Dissecting affinity maturation: A model explaining selection of antibody-forming cells and memory B cells in the germinal centre

Immunology Today

Volumn 21, Issue 9, 2000, Pages 436-441

  Tarlinton, David M ^a   Smith, Kenneth G C ^b  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BCL 2;

ANTIBODY PRODUCTION; APOPTOSIS; B LYMPHOCYTE; GERMINAL CENTER; HUMAN; MEMORY CELL; PRIORITY JOURNAL; REVIEW;

EID: 0033831224     PISSN: 01675699     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-5699(00)01687-X     Document Type: Note

References (37)

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3. Germinal centers: Form and function
4. Germinal centers
5. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells
6. Antigen-driven B cell differentiation in vivo
7. Affinity maturation of the primary response by V gene diversification
8. The phenotype and fate of the antibody-forming cells of the splenic foci
9. The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response
10. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection
11. Relaxed negative selection in germinal centers and impaired affinity maturation in bcl-xL transgenic mice
12. bcl-2 Transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells
13. The bone marrow: The major source of serum immunoglobulins, but still a neglected site of antibody formation
14. Germinal centers and antibody production in bone marrow
15. Kinetics of establishing the memory B cell population as revealed by CD38 expression
16. Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens
17. Induction of long-lived germinal centers associated with persisting antigen after viral infection
18. B cells extract and present immobilized antigen: Implications for affinity discrimination
19. The Bcl-2 protein family: Arbiters of cell survival
20. Bcl-x rather than Bcl-2 mediates CD40-dependent centrocyte survival in the germinal center
21. Bcl-2 increases memory B cell recruitment but does not perturb selection in germinal centers
22. Self-reactive B lymphocytes overexpressing Bcl-xL escape negative selection and are tolerized by clonal anergy and receptor editing
23. Soluble antigen can cause enhanced apoptosis of germinal-centre B cells
24. Antigen-induced B-cell death and elimination during germinal-centre immune responses
25. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance
26. Negative selection of human germinal center B cells by prolonged BCR cross-linking
27. FAS is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigen
28. Predicted and inferred waiting times for key mutations in the germinal centre reaction: Evidence for stochasticity in selection
29. Survival of long-lived plasma cells is independent of antigen
30. Dependence of germinal center B cells on expression of CD21/CD35 for survival
31. B cell differentiation and isotype switching is related to division cycle number
32. Cell division regulates the T cell cytokine repertoire, revealing a mechanism underlying immune class regulation
33. Linear differentiation of cytotoxic effectors into memory T lymphocytes
34. SHIP recruitment attenuates Fc gamma RIIB-induced B cell apoptosis
35. Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice
36. Autoimmune-prone mice share a promoter haplotype associated with reduced expression and function of the Fc receptor Fcgamma RII
37. Humoral immune responses in Cr2-/- mice: Enhanced affinity maturation but impaired antibody persistence