyte-predominance Hodgkin's lymphoma. Cancer Res. 63:2003;1644-1651.
    • (2003) Cancer Res. , vol.63 , pp. 1644-1651
    • Brauninger, A.1
  • 10
    • 0035863760 scopus 로고    scopus 로고
    • Down-regulation of BOB.1/OBF.1 and Oct2 in classical Hodgkin disease but not in lymphocyte predominant Hodgkin disease correlates with immunoglobulin transcription
    • Stein H., et al. Down-regulation of BOB.1/OBF.1 and Oct2 in classical Hodgkin disease but not in lymphocyte predominant Hodgkin disease correlates with immunoglobulin transcription. Blood. 97:2001;496-501.
    • (2001) Blood , vol.97 , pp. 496-501
    • Stein, H.1
  • 11
    • 0037089229 scopus 로고    scopus 로고
    • Loss of PU.1 expression is associated with defective immunoglobulin transcription in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease
    • Jundt F., et al. Loss of PU.1 expression is associated with defective immunoglobulin transcription in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease. Blood. 99:2002;3060-3062.
    • (2002) Blood , vol.99 , pp. 3060-3062
    • Jundt, F.1
  • 12
    • 0037173743 scopus 로고    scopus 로고
    • Loss of B cell identity correlates with loss of B cell-specific transcription factors in Hodgkin/Reed-Sternberg cells of classical Hodgkin lymphoma
    • Hertel C.B., et al. Loss of B cell identity correlates with loss of B cell-specific transcription factors in Hodgkin/Reed-Sternberg cells of classical Hodgkin lymphoma. Oncogene. 21:2002;4908-4920.
    • (2002) Oncogene , vol.21 , pp. 4908-4920
    • Hertel, C.B.1
  • 13
    • 0036193609 scopus 로고    scopus 로고
    • Constitutive expression of PU.1 in fetal hematopoietic progenitors blocks T cell development at the pro-T cell stage
    • Anderson M.K., et al. Constitutive expression of PU.1 in fetal hematopoietic progenitors blocks T cell development at the pro-T cell stage. Immunity. 16:2002;285-296.
    • (2002) Immunity , vol.16 , pp. 285-296
    • Anderson, M.K.1
  • 14
    • 0035313994 scopus 로고    scopus 로고
    • Selection events operating at various stages in B cell development
    • Rolink A.G., et al. Selection events operating at various stages in B cell development. Curr. Opin. Immunol. 13:2001;202-207.
    • (2001) Curr. Opin. Immunol. , vol.13 , pp. 202-207
    • Rolink, A.G.1
  • 15
    • 0013449584 scopus 로고    scopus 로고
    • Roles of EBF and Pax-5 in B lineage commitment and development
    • Maier H., Hagman J. Roles of EBF and Pax-5 in B lineage commitment and development. Semin. Immunol. 14:2002;415-422.
    • (2002) Semin. Immunol. , vol.14 , pp. 415-422
    • Maier, H.1    Hagman, J.2
  • 16
    • 0034994533 scopus 로고    scopus 로고
    • Pax5 determines the identity of B cells from the beginning to the end of B-lymphopoiesis
    • Nutt S.L., et al. Pax5 determines the identity of B cells from the beginning to the end of B-lymphopoiesis. Int. Rev. Immunol. 20:2001;65-82.
    • (2001) Int. Rev. Immunol. , vol.20 , pp. 65-82
    • Nutt, S.L.1
  • 17
    • 0033485592 scopus 로고    scopus 로고
    • BSAP/Pax5A expression blocks survival and expansion of early myeloid cells implicating its involvement in maintaining commitment to the B-lymphocyte lineage
    • Chiang M.Y., Monroe J.G. BSAP/Pax5A expression blocks survival and expansion of early myeloid cells implicating its involvement in maintaining commitment to the B-lymphocyte lineage. Blood. 94:1999;3621-3632.
    • (1999) Blood , vol.94 , pp. 3621-3632
    • Chiang, M.Y.1    Monroe, J.G.2
  • 18
    • 0037025198 scopus 로고    scopus 로고
    • Reversion of B cell commitment upon loss of Pax5 expression
    • Mikkola I., et al. Reversion of B cell commitment upon loss of Pax5 expression. Science. 297:2002;110-113.
    • (2002) Science , vol.297 , pp. 110-113
    • Mikkola, I.1
  • 19
    • 0036533340 scopus 로고    scopus 로고
    • Transcriptional control of B-cell development
    • Schebesta M., et al. Transcriptional control of B-cell development. Curr. Opin. Immunol. 14:2002;216-223.
    • (2002) Curr. Opin. Immunol. , vol.14 , pp. 216-223
    • Schebesta, M.1
  • 20
    • 0033230394 scopus 로고    scopus 로고
    • Frequent expression of the B-cell-specific activator protein in Reed-Sternberg cells of classical Hodgkin's disease provides further evidence for its B-cell origin
    • Foss H.D., et al. Frequent expression of the B-cell-specific activator protein in Reed-Sternberg cells of classical Hodgkin's disease provides further evidence for its B-cell origin. Blood. 94:1999;3108-3113.
    • (1999) Blood , vol.94 , pp. 3108-3113
    • Foss, H.D.1
  • 21
    • 0037441887 scopus 로고    scopus 로고
    • Loss of the B-lineage-specific gene expression program in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma
    • Schwering I., et al. Loss of the B-lineage-specific gene expression program in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma. Blood. 101:2003;1505-1512.
    • (2003) Blood , vol.101 , pp. 1505-1512
    • Schwering, I.1
  • 22
    • 0036566557 scopus 로고    scopus 로고
    • Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma
    • Jundt F., et al. Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma. Blood. 99:2002;3398-3403.
    • (2002) Blood , vol.99 , pp. 3398-3403
    • Jundt, F.1
  • 23
    • 0036906546 scopus 로고    scopus 로고
    • Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1
    • Souabni A., et al. Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1. Immunity. 17:2002;781-793.
    • (2002) Immunity , vol.17 , pp. 781-793
    • Souabni, A.1
  • 24
    • 20244389684 scopus 로고    scopus 로고
    • Notch1 expression in early lymphopoiesis influences B versus T lineage determination
    • Pui J.C., et al. Notch1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity. 11:1999;299-308.
    • (1999) Immunity , vol.11 , pp. 299-308
    • Pui, J.C.1
  • 25
    • 0037213918 scopus 로고    scopus 로고
    • Epstein-Barr virus LMP2A interferes with global transcription factor regulation when expressed during B-lymphocyte development
    • Portis T., Longnecker R. Epstein-Barr virus LMP2A interferes with global transcription factor regulation when expressed during B-lymphocyte development. J. Virol. 77:2003;105-114.
    • (2003) J. Virol. , vol.77 , pp. 105-114
    • Portis, T.1    Longnecker, R.2
  • 26
    • 0033831224 scopus 로고    scopus 로고
    • Dissecting affinity maturation: A model explaining selection of antibody-forming cells and memory B cells in the germinal center
    • Tarlington D.M., Smith K.G.C. Dissecting affinity maturation: a model explaining selection of antibody-forming cells and memory B cells in the germinal center. Immunol. Today. 21:2000;436-441.
    • (2000) Immunol. Today , vol.21 , pp. 436-441
    • Tarlington, D.M.1    Smith, K.G.C.2
  • 27
    • 0036386325 scopus 로고    scopus 로고
    • The life and death of a B cell
    • Defrance T., et al. The life and death of a B cell. Adv. Cancer Res. 86:2002;195-225.
    • (2002) Adv. Cancer Res. , vol.86 , pp. 195-225
    • Defrance, T.1
  • 28
    • 0036408959 scopus 로고    scopus 로고
    • Life and death within germinal centres: A double-edged sword
    • Guzman-Rojas L., et al. Life and death within germinal centres: a double-edged sword. Immunology. 107:2002;167-175.
    • (2002) Immunology , vol.107 , pp. 167-175
    • Guzman-Rojas, L.1
  • 29
    • 18844465632 scopus 로고    scopus 로고
    • Constitutive nuclear factor-κB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells
    • Bargou R.C., et al. Constitutive nuclear factor-κB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells. J. Clin. Invest. 100:1997;2961-2969.
    • (1997) J. Clin. Invest. , vol.100 , pp. 2961-2969
    • Bargou, R.C.1
  • 30
    • 0033611588 scopus 로고    scopus 로고
    • Molecular mechanisms of constitutive NF-κB/Rel activation in Hodgkin/Reed-Sternberg cells
    • Krappmann D., et al. Molecular mechanisms of constitutive NF-κB/ Rel activation in Hodgkin/Reed-Sternberg cells. Oncogene. 18:1999;943-953.
    • (1999) Oncogene , vol.18 , pp. 943-953
    • Krappmann, D.1
  • 31
    • 0032536860 scopus 로고    scopus 로고
    • Epstein-Barr virus-mediated B-cell proliferation is dependent upon latent membrane protein 1, which simulates an activated CD40 receptor
    • Kilger E., et al. Epstein-Barr virus-mediated B-cell proliferation is dependent upon latent membrane protein 1, which simulates an activated CD40 receptor. EMBO J. 17:1998;1700-1709.
    • (1998) EMBO J. , vol.17 , pp. 1700-1709
    • Kilger, E.1
  • 32
    • 0034847766 scopus 로고    scopus 로고
    • Epstein-Barr virus LMP-1 natural sequence variants differ in their potential to activate cellular signaling pathways
    • Fielding C.A., et al. Epstein-Barr virus LMP-1 natural sequence variants differ in their potential to activate cellular signaling pathways. J. Virol. 75:2001;9129-9141.
    • (2001) J. Virol. , vol.75 , pp. 9129-9141
    • Fielding, C.A.1
  • 33
    • 0034823202 scopus 로고    scopus 로고
    • Signaling by CD40 and its mimics in B cell activation
    • Bishop G.A., Hostager B.S. Signaling by CD40 and its mimics in B cell activation. Immunol. Res. 24:2001;97-109.
    • (2001) Immunol. Res. , vol.24 , pp. 97-109
    • Bishop, G.A.1    Hostager, B.S.2
  • 34
    • 0036092336 scopus 로고    scopus 로고
    • Cytoplasmic aggregation of TRAF2 and TRAF5 proteins in the Hodgkin-Reed-Sternberg cells
    • Horie R., et al. Cytoplasmic aggregation of TRAF2 and TRAF5 proteins in the Hodgkin-Reed-Sternberg cells. Am. J. Pathol. 160:2002;1647-1654.
    • (2002) Am. J. Pathol. , vol.160 , pp. 1647-1654
    • Horie, R.1
  • 35
    • 85047695761 scopus 로고    scopus 로고
    • Ligand-independent signaling by overexpressed CD30 drives NF-κB activation in Hodgkin-Reed-Sternberg cells
    • Horie R., et al. Ligand-independent signaling by overexpressed CD30 drives NF-κB activation in Hodgkin-Reed-Sternberg cells. Oncogene. 21:2002;2493-2503.
    • (2002) Oncogene , vol.21 , pp. 2493-2503
    • Horie, R.1
  • 36
    • 0041998173 scopus 로고    scopus 로고
    • Differential expression and function of A20 and TRAF1 in Hodgkin lymphoma and anaplastic large cell lymphoma and their induction by CD30 stimulation
    • Durkop H., et al. Differential expression and function of A20 and TRAF1 in Hodgkin lymphoma and anaplastic large cell lymphoma and their induction by CD30 stimulation. J. Pathol. 200:2003;214-221.
    • (2003) J. Pathol. , vol.200 , pp. 214-221
    • Durkop, H.1
  • 37
    • 0034677104 scopus 로고    scopus 로고
    • Clonal deleterious mutations in the IκBα gene in the malignant cells in Hodgkin's lymphoma
    • Jungnickel B., et al. Clonal deleterious mutations in the IκBα gene in the malignant cells in Hodgkin's lymphoma. J. Exp. Med. 191:2000;395-402.
    • (2000) J. Exp. Med. , vol.191 , pp. 395-402
    • Jungnickel, B.1
  • 38
    • 0024564527 scopus 로고
    • Detection of Epstein-Barr viral genomes in Reed-Sternberg cells of Hodgkin's disease
    • Weiss L.M., et al. Detection of Epstein-Barr viral genomes in Reed-Sternberg cells of Hodgkin's disease. N. Engl. J. Med. 320:1989;502-506.
    • (1989) N. Engl. J. Med. , vol.320 , pp. 502-506
    • Weiss, L.M.1
  • 39
    • 0033995792 scopus 로고    scopus 로고
    • Epstein-Barr virus-associated malignancies: Epidemiologic patterns and etiologic implications
    • Hsu J.L., Glaser S.L. Epstein-Barr virus-associated malignancies: epidemiologic patterns and etiologic implications. Crit. Rev. Oncol. Hematol. 34:2000;27-53.
    • (2000) Crit. Rev. Oncol. Hematol. , vol.34 , pp. 27-53
    • Hsu, J.L.1    Glaser, S.L.2
  • 40
    • 0037838706 scopus 로고    scopus 로고
    • Expression of Epstein-Barr virus latent membrane protein-1 in Hodgkin and Reed-Sternberg cells of classical Hodgkin's lymphoma: Associations with presenting features, serum interleukin 10 levels, and clinical outcome
    • Herling M., et al. Expression of Epstein-Barr virus latent membrane protein-1 in Hodgkin and Reed-Sternberg cells of classical Hodgkin's lymphoma: Associations with presenting features, serum interleukin 10 levels, and clinical outcome. Clin. Cancer Res. 9:2003;2114-2120.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 2114-2120
    • Herling, M.1
  • 41
    • 0037633965 scopus 로고    scopus 로고
    • Epstein-Barr virus encoded latent membrane protein 1 (LMP1) and TNF receptor associated factors (TRAF): Colocalisation of LMP1 and TRAF1 in primary EBV infection and in EBV associated Hodgkin lymphoma
    • Siegler G., et al. Epstein-Barr virus encoded latent membrane protein 1 (LMP1) and TNF receptor associated factors (TRAF): colocalisation of LMP1 and TRAF1 in primary EBV infection and in EBV associated Hodgkin lymphoma. Mol. Pathol. 56:2003;156-161.
    • (2003) Mol. Pathol. , vol.56 , pp. 156-161
    • Siegler, G.1
  • 42
    • 0037097818 scopus 로고    scopus 로고
    • The role of cytokines in classical Hodgkin lymphoma
    • Skinnider B.F., Mak T.W. The role of cytokines in classical Hodgkin lymphoma. Blood. 99:2002;4283-4297.
    • (2002) Blood , vol.99 , pp. 4283-4297
    • Skinnider, B.F.1    Mak, T.W.2
  • 43
    • 0035170688 scopus 로고    scopus 로고
    • Interleukin 13 and interleukin 13 receptor are frequently expressed by Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma
    • Skinnider B.F., et al. Interleukin 13 and interleukin 13 receptor are frequently expressed by Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma. Blood. 97:2001;250-255.
    • (2001) Blood , vol.97 , pp. 250-255
    • Skinnider, B.F.1
  • 44
    • 0037079728 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 6 is frequently activated in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma
    • Skinnider B.F., et al. Signal transducer and activator of transcription 6 is frequently activated in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma. Blood. 99:2002;618-626.
    • (2002) Blood , vol.99 , pp. 618-626
    • Skinnider, B.F.1
  • 45
    • 0037324651 scopus 로고    scopus 로고
    • Identification of Hodgkin and Reed-Sternberg cell-specific genes by gene expression profiling
    • Küppers R., et al. Identification of Hodgkin and Reed-Sternberg cell-specific genes by gene expression profiling. J. Clin. Invest. 111:2003;529-537.
    • (2003) J. Clin. Invest. , vol.111 , pp. 529-537
    • Küppers, R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.