Furin-mediated processing in the early secretory pathway: Sequential cleavage and degradation of misfolded insulin receptors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 22, 2000, Pages 11905-11909

  Bass, Joseph ^a,c   Turck, Christopher ^b   Rouard, Mathias ^a,d   Steiner, Donald F ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Biosynthesis; Calnexin; Calreticulin; Degradation; Endoplasmic reticulum

Indexed keywords

CHAPERONE; FURIN; INSULIN RECEPTOR; MUTANT PROTEIN; PROTEINASE; RECEPTOR PROTEIN; SUBTILISIN; SUBTILISIN LIKE PROTEASE FURIN; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; CONTROLLED STUDY; EMBRYO; ENDOPLASMIC RETICULUM; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; SITE DIRECTED MUTAGENESIS;

BASE SEQUENCE; CELL LINE; DNA PRIMERS; ENDOPLASMIC RETICULUM; FURIN; HUMANS; HYDROLYSIS; MOLECULAR CHAPERONES; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN FOLDING; RECEPTOR, INSULIN; SUBTILISINS;

EID: 0034710889     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.97.22.11905     Document Type: Article

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