Immunopathogenesis, loss of T cell tolerance and genetics of autoimmune gastritis

Autoimmunity Reviews

Volumn 1, Issue 5, 2002, Pages 290-297

  Van Driel, Ian R ^a   Baxter, Alan G ^b   Laurie, Karen L ^a   Zwar, Tricia D ^a   La Gruta, Nicole L ^a   Judd, Louise M ^a   Scarff, Katrina L ^a   Silveira, Pablo A ^b   Gleeson, Paul A ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b CENTENARY INSTITUTE   (Australia)

Author keywords

Autoimmune gastritis; CD25+CD4+ T cells, T cell tolerance.; Gastric H K ATPase; H K ATPase subunit, H K ; H K ATPase subunit, H K .

Indexed keywords

AUTOANTIGEN; CD4 ANTIGEN; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; INTERLEUKIN 2 RECEPTOR;

ALPHA CHAIN; AUTOIMMUNE DISEASE; AUTOIMMUNITY; BETA CHAIN; CELL MATURATION; DISEASE COURSE; DISEASE PREDISPOSITION; ENZYME DEFICIENCY; GASTRITIS; GENE DISRUPTION; GENETIC IDENTIFICATION; HUMAN; IMMUNOPATHOLOGY; IMMUNOREGULATION; MOLECULAR GENETICS; NONHUMAN; REGULATORY MECHANISM; REVIEW; STOMACH MUCOSA; T LYMPHOCYTE; TRANSGENIC MOUSE; ANIMAL; CD4+ T LYMPHOCYTE; DISEASE MODEL; GENETICS; GROWTH, DEVELOPMENT AND AGING; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; MOUSE; PATHOLOGY;

ANIMALS; AUTOANTIGENS; AUTOIMMUNE DISEASES; CD4-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; GASTRIC MUCOSA; GASTRITIS; H(+)-K(+)-EXCHANGING ATPASE; HUMANS; IMMUNE TOLERANCE; MICE;

EID: 0041968540     PISSN: 15689972     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1568-9972(02)00066-6     Document Type: Review

References (43)

1. Fukuma K., Sakaguchi S., Kuribayashi K., Chen W.L., Morishita R., Sekita K., et al. Immunologic and clinical studies on murine experimental autoimmune gastritis induced by neonatal thymectomy. Gastroenterology. 94:1988;274-283.
2. Gleeson P.A., Toh B.H., Vandriel I.R. Organ-specific autoimmunity induced by lymphopenia. Immunol Rev. 149:1996;97-125.
3. Toh B.H., van Driel I.R., Gleeson P.A. Pernicious anemia. New Eng J Med. 337:1997;1441-1448.
4. +-ATPase induces a reversible autoimmune gastritis. Immunology. 92:1997;91-98.
5. La Gruta N.L., Driel I.R., Gleeson P.A. Peripheral T cell expansion in lymphopenic mice results in a restricted T cell repertoire. Eur J Immunol. 30:2000;3380-3386.
6. Barrett S.P., Riordon A., Toh B.H., Gleeson P.A., van Driel I.R. Homing and adhesion molecules in autoimmune gastritis. J Leukocyte Biol. 67:2000;169-173.
7. Barrett S.P., Gleeson P.A., de Silva H., Toh B.H., van Driel I.R. Interferon-gamma is required during the initiation of an organ-specific autoimmune disease. Eur J Immunol. 26:1996;1652-1655.
8. La Gruta N.L., van Driel I.R., Toh B.H., Gleeson P.A. The role of natural killer cells in the induction of autoimmune gastritis. Autoimmunity. 34:2001;147-154.
9. Alderuccio F., Toh B.H., Tan S.S., Gleeson P.A., van Driel I.R. An autoimmune disease with multiple molecular targets abrogated by the transgenic expression of a single autoantigen in the thymus. J Exp Med. 178:1993;419-426.
10. Alderuccio F., Gleeson P.A., Berzins S.P., Martin M., van Driel I.R., Toh B.H. Expression of the gastric H/K-ATPase alpha-subunit in the thymus may explain the dominant role of the beta-subunit in the pathogenesis of autoimmune gastritis. Autoimmunity. 25:1997;167-175.
11. Barrett S.P., Toh B.H., Alderuccio F., van Driel I.R., Gleeson P.A. Organ-specific autoimmunity induced by adult thymectomy and cyclophosphamide- induced lymphopenia. Eur J Immunol. 25:1995;238-244.
12. Suri-Payer E., Amar A.Z., McHugh R., Natarajan K., Margulies D.H., Shevach E.M. Post-thymectomy autoimmune gastritis: fine specificity and pathogenicity of anti-H/K ATPase-reactive T cells. Eur J Immunol. 29:1999;669-677.
13. De Silva H.D., Gleeson P.A., Toh B.H., van Driel I.R., Carbone F.R. Identification of a gastritogenic epitope of the H/K ATPase beta-subunit. Immunology. 96:1999;145-151.
14. Alderuccio F., Cataldo V., van Driel I.R., Gleeson P.A., Toh B.H. Tolerance and autoimmunity to a gastritogenic peptide in TCR transgenic mice. Int Immunol. 12:2000;343-352.
15. Judd L.M., Gleeson P.A., Toh B.H., van Driel I.R. Autoimmune gastritis results in disruption of gastric epithelial cell development. Am. J. Physiol. 277:1999;G209-18.
16. Derbinski J., Schulte A., Kyewski B., Klein L. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat Immunol. 2:2001;1032-1039.
17. Peterson P., Nagamine K., Scott H., Heino M., Kudoh J., Shimizu N., et al. APECED: a monogenic autoimmune disease providing new clues to self-tolerance. Immunol Today. 19:1998;384-386.
18. Sakaguchi S., Sakaguchi N., Asano M., Itoh M., Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol. 155:1995;1151-1164.
19. Shevach E.M. Regulatory T cells in autoimmmunity. Ann Rev Immunol. 18:2000;423-449.
20. + regulatory T cells induced by an agonist self-peptide. Nat Immunol. 2:2001;301-306.
21. Read S., Malmstrom V., Powrie F. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. J Exp Med. 192:2000;295-302.
22. Takahashi T., Tagami T., Yamazaki S., Uede T., Shimizu J., Sakaguchi N., et al. Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med. 192:2000;303-309.
23. Maloy K.J., Powrie F. Regulatory T cells in the control of immune pathology. Nat Immunol. 2:2001;816-822.
24. + regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol. 3:2002;135-142.
25. Seddon B., Mason D. Peripheral autoantigen induces regulatory T cells that prevent autoimmunity. J Exp Med. 189:1999;877-882.
26. Garza K.M., Agersborg S.S., Baker E., Tung K.S. Persistence of physiological self antigen is required for the regulation of self tolerance. J Immunol. 164:2000;3982-3989.
27. Bensinger S.J., Bandeira A., Jordan M.S., Caton A.J., Laufer T.M. Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells. J Exp Med. 194:2001;427-438.
28. Stewart L.A., van Driel I.R., Gleeson P.A. Perturbation of gastric mucosa in mice expressing the temperature-sensitive mutant of SV40 large T antigen. Potential for establishment of an immortalised parietal cell line. Eur J Cell Biol. 81:2002;281-293.
29. Scarff K.L., Judd L.M., Toh B.H., Gleeson P.A., van Driel I.R. Gastric H(+),K(+)-adenosine triphosphatase beta subunit is required for normal function, development and membrane structure of mouse parietal cells. Gastroenterology. 117:1999;605-618.
30. Spicer Z., Miller M.L., Andringa A., Riddle T.M., Duffy J.J., Doetschman T., et al. Stomachs of mice lacking the gastric H,K-ATPase alpha-subunit have achlorhydria, abnormal parietal cells and ciliated metaplasia. J Biol Chem. 275:2000;21555-21565.
31. De Silva H.D., Alderuccio F., Hock Toh B., van Driel I.R., Gleeson P.A. Defining T cell receptors which recognise the immunodominant epitope of the gastric autoantigen, the H/K ATPase beta-subunit. Autoimmunity. 33:2001;1-4.
32. Laurie KL, van Driel IR, Zwar TD, Barrett SP, Gleeson PA. Endogenous H/K ATPase β-subunit promotes T cell tolerance to the immunodominant gastritogenic determinant. J Immunol 2002; in press.
33. Steinman R.M., Turley S., Mellman I., Inaba K. The induction of tolerance by dendritic cells that have captured apoptotic cells. J Exp Med. 191:2000;411-416.
34. Silveira P.A., Baxter A.G., Cain W.E., van Driel I.R. A major linkage region on distal chromosome 4 confers susceptibility to mouse autoimmune gastritis. J Immunol. 162:1999;5106-5111.
35. + exchange activity. Proc Natl Acad Sci USA. 91:1994;5898-5902.
36. Rodrigues N.R., Cornall R.J., Chandler P., Simpson E., Wicker L.S., Peterson L.B., et al. Mapping of an insulin-dependent diabetes locus, Idd9, in NOD mice to chromosome 4. Mamm Genome. 5:1994;167-170.
37. Silveira P.A., Wilson W.E., Esteban L.M., Jordan M.A., van Driel I.R., Baxter A.G. Identification of the Gasa3 and Gasa4 autoimmune gastritis susceptibility genes using congenic mice and partitioned, segregative and interaction analyses. Immunogenetics. 53:2001;741-750.
38. de Gouyon B., Melanitou E., Richard M.F., Requarth M., Hahn I.H., Guener J.L., et al. Genetic analysis of diabetes and insulitis in an interspecific cross of the non-obese diabetic mouse with Mus spretus. Proc Natl Acad Sci USA. 90:1993;1877-1881.
39. Ghosh S., Palmer S.M., Rodrigues N.R., Cordell H.J., Hearne C.M., Cornall R.J., et al. Polygenic control of autoimmune diabetes in non-obese diabetic mice. Nat Genet. 4:1993;404-409.
40. Rogner U.C., Boitard C., Morin J., Melanitou E., Avner P. Three loci on mouse chromosome 6 influence onset and final incidence of type I diabetes in NOD.C3H congenic strains. Genomics. 74:2001;163-171.
41. Hattori M., Buse J.B., Jackson R.A., Glimcher L., Dorf M.E., Minami M., et al. The NOD mouse: recessive diabetogenic gene in the major histocompatibility complex. Science. 231:1986;733-775.
42. Becker K.G. Comparative genetics of type 1 diabetes and autoimmune disease: common loci, common pathways? Diabetes. 48:1999;1353-1358.
43. Esteban L.M., Baxter A.G. Polyspecificity of autoimmune responses in type 1 (autoimmune) diabetes. Clin Exp Immunol. 126:2001;184-186.