Shear stress activates p60src-Ras-MAPK signaling pathways in vascular endothelial cells

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 18, Issue 2, 1998, Pages 227-234

  Jalali, Shila ^a   Li, Yi Shuan ^a   Sotoudeh, Mohammad ^a   Yuan, Suli ^a   Li, Song ^a   Chien, Shu ^a   Shyy, John Y J ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Endothelial cells; MAPK; Mechanotransduction; Shear stress; Src

Indexed keywords

CELL PROTEIN; GENE PRODUCT; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; MUTANT PROTEIN; PROTEIN P21; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CATTLE; DNA RESPONSIVE ELEMENT; ENZYME ACTIVATION; GENETIC TRANSCRIPTION; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; SHEAR STRESS; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM;

EID: 0031838055     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.18.2.227     Document Type: Article

References (18)

1. Davies PF. Flow-mediated endothelial mechanotransduction. Physiol Rev. 1995;75:519-560.
2. Shyy Y-J, Hsieh H-J, Usami S, Chien S. Fluid shear stress induces a biphasic response of human monocyte chemotactic protein 1 gene expression in vascular endothelium. Proc Natl Acad Sci USA. 1994;91:4678-4682.
3. Nagel T, Reswick N, Atkinson WJ, Dewey CF Jr, Gimbrone MA Jr. Shear stress selectively upregulates intercellular adhesion molecule-1 expression in cultured human vascular endothelial cells. J Clin Invest. 1994;94:885-891.
4. Morita T, Yoshizumi M, Kurihara H, Maemura K, Nagai R, Yazaki Y. Shear stress increases heparin-binding epidermal growth factor-like growth factor mRNA levels in human vascular endothelial cells. Biochem Biophys Res Commun. 1993;197:256-262.
5. Hsieh HJ, Li NQ, Frangos JA. Shear-induced platelet-derived growth factor gene expression in human endothelial cells is mediated by protein kinase C. J Cell Physiol. 1992;150:552-558.
6. Hsieh HJ, Li NQ, Frangos JA. Pulsatile and steady flow induces c-fos expression in human endothelial cells. J Cell Physiol. 1993;154:143-151.
7. Ranjan V, Xiao Z, Diamond SL. Constitutive NOS expression in cultured endothelial cells is elevated by fluid shear stress. Am J Physiol. 1995;269:H550-H555.
8. Uematsu M, Ohara Y, Navas JP, Nishida K, Murphy TJ, Alexander RW, Nerem RM, Harrison DG. Regulation of endothelial cell nitric oxide synthase mRNA expression by shear stress. Am J Physiol. 1995;269:C1371-C1378.
9. Shyy J, Lin MC, Han J, Lu Y, Petrime M, Chien S. The ris-acting phorbol ester "12-O-tetradecanoylphorbol 13-acetate"-responsive element is involved in shear stress-induced monocyte chemotactic protein 1 gene expression. Proc Natl Acad Sci USA. 1995;92:8069-8073.
10. Li Y-S, Shyy Y-J, Li S, Lee JD, Su B. Karin M, Chien S. The Ras/JNK pathway is involved in the shear-induced gene expression. Moll Cell Biol. 1996;16:5947-5954.
11. Tseng H, Peterson TE, Berk BC. Fluid shear stress stimulates mitogen-activated protein kinase in endothelial cells. Circ Res. 1995;77:869-878.
12. Jo H, Sipos K, Go Y-M, Law R, Rong J, McDonald JM. Differential effect of shear stress on extracellular signal-regulated kinase and N-terminal Jun kinase in endothelial cells. J Biol Chem. 1997;272:1395-1401.
13. Pearce MJ, McIntyre TM, Prescott SM, Zimmerman GA, Whatley RE. Shear stress activates cytosolic phospholipase A2 (cPLA2) and MAP kinase in human endothelial cells. Biochem Biophys Res Commun. 1996;218:500-504.
14. Takahashi M, Berk BC. Mitogen-activated protein kinase (ERK1/2) activation by shear stress and adhesion in endothelial cells. Essential role for a herbimycin-sensitive kinase. J Clin Invest. 1996;98:2623-2631.
15. Karin M. The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem. 1995;270:16483-16486.
16. Hill CS, Treisman R. Transcriptional regulation by extracellular signals: mechanisms and specificity. Cell. 1995;80:199-211.
17. Gille H, Sharrocks A, Shaw P. Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter. Nature. 1992;358:414-417.
18. Treisman R. The serum response element. Trends Biochem Sci. 1992;17:423-426.