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Volumn 23, Issue 15, 2003, Pages 5174-5185

Direct repression of splicing by transformer-2

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TRANSFORMER 2; RECOMBINANT PROTEIN; RNA; UNCLASSIFIED DRUG;

EID: 0042092002     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.23.15.5174-5185.2003     Document Type: Article
Times cited : (22)

References (48)
  • 1
    • 0025037192 scopus 로고
    • Alternatively spliced transcripts of the sex-determining gene tra-2 of Drosophila encode functional proteins of different size
    • Amrein, H., T. Maniatis, and R. Nothiger. 1990. Alternatively spliced transcripts of the sex-determining gene tra-2 of Drosophila encode functional proteins of different size. EMBO J. 9:3619-3629.
    • (1990) EMBO J. , vol.9 , pp. 3619-3629
    • Amrein, H.1    Maniatis, T.2    Nothiger, R.3
  • 2
    • 0030777180 scopus 로고    scopus 로고
    • A neuron-specific splicing switch mediated by an array of pre-mRNA repressor sites: Evidence of a regulatory role for the polypyrimidine tract binding protein and a brain-specific PTB counterpart
    • Ashiya, M., and P. J. Grabowski. 1997. A neuron-specific splicing switch mediated by an array of pre-mRNA repressor sites: evidence of a regulatory role for the polypyrimidine tract binding protein and a brain-specific PTB counterpart. RNA 3:996-1015.
    • (1997) RNA , vol.3 , pp. 996-1015
    • Ashiya, M.1    Grabowski, P.J.2
  • 3
    • 0024328766 scopus 로고
    • Sex in flies: The splice of life
    • Baker, B. S. 1989. Sex in flies: the splice of life. Nature 340:521-524.
    • (1989) Nature , vol.340 , pp. 521-524
    • Baker, B.S.1
  • 4
    • 0025890081 scopus 로고
    • Positive autoregulation of sex-lethal by alternative splicing maintains the female determined state in Drosophila
    • Bell, L. R., J. I. Horabin, P. Schedl, and T. W. Cline. 1991. Positive autoregulation of sex-lethal by alternative splicing maintains the female determined state in Drosophila. Cell 65:229-239.
    • (1991) Cell , vol.65 , pp. 229-239
    • Bell, L.R.1    Horabin, J.I.2    Schedl, P.3    Cline, T.W.4
  • 5
    • 0024021747 scopus 로고
    • Splice site selection, rate of splicing, and alternative splicing on nascent transcripts
    • Beyer, A. L., and Y. N. Osheim. 1988. Splice site selection, rate of splicing, and alternative splicing on nascent transcripts. Genes Dev. 2:754-765.
    • (1988) Genes Dev. , vol.2 , pp. 754-765
    • Beyer, A.L.1    Osheim, Y.N.2
  • 6
    • 0026134483 scopus 로고
    • Visualization of RNA transcription and processing
    • Beyer, A. L., and Y. N. Osheim. 1991. Visualization of RNA transcription and processing. Semin. Cell Biol. 2:131-140.
    • (1991) Semin. Cell Biol. , vol.2 , pp. 131-140
    • Beyer, A.L.1    Osheim, Y.N.2
  • 7
    • 0034968065 scopus 로고    scopus 로고
    • Functional selection of splicing enhancers that stimulate trans-splicing in vitro
    • Boukis, L. A., and J. P. Bruzik. 2001. Functional selection of splicing enhancers that stimulate trans-splicing in vitro. RNA 7:793-805.
    • (2001) RNA , vol.7 , pp. 793-805
    • Boukis, L.A.1    Bruzik, J.P.2
  • 8
    • 0032740121 scopus 로고    scopus 로고
    • Identification of a bidirectional splicing enhancer: Differential involvement of SR proteins in 5′ or 3′0 splice site activation
    • Bourgeois, C. F., M. Popielarz, G. Hildwein, and J. Stevenin. 1999. Identification of a bidirectional splicing enhancer: differential involvement of SR proteins in 5′ or 3′0 splice site activation. Mol. Cell. Biol. 19:7347-7356.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 7347-7356
    • Bourgeois, C.F.1    Popielarz, M.2    Hildwein, G.3    Stevenin, J.4
  • 9
    • 0024539898 scopus 로고
    • Drosophila doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sex-specific polypeptides
    • Burtis, K. C., and B. S. Baker. 1989. Drosophila doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sex-specific polypeptides. Cell 56:997-1010.
    • (1989) Cell , vol.56 , pp. 997-1010
    • Burtis, K.C.1    Baker, B.S.2
  • 10
    • 0035878744 scopus 로고    scopus 로고
    • Functionally antagonistic sequences are required for normal autoregulation of Drosophila tra-2 pre-mRNA splicing
    • Chandler, D. S., M. E. McGuffin, and W. Mattox. 2001. Functionally antagonistic sequences are required for normal autoregulation of Drosophila tra-2 pre-mRNA splicing. Nucleic Acids Res. 29:3012-3019.
    • (2001) Nucleic Acids Res. , vol.29 , pp. 3012-3019
    • Chandler, D.S.1    McGuffin, M.E.2    Mattox, W.3
  • 11
    • 0036203307 scopus 로고    scopus 로고
    • Dynamic antagonism between ETR-3 and PTB regulates cell type-specific alternative splicing
    • Charlet, B. N., P. Logan, G. Singh, and T. A. Cooper. 2002. Dynamic antagonism between ETR-3 and PTB regulates cell type-specific alternative splicing. Mol. Cell 9:649-658.
    • (2002) Mol. Cell , vol.9 , pp. 649-658
    • Charlet, B.N.1    Logan, P.2    Singh, G.3    Cooper, T.A.4
  • 12
    • 0030988942 scopus 로고    scopus 로고
    • Identification of a new class of exonic splicing enhancers by in vivo selection
    • Erratum, 17:3468
    • Coulter, L. R., M. A. Landree, and T. A. Cooper. 1997. Identification of a new class of exonic splicing enhancers by in vivo selection. Mol. Cell Biol. 17:2143-2150. (Erratum, 17:3468.)
    • (1997) Mol. Cell Biol. , vol.17 , pp. 2143-2150
    • Coulter, L.R.1    Landree, M.A.2    Cooper, T.A.3
  • 13
    • 0021100690 scopus 로고
    • Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
    • Dignam, J. D., R. M. Lebovitz, and R. G. Roeder. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475-1489.
    • (1983) Nucleic Acids Res. , vol.11 , pp. 1475-1489
    • Dignam, J.D.1    Lebovitz, R.M.2    Roeder, R.G.3
  • 14
    • 0033552901 scopus 로고    scopus 로고
    • SR proteins are locators' of the RNA splicing machinery
    • Graveley, B. R., K. J. Hertel, and T. Maniatis. 1999. SR proteins are locators' of the RNA splicing machinery. Curr. Biol. 9:R6-R7.
    • (1999) Curr. Biol. , vol.9
    • Graveley, B.R.1    Hertel, K.J.2    Maniatis, T.3
  • 15
    • 0032038213 scopus 로고    scopus 로고
    • Arginine/serine-rich domains of SR proteins can function as activators of pre-mRNA splicing
    • Graveley, B. R., and T. Maniatis. 1998. Arginine/serine-rich domains of SR proteins can function as activators of pre-mRNA splicing. Mol. Cell 1:765-771.
    • (1998) Mol. Cell , vol.1 , pp. 765-771
    • Graveley, B.R.1    Maniatis, T.2
  • 16
    • 0035370845 scopus 로고    scopus 로고
    • Pre-mRNA splicing in the new millennium
    • Hastings, M. L., and A. R. Krainer. 2001. Pre-mRNA splicing in the new millennium. Curr. Opin. Cell Biol. 13:302-309.
    • (2001) Curr. Opin. Cell Biol. , vol.13 , pp. 302-309
    • Hastings, M.L.1    Krainer, A.R.2
  • 17
    • 0031972648 scopus 로고    scopus 로고
    • Regulation of sex-specific selection of fruitless 5′ splice sites by transformer and transformer-2
    • Heinrichs, V., L. C. Ryner, and B. S. Baker. 1998. Regulation of sex-specific selection of fruitless 5′ splice sites by transformer and transformer-2. Mol. Cell Biol. 18:450-458.
    • (1998) Mol. Cell Biol. , vol.18 , pp. 450-458
    • Heinrichs, V.1    Ryner, L.C.2    Baker, B.S.3
  • 18
    • 0031990320 scopus 로고    scopus 로고
    • The function of multisite splicing enhancers
    • Hertel, K. J., and T. Maniatis. 1998. The function of multisite splicing enhancers. Mol. Cell 1:449-455.
    • (1998) Mol. Cell , vol.1 , pp. 449-455
    • Hertel, K.J.1    Maniatis, T.2
  • 19
    • 0034662922 scopus 로고    scopus 로고
    • Htra2-beta 1 stimulates an exonic splicing enhancer and can restore full-length SMN expression to survival motor neuron 2 (SMN2)
    • Hofmann, Y., C. L. Lorson, S. Stamm, E. J. Androphy, and B. Wirth. 2000. Htra2-beta 1 stimulates an exonic splicing enhancer and can restore full-length SMN expression to survival motor neuron 2 (SMN2). Proc. Natl. Acad. Sci. USA 97:9618-9623.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 9618-9623
    • Hofmann, Y.1    Lorson, C.L.2    Stamm, S.3    Androphy, E.J.4    Wirth, B.5
  • 20
    • 0026756495 scopus 로고
    • Binding of the Drosophila transformer and transformer-2 proteins to the regulatory elements of doublesex primary transcript for sex-specific RNA processing
    • Inoue, K., K. Hoshijima, I. Higuchi, H. Sakamoto, and Y. Shimura. 1992. Binding of the Drosophila transformer and transformer-2 proteins to the regulatory elements of doublesex primary transcript for sex-specific RNA processing. Proc. Natl. Acad. Sci. USA 89:8092-8096.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 8092-8096
    • Inoue, K.1    Hoshijima, K.2    Higuchi, I.3    Sakamoto, H.4    Shimura, Y.5
  • 21
    • 0033557806 scopus 로고    scopus 로고
    • Pre-mRNA splicing of IgM exons M1 and M2 is directed by a juxtaposed splicing enhancer and inhibitor
    • Kan, J. L., and M. R. Green. 1999. Pre-mRNA splicing of IgM exons M1 and M2 is directed by a juxtaposed splicing enhancer and inhibitor. Genes Dev. 13:462-471.
    • (1999) Genes Dev. , vol.13 , pp. 462-471
    • Kan, J.L.1    Green, M.R.2
  • 22
    • 0033521126 scopus 로고    scopus 로고
    • Distinct factor requirements for exonic splicing enhancer function and binding of U2AF to the polypyrimidine tract
    • Li, Y., and B. J. Blencowe. 1999. Distinct factor requirements for exonic splicing enhancer function and binding of U2AF to the polypyrimidine tract. J. Biol. Chem. 274:35074-35079.
    • (1999) J. Biol. Chem. , vol.274 , pp. 35074-35079
    • Li, Y.1    Blencowe, B.J.2
  • 23
    • 0032435862 scopus 로고    scopus 로고
    • Alternative splicing of pre-mRNA: Developmental consequences and mechanisms of regulation
    • Lopez, A. J. 1998. Alternative splicing of pre-mRNA: developmental consequences and mechanisms of regulation. Annu. Rev. Genet. 32:279-305.
    • (1998) Annu. Rev. Genet. , vol.32 , pp. 279-305
    • Lopez, A.J.1
  • 24
    • 0029858338 scopus 로고    scopus 로고
    • Assembly Of specific SR protein complexes on distinct regulatory elements of the Drosophila Doublesex splicing enhancer
    • Lynch, K. W., and T. Maniatis. 1996. Assembly Of specific SR protein complexes on distinct regulatory elements of the Drosophila Doublesex splicing enhancer. Genes Dev. 10:2089-2101.
    • (1996) Genes Dev. , vol.10 , pp. 2089-2101
    • Lynch, K.W.1    Maniatis, T.2
  • 25
    • 0028926275 scopus 로고
    • Synergistic interactions between two distinct elements of a regulated splicing enhancer
    • Lynch, K. W., and T. Maniatis. 1995. Synergistic interactions between two distinct elements of a regulated splicing enhancer. Genes Dev. 9:284-293.
    • (1995) Genes Dev. , vol.9 , pp. 284-293
    • Lynch, K.W.1    Maniatis, T.2
  • 26
    • 0037062982 scopus 로고    scopus 로고
    • Alternative pre-mRNA splicing and proteome expansion in metazoans
    • Maniatis, T., and B. Tasic. 2002. Alternative pre-mRNA splicing and proteome expansion in metazoans. Nature 418:236-243.
    • (2002) Nature , vol.418 , pp. 236-243
    • Maniatis, T.1    Tasic, B.2
  • 27
    • 0033800453 scopus 로고    scopus 로고
    • Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein
    • Markovtsov, V., J. M. Nikolic, J. A. Goldman, C. W. Turck, M. Y. Chou, and D. L. Black. 2000. Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein. Mol. Cell. Biol. 20:7463-7479.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 7463-7479
    • Markovtsov, V.1    Nikolic, J.M.2    Goldman, J.A.3    Turck, C.W.4    Chou, M.Y.5    Black, D.L.6
  • 28
    • 0025732078 scopus 로고
    • Autoregulation of the splicing of transcripts from the transformer-2 gene of Drosophila
    • Mattox, W., and B. S. Baker. 1991. Autoregulation of the splicing of transcripts from the transformer-2 gene of Drosophila. Genes Dev. 5:786-796.
    • (1991) Genes Dev. , vol.5 , pp. 786-796
    • Mattox, W.1    Baker, B.S.2
  • 29
    • 0029912882 scopus 로고    scopus 로고
    • A negative feedback mechanism revealed by functional analysis of the alternative isoforms of the Drosophila splicing regulator Transformer-2
    • Mattox, W., M. E. McGuffin, and B. S. Baker. 1996. A negative feedback mechanism revealed by functional analysis of the alternative isoforms of the Drosophila splicing regulator Transformer-2. Genetics 143:303-314.
    • (1996) Genetics , vol.143 , pp. 303-314
    • Mattox, W.1    McGuffin, M.E.2    Baker, B.S.3
  • 30
    • 0025374457 scopus 로고
    • Alternative splicing of the sex determination gene transformer-2 is sex-specific in the germ line but not in the soma
    • Mattox, W., M. J. Palmer, and B. S. Baker. 1990. Alternative splicing of the sex determination gene transformer-2 is sex-specific in the germ line but not in the soma. Genes Dev. 4:789-805.
    • (1990) Genes Dev. , vol.4 , pp. 789-805
    • Mattox, W.1    Palmer, M.J.2    Baker, B.S.3
  • 31
    • 0031854927 scopus 로고    scopus 로고
    • Autoregulation of transformer-2 alternative splicing is necessary for normal male fertility in Drosophila
    • McGuffin, M. E., D. Chandler, D. Somaiya, B. Dauwalder, and W. Mattox. 1998. Autoregulation of transformer-2 alternative splicing is necessary for normal male fertility in Drosophila. Genetics 149:1477-1486.
    • (1998) Genetics , vol.149 , pp. 1477-1486
    • McGuffin, M.E.1    Chandler, D.2    Somaiya, D.3    Dauwalder, B.4    Mattox, W.5
  • 32
    • 0024294339 scopus 로고
    • The control of alternative splicing at genes regulating sexual differentiation in D. melanogaster
    • Nagoshi, R. N., M. McKeown, K. C. Burtis, J. M. Belote, and B. S. Baker. 1988. The control of alternative splicing at genes regulating sexual differentiation in D. melanogaster. Cell 53:229-236.
    • (1988) Cell , vol.53 , pp. 229-236
    • Nagoshi, R.N.1    McKeown, M.2    Burtis, K.C.3    Belote, J.M.4    Baker, B.S.5
  • 33
    • 0034612372 scopus 로고    scopus 로고
    • A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing
    • Polydorides, A. D., H. J. Okano, Y. Y. Yang, G. Stefani, and R. B. Darnell. 2000. A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing. Proc. Natl. Acad. Sci. USA 97:6350-6355.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 6350-6355
    • Polydorides, A.D.1    Okano, H.J.2    Yang, Y.Y.3    Stefani, G.4    Darnell, R.B.5
  • 34
    • 0024003023 scopus 로고
    • Accurate and efficient pre-mRNA splicing in Drosophila cell-free extracts
    • Rio, D. C. 1988. Accurate and efficient pre-mRNA splicing in Drosophila cell-free extracts. Proc. Natl. Acad. Sci. USA 85:2904-2908.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 2904-2908
    • Rio, D.C.1
  • 35
    • 0025988927 scopus 로고
    • Regulation of doublesex pre-mRNA processing occurs by 3′-splice site activation
    • Ryner, L. C., and B. S. Baker. 1991. Regulation of doublesex pre-mRNA processing occurs by 3′-splice site activation. Genes Dev. 5:2071-2085.
    • (1991) Genes Dev. , vol.5 , pp. 2071-2085
    • Ryner, L.C.1    Baker, B.S.2
  • 37
    • 0032947182 scopus 로고    scopus 로고
    • Multiple distinct splicing enhancers in the protein-coding sequences of a constitutively spliced pre-mRNA
    • Schaal, T. D., and T. Maniatis. 1999. Multiple distinct splicing enhancers in the protein-coding sequences of a constitutively spliced pre-mRNA. Mol. Cell. Biol. 19:261-273.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 261-273
    • Schaal, T.D.1    Maniatis, T.2
  • 38
    • 0033019048 scopus 로고    scopus 로고
    • Selection and characterization of pre-mRNA splicing enhancers: Identification of novel SR protein-specific enhancer sequences
    • Schaal, T. D., and T. Maniatis. 1999. Selection and characterization of pre-mRNA splicing enhancers: identification of novel SR protein-specific enhancer sequences. Mol. Cell. Biol. 19:1705-1719.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 1705-1719
    • Schaal, T.D.1    Maniatis, T.2
  • 39
    • 0015328565 scopus 로고
    • Cell lines derived from late embryonic stages of Drosophila melanogaster
    • Schneider, I. 1972. Cell lines derived from late embryonic stages of Drosophila melanogaster. J. Embryol. Exp. Morphol. 27:353-365.
    • (1972) J. Embryol. Exp. Morphol. , vol.27 , pp. 353-365
    • Schneider, I.1
  • 40
    • 0035898616 scopus 로고    scopus 로고
    • The RNA binding protein YB-1 binds A/C-rich exon enhancers and stimulates splicing of the CD44 alternative exon v4
    • Stickeler, E., S. D. Fraser, A. Honig, A. L. Chen, S. M. Berget, and T. A. Cooper. 2001. The RNA binding protein YB-1 binds A/C-rich exon enhancers and stimulates splicing of the CD44 alternative exon v4. EMBO J. 20:3821-3830.
    • (2001) EMBO J. , vol.20 , pp. 3821-3830
    • Stickeler, E.1    Fraser, S.D.2    Honig, A.3    Chen, A.L.4    Berget, S.M.5    Cooper, T.A.6
  • 41
    • 0032478506 scopus 로고    scopus 로고
    • Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing
    • Tacke, R., M. Tohyama, S. Ogawa, and J. L. Manley. 1998. Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing. Cell 93:139-148.
    • (1998) Cell , vol.93 , pp. 139-148
    • Tacke, R.1    Tohyama, M.2    Ogawa, S.3    Manley, J.L.4
  • 42
    • 0026579802 scopus 로고
    • Positive control of pre-mRNA splicing in vitro
    • Tian, M., and T. Maniatis. 1992. Positive control of pre-mRNA splicing in vitro. Science 256:237-240.
    • (1992) Science , vol.256 , pp. 237-240
    • Tian, M.1    Maniatis, T.2
  • 43
    • 0027185151 scopus 로고
    • A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA
    • Tian, M., and T. Maniatis. 1993. A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA. Cell 74:105-114.
    • (1993) Cell , vol.74 , pp. 105-114
    • Tian, M.1    Maniatis, T.2
  • 44
    • 0028025033 scopus 로고
    • A splicing enhancer exhibits both constitutive and regulated activities
    • Tian, M., and T. Maniatis. 1994. A splicing enhancer exhibits both constitutive and regulated activities. Genes Dev. 8:1703-1712.
    • (1994) Genes Dev. , vol.8 , pp. 1703-1712
    • Tian, M.1    Maniatis, T.2
  • 45
    • 0031282306 scopus 로고    scopus 로고
    • Post-transcriptional regulation: The dawn of PTB
    • Valcarcel, J., and F. Gebauer. 1997. Post-transcriptional regulation: the dawn of PTB. Curr. Biol. 7:R705-R708.
    • (1997) Curr. Biol. , vol.7
    • Valcarcel, J.1    Gebauer, F.2
  • 46
    • 0029797697 scopus 로고    scopus 로고
    • A complex of nuclear proteins mediates Sr protein binding to a purine-rich splicing enhancer
    • Yeakley, J. M., J. P. Morfin, M. G. Rosenfeld, and X. D. Fu. 1996. A complex of nuclear proteins mediates Sr protein binding to a purine-rich splicing enhancer. Proc. Natl. Acad. Sci. USA 93:7582-7587.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 7582-7587
    • Yeakley, J.M.1    Morfin, J.P.2    Rosenfeld, M.G.3    Fu, X.D.4
  • 47
    • 0035691667 scopus 로고    scopus 로고
    • Exon identity established through differential antagonism between exonic splicing silencer-bound hnRNP A1 and enhancer-bound SR proteins
    • Zhu, J., A. Mayeda, and A. R. Krainer. 2001. Exon identity established through differential antagonism between exonic splicing silencer-bound hnRNP A1 and enhancer-bound SR proteins. Mol. Cell 8:1351-1361.
    • (2001) Mol. Cell , vol.8 , pp. 1351-1361
    • Zhu, J.1    Mayeda, A.2    Krainer, A.R.3
  • 48
    • 0029665533 scopus 로고    scopus 로고
    • The splicing factor U2af(35) mediates critical protein-protein interactions in constitutive and enhancer-dependent splicing
    • Zuo, P., and T. Maniatis. 1996. The splicing factor U2af(35) mediates critical protein-protein interactions in constitutive and enhancer-dependent splicing. Genes Dev. 10:1356-1368.
    • (1996) Genes Dev. , vol.10 , pp. 1356-1368
    • Zuo, P.1    Maniatis, T.2


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