Synthesis and evaluation of 1,4,5,6-tetrahydropyridazine derivatives as influenza neuraminidase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 13, 1999, Pages 1751-1756

  Zhang, Lijun ^a   Williams, Matthew A ^a   Mendel, Dirk B ^a   Escarpe, Paul A ^a,b   Chen, Xiaowu ^a   Wang, Ke Yu ^a   Graves, Bradford J ^c   Lawton, Geoff ^c   Kim, Choung U ^a  

^a GILEAD SCIENCES   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

^c ROCHE PRODUCTS LTD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 ACETAMIDO 5 AMINO 3 (1 ETHYLPROPOXY) 1 CYCLOHEXENE 1 CARBOXYLIC ACID; OSELTAMIVIR; PYRIDAZINE DERIVATIVE; SIALIDASE INHIBITOR;

ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG BINDING; DRUG INHIBITION; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; INFLUENZA; STEREOCHEMISTRY;

CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; INFLUENZA A VIRUS; INFLUENZA B VIRUS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; MODELS, MOLECULAR; NEURAMINIDASE; PYRIDAZINES;

EID: 0033526887     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00280-2     Document Type: Article

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