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Volumn 60, Issue 6, 2003, Pages 1107-1117

Initiation of genetic instability and tumour formation: A review and hypothesis of a nongenotoxic mechanism

Author keywords

Carcinogenesis; DNA polymerase; DNA proofreading; Genetic instability; Mutation; Nongenotoxic; Stem cells; Tumour

Indexed keywords

CARCINOGEN; DNA; DNA POLYMERASE; MUTAGENIC AGENT;

EID: 0038724559     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00018-003-2314-6     Document Type: Review
Times cited : (17)

References (137)
  • 2
    • 0036304331 scopus 로고    scopus 로고
    • The mutator phenotype/clonal selection hypothesis can provide a basis for the complex and variable morphological and behavioural features of solid tumour malignancies
    • Bignold L. P. (2002) The mutator phenotype/clonal selection hypothesis can provide a basis for the complex and variable morphological and behavioural features of solid tumour malignancies. Cell Mol. Life Sci. 59: 950-958
    • (2002) Cell Mol. Life Sci. , vol.59 , pp. 950-958
    • Bignold, L.P.1
  • 3
    • 85039664040 scopus 로고    scopus 로고
    • The mutator phenotype theory of carcinogenesis and the complex histopathology of tumours: Support for the theory from the independent occurrence of nuclear abnormality, loss of specialisation and invasiveness among occasional neoplastic lesions
    • in press
    • Bignold L. P. The mutator phenotype theory of carcinogenesis and the complex histopathology of tumours: support for the theory from the independent occurrence of nuclear abnormality, loss of specialisation and invasiveness among occasional neoplastic lesions. Cell Mol. Life Sci., in press
    • Cell Mol. Life Sci.
    • Bignold, L.P.1
  • 4
    • 0004789413 scopus 로고
    • Cell and molecular mechansims in chemical carcinogenesis
    • Peckham M., Pinedo H. and Veronesi U. (eds), Oxford University Press, Oxford
    • Cooper D. P., O'Connor P. J., Povey A. C. and Rafferty J. A. (1995) Cell and molecular mechansims in chemical carcinogenesis. In: Oxford Textbook of Oncology, pp. 135-147, Peckham M., Pinedo H. and Veronesi U. (eds), Oxford University Press, Oxford
    • (1995) Oxford Textbook of Oncology , pp. 135-147
    • Cooper, D.P.1    O'Connor, P.J.2    Povey, A.C.3    Rafferty, J.A.4
  • 5
    • 0002051192 scopus 로고    scopus 로고
    • Etiology of cancer. Chemical factors
    • DeVita V. T. Jr, Hellman S. and Rosenberg S. A. (eds), Lippincott-Raven, Philadelphia
    • Yuspa S. H. and Shields P. G. (1997) Etiology of cancer. Chemical factors. In: Cancer, Principles and Practice of Oncology, 5th edn, pp. 185-202, DeVita V. T. Jr, Hellman S. and Rosenberg S. A. (eds), Lippincott-Raven, Philadelphia
    • (1997) Cancer, Principles and Practice of Oncology, 5th Edn. , pp. 185-202
    • Yuspa, S.H.1    Shields, P.G.2
  • 6
    • 0033367088 scopus 로고    scopus 로고
    • The role of genomic instability in human carcinogenesis
    • Coleman W. B. and Tsongalis G. J. (1999) The role of genomic instability in human carcinogenesis. Anticancer Res. 19: 4645-4664
    • (1999) Anticancer Res. , vol.19 , pp. 4645-4664
    • Coleman, W.B.1    Tsongalis, G.J.2
  • 7
    • 0033035955 scopus 로고    scopus 로고
    • Genomic changes defining the genesis, progression and malignancy potential in solid human tumors: A phenotype/genotype correlation
    • Ried T., Heselmeyer-Haddad K., Blegen H., Schrock E. and Auer G. (1999) Genomic changes defining the genesis, progression and malignancy potential in solid human tumors: a phenotype/genotype correlation. Genes Chromosomes Cancer 25:195-204
    • (1999) Genes Chromosomes Cancer , vol.25 , pp. 195-204
    • Ried, T.1    Heselmeyer-Haddad, K.2    Blegen, H.3    Schrock, E.4    Auer, G.5
  • 8
    • 0036317839 scopus 로고    scopus 로고
    • Loss of heterozygosity or allele imbalance in histologically normal breast epithelium is distinct from loss of heterozygosity or allele imbalance in co-existing carcinomas
    • Larson P. S., de las Morenas A., Bennett S. R., Cupples L. A. and Rosenberg C. L. (2002) Loss of heterozygosity or allele imbalance in histologically normal breast epithelium is distinct from loss of heterozygosity or allele imbalance in co-existing carcinomas. Am. J. Pathol. 161: 283-290
    • (2002) Am. J. Pathol. , vol.161 , pp. 283-290
    • Larson, P.S.1    De Las Morenas, A.2    Bennett, S.R.3    Cupples, L.A.4    Rosenberg, C.L.5
  • 9
    • 0035687513 scopus 로고    scopus 로고
    • Genetic instability in epithelial tissues at risk of cancer
    • Hittelman W. N. (2001) Genetic instability in epithelial tissues at risk of cancer. Ann. N. Y. Acad. Sci. 952: 1-12
    • (2001) Ann. N. Y. Acad. Sci. , vol.952 , pp. 1-12
    • Hittelman, W.N.1
  • 10
    • 0008006662 scopus 로고
    • Saunders, Philadelphia
    • rd edn, Saunders, Philadelphia
    • (1928) rd Edn.
    • Ewing, J.1
  • 13
    • 0034758874 scopus 로고    scopus 로고
    • Current molecular aspects of the carcinogenesis of the uterine endometrium
    • Inoue M. (2001) Current molecular aspects of the carcinogenesis of the uterine endometrium. Int. J. Gynecol. Cancer 11: 339-348
    • (2001) Int. J. Gynecol. Cancer , vol.11 , pp. 339-348
    • Inoue, M.1
  • 14
    • 0021868850 scopus 로고
    • Regeneration and the mechanism of epidermal tumor promotion
    • Argyris T. S. (1985) Regeneration and the mechanism of epidermal tumor promotion. Crit. Rev. Toxicol. 14: 211-258
    • (1985) Crit. Rev. Toxicol. , vol.14 , pp. 211-258
    • Argyris, T.S.1
  • 15
    • 0015489740 scopus 로고
    • Molecular repair, wound healing and carcinogenesis: Tumor production a possible overhealing?
    • Haddow A. (1972) Molecular repair, wound healing and carcinogenesis: tumor production a possible overhealing? Adv. Cancer Res. 6: 181-234
    • (1972) Adv. Cancer Res. , vol.6 , pp. 181-234
    • Haddow, A.1
  • 16
    • 0017153121 scopus 로고
    • Nonimmunological host defenses: A review
    • Apffel C. A. (1976) Nonimmunological host defenses: a review. Cancer Res. 36: 1527-1537
    • (1976) Cancer Res. , vol.36 , pp. 1527-1537
    • Apffel, C.A.1
  • 17
    • 0017379403 scopus 로고
    • Relationship between differentiation and carcinogenesis
    • Pierce G. B. (1977) Relationship between differentiation and carcinogenesis. J Toxicol. Environ. Health 2: 1335-1342
    • (1977) J. Toxicol. Environ. Health , vol.2 , pp. 1335-1342
    • Pierce, G.B.1
  • 18
    • 0014377762 scopus 로고
    • The cancer cell as a stem cell unable to differentiate
    • Fiala S. (1968) The cancer cell as a stem cell unable to differentiate. Neoplasma 15: 607-622
    • (1968) Neoplasma , vol.15 , pp. 607-622
    • Fiala, S.1
  • 19
    • 0016605336 scopus 로고
    • The role of DNA repair and somatic mutation in carcinogenesis
    • Trosko J. E. and Chu E. H. (1975) The role of DNA repair and somatic mutation in carcinogenesis. Adv. Cancer Res. 21: 391-425
    • (1975) Adv. Cancer Res. , vol.21 , pp. 391-425
    • Trosko, J.E.1    Chu, E.H.2
  • 20
    • 0019548446 scopus 로고
    • An epigenetic model for the origin of cancer
    • Braun A. C. (1981) An epigenetic model for the origin of cancer. Q. Rev. Biol. 56: 33-60
    • (1981) Q. Rev. Biol. , vol.56 , pp. 33-60
    • Braun, A.C.1
  • 21
    • 0032862236 scopus 로고    scopus 로고
    • Differentiation: A central topic in developmental and cell biology
    • Muller W. A. (1999) Differentiation: a central topic in developmental and cell biology. Naturwissenschaften 86: 457-467
    • (1999) Naturwissenschaften , vol.86 , pp. 457-467
    • Muller, W.A.1
  • 22
    • 0002477990 scopus 로고
    • Epithelial proliferative subpopulations
    • Cambridge University Press, Cambridge
    • Potten C. S. (1978) Epithelial proliferative subpopulations. In: Stem Cells and Tissue Homeostasis, pp. 315-334, Cambridge University Press, Cambridge
    • (1978) Stem Cells and Tissue Homeostasis , pp. 315-334
    • Potten, C.S.1
  • 25
    • 0017261616 scopus 로고
    • Carcinogenic mechanisms: A critical review and a suggestion that oncogenesis may be adaptive ontogenesis
    • Nery R. (1976) Carcinogenic mechanisms: a critical review and a suggestion that oncogenesis may be adaptive ontogenesis. Chem. Biol. Interact. 12: 145-69
    • (1976) Chem. Biol. Interact. , vol.12 , pp. 145-169
    • Nery, R.1
  • 26
    • 0027892512 scopus 로고
    • Cellular origin of cancer: Dedifferentiation or stem cell maturation arrest?
    • Sell S. (1993) Cellular origin of cancer: dedifferentiation or stem cell maturation arrest? Environ. Health Perspect. 101 Suppl. 5: 15-26
    • (1993) Environ. Health Perspect. , vol.101 , Issue.SUPPL. 5 , pp. 15-26
    • Sell, S.1
  • 28
    • 0016195699 scopus 로고
    • Regulation of membrane changes, differentiation and malignancy in carcinogenesis
    • Sachs L. (1974) Regulation of membrane changes, differentiation and malignancy in carcinogenesis. Harvey Lect. 68: 1-35
    • (1974) Harvey Lect. , vol.68 , pp. 1-35
    • Sachs, L.1
  • 29
    • 0019493823 scopus 로고
    • Alterations in surface ultrastructure and anionic sites of rat dimethylhydrazine-induced intestinal tumors
    • Jacobs I. R. (1981) Alterations in surface ultrastructure and anionic sites of rat dimethylhydrazine-induced intestinal tumors. Virchows Arch. B Cell Pathol. Incl. Mol. Pathol. 37: 207-216
    • (1981) Virchows Arch. B Cell Pathol. Incl. Mol. Pathol. , vol.37 , pp. 207-216
    • Jacobs, I.R.1
  • 30
    • 0034080924 scopus 로고    scopus 로고
    • Connexin gene mutations in human genetic diseases
    • Krutovskikh V. andYamasaki H. (2000) Connexin gene mutations in human genetic diseases. Mutat. Res. 462: 197-207
    • (2000) Mutat. Res. , vol.462 , pp. 197-207
    • Krutovskikh, V.1    Yamasaki, H.2
  • 31
    • 0035451330 scopus 로고    scopus 로고
    • Mechanism of up-regulated gap junctional intercellular communication during chemoprevention and chemotherapy of cancer
    • Trosko J. E. and Chang C. C. (2001) Mechanism of up-regulated gap junctional intercellular communication during chemoprevention and chemotherapy of cancer. Mutat. Res. 480-481: 219-229.
    • (2001) Mutat. Res. , vol.480-481 , pp. 219-229
    • Trosko, J.E.1    Chang, C.C.2
  • 33
    • 0027361208 scopus 로고
    • Models of neoplasia and their diagnostic implications: A historical perspective
    • Goldberg D. M. and Diamandis E. P. (1993) Models of neoplasia and their diagnostic implications: a historical perspective. Clin. Chem. 39: 2360-2374
    • (1993) Clin. Chem. , vol.39 , pp. 2360-2374
    • Goldberg, D.M.1    Diamandis, E.P.2
  • 34
    • 0029077985 scopus 로고
    • The significance of the cholesterol biosynthetic pathway in cell growth and carcinogenesis
    • Rao K. N. (1995) The significance of the cholesterol biosynthetic pathway in cell growth and carcinogenesis (review). Anticancer Res. 15: 309-314
    • (1995) Anticancer Res. , vol.15 , pp. 309-314
    • Rao, K.N.1
  • 35
    • 0034011261 scopus 로고    scopus 로고
    • Oxyradicals and DNA damage
    • Marnett L. J. (2000) Oxyradicals and DNA damage. Carcinogenesis 21: 361-370
    • (2000) Carcinogenesis , vol.21 , pp. 361-370
    • Marnett, L.J.1
  • 36
    • 0027938689 scopus 로고
    • Oxy-radicals and cancer
    • Cerutti P. A. (1994) Oxy-radicals and cancer. Lancet 344: 862-863
    • (1994) Lancet , vol.344 , pp. 862-863
    • Cerutti, P.A.1
  • 37
    • 0034676492 scopus 로고    scopus 로고
    • A causal relationship between unscheduled eicosanoid signaling and tumor development: Cancer chemoprevention by inhibitors of arachidonic acid metabolism
    • Marks F., Muller-Decker K. and Furstenberger G. (2000) A causal relationship between unscheduled eicosanoid signaling and tumor development: cancer chemoprevention by inhibitors of arachidonic acid metabolism. Toxicology 153: 11-26
    • (2000) Toxicology , vol.153 , pp. 11-26
    • Marks, F.1    Muller-Decker, K.2    Furstenberger, G.3
  • 38
    • 0035296203 scopus 로고    scopus 로고
    • Role of nitric oxide in carcinogenesis and tumour progression
    • Lala P. K. and Chakraborty C. (2001) Role of nitric oxide in carcinogenesis and tumour progression. Lancet Oncol. 2: 149-156
    • (2001) Lancet Oncol. , vol.2 , pp. 149-156
    • Lala, P.K.1    Chakraborty, C.2
  • 39
    • 0026072467 scopus 로고
    • Nonmutagenic mechanisms in carcinogenesis: Role of protein kinase C in signal transduction and growth control
    • Weinstein I. B. (1991) Nonmutagenic mechanisms in carcinogenesis: role of protein kinase C in signal transduction and growth control. Environ. Health Perspect. 93: 175-179
    • (1991) Environ. Health Perspect. , vol.93 , pp. 175-179
    • Weinstein, I.B.1
  • 40
    • 0036490157 scopus 로고    scopus 로고
    • Id proteins - Tumor markers or oncogenes?
    • Hasskarl J. and Munger K. (2002) Id proteins - tumor markers or oncogenes? Cancer Biol. Ther. 1: 91-96
    • (2002) Cancer Biol. Ther. , vol.1 , pp. 91-96
    • Hasskarl, J.1    Munger, K.2
  • 42
    • 54249116230 scopus 로고
    • Genetic regulatory mechanisms in the synthesis of proteins
    • Jacob F. and Monod J (1961) Genetic regulatory mechanisms in the synthesis of proteins. J Mol. Biol. 3: 318-356
    • (1961) J. Mol. Biol. , vol.3 , pp. 318-356
    • Jacob, F.1    Monod, J.2
  • 43
    • 0014720786 scopus 로고
    • Epigenetic processes and their relevance to the study of neoplasia
    • Sherbert G. V. (1970) Epigenetic processes and their relevance to the study of neoplasia. Adv. Cancer Res. 13: 97-167
    • (1970) Adv. Cancer Res. , vol.13 , pp. 97-167
    • Sherbert, G.V.1
  • 45
    • 0033382990 scopus 로고    scopus 로고
    • Cell damage, aging and transformation: A multilevel analysis of carcinogenesis
    • Rubin H. (1999) Cell damage, aging and transformation: a multilevel analysis of carcinogenesis. Anticancer Res. 19: 4877-4886
    • (1999) Anticancer Res. , vol.19 , pp. 4877-4886
    • Rubin, H.1
  • 46
    • 0002861227 scopus 로고
    • Principles of molecular cell biology of cancer: Growth factors
    • DeVita V. T. Jr, Hellman S. and Rosenberg S. A. (eds), Lippincott-Raven, Philadelphia
    • Mendelson J. and Lippman M. E. (1993). Principles of molecular cell biology of cancer: growth factors. In: Cancer, Principles and Practice of Oncology, 4th edn, pp. 114-133, DeVita V. T. Jr, Hellman S. and Rosenberg S. A. (eds), Lippincott-Raven, Philadelphia
    • (1993) Cancer, Principles and Practice of Oncology, 4th Edn. , pp. 114-133
    • Mendelson, J.1    Lippman, M.E.2
  • 47
    • 0010523031 scopus 로고
    • Polypeptide and neuropeptide grqoth factos: Signalling pathways and role in cancer
    • Peckham M., Pinedo H. and U Veronesi U. (eds), Oxford University Press, Oxford
    • Rozengurt E. (1995) Polypeptide and neuropeptide grqoth factos: signalling pathways and role in cancer. In: Peckham M., Pinedo H. and U Veronesi U. (eds), Oxford Textbook of Oncology, pp. 12-20, Oxford University Press, Oxford
    • (1995) Oxford Textbook of Oncology , pp. 12-20
    • Rozengurt, E.1
  • 48
    • 0021958679 scopus 로고
    • Autocrine growth factors and cancer
    • Sporn M. B. and Roberts A. B. (1985) Autocrine growth factors and cancer. Nature 313: 745-747
    • (1985) Nature , vol.313 , pp. 745-747
    • Sporn, M.B.1    Roberts, A.B.2
  • 50
    • 0012018756 scopus 로고
    • Oncogenes and cell proliferation: An overview
    • D. M. Glover, and B. D. Hames (eds), IRL Press, Oxford
    • Marshall C. J. (1989) Oncogenes and cell proliferation: an overview. In: Oncogenes, pp. 1-21, D. M. Glover, and B. D. Hames (eds), IRL Press, Oxford
    • (1989) Oncogenes , pp. 1-21
    • Marshall, C.J.1
  • 52
    • 0004191854 scopus 로고
    • Oxford University Press, Oxford
    • rd edn, p. 222, Oxford University Press, Oxford
    • (1991) rd Edn. , pp. 222
    • Weatherall, D.J.1
  • 53
    • 0038227159 scopus 로고    scopus 로고
    • Principles of cancer management: Cancer genetics
    • DeVita, V. T., Hellman S. and Rosenberg S. A. (eds), Lippincott-Raven, Philadelphia
    • Bale A. E. and Li F. P. (1997) Principles of cancer management: cancer genetics. In: Cancer: Principles and Practice of Oncology, 5th edn, pp. 285-293, DeVita, V. T., Hellman S. and Rosenberg S. A. (eds), Lippincott-Raven, Philadelphia
    • (1997) Cancer: Principles and Practice of Oncology, 5th Edn. , pp. 285-293
    • Bale, A.E.1    Li, F.P.2
  • 54
    • 0026059515 scopus 로고
    • Tumor suppressor genes
    • Marshall C. J. (1991) Tumor suppressor genes. Cell 64: 313-326
    • (1991) Cell , vol.64 , pp. 313-326
    • Marshall, C.J.1
  • 55
    • 0025976103 scopus 로고
    • Recessive oncogenes, antioncogenes and tumour suppression
    • Mitchell C. D. (1991) Recessive oncogenes, antioncogenes and tumour suppression. Br. Med. Bull. 47: 136-56
    • (1991) Br. Med. Bull. , vol.47 , pp. 136-156
    • Mitchell, C.D.1
  • 56
    • 0021332973 scopus 로고
    • Retinoblastoma: Clues to human oncogenesis
    • Murphree A. L. and Benedict W. F. (1984) Retinoblastoma: clues to human oncogenesis. Science 223: 1028-1033
    • (1984) Science , vol.223 , pp. 1028-1033
    • Murphree, A.L.1    Benedict, W.F.2
  • 57
    • 0344766067 scopus 로고    scopus 로고
    • The emerging p53 gene family
    • Kaelin W. G. (1999) The emerging p53 gene family. J. Natl. Cancer Inst. 91: 594-598
    • (1999) J. Natl. Cancer Inst. , vol.91 , pp. 594-598
    • Kaelin, W.G.1
  • 58
    • 0032988122 scopus 로고    scopus 로고
    • Introduction: p53 - The first twenty years
    • Oren M. and Rotter V. (1999) Introduction: p53 - the first twenty years. Cell Mol. Life Sci. 55: 9-11
    • (1999) Cell Mol. Life Sci. , vol.55 , pp. 9-11
    • Oren, M.1    Rotter, V.2
  • 59
    • 0027401607 scopus 로고
    • The multistep nature of cancer
    • Vogelstein B. and Kinzler K. W. (1993) The multistep nature of cancer. Trends Genet. 9: 138-141
    • (1993) Trends Genet. , vol.9 , pp. 138-141
    • Vogelstein, B.1    Kinzler, K.W.2
  • 60
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • Kinzler K. W. and Vogelstein B. (1996) Lessons from hereditary colorectal cancer. Cell 87: 159-170
    • (1996) Cell , vol.87 , pp. 159-170
    • Kinzler, K.W.1    Vogelstein, B.2
  • 61
    • 0028559017 scopus 로고
    • Hypomethylation of DNA: An epigenetic mechanism involved in tumor promotion
    • Counts J. L. and Goodman J. I. (1994) Hypomethylation of DNA: an epigenetic mechanism involved in tumor promotion. Mol. Carcinog. 11: 185-188
    • (1994) Mol. Carcinog. , vol.11 , pp. 185-188
    • Counts, J.L.1    Goodman, J.I.2
  • 62
    • 0031467130 scopus 로고    scopus 로고
    • X-chromosome inactivation in mammals
    • Heard E., Clerc P. and Avner P. (1997) X-chromosome inactivation in mammals. Annu. Rev. Genet. 31: 571-610
    • (1997) Annu. Rev. Genet. , vol.31 , pp. 571-610
    • Heard, E.1    Clerc, P.2    Avner, P.3
  • 63
    • 0034003798 scopus 로고    scopus 로고
    • Epigenetic gene silencing in cancer
    • Tycko B. (2000) Epigenetic gene silencing in cancer. J. Clin. Invest. 105: 401-407
    • (2000) J. Clin. Invest. , vol.105 , pp. 401-407
    • Tycko, B.1
  • 64
    • 0032960181 scopus 로고    scopus 로고
    • Cancer epigenetics comes of age
    • Jones P. A. and Laird P. W. (1999) Cancer epigenetics comes of age. Nat. Genet. 21: 163-167
    • (1999) Nat. Genet. , vol.21 , pp. 163-167
    • Jones, P.A.1    Laird, P.W.2
  • 65
    • 0034176798 scopus 로고    scopus 로고
    • DNA hypermethylation in tumorigenesis: Epigenetics joins genetics
    • Baylin S. B. and Herman J. G. (2000) DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet. 16: 168-174
    • (2000) Trends Genet. , vol.16 , pp. 168-174
    • Baylin, S.B.1    Herman, J.G.2
  • 66
    • 0037068353 scopus 로고    scopus 로고
    • DNA methylation in cancer: Too much, but also too little
    • Ehrlich M. (2002) DNA methylation in cancer: too much, but also too little. Oncogene 21: 5400-1354
    • (2002) Oncogene , vol.21 , pp. 5400-1354
    • Ehrlich, M.1
  • 67
    • 0025805631 scopus 로고
    • Transcription and cancer
    • Cox P. M. and Goding C. R. (1991) Transcription and cancer. Br. J. Cancer 63: 651-662
    • (1991) Br. J. Cancer , vol.63 , pp. 651-662
    • Cox, P.M.1    Goding, C.R.2
  • 70
    • 0027880281 scopus 로고
    • Cell cycle controls: Potential targets for chemical carcinogens?
    • Afshari C. A. and Barrett J. C. (1993) Cell cycle controls: potential targets for chemical carcinogens? Environ. Health Perspect. 101 Suppl. 5: 9-14
    • (1993) Environ. Health Perspect. , vol.101 , Issue.SUPPL. 5 , pp. 9-14
    • Afshari, C.A.1    Barrett, J.C.2
  • 71
    • 0035063789 scopus 로고    scopus 로고
    • Molecular profiling of breast cancer: Portraits but not physiognomy
    • Brenton J. D., Aparicio S. A. and Caldas C. (2001) Molecular profiling of breast cancer: portraits but not physiognomy. Breast Cancer Res. 3: 77-80
    • (2001) Breast Cancer Res. , vol.3 , pp. 77-80
    • Brenton, J.D.1    Aparicio, S.A.2    Caldas, C.3
  • 73
    • 0038227158 scopus 로고
    • The study of tumours in animals
    • rd edn, Lloyd-Luke, London
    • rd edn, pp. 622-658, Lloyd-Luke, London
    • (1964) General Pathology , pp. 622-658
    • Berenblum, I.1
  • 74
    • 0019829342 scopus 로고
    • Mechanisms of chemical carcinogenesis
    • Miller E. C. and Miller J. A. (1981) Mechanisms of chemical carcinogenesis. Cancer 47 (5 Suppl.): 1055-1064
    • (1981) Cancer , vol.47 , Issue.5 SUPPL. , pp. 1055-1064
    • Miller, E.C.1    Miller, J.A.2
  • 76
    • 0027274815 scopus 로고
    • The molecular biology of carcinogenesis
    • Pitot H. C. (1993) The molecular biology of carcinogenesis. Cancer 72 (3 Suppl.): 962-70
    • (1993) Cancer , vol.72 , Issue.3 SUPPL. , pp. 962-970
    • Pitot, H.C.1
  • 77
    • 0033782874 scopus 로고    scopus 로고
    • The origin of oncogenic mutations: Where is the primary damage?
    • Steen H. B. (2000) The origin of oncogenic mutations: where is the primary damage? Carcinogenesis 21: 1773-1776
    • (2000) Carcinogenesis , vol.21 , pp. 1773-1776
    • Steen, H.B.1
  • 79
    • 0022160578 scopus 로고
    • Multistage models of carcinogenesis
    • Armitage P. (1985) Multistage models of carcinogenesis. Environ. Health Perspect. 63: 195-201
    • (1985) Environ. Health Perspect. , vol.63 , pp. 195-201
    • Armitage, P.1
  • 80
    • 0025312380 scopus 로고
    • The Armitage-Doll multistage model of carcinogenesis
    • Day N. E. (1990) The Armitage-Doll multistage model of carcinogenesis. Stat. Med. 9: 677-679
    • (1990) Stat. Med. , vol.9 , pp. 677-679
    • Day, N.E.1
  • 81
    • 0027130929 scopus 로고    scopus 로고
    • Multistage carcinogenesis - Genetic and epigenetic mechanisms in relation to cancer prevention
    • 11993
    • Pitot H. C. (11993) Multistage carcinogenesis - genetic and epigenetic mechanisms in relation to cancer prevention. Cancer Detect. Prev. 17: 567-573
    • Cancer Detect. Prev. , vol.17 , pp. 567-573
    • Pitot, H.C.1
  • 82
    • 0025486010 scopus 로고
    • Modulation of intercellular communication during radiation and chemical carcinogenesis
    • Trosko J. E., Chang C. C. and Madhukar B. V. (1990) Modulation of intercellular communication during radiation and chemical carcinogenesis. Radiat. Res. 123: 241-251
    • (1990) Radiat. Res. , vol.123 , pp. 241-251
    • Trosko, J.E.1    Chang, C.C.2    Madhukar, B.V.3
  • 84
    • 0000078117 scopus 로고    scopus 로고
    • Molecular biology of cancer: Invasion and metastasis
    • DeVita, V. T., Hellman S. and Rosenberg S. A. (eds), Lippincott-Raven, Philadelphia
    • Fidler I. J. (1997). Molecular biology of cancer: invasion and metastasis. In: Cancer: Principles and Practice of Oncology, 5th edn, pp. 135-152, DeVita, V. T., Hellman S. and Rosenberg S. A. (eds), Lippincott-Raven, Philadelphia
    • (1997) Cancer: Principles and Practice of Oncology, 5th Edn. , pp. 135-152
    • Fidler, I.J.1
  • 85
    • 0029919109 scopus 로고    scopus 로고
    • Hereditary cancer: Two hits revisited
    • Knudson A. G. (1996) Hereditary cancer: two hits revisited. J. Cancer Res. Clin. Oncol. 122: 135-140
    • (1996) J. Cancer Res. Clin. Oncol. , vol.122 , pp. 135-140
    • Knudson, A.G.1
  • 86
    • 0034511179 scopus 로고    scopus 로고
    • Chasing the cancer demon
    • Knudson A. G. (2000) Chasing the cancer demon. Annu. Rev. Genet. 34: 1-19
    • (2000) Annu. Rev. Genet. , vol.34 , pp. 1-19
    • Knudson, A.G.1
  • 87
    • 0035522894 scopus 로고    scopus 로고
    • Two genetic hits (more or less) to cancer
    • Knudson A. G. (2001) Two genetic hits (more or less) to cancer. Nat. Rev. Cancer. 1: 157-162
    • (2001) Nat. Rev. Cancer. , vol.1 , pp. 157-162
    • Knudson, A.G.1
  • 89
    • 0028691022 scopus 로고
    • From fluorescence spectra to mutational spectra, a historical overview and DNA-reactive compounds
    • Lawley P. D. (1994) From fluorescence spectra to mutational spectra, a historical overview and DNA-reactive compounds. IARC Scientific Publication No. 125: 3-22.
    • (1994) IARC Scientific Publication , vol.125 , pp. 3-22
    • Lawley, P.D.1
  • 90
    • 0025250171 scopus 로고
    • Protein adducts in the molecular dosimetry of chemical carcinogens
    • Skipper P. L. and Tannenbaum S. R. (1990) Protein adducts in the molecular dosimetry of chemical carcinogens. Carcinogenesis 11: 507-518
    • (1990) Carcinogenesis , vol.11 , pp. 507-518
    • Skipper, P.L.1    Tannenbaum, S.R.2
  • 91
    • 0034027867 scopus 로고    scopus 로고
    • Studies on biomarkers in cancer etiology and prevention: A summary and challenge of 20 years of inter-disciplinary research
    • Bartsch H. (2000) Studies on biomarkers in cancer etiology and prevention: a summary and challenge of 20 years of inter-disciplinary research. Mutat. Res. 462: 255-279
    • (2000) Mutat. Res. , vol.462 , pp. 255-279
    • Bartsch, H.1
  • 92
    • 0034092008 scopus 로고    scopus 로고
    • Carcinogen macromolecular adducts and their measurement
    • Poirier M. C., Santella R. M. and Weston A. (2000) Carcinogen macromolecular adducts and their measurement. Carcinogenesis 21: 353-359
    • (2000) Carcinogenesis , vol.21 , pp. 353-359
    • Poirier, M.C.1    Santella, R.M.2    Weston, A.3
  • 93
    • 0037192321 scopus 로고    scopus 로고
    • Molecular epidemiology and cancer: Promising areas for future research in the post-genomic era
    • Wild C. P., Law G. R. and Roman E. (2002) Molecular epidemiology and cancer: promising areas for future research in the post-genomic era. Mutat. Res. 499: 3-512
    • (2002) Mutat. Res. , vol.499 , pp. 3-512
    • Wild, C.P.1    Law, G.R.2    Roman, E.3
  • 94
    • 0027881803 scopus 로고
    • Absence of morphologic correlation between chemical toxicity and chemical carcinogenesis
    • Huff J. (1993) Absence of morphologic correlation between chemical toxicity and chemical carcinogenesis. Environ. Health Perspect. 101 Suppl. 5: 45-53
    • (1993) Environ. Health Perspect. , vol.101 , Issue.SUPPL. 5 , pp. 45-53
    • Huff, J.1
  • 95
    • 0029314191 scopus 로고    scopus 로고
    • DNA adducts in human carcinogenesis: Etiological relevance and structure-activity relationship
    • Bartsch H. (1996) DNA adducts in human carcinogenesis: etiological relevance and structure-activity relationship. Mutat. Res. 340: 67-79
    • (1996) Mutat. Res. , vol.340 , pp. 67-79
    • Bartsch, H.1
  • 96
    • 0032543359 scopus 로고    scopus 로고
    • The role of DNA adducts in chemical carcinogenesis
    • Garner R. C. (1998) The role of DNA adducts in chemical carcinogenesis. Mutat. Res. 402: 67-75
    • (1998) Mutat. Res. , vol.402 , pp. 67-75
    • Garner, R.C.1
  • 97
    • 0034125042 scopus 로고    scopus 로고
    • DNA adducts: Endogenous and induced
    • Povey A. C. (2000) DNA adducts: endogenous and induced. Toxicol. Pathol. 28: 405-414
    • (2000) Toxicol. Pathol. , vol.28 , pp. 405-414
    • Povey, A.C.1
  • 98
    • 0033804390 scopus 로고    scopus 로고
    • Factors that influence the mutagenic patterns of DNA adducts from chemical carcinogens
    • Seo K. Y., Jelinsky S. A. and Loechler E. L. (2000) Factors that influence the mutagenic patterns of DNA adducts from chemical carcinogens. Mutat. Res. 463: 215-246
    • (2000) Mutat. Res. , vol.463 , pp. 215-246
    • Seo, K.Y.1    Jelinsky, S.A.2    Loechler, E.L.3
  • 99
    • 0036382913 scopus 로고    scopus 로고
    • Toward understanding the mutagenicity of an environmental carcinogen: Structural insights into nucleotide incorporation preferences
    • Perlow RA, Broyde S. (2002) Toward understanding the mutagenicity of an environmental carcinogen: structural insights into nucleotide incorporation preferences. J. Mol. Biol. 322: 291-309
    • (2002) J. Mol. Biol. , vol.322 , pp. 291-309
    • Perlow, R.A.1    Broyde, S.2
  • 100
    • 0035366319 scopus 로고    scopus 로고
    • Evading the proofreading machinery of a replicative DNA polymerase: Induction of a mutation by an environmental carcinogen
    • Perlow R. A. and Broyde S. (2001) Evading the proofreading machinery of a replicative DNA polymerase: induction of a mutation by an environmental carcinogen. J. Mol. Biol. 309: 519-536
    • (2001) J. Mol. Biol. , vol.309 , pp. 519-536
    • Perlow, R.A.1    Broyde, S.2
  • 103
    • 0030904893 scopus 로고    scopus 로고
    • DNA methylation, heterochromatin and epigenetic carcinogens
    • Klein C. B. and Costa M. (1997) DNA methylation, heterochromatin and epigenetic carcinogens. Mutat. Res. 386: 163-180
    • (1997) Mutat. Res. , vol.386 , pp. 163-180
    • Klein, C.B.1    Costa, M.2
  • 104
    • 0027463052 scopus 로고
    • Comparison of target organs of carcinogenicity for mutagenic and non-mutagenic chemicals
    • Gold L. S., Slone T. H., Stern B. R. and Bernstein L. (1993) Comparison of target organs of carcinogenicity for mutagenic and non-mutagenic chemicals. Mutat. Res. 286: 75-100
    • (1993) Mutat. Res. , vol.286 , pp. 75-100
    • Gold, L.S.1    Slone, T.H.2    Stern, B.R.3    Bernstein, L.4
  • 105
    • 0026683780 scopus 로고
    • Non-genotoxic factors in the carcinogenetic process: Problems of detection and hazard evaluation
    • Parodi S., Malacarne D. and Taningher M. (1992) Non-genotoxic factors in the carcinogenetic process: problems of detection and hazard evaluation. Toxicol. Lett. 64-65: 621-630
    • (1992) Toxicol. Lett. , vol.64-65 , pp. 621-630
    • Parodi, S.1    Malacarne, D.2    Taningher, M.3
  • 106
    • 0035061652 scopus 로고    scopus 로고
    • Commentary: Is the concept of 'tumour promotion' a useful paradigm?
    • Trosko J. E. (2001) Commentary: is the concept of 'tumour promotion' a useful paradigm? Mol. Carcinog. 30: 131-137
    • (2001) Mol. Carcinog. , vol.30 , pp. 131-137
    • Trosko, J.E.1
  • 108
    • 0034509118 scopus 로고    scopus 로고
    • Epigenetic mechanisms of chemical carcinogenesis
    • Klaunig J. E., Kamendulis L. M. and Xu Y. (2000) Epigenetic mechanisms of chemical carcinogenesis. Hum. Exp. Toxicol. 19: 543-555
    • (2000) Hum. Exp. Toxicol. , vol.19 , pp. 543-555
    • Klaunig, J.E.1    Kamendulis, L.M.2    Xu, Y.3
  • 109
    • 0033163236 scopus 로고    scopus 로고
    • Epigenetic events during the process of cell transformation induced by carcinogens
    • Nguyen-Ba G. and Vasseur P. (1999) Epigenetic events during the process of cell transformation induced by carcinogens (review). Oncol. Rep. 6: 925-932
    • (1999) Oncol. Rep. , vol.6 , pp. 925-932
    • Nguyen-Ba, G.1    Vasseur, P.2
  • 110
    • 0035978873 scopus 로고    scopus 로고
    • Mutagens that are not carcinogens: Faulty theory or faulty tests?
    • Zeiger E. (2001) Mutagens that are not carcinogens: faulty theory or faulty tests? Mutat. Res. 492: 29-38
    • (2001) Mutat. Res. , vol.492 , pp. 29-38
    • Zeiger, E.1
  • 111
    • 0029435518 scopus 로고
    • Of mice and men: A critical reappraisal of the two-stage theory of carcinogenesis
    • Iversen O. H. (1995) Of mice and men: a critical reappraisal of the two-stage theory of carcinogenesis. Crit. Rev. Oncog. 6: 357-405
    • (1995) Crit. Rev. Oncog. , vol.6 , pp. 357-405
    • Iversen, O.H.1
  • 112
    • 0037611834 scopus 로고
    • Genetic instability in Escherichia coli
    • Schwartz N. M. (1965) Genetic instability in Escherichia coli. J. Bacteriol. 89: 712-717.
    • (1965) J. Bacteriol. , vol.89 , pp. 712-717
    • Schwartz, N.M.1
  • 113
    • 0014151680 scopus 로고
    • Altered base ratios in the DNA of an Escherichia coli mutator strain
    • Cox E. C. and Yanofsky C. (1967) Altered base ratios in the DNA of an Escherichia coli mutator strain. Proc. Natl Acad. Sci. USA 58: 1895-1902
    • (1967) Proc. Natl. Acad. Sci. USA , vol.58 , pp. 1895-1902
    • Cox, E.C.1    Yanofsky, C.2
  • 115
    • 0034500024 scopus 로고    scopus 로고
    • DNA mismatch repair and genetic instability
    • Harfe B. D. and Jinks-Robertson S. (2000) DNA mismatch repair and genetic instability. Annu. Rev. Genet. 34: 359-399
    • (2000) Annu. Rev. Genet. , vol.34 , pp. 359-399
    • Harfe, B.D.1    Jinks-Robertson, S.2
  • 116
    • 0002002741 scopus 로고
    • Genetic stability and instability in turnouts
    • M. Sluyser (ed.), Ellis Horwood, New York
    • Volpe J. (1990) Genetic stability and instability in turnouts. In: Molecular Biology of Cancer Genes, pp. 9-23. M. Sluyser (ed.), Ellis Horwood, New York
    • (1990) Molecular Biology of Cancer Genes , pp. 9-23
    • Volpe, J.1
  • 117
    • 0015083627 scopus 로고
    • Genetic implication of karyological instability of malignant somatic cells
    • Ono S. (1971) Genetic implication of karyological instability of malignant somatic cells. Physiol. Rev. 51: 496-526.
    • (1971) Physiol. Rev. , vol.51 , pp. 496-526
    • Ono, S.1
  • 118
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • Nowell P. C. (1976) The clonal evolution of tumor cell populations. Science 194: 23-28
    • (1976) Science , vol.194 , pp. 23-28
    • Nowell, P.C.1
  • 119
    • 0016692602 scopus 로고
    • Mutation selection and the natural history of cancer
    • Cairns J. (1975) Mutation selection and the natural history of cancer. Nature 255: 197-200
    • (1975) Nature , vol.255 , pp. 197-200
    • Cairns, J.1
  • 120
    • 0014421995 scopus 로고
    • Defective repair replication of DNA in xeroderma pigmentosum
    • Cleaver J. E. (1968) Defective repair replication of DNA in xeroderma pigmentosum. Nature 218: 652-656
    • (1968) Nature , vol.218 , pp. 652-656
    • Cleaver, J.E.1
  • 122
    • 0020286123 scopus 로고
    • Is the establishment of a clone exhibiting defective DNA repair the initial stage of carcinogenesis?
    • Riley P. A. (1982) Is the establishment of a clone exhibiting defective DNA repair the initial stage of carcinogenesis? Med. Hypotheses 9: 163-168
    • (1982) Med. Hypotheses , vol.9 , pp. 163-168
    • Riley, P.A.1
  • 123
    • 0025615595 scopus 로고
    • Is the initial event in carcinogenesis an enhancement of the mutation rate?
    • Riley P. A. (1990) Is the initial event in carcinogenesis an enhancement of the mutation rate? Free Radic. Res. Commun. 11: 59-63
    • (1990) Free Radic. Res. Commun. , vol.11 , pp. 59-63
    • Riley, P.A.1
  • 124
    • 0030442815 scopus 로고    scopus 로고
    • Many mutations in cancers
    • Loeb L. A. (1996) Many mutations in cancers. Cancer Surv. 28: 329-342
    • (1996) Cancer Surv. , vol.28 , pp. 329-342
    • Loeb, L.A.1
  • 125
    • 0034011427 scopus 로고    scopus 로고
    • Significance of multiple mutations in cancer
    • Loeb K. R. and Loeb L. A. (2000) Significance of multiple mutations in cancer. Carcinogenesis 21: 379-385
    • (2000) Carcinogenesis , vol.21 , pp. 379-385
    • Loeb, K.R.1    Loeb, L.A.2
  • 126
    • 0035870243 scopus 로고    scopus 로고
    • A mutator phenotype in cancer
    • Loeb L. A. (2001) A mutator phenotype in cancer. Cancer Res. 61: 230-239
    • (2001) Cancer Res. , vol.61 , pp. 230-239
    • Loeb, L.A.1
  • 127
    • 0033395272 scopus 로고    scopus 로고
    • Genomic instability: First step to carcinogenesis
    • Schmutte C. and Fishel R. (1999) Genomic instability: first step to carcinogenesis. Anticancer Res. 19: 4665-4696
    • (1999) Anticancer Res. , vol.19 , pp. 4665-4696
    • Schmutte, C.1    Fishel, R.2
  • 129
    • 0029095626 scopus 로고
    • Interaction of bulky chemical carcinogens with DNA in chromatin
    • MacLeod M. C. (1995) Interaction of bulky chemical carcinogens with DNA in chromatin. Carcinogenesis 16: 2009-2014
    • (1995) Carcinogenesis , vol.16 , pp. 2009-2014
    • MacLeod, M.C.1
  • 130
    • 0028073444 scopus 로고
    • Base-specific arrest of in vitro DNA replication by carcinogenic chromium: Relationship to DNA interstrand crosslinking
    • Bridgewater L. C., Manning F. C. and Patierno S. R. (1994) Base-specific arrest of in vitro DNA replication by carcinogenic chromium: relationship to DNA interstrand crosslinking. Carcinogenesis 15: 2421-2427
    • (1994) Carcinogenesis , vol.15 , pp. 2421-2427
    • Bridgewater, L.C.1    Manning, F.C.2    Patierno, S.R.3
  • 133
    • 0023219250 scopus 로고
    • Persistent structural change in replicating hepatic DNA isolated from diethylnitrosamine-treated rats
    • Stewart B. W. and Hristoforidis C. (1987) Persistent structural change in replicating hepatic DNA isolated from diethylnitrosamine-treated rats. Cancer Lett. 35: 263-269
    • (1987) Cancer Lett. , vol.35 , pp. 263-269
    • Stewart, B.W.1    Hristoforidis, C.2
  • 135
    • 0002926374 scopus 로고    scopus 로고
    • Hormonal therapies
    • DeVita, V. T., Hellman S. and Rosenberg S. A. (eds), Lippincott-Raven, Philadelphia
    • Ehrlichman C. and Loprinzi C. L. (1997) Hormonal therapies. In: Cancer: Principles and Practice of Oncology, 5th edn, pp. 395-405, DeVita, V. T., Hellman S. and Rosenberg S. A. (eds), Lippincott-Raven, Philadelphia
    • (1997) Cancer: Principles and Practice of Oncology, 5th Edn. , pp. 395-405
    • Ehrlichman, C.1    Loprinzi, C.L.2
  • 136
    • 84989405875 scopus 로고
    • Synchronization of mammalian cells with respect to the mitotic cycle
    • Nais A.H. and Fox M. (1971) Synchronization of mammalian cells with respect to the mitotic cycle. Cell Tissue Kinet. 4: 375-398
    • (1971) Cell Tissue Kinet. , vol.4 , pp. 375-398
    • Nais, A.H.1    Fox, M.2
  • 137
    • 0032925857 scopus 로고    scopus 로고
    • Genetic factors affecting the impact of DNA polymerase delta proofreading activity on mutation avoidance in yeast
    • Tran H. T., Degtyareva N. P., Gordenin D. A. and Resnick M. A. (1999) Genetic factors affecting the impact of DNA polymerase delta proofreading activity on mutation avoidance in yeast. Genetics 152: 47-59
    • (1999) Genetics , vol.152 , pp. 47-59
    • Tran, H.T.1    Degtyareva, N.P.2    Gordenin, D.A.3    Resnick, M.A.4


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