Differential expression, localization and activity of two alternatively spliced isoforms of human APC regulator CDH1

Biochemical Journal

Volumn 374, Issue 2, 2003, Pages 349-358

  Zhou, Yuan ^a   Ching, Yick Pang ^a   Ng, Raymond W M ^a   Jin, Dong Yan ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Anaphase promoting complex (APC); CDH1; Cell cycle control

Indexed keywords

CELLS; DEGRADATION; PROTEINS; TISSUE;

PROTEOLYSIS;

BIOCHEMISTRY;

ANAPHASE PROMOTING COMPLEX; CDH1 ALPHA PROTEIN; CDH1 BETA PROTEIN; CELL CYCLE PROTEIN; CELL CYCLE PROTEIN 20; CYCLIN A; CYCLIN B1; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ANIMAL EMBRYO; ARTICLE; BLASTULA; CELL CYCLE; CELL CYCLE G1 PHASE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EMBRYO; FEMALE; GENE MAPPING; HUMAN; HUMAN CELL; HUMAN TISSUE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; TISSUE DISTRIBUTION; XENOPUS;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; BRAIN; CADHERINS; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 19; FEMALE; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; LIGASES; LIVER; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; MYOCARDIUM; OOCYTES; ORGAN SPECIFICITY; PROTEIN BINDING; PROTEIN ISOFORMS; SEQUENCE HOMOLOGY, NUCLEIC ACID; SPLEEN; TUMOR CELLS, CULTURED; UBIQUITIN-PROTEIN LIGASE COMPLEXES; XENOPUS LAEVIS;

ANIMALIA;

EID: 0041328591     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20030600     Document Type: Article

References (57)

1. Harper, J. W., Burton, J. L. and Solomon, M. J. (2002) The anaphase-promoting complex: it's not just for mitosis any more. Genes Dev. 16, 2179-2206
2. Peters, J. M. (2002) The anaphase-promoting complex: proteolysis in mitosis and beyond. Mol. Cell 9, 931-943
3. Kotani, S., Tanaka, H., Yasuda, H. and Todokoro, K. (1999) Regulation of APC activity by phosphorylation and regulatory factors. J. Cell Biol. 146, 791-800
4. Kramer, E. R., Scheuringer, N., Podtelejnikov, A. V., Mann, M. and Peters, J. M. (2000) Mitotic regulation of the APC activator proteins CDC20 and CDH1. Mol. Biol. Cell 11, 1555-1569
5. Visintin, R., Prinz, S. and Amon, A. (1997) CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis. Science 278, 460-463
6. Yamaguchi, S., Okayama, H. and Nurse, P. (2000) Fission yeast Fizzy-related protein srw1p is a G1-specific promoter of mitotic cydin B degradation. EMBO J. 19, 3968-3977
7. Dawson, I. A., Roth, S. and Artavanis-Tsakonsa, S. (1993) The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae. J. Cell Biol. 129, 725-737
8. Sigrist, S. J. and Lehner, C. F. (1997) Drosophila fizzy-rerated down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles. Cell 90, 671-681
9. Jacobs, H. W., Richter, D. O., Venkatesh, T. R. and Lehner, C. F. (2002) Completion of mitosis requires neither fzr/rap nor fzr2, a male germline-specific Drosophila Cdh1 homolog. Curr. Biol. 12, 1435-1441
10. Lorca, T., Castro, A., Martinez, A. M., Vigneron, S., Morin, N., Sigrist, S., Lehner, C., Doree, M. and Labbe, J. C. (1998) Fizzy is required for activation of the APC/cyclosome in Xenopus egg extracts. EMBO J. 17, 3565-3575
11. Burton, J. L. and Solomon, M. J. (2001) D box and KEN box motifs in budding yeast Hsl1p are required for APC-mediated degradation and direct binding to Cdc20p and Cdh1p. Genes Dev. 15, 2381-2395
12. Hilioti, Z., Chung, Y. S., Mochizuki, Y., Hardy, C. F. J. and Cohen-Fix, O. (2001) The anaphase inhibitor Pds1 binds to the APC/C-associated protein Cdc20 in a destruction box-dependent manner. Curr. Biol. 11, 1347-1352
13. Glotzer, M., Murray, A. W. and Kirschner, M. W. (1991) Cyclin is degraded by the ubiquitin pathway. Nature (London) 349, 438-441
14. Fang, G., Yu, H. and Kirschner, M. W. (1998) Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1. Mol. Cell 2, 163-171
15. Pfleger, C. M. and Kirschner, M. W. (2000) The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1. Genes Dev. 14, 655-665
16. Hagting, A., den Elzen, N., Vodermaier, H. C., Waizenegger, I. C., Peters, J.-M. and Pines, J. (2002) Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1. J. Cell Biol. 157, 1125-1137
17. Littlepage, L. E. and Ruderman, J. V. (2002) Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit. Genes Dev. 16, 2274-2285
18. Weinstein, J. (1997) Cell cycle-regulated expression, phosphorylation, and degradation of p55Cdc: A mammalian homolog of CDC20/Fizzy/slp1. J. Biol. Chem. 272, 28501-28511
19. Inbal, N., Listovsky, T. and Brandeis, M. (1999) The mammalian Fizzy and Fizzy-related genes are regulated at the transcriptional and post-transcriptional levels. FEBS Lett. 463, 350-354
20. Gieffers, C., Peters, B. H., Kramer, E. R., Dotti, C. G. and Peters, J. M. (1999) Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons. Proc. Natl. Acad. Sci. U.S.A. 96, 11317-11322
21. Wang, C. X., Fisk, B. C., Wadehra, M., Su, H. and Braun, J. (2000) Overexpression of murine fizzy-related (fzr) increases natural killer cell-mediated cell death and suppresses tumor growth. Blood 96, 259-263
22. Fay, D. S., Keenan, S. and Han, M. (2002) fzr-1 and lin-35/Rb function redundantly to control cell proliferation in C. elegans as revealed by a nonbiased synthetic screen. Genes Dev. 16, 503-517
23. Yudkovsky, Y., Shteinberg, M., Listovsky, T., Brandeis, M. and Hershko, A. (2000) Phosphorylation of Cdc20/fizzy negatively regulates the mammalian cyclosome/APC in the mitotic checkpoint. Biochem. Biophys. Res. Commun. 271, 299-304
24. Lukas, C., Sørensen, C. S., Kramer, E., Santoni-Rugiu, E., Lindeneg, C., Peters, J. M., Bartek, J. and Lukas, J. (1999) Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex. Nature (London) 401, 815-818
25. Cdc20 promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5. Nature (London) 402, 203-207
26. Wassmann, K. and Benezra, R. (2001) Mitotic checkpoints: from yeast to cancer. Curr. Opin. Gen. Dev 11, 83-90
27. Musacchio, A. and Hardwick, K. G. (2002) The spindle checkpoint: structural insights into dynamic signalling. Nat. Rev. Mol. Cell Biol. 3, 731-741
28. Taylor, S. S. (1999) Chromosome segregation: dual control ensures fidelity. Curr. Biol. 9, R562-R564
29. Chen, J. and Fang, G. (2001) MAD2B is an inhibitor of the anaphase-promoting complex. Genes Dev. 15, 1765-1770
30. Pfleger, C. M., Salic, A., Lee, E. and Kirschner, M. W. (2001) Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1. Genes Dev. 15, 1759-1764
31. Jin, D.-Y., Spencer, F. and Jeang, K.-T. (1998) Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1. Cell 93, 81-91
32. Jin, D.-Y., Wang, H.-L., Zhou, Y., Chun, A. C. S., Kibler, K. V., Hou, Y.-D., Kung, H. and Jeang, K.-T. (2000) Hepatitis C virus core protein-induced loss of LZIP function correlates with cellular transformation. EMBO J. 19, 729-740
33. Jin, D.-Y., Chae, H. Z., Rhee, S. G. and Jeang, K.-T. (1997) Regulatory role for a novel human thioredoxin peroxidase in NF-κB activation. J Biol. Chem. 272, 30952-30961
34. Jin, D.-Y., Giordano, V., Kibler, K. V., Nakano, H. and Jeang, K.-T. (1999) Role of adapter function in oncoprotein-mediated activation of NF-κB: human T-cell leukemia virus type I Tax interacts directly with IκB kinase γ. J. Biol. Chem. 274, 17402-17405
35. Zhou, H.-J., Wong, C.-M., Chen, J.-H., Qiang, B.-Q., Yuan, J.-G. and Jin, D.-Y. (2001) Inhibition of LZIP-mediated transcription through direct interaction with a novel host cell factor-like protein. J. Biol. Chem. 276, 28933-28938
36. Yam, C. H., Siu, W. Y., Lau, A. and Poon, R. Y. C. (2000) Degradation of cyclin A does not require its phosphorylation by CDC2 and cyclin-dependent kinase 2. J. Biol. Chem. 275, 3158-3167
37. Nieuwkoop, P. D. and Faber, J. (1967) A Normal Table of Xenopus laevis (Daudin), North Holland Publishing Co., Amsterdam
38. Ching, Y.-P., Zhou, H.-J., Yuan, J.-G., Qiang, B.-Q., Kung, H.-F. and Jin, D.-Y. (2002) Identification and characterization of FTSJ2, a novel human nucleolar protein homologous to bacterial ribosomal RNA methyltransferase. Genomics 79, 2-6
39. Kramer, E. R., Gieffers, C. Hölzl, G., Hengstschläger, M. and Peters, J. M. (1998) Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family. Curr. Biol. 8, 1207-1210
40. Cooper, K. F., Mallory, M. J., Egeland, D. B., Jarnik, M. and Strich, R. (2000) Ama1p is a meiosis-specific regulator of the anaphase promoting complex/cyclosome in yeast. Proc. Natl. Acad. Sci. U.S.A. 97, 14548-14553
41. Asakawa, H., Kitamura, K. and Shimoda, C. (2001) A novel Cdc20-related WD-repeat protein, Fzr1, is required for spore formation in Schizosaccharomyces pombe. Mol. Genet. Genomics 265, 424-435
42. Blanco, M. A., Pelloquin, L. and Moreno, S. (2001) Fission yeast mfr1 activates APC and coordinates meiotic nuclear division with sporulation. J. Cell Sci. 114, 2135-2143
43. Wan, Y. and Kirschner, M. W. (2001) Identification of multiple CDH1 homologues in vertebrates conferring different substrate specificities. Proc. Natl. Acad. Sci. U.S.A. 98, 13066-13071
44. Sørensen, C. S., Lukas, C., Kramer, E. R., Peters, J. M., Bartek, J. and Lukas, J. (2000) Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoulred from mitosis. Mol. Cell. Biol. 20, 7613-7623
45. Cdh1. EMBO J. 21, 6515-6526
46. Zhou, Y., Ching, Y.-P., Chun, A. C. S. and Jin, D. Y. (2003) Nuclear localization of the cell cycle regulator CDH1 and its regulation by phosphorylation. J. Biol. Chem. 278, 12530-12536
47. Pines, J. (1999) Four-dimensional control of the cell cycle. Nat. Cell Biol. 1, E73-E79
48. Zhou, Y., Ching, Y.-P., Ng, R. W. M. and Jin, D.-Y. (2002) The APC regulator CDH1 is essential for the progression of embryonic cell cycles in Xenopus Biochem. Biophys. Res. Commun. 2g4, 1120-1126
49. Modrek, B. and Lee, C. (2002) A genomic view of alternative splicing. Nat. Genet. 30, 13-19
50. Cartegni, L., Chew, S. L. and Krainer, A. R. (2002) Listening to silence and understanding nonsense: exonic mutations that affect splicing. Nat. Rev. Genet. 3, 285-298
51. Clute, P. and Pines, J. (1999) Temporal and spatial control of cyclin B1 destruction in metaphase. Nat. Cell Biol. 1, 82-87
52. Bembenek, J. and Yu, H. (2001) Regulation of the anaphase-promoting complex by the dual specificity phosphatase human Cdc14a. J. Biol. Chem. 276, 48237-48242
53. Cdh1. Nat. Cell Biol. 4, 358-366
54. Jorgensen, P. M., Brundell, E., Starborg, M. and Hoog, C. (1998) A subunit of the anaphase-promoting complex is a centromere-associated protein in mammalian cells. Mol. Cell Biol. 18, 468-476
55. Sørensen, C. S., Lukas, C., Kramer, E. R., Peters, J. M., Bartek, J. and Lukas, J. (2001) A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression. Mol. Cell. Biol. 21, 3692-3703
56. Jackman, M., Kubota, Y., den Elzen, N., Hagting, A. and Pines, J. (2002) Cyclin A- and cyclin E-Cdk complexes shuttle between the nucleus and the cytoplasm. Mol. Biol. Cell 13, 1030-1045
57. Weis, K. (2003) Regulating access to the genome: nucleocytoplasmic transport throughout the cell cycle. Cell 112, 441-451