Perturbation of gastric mucosa in mice expressing the temperature-sensitive mutant of SV40 large T antigen. Potential for establishment of an immortalised parietal cell line

European Journal of Cell Biology

Volumn 81, Issue 5, 2002, Pages 281-293

  Ann Stewart, L ^a,c   Van Driel, Ian R ^b   Gleeson, Paul A ^b  

^a MONASH UNIVERSITY MEDICAL SCHOOL   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c ALFRED HOSPITAL   (Australia)

Author keywords

Gastric mucosa; H+ K+ ATPase; Parietal cells; SV40 T antigen

Indexed keywords

HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; VIRUS LARGE T ANTIGEN; PROTEIN SUBUNIT; VIRUS T ANTIGEN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BETA CHAIN; CELL CULTURE; CELL DIFFERENTIATION; CELL IMMORTALIZATION; CELL ISOLATION; CELL MATURATION; CELL TYPE; CONTROLLED STUDY; ELECTRON MICROSCOPY; HYPERTROPHY; IMMUNOFLUORESCENCE; MICROSCOPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; REGULATORY MECHANISM; SIMIAN VIRUS 40; STEM CELL; STOMACH ACID SECRETION; STOMACH EPITHELIUM; STOMACH MUCOSA; STOMACH PARIETAL CELL; TEMPERATURE; TEMPERATURE SENSITIVE MUTANT; TRANSGENIC MOUSE; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CELL LINE; CELL LINEAGE; CYTOLOGY; FEMALE; GENETICS; METABOLISM; REGULATORY SEQUENCE; ULTRASTRUCTURE;

ANIMALIA; MUS MUSCULUS; SIMIAE; SIMIAN VIRUS 40;

ANIMALS; ANTIGENS, POLYOMAVIRUS TRANSFORMING; CELL LINE, TRANSFORMED; CELL LINEAGE; FEMALE; GASTRIC MUCOSA; H(+)-K(+)-EXCHANGING ATPASE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; PARIETAL CELLS, GASTRIC; PROTEIN SUBUNITS; REGULATORY SEQUENCES, NUCLEIC ACID; TEMPERATURE;

EID: 0036014856     PISSN: 01719335     EISSN: None     Source Type: Journal    
DOI: 10.1078/0171-9335-00249     Document Type: Article

References (45)

1. Cytological transformations associated with parietal cell stimulation: Critical steps in the activation cascade
2. A novel method for isolating mononuclear cells from the stomachs of mice with experimental autoimmune gastritis
3. Expression of a gastric autoantigen in pancreatic islets results in non-destructive insulitis after neonatal thymectomy
4. Isolation, identification and quantitative evaluation of specific cell types from the mammalian gastric mucosa
5. +-ATPase beta-subunit
6. Genetic ablation of parietal cells in transgenic mice: A new model for analyzing cell lineage relationships in the gastric mucosa
7. Parietal cell culture - New models and directions
8. Primary culture of secretagogue-responsive parietal cells from rabbit gastric mucosa
9. Differentiated mammalian cell lines immortalized by temperature-sensitive tumor viruses
10. Semi-quantitative PCR for the analysis of gene expression
11. +-ATPase
12. Membrane and protein recycling associated with gastric HCl secretion
13. State of actin in gastric parietal cells
14. The membrane-recruitment-and-recycling hypothesis of gastric HCl secretion
15. +-ATPase β-subunit- and gastrin-deficient mice
16. Impaired gastric acid secretion in gastrin-deficient mice
17. Molecular requirements for the cell-surface expression of multisubunit ion-transporting ATPases: Identification of protein domains that participate in Na,K-ATPase and H/K-ATPase subunit assembly
18. The secretion-stimulated 80K phosphoprotein of parietal cells is ezrin, and has properties of a membrane cytoskeletal linker in the induced apical microvilli
19. Monoclonal antibodies specific for simian virus 40 tumor antigens
20. Direct derivation of conditionally immortal cell lines from an H-2Kb-tsA58 transgenic mouse
21. Cell lines established by a temperature-sensitive simian virus 40 large-T-antigen gene are growth restricted at the nonpermissive temperature
22. Autoimmune gastritis results in disruption of gastric epithelial cell development
23. +-ATPase activity by omeprazole promotes degeneration and production of parietal cells
24. Dynamics of epithelial cells in the corpus of the mouse stomach. I. Identification of proliferative cell types and pinpointing of the stem cell
25. Gastric epithelial morphogenesis in normal and transgenic mice
26. Establishment and characteristics of a practical and useful astrocyte cell line transformed by a temperature-sensitive mutant of simian virus 40
27. A standardized mouse model of Helicobacter pylori infection: Introducing the Sydney strain
28. Diphtheria toxin-mediated ablation of parietal cells in the stomach of transgenic mice
29. Simian virus 40 T antigen-induced amplification of pre-parietal cells in transgenic mice - Effects on other gastric epithelial cell lineages and mechanism that operates in a committed progenitor
30. Simian virus 40 functions required for the establishment and maintenance of malignant transformation
31. The alcian dyes applied to gastric mucosa
32. Characterisation of parietal cell autoantigens involved in neonatal thymectomy-induced murine autoimmune gastritis using monoclonal antibodies
33. The mouse gastric H,K ATPase β-subunit. Gene structure and co-ordinate expression with the α subunit during ontogeny
34. Effects of intrathymic injection of organ-specific autoantigens, parietal cells, at the neonatal stage on autoreactive effector and suppressor T cell precursors
35. Clathrin in gastric acid secretory (parietal) cells: Biochemical characterization and subcellular localization
36. Fast freeze-fixation/freeze-substitution reveals the secretory membranes of the gastric parietal cell as a network of helically coiled tubules: A new model for parietal cell transformation
37. + ATPase subunits coincides with the biogenesis of the secretory membranes
38. The gastric H,K ATPase - Regulation and structure/function of the acid pump of the stomach
39. Characterization of membrane and cytoskeletal compartments in cultured parietal cells: Immunofluorescence and confocal microscopic examination
40. Stomachs of mice lacking the gastric H,K-ATPase alpha-subunit have achlorhydria, abnormal parietal cells, and ciliated metaplasia
41. Production and characterization of murine monoclonal antibody to human alpha-lactalbumin
42. +-ATPases
43. A new colon carcinoma cell line (LIM1863) that grows as organoids with spontaneous differentiation into crypt-like structures in vitro
44. Establishment of conditionally immortalized epithelial cell lines from both colon and small intestine of adult H-2Kb-tsA58 transgenic mice
45. Conditional immortalization of human thyroid epithelial cells: A tool for analysis of oncogene action