Stereoselective total synthesis of racemic BCX-1812 (RWJ-270201) for the development of neuraminidase inhibitors as anti-influenza agents

Journal of Organic Chemistry

Volumn 68, Issue 17, 2003, Pages 6591-6596

  Mineno, Tomoko ^a   Miller, Marvin J ^a  

^a UNIVERSITY OF NOTRE DAME   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-INFLUENZA AGENTS;

OPTIMIZATION; REACTION KINETICS; SYNTHESIS (CHEMICAL);

STEREOCHEMISTRY;

2 DEOXY 2,3 DIDEHYDRO DEXTRO N ACETYLNEURAMINIC ACID; AMANTADINE; ISOXAZOLINE DERIVATIVE; OSELTAMIVIR; PERAMIVIR; RIMANTADINE; SIALIC ACID; SIALIDASE INHIBITOR; UNCLASSIFIED DRUG; ZANAMIVIR;

ARTICLE; CYCLOADDITION; DERIVATIZATION; DIARRHEA; DIELS ALDER REACTION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; HEADACHE; HUMAN; INFLUENZA; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; VOMITING;

ANTIVIRAL AGENTS; CATALYSIS; CYCLOPENTANES; ENZYME INHIBITORS; GUANIDINES; HUMANS; INDICATORS AND REAGENTS; INFLUENZA, HUMAN; NEURAMINIDASE; STEREOISOMERISM; TRIAZINES;

EID: 0042009286     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo034316b     Document Type: Article

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