The self-directed T cell repertoire against mouse lysozyme reflects the influence of the hierarchy of its own determinants and can be engaged by a foreign lysozyme

Journal of Immunology

Volumn 163, Issue 8, 1999, Pages 4232-4237

  Moudgil, Kamal D ^a,d   Southwood, Scott ^b   Ametani, Akio ^c,d   Kim, Kasey ^a   Sette, Alessandro ^b   Sercarz, Eli E ^a,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Epimmune   (United States)

^c UNIVERSITY OF TOKYO   (Japan)

^d LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LYSOZYME;

ANIMAL CELL; ANTIGEN RECOGNITION; ARTICLE; AUTOIMMUNITY; CELL MATURATION; CELL SELECTION; CROSS REACTION; CYTOKINE RELEASE; IMMUNOGENICITY; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE PROLIFERATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; T LYMPHOCYTE;

EID: 0032845223     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.163.8.4232     Document Type: Article

References (44)

1. Benoist, C., and D. Mathis. 1997. Posilive selection of T cells: fastidious or promiscuous? Curr. Opin. Immunol. 9:245.
2. Kisielow, P., and H. von Boehmer. 1995. Development and selection of T cells: facts and puzzles. Adv. Immunol. 58:87.
3. Marrack, P., and J. Kappler. 1997. Positive selection of thymocytes bearing αβ T cell receptors. Curr. Opin. Immunol. 9:250.
4. Sebzda, E., S. Mariathasan, T. Ohteki, R. Jones, M. F. Bachmann, and P. S. Ohashi. 1999. Selection of the T cell repertoire. Annu. Rev. Immunol. 17: 829.
5. Savage, P. A., J. J. Boniface, and M. M. Davis. 1999. A kinetic basis for T cell receptor repertoire selection during an immune response. Immunity 10:485.
6. Williams, C. B., D. L. Engle, G. J. Kersh, J. Michael White, and P. M. Allen. 1999. A kinetic threshold between negative and positive selection based on the longevity of the T cell receptor-ligand complex. J. Exp. Med. 189:1531.
7. Gammon, G., and E. Sercarz. 1989. How some T cells escape tolerance induction. Nature 342:183.
8. Cibotti, R., J. M. Kanellopoulos, J. P. Cabaniols, O. Halle-Panenko, K. Kosmatopoulos, E. Sercarz, and P. Kourilsky. 1992. Tolerance to a self-protein involves its immunodominant but does not involve its subdominant determinants. Proc. Natl. Acad Sci. USA 89:416.
9. Moudgil, K. D., and E. E. Sercarz. 1993. Dominant determinants in hen egg white lysozyme correspond to the cryptic determinants within its self-homologue, mouse lysozyme: implications in shaping of the T cell repertoire and autoimmunity. J. Exp. Med. 178:2131.
10. Moudgil, K. D., and E. E. Sercarz. 1994. The T cell repertoire against cryptic self determinants and its involvement in autoimmunity and cancer. Clin. Immunol. Immunopathol. 73:283.
11. Shastri, N., G. Gammon, S. Horvath, A. Miller, and E. E. Sercarz. 1986. The choice between two distinct T cell determinants within a 23-amino acid region of lysozyme depends on their structural context. J. Immunol. 137:911.
12. Cross, M., I. Mangelsdorf, A. Wedel, and R. Renkawitz. 1988. Mouse lysozyme M gene: isolation, characterization, and expression studies. Proc. Natl. Acad Sci. USA 85:6232.
13. Riblet, R. J., and L. A. Herzenberg. 1970. Mouse lysozyme production by a monocytoma: isolation and comparison with other lysozymes. Science 168:1595.
14. Moudgil, K. D., D. Sekiguchi, S. Y. Kirn, and E. E. Sercarz. 1997. Immunodominance is independent of structural constraints: each region within hen egg white lysozyme is potentially available upon processing of native antigen. J. Immunol. 159:2574.
15. Houghten, R. A. 1985. General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids. Proc. Natl. Acad. Sci. USA 82:5131.
16. Moudgil, K. D., I. S. Grewal, P. E. Jensen, and E. E. Sercarz. 1996. Unresponsiveness to a self-peptide of mouse lysozyme owing to hindrance of T cell receptor-major histocompatibility complex/peptide interaction caused by flanking epitopic residues. J. Exp. Med. 183:535.
17. Cohen, S. A., and D. J. Strydom. 1988. Ammo acid analysis utilizing phenylisothiocyanate derivatives. Anal. Biochem. 174:1.
18. 1 mice: implications for autoimmunity and infection. J. Immunol. 161:6046.
19. Gorga, J. C., V. Horejsi, D. R. Johnson, R. Raghupathy, and J. L. Strominger. 1987. Purification and characterization of class II histocompatibility antigens from a homozygous human B cell line. J. Biol. Chem. 262:16087.
20. Sette, A., S. Buus, S. Colon, C. Miles, and H. M. Grey. 1989. Structural analysis of peptides capable of binding to more than one Ia antigen. J. Immunol. 142:35.
21. Buus, S., A. Sette, S. M. Colon, C. Miles, and H. M. Grey. 1987. The relation between major histocompatibility complex (MHC) restriction and the capacity of Ia to bind immunogenic peplides. Science 235:1353.
22. Sette, A., S. Southwood, D. O'Sullivan, F. C. Gaeta, J. Sidney, and H. M. Grey. 1992. Effect of pH on MHC class II-peptide interactions. J. Immunol. 148:844.
23. Jensen, P. E. 1991. Enhanced binding of peptide antigen to purified class II major histocompatibility glycoproteins at acidic pH. J. Exp. Med. 174:1111.
24. Schaeffer, E. B., A. Sette, D. L. Johnson, M. C. Bekoff, J. A. Smith, H. M. Grey, and S. Buus. 1989. Relative contribution of "determinant selection" and "holes in the T-cell repertoire" to T-cell responses. Proc. Natl. Acad. Sci. USA 86:4649.
25. Mamula, M. J. 1993. The inability to process a self-peptide allows auloreactive T cells to escape tolerance. J. Exp. Med. 177:567.
26. Agrawal, B., M. Manickasundari, E. Fraga, and B. Singh. 1991. T cells that recognize peptide sequences of self MHC class II molecules exist in syngeneic mice. J. Immunol. 147:383.
27. Kim, D. T., J. B. Rothbard, D. D. Bloom, and C. G Fathman. 1996. Quantitative analysis of T cell activation: role of TCR/ligand density and TCR affinity. J. Immunol. 156:2737.
28. Sant' Angelo, D. B., P. G. Waterbury, B. E. Cohen, W. D. Martin, L. Van Kaer, A. C. Hayday, and C. A. Janeway, Jr. 1997. The imprint of intrathymic self-peptides on the mature T cell receptor repertoire. Immunity 7:517.
29. + thymocyte selection by a single MHC class II/peptide ligand affected by its expression level in the thymus. Immunity 6:401.
30. Ridgway, W. M., M. Fasso, and C. G. Fathman. 1999. A new look at MHC and autoimmune disease. Science 284:749.
31. Lehmann, P. V., T. Forsthuber, A. Miller, and E. E. Sercarz. 1992. Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature 358:155.
32. Drakesmith, H., D. O'Neil, S. C. Schneider, M. Binks, P. Medd, E. Sercarz, P. Beverley, and B. Chain. 1998. In vivo priming of T cells against cryptic determinants by dendritic cells exposed to interleukin 6 and native antigen. Proc. Natl. Acad. Sci. USA 95:14903.
33. Mamula, M. J., R. H. Lin, C. A. Janeway, Jr., and J. A. Hardin. 1992. Breaking T cell tolerance with foreign and self co-immunogens: a study of autoimmune B and T cell epitopes of cytochrome c. J. Immunol. 149:789.
34. Lipham, W. J., T. M. Redmond, H. Takahashi, J. A. Berzofsky, B. Wiggert, G. J. Chader, and I. Gery. 1991. Recognition of peptides that are immunopathogenic but cryptic: mechanisms that allow lymphocytes sensitized against cryptic peptides to initiate pathogenic autoimmune processes. J. Immunol. 146:3757.
35. Lanzavecchia, A. 1995. How can cryptic epitopes trigger autoimmunity? J. Exp. Med. 181:1945.
36. Benichou, G., R. C. Tam, P. I. Orr, M. R. Garovoy, and E. V. Fedoseyeva. 1996. Self determinant selection and acquisition of the autoimmune T cell repertoire. Immunol. Res. 15:234.
37. Oldstone, M. B., M. Nerenberg, P. Southern, J. Price, and H. Lewicki. 1991. Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response. Cell 65:319.
38. Wucherpfennig, K. W., and J. L. Strominger. 1995. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell 80:695.
39. Zhao, Z. S., F. Granucci, L. Yeh, P. A. Schaffer, and H. Cantor. 1998. Molecular mimicry by herpes simplex virus-type 1: autoimmune disease after viral infection. Science 279:1344.
40. Ufret-Vincenty, R. L., L. Quigley, N. Tresser, S. H. Pak, A. Gado, S. Hausmann, K. W. Wucherpfennig, and S. Brocke. 1998. In vivo survival of viral antigen-specific T cells that induce experimental autoimmune encephalomyelitis. J. Exp. Med. 188:1725.
41. Ohashi, P. S. 1996. T cell selection and autoimmunity: flexibility and tuning. Curr. Opin. Immunol. 8:808.
42. Nanda, N. K., K. K. Arzoo, H. M. Geysen, A. Sette, and E. E. Sercarz. 1995. Recognition of multiple peptide cores by a single T cell receptor. J. Exp. Med. 182:531.
43. Bhardwaj, V., V. Kumar, H. M. Geysen, and E. E. Sercarz. 1993. Degenerate recognition of a dissimilar antigenic peptide by myelin basic protein-reactive T cells: implications for thymic education and autoimmunity. J. Immunol. 151: 5000.
44. Rouse, B. T. 1996. Virus-induced immunopathology. Adv. Virus Res. 47:353.