RWJ-270201. Anti-influenza neuraminidase (sialidase) inhibitor

Drugs of the Future

Volumn 25, Issue 3, 2000, Pages 249-251

  Sorbera, L A ^a   Graul, A ^a   Castaner, J ^a  

^a PROUS SCIENCE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

3(1 ACETAMIDO 2 ETHYLBUTYL)4C GUANIDINO 2T HYDROXYCYCLOPENTANE 1 CARBOXYLIC ACID; OSELTAMIVIR; PERAMIVIR; SIALIDASE INHIBITOR; UNCLASSIFIED DRUG; ZANAMIVIR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOLERABILITY; INFLUENZA; MOUSE; NONHUMAN; REVIEW;

EID: 0034008385     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.2000.025.03.565302     Document Type: Review

References (10)

1. Babu, Y.S., Chand, P., Montgomery, J.A. (BioCryst Pharmaceuticals, Inc.). Substd. cyclopentane and cyclopentene cpds. useful as neuraminidase inhibitors. WO 9933781.
2. Graul, A., Leeson, P., Castan̄er, J. Oseltamivir phosphate. Drugs Fut 1999, 24: 1189-202.
3. Gubareva, L.V., Kaiser, L., Hayden, F.G. Influenza virus neuraminidase inhibitors. Lancet 2000, 355: 827-35.
4. Bantia, S., Ananth, S., Andries, K., Horn, L., Parker, C., Chand, P., Babu, Y. In vitro activity of the neuraminidase inhibitor RWJ-270201 (BCX-1812) against influenza virus. 39th Intersci Conf Antimicrob Agents Chemother (Sept 26-29, San Francisco) 1999, AbSt F947.
5. Huffman, J.H., Morrison, A., Stowell, V., Barnard, D.L., Bush, K., Sidwell, R.W. Potent in vitro influenza virus-inhibitory activity of a series of cyclopentane neuraminidase inhibitors. 39th Intersci Conf Antimicrob Agents Chemother (Sept 26-29, San Francisco) 1999, Abst F946.
6. Bantia, S., Chand, P., Parker, C. et al. In vivo activity of RWJ-270201 (BCX-1812), a novel and potent inhibitor of influenza neuraminidase. 39th Intersci Conf Antimicrob Agents Chemother (Sept 26-29, San Francisco) 1999, Abst F948.
7. Sidwell, R.W., Huffman, J.H., Bailey, K.W., Bemis, P.A., Coogan, T., Bush, K., Babu, Y.S. Effect of the orally administered neuraminidase inhibitor RWJ-270201 in influenza virus in mice. 39th Intersci Conf Antimicrob Agents Chemother (Sept 26-29, San Francisco) 1999, Abst F949.
8. Sidwell, R.W., Bailey, K.W., Bemis, P.A., Burger, R.A. Primary immune system effects of the orally administered cyclopentane neuraminidase inhibitor RWJ-270201 in influenza virus-infected mice. 37th Annu Meet Infect Dis Soc Am (Nov 18-21, Philadelphia) 1999, Abst 716.
9. BioCryst reports initial phase II results from worldwide influenza collaboration. DailyDrugNews.com (Daily Essentials) Aug 25, 1999.
10. Phase III trials to begin for BioCryst's influenza therapy. DailyDrugNews.com (Daily Essentials) February 10, 2000.