Promiscuous presentation and recognition of nucleosomal autoepitopes in lupus: Role of autoimmune T cell receptor α chain

Journal of Experimental Medicine

Volumn 187, Issue 3, 1998, Pages 367-378

  Shi, Yan ^a   Kaliyaperumal, Arunan ^a   Lu, Liangjun ^a   Southwood, Scott ^b   Sette, Alessandro ^b   Michaels, Marissa A ^a   Datta, Syamal K ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b CYTEL CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; T LYMPHOCYTE RECEPTOR;

ALLELE; ANIMAL CELL; ANTIGEN ANTIBODY COMPLEX; ANTIGEN RECOGNITION; ARTICLE; AUTOIMMUNITY; HLA SYSTEM; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SYSTEMIC LUPUS ERYTHEMATOSUS;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD4; AUTOANTIBODIES; AUTOANTIGENS; AUTOIMMUNITY; CLONING, MOLECULAR; EPITOPES; HISTOCOMPATIBILITY ANTIGENS CLASS II; HISTONES; HUMANS; INTERLEUKIN-2; LUPUS; MICE; MICE, INBRED STRAINS; MOLECULAR SEQUENCE DATA; NUCLEOSOMES; PEPTIDE FRAGMENTS; RECEPTORS, ANTIGEN, T-CELL; TRANSFECTION;

EID: 0032472801     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.187.3.367     Document Type: Article

References (52)

1. - T helper cell lines augment the production of idiotypes shared by pathogenic anti-DNA autoantibodies in the NZB X SWR model of lupus nephritis. J. Immunol. 140:2215-2224.
2. Adams, S., P. Leblanc, and S.K. Datta. 1991. Junctional region sequences of T-cell receptor β chain genes expressed by pathogenic anti-DNA autoantibody-inducing T helper cells from lupus mice: possible selection by cationic autoantigens. Proc. Natl. Acad. Sci. USA. 88:11271-11275.
3. Mohan, C., S. Adams, V. Stanik, and S.K. Datta. 1993. Nucleosome: a major immunogen for the pathogenic autoantibody-inducing T cells of lupus. J. Exp. Med. 177:1367-1381.
4. Mohan, C., Y. Shi, J.D. Laman, and S.K. Datta. 1995. Interaction between CD40 and its ligand gp39 in the development of murine lupus nephritis. J. Immunol. 154:1470-1480.
5. - T helper cell lines that express the γ/δ T-cell receptor. Prof. Natl. Acad. Sci. USA. 87:7020-7024.
6. Kaliyaperumal, A., C. Mohan, W. Wu, and S.K. Datta. 1996. Nucleosomal peptide epitopes for nephritis-inducing T helper cells of murine lupus. J. Exp. Med. 183:2459-2469.
7. Desai-Mehta, A., C. Mao, S. Rajagopalan, T. Robinson, and S.K. Datta. 1995. Structure and specificity of T-cell receptors expressed by pathogenic anti-DNA autoantibody-inducing T cells in human lupus. J. Clin. Invest. 95:531-541.
8. Casciola-Rosen, L.A., G. Anhalt, and A. Rosen. 1994. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J. Exp. Med. 179:1317-1330.
9. Lorenz, H.-M., M. Grunke, T. Hieronymus, M. Herrmann, A. Kuhnel, B. Manger, and J.R. Kalden. 1997. In vitro apoptosis and expression of apoptosis-related molecules in lymphocytes from patients with systemic lupus erythematosus and other autoimmune diseases. Arthritis Rheum. 40:306-317.
10. Yu, D., P.M. Rumore, Q. Liu, and C.R. Steinman. 1997. Soluble oligonucleosomal complexes in synovial fluid from inflamed joints. Arthritis Rheum. 40:648-654.
11. Ray, S.K., C. Putterman, and B. Diamond. 1996. Pathogenic autoantibodies are routinely generated during the response to foreign antigen: a paradigm for autoimmune disease. Proc. Natl. Acad. Sci. USA. 93:2019-2024.
12. Datta, S.K., B.D. Stollar, and R.S. Schwartz. 1983. Normal mice express idiotypes related to autoantibody idiotypes of lupus mice. Proc. Natl. Acad. Sci. USA. 80:2723-2727.
13. Mao, C., G.E. Osman, S. Adams, and S.K. Datta. 1994. T cell receptor α-chain repertoire of pathogenic autoantibody-inducing T cells in lupus mice. J. Immunol. 152:1462-1470.
14. Jorgensen, J.L., U. Esser, P.A. Reay, B. Fazekas de St. Groth, and M.M. Davis. 1992. Mapping T cell receptor/peptide contacts by variant peptide immunization of single-chain transgenics. Nature. 355:224-230.
15. Hong, S.-C., A. Chelouche, R.-H. Lin, D. Shaywitz, N.S. Braunstein, L. Glimcher, and C.A. Janeway, Jr. 1992. An MHC interaction site maps to the amino-terminal half of the T cell receptor alpha chain variable domain. Cell. 69:999-1009.
16. Patten, P.A., E.P. Rock, T. Sonoda, B. Fazekas de St. Groth, J.L. Jorgensen, and M.M. Davis. 1993. Transfer of putative complementarity-determining region loops of T cell receptor V domains confers toxin reactivity but not peptide/MHC specificity. J. Immunol. 150:2281-2294.
17. + T cells. J. Exp. Med. 179: 1539-1549.
18. Casanova, J.L., P. Romero, C. Widmann, P. Kourilsky, and J.L. Maryanski. 1991. T cell receptor genes in a series of class I major histocompatibility complex-restricted cytotoxic T lymphocyte clones specific for a plasmodium berghei non-apeptide: implications for T cell allelic exclusion and antigen-specific repertoire. J. Exp. Med. 174:1371-1383.
19. Sette, A., S. Buus, S. Colon, C. Miles, and H.M. Grey. 1989. Structural analysis of peptides capable of binding to more than one Ia antigen. J. Immunol. 142:35-40.
20. Alexander, J., J. Sidney, S. Southwood, J. Rupert, C. Oseroff, A. Maewal, K. Snoke, H.M. Serra, R.T. Kubo, A. Sette, and H.M. Grey. 1994. Development of high potency universal DR-restricted helper epitopes by modification of high-affinity DR-blocking peptides. Immunity. 1:751-761.
21. Arden, B., S.P. Clark, D. Kabelitz, and T.W. Mak. 1995. Mouse T-cell receptor variable gene segment families. Immunogenetics. 42:501-530.
22. Allen, P., D.J. McKean, B.N. Beck, J. Sheffield, and L.H. Glimcher. 1985. Direct evidence that a class II molecule and a simple globular protein generate multiple determinants. J. Exp. Med. 162:1264-1274.
23. Nanda, N.K., K.K. Arzoo, H.M. Geysen, A. Sette, and E.E. Sercarz. 1995. Recognition of multiple peptide cores by a single T cell receptor. J. Exp. Med. 182:531-539.
24. Evavold, B.D., J. Sloan-Lancaster, K.J. Wilson, J.B. Rothbard, and P.M. Allen. 1995. Specific T cell recognition of minimally homologous peptides: evidence for multiple endogenous ligands. Immunity. 2:655-663.
25. Madrenas, J., L.A. Chau, J. Smith, J.A. Bluestone, and R.N. Germain. 1997. The efficacy of CD4 requirement to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands. J. Exp. Med. 185:219-229.
26. Lundsberg, A.S., and H.O. McDevitt. 1992. Evolution of major histocompatibility complex class II allelic diversity: direct descent in mice and humans. Proc. Natl. Acad. Sci. USA. 89:6545-6549.
27. Kaliyaperumal, A., R. Falchetto, A. Cox, R. Dick II, J. Shabanowitz, Y.H. Chien, L. Matis, and J.A. Bluestone. 1995. Functional expression and recognition of nonclassical MHC class I T10b is not peptide-dependent. J. Immunol. 155:2379-2386.
28. Vignali, D.A.A., and J.L. Strominger. 1994. Amino acid residues that flank core peptide epitopes and the extracellular domains of CD4 modulate differential signaling through the T cell receptor. J. Exp. Med. 179:1945-1956.
29. Moudgil, K.D., I.S. Grewal, P.E. Jensen, and E.E. Sercarz. 1996. Unresponsiveness to a self-peptide of mouse lysozyme owing to hindrance of T cell receptor-major histocompatibility complex/peptide interaction caused by flanking epitopic residues. J. Exp. Med. 183:535-546.
30. Valli, A., A. Sette, L. Kappos, C. Oseroff, J. Sidney, G. Miescher, M. Hochberger, E.D. Albert, and L. Adorini. 1993. Binding of myelin basic protein peptides to human HLA class II molecules and their recognition by T cells of multiple sclerosis patients. J. Clin. Invest. 91:616-628.
31. Panina-Bordignon, P., A. Tan, A. Termijtelen, S. Demotz, G. Corradin, and A. Lanzavecchia. 1989. Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells. Eur. J. Immunol. 19:2237-2242.
32. Blank, U., B. Boitel, D. Mege, M. Ermonval, and O. Acuto. 1993. Analysis of tetanus toxin peptide/DR recognition by human T cell receptors reconstituted into a murine T cell hybridoma. Eur. J. Immunol. 23:3057-3065.
33. Vordermeier, H.M., D.P. Harris, C. Moreno, and J. Ivanyi. 1994. Promiscuous T cell recognition of an H-2 IA-presented mycobacterial epitope. Eur. J. Immunol. 24:2061-2067.
34. Sinigaglia, F., M. Guttinger, J. Kilgus, D.M. Doran, H. Matile, H. Etlinger, A. Trzediak, D. Gillessen, and J.R.L. Pink. 1988. A malaria T-cell epitope recognized in association with most mouse and human class II molecules. Nature. 336:778-780.
35. Ignatowicz, L., J. Kappler, and P. Marrack. 1996. The repertoire of T cells shaped by a single MHC/peptide ligand. Cell. 84:521-529.
36. Nakano, N., R. Rooke, C. Benoist, and D. Mathis. 1997. Positive selection of T cells induced by viral delivery of neopeptides to the thymus. Science. 275:678-683.
37. Zerrahn, J., W. Held, and D.H. Raulet. 1997. The MHC reactivity of the T cell repertoire prior to positive and negative selection. Cell. 88:627-636.
38. Brawley, J.V., and P. Concannon. 1996. Modulation of promiscuous T cell receptor recognition by mutagenesis of CDR2 residues. J. Exp. Med. 183:2043-2051.
39. Sim, B.C., L. Zerva, M.I. Greene, and N.R.J. Gascoigne. 1996. Control of MHC restriction by TCR Vα CDR1 and CDR2. Science. 273:963-966.
40. Kasibhatla, S., E.A. Nalefski, and A. Rao. 1993. Simultaneous involvement of all six predicted antigen binding loops of the T cell receptor in recognition of the MHC/antigenic peptide complex. J. Immunol. 151:3140-3151.
41. Sant'Angelo, D.B., G. Waterbury, P. Preston-Hulbert, R. Medzhitov, S.C. Hong, and C.A. Janeway, Jr. 1996. The specificty and orientation of a TCR to its peptide-MHC class II ligands. Immunity. 4:367-376.
42. Clark, S.P., B. Arden, D. Kabelitz, and T.W. Mak. 1995. Comparison of human and mouse T-cell receptor variable gene segment families. Immunogenetics. 42:531-540.
43. Garboczi, D.N., P. Ghosh, U. Utz, Q.R. Fan, W.E. Biddison, and D. C. Wiley. 1996. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature. 384:134-141.
44. Garcia, K.C., M. Degano, R.L. Stanfield, A. Brunmark, M.R. Jackson, P.A. Peterson, L. Teyton, and I.A. Wilson. 1996. An alpha-beta T cell receptor structure at 2.5 angstrom and its orientation in the TCR-MHC complex. Science. 274: 209-219.
45. Carteron, N.L., C.L. Schimenti, and D. Wofsy. 1989. Treatment of murine lupus with (Fab′)2 fragment of monoclonal antibody to L3T4. Suppression of autoimmunity does not depend on T helper cell depletion. J. Immunol. 142:1470-1475.
46. Fredrickson, G.G., and R.S. Basch. 1989. L3T4 antigen expression by hemopoietic precursor cells. J. Exp. Med. 169: 1473-1478.
47. Steinman, R.M. 1991. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9:271-296.
48. Scully, R., S. Qin, S. Cobbold, and H. Waldmann. 1994. Mechanisms in CD4 antibody-mediated transplantation tolerance: kinetics of induction, antigen dependency and role of regulatory T cells. Eur. J. Immunol. 24:2383-2392.
49. Sun, R., S.E. Shepherd, S.S. Geier, C.T. Thomson, J.M. Sheil, and S.G. Nathenson. 1995. Evidence that the antigen receptors of cytotoxic T lymphocytes interact with a common recognition pattern on the H-2Kb molecule. Immunity. 3:573-582.
50. Brock, R., K.H. Wiesmuller, G. Jung, and P. Walden. 1996. Molecular basis for recognition of two structurally different MHC-peptide complexes by a single T cell receptor. Proc. Natl. Acad. Sci. USA. 93:13108-13113.
51. Ehrich, E.W., B. Devaux, E.P. Rock, J.L. Jorgensen, M.M. Davis, and Y.-h. Chien. 1993. T cell receptor interaction with peptide/Major histocompatibilily complex (MHC) and superantigen/MHC ligands is dominated by antigen. J. Exp. Med. 178:713-723.
52. k restricted T helper hybridomas. J. Immunol. 142:3298-3304.