Activation and dimerization of type III nitric oxide synthase by submicromolar concentrations of tetrahydrobiopterin in microsomal preparations from human primordial placenta

Placenta

Volumn 18, Issue 2-3, 1997, Pages 189-196

  Toth M ^a   Kukor, Z ^a   Sahin Toth M ^a  

^a SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CALCIUM ION; NITRIC OXIDE SYNTHASE; TETRAHYDROBIOPTERIN;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DENSITOMETRY; DIMERIZATION; ELECTROPHORETIC MOBILITY; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; MICROSOME; PLACENTA; PRIORITY JOURNAL;

EID: 0030903552     PISSN: 01434004     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0143-4004(97)90092-8     Document Type: Article

References (41)

1. Baek, K. J., Thiel, B. A., Lucas, S. & Stuehr, D. J. (1993) Macrophage nitric-oxide synthase subunits. Purification, characterization and role of prosthetic groups and substrate in regulating their association into a dimeric enzyme. Journal of Biological Chemistry, 268, 21120-21129.
2. Bártfai, T. (1979) Preparation of metal-chelate complexes and the design of steady-state kinetic experiments involving metal nucleotide complexes. In Advances in Cyclic Nucleotide Research, Vol. 10, (Ed.) Brooker, G., Greengard, P. & Robinson, G. A. pp. 219-242. New York: Raven Press.
3. Bredt, D. S. & Snyder, S. H. (1994) Nitric oxide: a physiologic messenger molecule. Annual Review of Biochemistry, 63, 175-195.
4. Buttery, L. D. K., McCarthy, A., Springall, D. R., Sullivan, M. H. F., Elder, M. G., Michel, T. & Polak, J. M. (1994) Endothelial nitric oxide synthase in the human placenta: regional distribution and proposed regulatory role at the feto-maternal interface. Placenta, 15, 257-265.
5. Campos, K. L., Giovanelli, J. & Kaufman, S. (1995) Characteristics of the nitric-oxide synthase-catalyzed conversion of arginine to N-hydroxy-arginine, the first oxygenation step in the enzymic synthesis of nitric oxide. Journal of Biological Chemistry, 270, 1721-1728.
6. Chaudhuri, G., Cuevas, J., Buga, G. M. & Ignarro, L. J. (1993) NO is more potent, than PGI2 in maintaining low vascular tone in fetoplacental vessels. American Journal of Physiology, 265, H2036-H2043.
7. Conrad, K. P., Vill, M., McGuire, P. G., Dail, W. G. & Davies, A. K. (1993) Expression of nitric oxide synthase by syncytiotrophoblast in human placetal villi. FASEB Journal, 7, 1269-1276.
8. Dikranian, K., Trosheva, M., Nikolov, S. & Bodin, P. (1994) Nitric oxide synthase (NOS) in the human umbilical cord vessels. An immunohistochemical study. Acta Histochemica, 96, 145-153.
9. Eis, A. L. W., Brockman, D. E., Pollock, J. S. & Myatt, L. (1995) Immunohistochemical localization of endothelial nitric oxide synthase in human villous and extravillous trophoblast populations and expression during syncytiotrophoblast formation in vitro. Placenta, 16, 113-126.
10. Garvey, E. P., Tuttle, J. V., Covington, K., Merrill, B. M., Wood, E. R., Baylis, S. A. & Charles, I. G. (1994) Purification and characterization of the constitutive nitric oxide synthase from human placenta. Archives of Biochemistry and Biophysics, 311, 235-241.
11. Giovanelli, J., Campos, K. L. & Kaufman, S. (1991) Tetrahydrobiopterin, a cofactor for rat cerebellar nitric oxide synthase, does not function as a reactant in the oxygenation of arginine. Proceedings of National Academy of Sciences of the USA, 88, 7091-7095.
12. Griscavage, J. M., Rogers, N. E., Sherman, M. P. & Ignarro, L. J. (1993) Inducible nitric oxide synthase from a rat alveolar macrophage cell line is inhibited by nitric oxide. Journal of Immunology, 151, 6329-6337.
13. Griscavage, J. M., Fukuto, J. M., Komori, Y. & Ignarro, L. J. (1994) Nitric oxide inhibits neuronal nitric oxide synthase by interacting with the heme prosthetic group. Role of tetrahydrobiopterin in modulating the inhibitory action of nitric oxide. Journal of Biological Chemistry, 269, 21644-21649.
14. Gude, N. M., King, R. G. & Brennecke, S. P. (1990) Role of endothelium-derived nitric oxide in maintenance of low fetal vascular resistance in placenta. Lancet, 336, 1589-1590.
15. Gude, N. M., Di Iulio, J., Brennecke, S. P. & King, R. G. (1994) Human placental villous nitric oxide synthase activity. Pharmacology Communications, 4, 163-171.
16. Hull, A, O., White, C. R. & Pearce, W. J. (1994) Endothelium derived relaxing factor and cyclic GMP-dependent vasorelaxation in human chorionic arteries. Placenta, 15, 365-375.
17. Hyun, J., Komori, Y., Chaudhuri, G., Ignarro, L. J. & Fukuto, J. M. (1995) The protective effect of tetrahydrobiopterin on the nitric-oxide-mediated inhibition of purified nitric oxide synthase. Biochemical and Biophysical Research Communications, 206, 380-386.
18. Jauniaux, E., Jurkovic, D. & Campbell, S. (1995) Current topic: in vivo investigation of the placental circulations by Doppler echography. Placenta, 16, 323-331.
19. Klatt, P., Schmid, M., Leopold, E., Schmidt, K., Werner, E. R. & Mayer, B. (1994) The pteridine binding site of brain nitric oxide synthase. Tetrahydrobiopterin binding kinetics, specificity and allosteric interaction with the substrate domain. Journal of Biological Chemistry, 269, 13861-13866.
20. Klatt, P., Schmidt, K., Lehner, D., Glatter, O., Bächinger, H. P. & Mayer, B. (1995) Structural analysis of porcine brain nitric oxide synthase reveals a role for tetrahydrobiopterin and L-arginine in the formation of an SDS-resistant dimer. EMBO Journal, 14, 3687-3695.
21. Klatt, P., Pfeiffer, S., List, B. M., Lehner, D., Glatter, O., Bächinger, H. P., Werner, E. R., Schmidt, K. & Mayer, B. (1996) Characterization of heme-deficient neuronal nitric-oxide synthase reveals a role for heme in subunit dimerization and binding of the amino acid substrate and tetrahydrobiopterin. Journal of Biological Chemistry, 271, 7336-7342.
22. Knowles, R. G. & Moncada, S. (1994) Nitric oxide synthases in mammals. Biochemical Journal, 298, 249-258.
23. 2+-independent NO-synthesizing activities of human primordial placenta. Acta Physiologica Hungarica, 82, 313-319.
24. Kukor, Z., Mészáros, G., Hertelendy, F. & Tóth, M. (1996) Calcium-dependent nitric-oxide synthesis is potently stimulated by tetrahydrobiopterin in human primordial placenta. Placenta, 17, 69-73.
25. Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. (1951) Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry, 143, 265-275.
26. Morris, N. H., Eaton, B. M. & Dekker, G. (1996) Nitric oxide, the endothelium, pregnancy and pre-eclampsia. British Journal of Obstetrics and Gynaecology, 103, 4-15.
27. Myatt, L., Brewer, A. S., & Brockman, D. E. (1991) The action of nitric oxide in the perfused human fetal-placental circulation. American Journal of Obstetrics and Gynecology, 164, 687-692.
28. Myatt, L., Brewer, A. S., Langdon, G. & Brockman, D. E. (1992) Attenuation of the vasoconstrictor effects of thromboxane and endothelin by nitric oxide in the human fetal-placental circulation. American Journal of Obstetrics and Gynecology, 166, 224-230.
29. Myatt, L., Brockman, D. E., Eis, A. L. W. & Pollock, J. S. (1993a) Immunochemical localization of nitric oxide synthase in the human placenta. Placenta, 14, 487-495
30. Myatt, L., Brockman, D. E., Langdon, G. & Pollock, J. S. (1993b) Constitutive calcium-dependent isoform of nitric oxide synthase in the human placental villous vascular tree. Placenta, 14, 373-383.
31. Nathan, C. (1992) Nitric oxide as a secretory product of mammalian cells. FASEB Journal, 6, 3051-3064.
32. Nichol, C. A., Smith, G. K. & Duch, D. S. (1985) Biosynthesis and metabolism of tetrahydrobiopterin and molybdopterin. Annual Review of Biochemistry, 54, 729-764.
33. Ramsey, B., Sooranna, S. R. & Johnson, M. R. (1996) Nitric oxide synthase activities in human myometrium and villous trophoblast throughout pregnancy. Obstetrics and Gynecology, 87, 249-253.
34. Robinson, L. J., Busconi, L. & Michel, T. (1995) Agonist modulated palmitoylation of endothelial nitric oxide synthase. Journal of Biological Chemistry, 270, 995-998.
35. Rodriguez-Crespo, I., Gerber, N. C. & Ortiz de Montellano (1996) Endothelial nitric-oxide synthase. Expression in Escherichia coli, spectroscopic characterization and role of tetrahydrobiopterin in dimer formation. Journal of Biological Chemistry, 271, 11462-11467.
36. Rutherford, R. A. D., McCarthy, A., Sullivan, M. H. F., Elder, M. G., Polak, J. M. & Wharton, J. (1995) Nitric oxide synthase in human placenta and umbilical cord from normal, intrauterine growth-retarded and pre-eclamptic pregnancies. British Journal of Pharmacology, 116, 3099-3109.
37. Schmidt, H. H. H. W., Pollock, J. S., Nakane, M., Gorsky, L. D., Förstermann, U. & Murad, F. (1991) Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase. Proceedings of National Academy of Sciences of the USA, 88, 365-369.
38. 2+/calmodulin-independent diaphorase and reductase activities. Biochemistry, 31, 3243-3249.
39. Stuehr, D. J., Cho, H. J., Kwon, N. S., Weise, M. F. & Nathan, C. F. (1991) Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: An FAD-and FMN-containing flavoprotein. Proceedings of National Academy of Sciences of the USA, 88, 7773-7777.
40. Tóth, M., Kukor, Z., Romero, R. & Hertelendy, F. (1995) Nitric oxide synthase in first trimester human placenta: characterization and subcellular distribution. Hypertension in Pregnancy, 14, 287-300.
41. 4B promotes assembly of enzyme subunits into an active dimer. Proceedings of the National Academy of Sciences of the USA, 92, 11771-11775.