New trends in photobiology (invited review). Photocarcinogenesis: An overview

Journal of Photochemistry and Photobiology B: Biology

Volumn 40, Issue 1, 1997, Pages 29-47

  Black, H S ^a   DeGruijl, F R ^b   Forbes, P D ^c   Cleaver, J E ^d   Ananthaswamy, H N ^e   DeFabo, E C ^f   Ullrich, S E ^e   Tyrrell, R M ^g  

^a MICHAEL E DEBAKEY VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c Argus Research Laboratories Inc   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^f GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^g University of Bath   (United Kingdom)

Author keywords

DNA photoproducts; DNA repair; Free radicals; Gene mutation; Photocarcinogenesis; Skin cancer

Indexed keywords

ANTIOXIDANT; DEOXYRIBODIPYRIMIDINE PHOTOLYASE; FREE RADICAL; PROTEIN P53; PYRIMIDINE DIMER; RADICAL; REACTIVE OXYGEN METABOLITE; DNA;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; CANCER PREVENTION; CANCER THERAPY; DIET; DNA DAMAGE; DNA REPAIR; DNA STRUCTURE; DOSIMETRY; FAT INTAKE; GENE INDUCTION; GENE MUTATION; HELPER CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOMODULATION; LIGHT DAMAGE; MOUSE; NONHUMAN; ONCOGENE RAS; OXIDATIVE STRESS; PHOTOCHEMISTRY; PRIORITY JOURNAL; PROTO ONCOGENE; RADIATION CARCINOGENESIS; RADIATION EXPOSURE; RADIATION PROTECTION; RAT; REVIEW; SKIN CANCER; SKIN CARCINOGENESIS; ULTRAVIOLET RADIATION; ANIMAL; DNA ADDUCT; GENETICS; MUTATION; RADIATION INJURY; RODENT; SKIN TUMOR; TUMOR SUPPRESSOR GENE;

ANIMALIA;

ANIMALS; DNA; DNA ADDUCTS; DNA DAMAGE; DNA REPAIR; GENES, TUMOR SUPPRESSOR; HUMANS; MUTATION; NEOPLASMS, RADIATION-INDUCED; PROTO-ONCOGENES; RODENTIA; SKIN NEOPLASMS; ULTRAVIOLET RAYS;

EID: 0031204599     PISSN: 10111344     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1011-1344(97)00021-3     Document Type: Article

References (194)

1. D.L. Miller, M.A. Weinstock, Nonmelanoma skin cancer in the United States: incidence, J. Amer. Acad. Dermatol. 30 (1994) 774-778.
2. H.K. Koh, R.A. Lew, A.C. Geller, D.R. Miller, B.E. Davis, Skin cancer: Prevention and control, in: P. Greenwald, B.S. Kramer,D.L. Weed (eds.), Cancer Prevention and Control, Marcel Dekker, Inc., New York, 1995, pp. 611-640.
3. F.R. De Gruijl, P.D. Forbes, UV-induced skin cancer in a hairless mouse model, Bio Essays 17 (1995) 651-660.
4. M.J. Peak, J.G. Peak, M.P. Moering, R.B. Webb, Ultraviolet action spectra for DNA dimer induction, lethality and mutatgenesis in Escherichia coli with emphasis on the UVB region, Photochem. Photobiol. 40 (1984) 613-620.
5. I.C. Enninga, R.T.L. Groenendijk, A.R. Filon, A.A. van Zeeland, J.W.I.M. Simons, The wavelength dependence of u.v.-induced pyrimidine dimer formation, cell killing and mutation induction in human diploid skin fibroblasts, Carcinogenesis 7 (1986) 1829-1836.
6. F.R. De Gruijl, H.J.C.M. Sterenborg, P.D. Forbes, R.E. Davies, C. Cole, G. Kelfkens, H. van Weelden, H. Slaper, J.C. van der Leun, Wavelength dependence of skin cancer induction by ultraviolet irradiation of albino hairless mice, Cancer Res. 53 (1993) 53-60.
7. R.J.W. Berg, A. de Laat, L. Roza, J.C. van der Leun, F.R. de Gruijl, Substitution of equally carcinogenic UV-A for UV-B irradiations lowers epidermal thymine dimer levels during skin cancer induction in hairless mice, Carcinogenesis 16 (1995) 2455-2459.
8. H.J. Van Kranen, J.M.T. de Laat, J. van Ven, P.W. Wester, A. de Vries, R.J.W. Berg, F.R. de Gruijl, Aberrant p53 less frequent in UVA- than in UVB-induced skin tumors, Photochem. Photobiol. 63S (1996) 108S.
9. R.J.W. Berg, F.R. de Gruijl, J.C. van der Leun, Interaction between ultraviolet-A and ultraviolet-B radiations in skin cancer induction in hairless mice, Cancer Res. 53 (1993) 4212-4217.
10. F.R. De Gruijl, J.C. van der Leun, Estimate of the wavelength dependency of ultraviolet Carcinogenesis in humans and its relevance to the risk assessment of a stratospheric ozone depletion, Health Phys. 67 (1994) 314-325.
11. S.E. Freeman, H. Hacham, R.W. Gange, D.J. Maytum, J.C. Sutherland, B.M. Sutherland, Wavelength dependence of pyrimidine dimer formation in DNA of human skin irradiated in situ with ultraviolet light, Proc. Natl. Acad. Sci. USA 86 (1989) 5605-5609.
12. F.R. De Gruijl, J.B. van der Meer, J.C. van der Leun, Dose-time dependency of tumor formation by chronic UV exposure, Photochem. Photobiol. 37 (1983) 53-62.
13. F.R. De Gruijl, J.C. van der Leun, Development of skin tumors in hairless mice after discontinuation of ultraviolet irradiation, Cancer Res. 51 (1991) 979-984.
14. I. Berenblum, Theoretical and practical aspects of the two-stage mechanism of Carcinogenesis, in: A.C. Griffin, C.R. Shaw (eds.), Carcinogens: Identification and Mechanisms of Action, Raven Press, New York, 1979, pp. 25-36.
15. E.C. Friedberg, DNA Repair, W.H. Freeman, New York, 1985.
16. B.M. Sutherland, L.C. Harber, I.E. Kochevar, Pyrimidine dimer formation and repair in human skin, Cancer Res. 40 (1980) 3181-3185.
17. A.R. Young, C.A. Chadwick, G.I. Harrison, J.L.M. Hawk, O. Nikaido, C.S. Potten, The in situ repair kinetics of epidermal thymine dimers and 6-4 photoproducts in human skin types I and II, J. Invest. Dermatol. 106 (1996) 1307-1313.
18. X. Qin, S. Zhang, Y. Nakatsuru, H. Oda, Y. Yamazaki, T. Suzuki, O. Nikaido, T. Ishikawa, Detection of active UV-photoproduct repair in monkey skin in vivo by quantitative immunohistochemistry, Cancer Lett. 83 (1994) 291-298.
19. J.E. Cleaver, K.H. Kraemer. Xeroderma pigmentosum and Cockayne Syndrome, in: C.R. Scriver, A.L. Beaudet, W.S. Sly, D. Valle (eds.), The Metabolic and Molecular Bases of Inherited Disease 6th edn., Vol. III, McGraw-Hill, New York, 1995, pp. 4393-4419.
20. A. Sancar, Mechanisms of DNA excision repair, Science 266 (1994) 1954-1956.
21. D.L. Mitchell, R.S. Nairn, The biology of the (6-4) photoproduct, Photochem. Photobiol. 49 (1989) 805-819.
22. D.L. Mitchell, D.E. Brash, R.S. Nairn, Rapid repair kinetics of pyrimidine (6-4) pyrimidinone photoproducts in human cells are due to excision rather than conformational change, Nucleic Acids Res. 18 (1990) 963-971.
23. D.L. Mitchell, J.E. Cleaver, J.H. Epstein, Repair of pyrimidine (6-4) pyrimidinone photoproducts in mouse skin, J. Invest. Dermatol. 95 (1990) 55-59.
24. J.E. Cleaver, DNA damage and repair in normal, xeroderma pigmentosum, and XP revertant cells analyzed by gel electrophoresis: excision of cyclobutane dimers from the whole genome is not necessary for cell survival, Carcinogenesis 10 (1989) 1691-1696.
25. K. Tanaka, I. Satokata, Z. Ogita, T. Uchida, Y. Okada, Molecular cloning of a mouse DNA repair gene that complements the defect in group A xeroderma pigmentosum, Proc. Natl. Acad. Sci. USA 86 (1989) 5512-5516.
26. I. Satokata, K. Iwa, T. Matsuda, Y. Okata, K. Tanaka, Genomic characterization of the human DNA excision repair-controlling gene XPAC, Gene 136 (1989) 345-348.
27. I. Miyamoto, N. Miura, H. Niwa, I. Miyamoto, Y. Satoh, S. Kondo, K. Tanaka, Mutational analysis of the structure and function of the xeroderma pigmentosum groupA complementing protein. Identification of essential domains for nuclear localization and DNA excision repair, J. Biol. Chem. 267 (1992) 19786-19789.
28. J.E. Cleaver, W.C. Charles, G.H. Thomas, M.L. McDowell, A deletion and an insertion in the alleles for the xeroderma pigmentosum (XPA) DNA-binding protein in mildly affected patients. Human Mol. Genetics 4 (1995) 1685-1687.
29. C.J. Jones, R.D. Wood, Preferential binding of the xeroderma pigmentosum group A complementing protein to damaged DNA, Biochem. 32 (1993) 12096-12116.
30. L. Li, S.J. Eledge, C.A. Pererson, E.S. Bales, R.J. Legerski, Specific association between the human DNA repair proteins XPA and ERCC1, Proc. Natl. Acad. Sci. USA 91 (1994) 5012-5016.
31. L. Schaeffer, R. Roy, S. Humbert, V. Moncollin, W. Vermeulen, J.H.J. Hoeijmakers, P. Chambon, J.M. Egly, DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor, Science 260 (1993) 58-63.
32. C.H. Park, D. Mu, J.T. Reardon, A. Sancar, The general transcription factor TFIIH is recruited to the excision repair complex by the XPA protein independent of the TFIIE transcription factor, J. Biol. Chem. 270 (1995) 4896-4902.
33. L. Li, X. Lu, C.A. Peterson, R.J. Legerski, An interaction between the DNA repair factor XPA and replication protein A appears essential for nucleotide excision repair, Mol. Cell. Biol. 15 (1995) 5396-5402.
34. A. Sancar, DNA excision repair, Ann. Rev. Biochem. 65 (1996) 43-81.
35. S. Tornaletti, G.P. Pfeifer, Slow repair of pyrimidine dimers at p53 mutation hotspots in skin cancer, Science 263 (1994) 1436-1438.
36. S. Tornaletti, G.P. Pfeifer, UV light as a footprinting agent: modulation of UV-induced DNA damage by transcription factors bound at the promoters of three human genes, J. Mol. Biol. 249 (1995) 714-728.
37. G.P. Pfeifer, R. Drouin, A.D. Riggs, G.P. Holmquist, Binding of transcription factors creates hotspots for UV photoproducts. Mol. Cell. Biol. 12 (1992) 1798-1804.
38. Y. Tu, S. Tornaletti, G.P. Pfeifer, DNA repair domains within a human gene: selective repair of sequences near the transcription initiation site, EMBO J. 15 (1996) 675-683.
39. S. Gao, R. Drouin, G.P. Holmquist, DNA repair rates mapped along the human PGK-1 gene at nucleotide resolution, Science 263 (1994) 1438-1440.
40. D.L. Mitchell, C.A. Haipe, J.M. Clarkson, (6-4) photoproducts are removed from the DNA of UV-irradiated mammalian cells more efficiently than cyclobutane dimers, Mutation Res. 143 (1985) 109-112.
41. V. Bohr, DNA repair fine structure and its relations to genomic instability, Carcinogenesis 16 (1995) 2885-2892.
42. J. Venema, Av Hoffen, V. Karcagi, A.T. Natarajan, Aav Zeeland, L.H. Mullenders, Xeroderma pigmentosum complementation group C cells remove pyrimidine dimers selectively from the transcribed strand of active genes, Mol. Cell. Biol. 11 (1991) 4128-4134.
43. J. Venema, Av Hoffen, A.T. Natarajan, A.A van Zeeland, L.H. Mullenders, The residual repair capacity of xeroderma pigmentosum complementation group C fibroblasts is highly specific for transcriptionally active DNA, Nucleic Acids Res. 18 (1990) 443-448.
44. A.T. Sands, A. Abuin, A. Sanchez, C.J. Conti, A. Bradley, High susceptibility to ultraviolet-induced carcinogenesis in mice lacking XPC, Nature 377 (1995) 162-165.
45. R. Verhage, A-M. Zeeman, N. de Groot, F. Gleig, D.D. Bang, P. van de Putte, J. Brouwer, The RAD7 and RAD16 genes, which are essential for pyrimidine dimer removal from the silent mating type loci, are also required for repair of the nontranscribed strand of an active gene in Sacchararomyces cerevisiae, Mol. Cell. Biol. 14 (1994) 6135-6142.
46. J.S. Kinley, G. Brunborg, J. Moan, A.R. Young, Detection of UVR-induced DNA damage in mouse epidermis in vivo using alkaline elution, Photochem. Photobiol. 61 (1995) 149-158.
47. D.B. Yarosh, V. Yee, SKH-1 hairless mice repair UV-induced pyrimidine dimers in epidermal DNA, J. Photochem. Photobiol. 7 (1990) 173-179.
48. M.E Baer, G.B. Sancar, Photolyases from Saccharomyces cerevisiae and Escherichia coli recognize common binding determinants in DNA containing pyrimidine dimers, Mol. Cell. Biol. 9 (1989) 4777-4788.
49. M.S. Jorns, B.Y. Wang, S. PJ, L.P. Chanderkar, Chromophore function and interaction in Escherichia coli DNA photolyase: reconstitution of the apoenzyme with ptenin and/or flavin derivatives, Biochemistry 29 (1990) 552-561.
50. T. Kato Jr, T. Todo, H. Ayaki, K. Ishizaki, T. Morita, S. Mitra, M. Ikenaga, Cloning of a marsupial DNA photolyase gene and the lack of related nucleic acid sequences in placental mammals, Nucleic Acids Res. 22 (1994) 4119-4124.
51. A. Kelner, Photoreactivation of ultraviolet-irradiated Escherichia coli, with special reference to the dose-reduction principle and to ultraviolet-induced mutation, J. Bacteriol. 58 (1949) 511-522.
52. H.W. Park, S.T. Kim, A. Sancar, J. Delsenhofer, Crystal structure of DNA photolyase from Escherichia coli, Science 268 (1995) 1866-1872.
53. A. Sancar, Structure and function of DNA photolyase, Biochemistry 33 (1994) 2-9.
54. D. Schild, J. Johnstone, C. Chang, R.K. Mortime, Cloning and mapping of Saccharomyces cerevesiae photoreactivation gene PHRI, Mol. Cell. Biol. 4 (1984) 1864-1870.
55. A. Yasui, A.P.M. Eker, S. Yasuhira, H. Yajima, T. Kobayashi, M. Takao, A. Oikawa, A new class of DNA photolyases present in various organisms including aplacental mammals, EMBO J. 13 (1994) 6143-6151.
56. T. Todo, H. Ryo, K. Yamamoto, H. Toh, T. Inul, H. Ayaki, T. Nomura, M. Ikenaga, Similarity among the Drosophila (6-4) photolyase, a human photolyase homolog, and the DNA photolyase-blue-light photoreceptor family, Science 272 (1996) 109-112.
57. T. Todo, H. Takemori, H. Ryo, M. Ihara, T. Matsunaga, O. Nikaido, K. Sata, T. Nomura, A new photoreactivation enzyme that specifically repairs ultraviolet induced (6-4) photoproducts, Nature 361 (1993) 371-374.
58. Z. Ozer, J.T. Reardon, D.S. Hsu, K. Malhotra, A. Sancar, The other function of DNA photolyase: stimulation of excision repair of chemical damage to DNA, Biochemistry 34 (1995) 15886-15889.
59. Y.F. Li, S.T. Kim, A. Sancar, Evidence for lack of DNA photoreactivation enzyme in humans, Proc. Natl. Acad. Sci. USA. 90 (1993) 4389-4393.
60. H.N. Ananthaswamy, W.E. Pierceall, Molecular mechanisms of ultraviolet radiation carcinogenesis, Photochem. Photobiol. 52 (1990) 1119-1136.
61. W.E. Pierceall, L.H. Goldberg, M.A. Tainsky, T. Mukhopadhyay, H.N. Ananthaswamy, Ras gene mutation and amplification in human nomnelanoma skin cancers, Mol. Carcinog. 4 (1991) 196-202.
62. J.L.M. van der Lubbe, H.J.M. Rosdorff, J.L. Bos, A.J. van der Eb, Activation of N-ras induced by ultraviolet irradiation in vitro, Oncogene Res. 3 (1988) 9-20.
63. W.E. Pierceall, H.N. Ananthaswamy, Transformation of NIH 3T3 cells by transfection with UV-irradiated human c-Ha-ras-1 protooncogene DNA, Oncogene 6 (1991) 2085-2091.
64. W.E. Pierceall, M.L. Kripke, H.N. Ananthaswamy, N-ras mutations in ultraviolet radiation-induced murine skin cancers, Cancer Res. 52 (1992) 3946-3951.
65. H.N. Ananthaswamy, L.A. Applegate, L.H. Goldberg, E.S. Bales, Deletion of the c-Ha-ra.s-1 allele in human skin cancers, Mol. Carcinogen. 2 (1989) 298-301.
66. W. Maltzman, L. Czyzyk, UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells, Mol. Cell. Biol. 4 (1984) 1689-1694.
67. M.B. Kastan, O. Onyekwere, D. Sidransky, B. Vogelstein, R.W. Craig, Participation of p53 protein in the cellular response to DNA damage, Mol. Cell. Biol. 51 (1991) 6304-6311.
68. S.J. Kuerbitz, B.S. Plunkett, W.V. Walsh, M.B. Kastan, Wild-type p53 is a cell cycle checkpoint determinant following irradiation, Proc. Natl. Acad. Sci. USA 89 (1992) 7491-7495.
69. Q. Zahn, F. Carrier, A.J. Fornace, Jr., Induction of cellular p53 activity by DNA-damaging agents and growth arrest, Mol Cell. Biol. 13 (1993) 4242-4250.
70. M. Fritsche, C. Haessler, G. Brandner, Induction of the nuclear accumulation of the tumor supressor gene p53 by DNA damaging agents, Oncogene 8 (1993) 307-318.
71. E. Healy, N.J. Reynolds, M.D. Smith, C. Campbell, P.M. Farr, J.L. Rees, Dissociation of erythema and p53 protein expression in human skin following UVB irradiation, and induction of p53 protein and mRNA following application of skin irritants, J. Invest. Dermatol. 103 (1994) 493-499.
72. P. Hall, P.H. McKee, H.P. Menage, R. Dover, D.P. Lane, High levels of p53 protein in UV-induced normal human skin, Oncogene 8 (1993) 203-207.
73. C. Campbell, A.G. Quinn, B. Angus, P.M. Farr, J.L. Rees, Wavelength specific patterns of p53 induction in human skin following exposure to UV radiation, Cancer Res. 53 (1993) 2697-2699.
74. D. Lane, p53, guardian of the genome, Nature 358 (1992) 15-16.
75. A. Ziegler, A.S. Jonason, D.J. Leffell, J.A. Simon, H.W. Sharma, J. Kimmelmann, L. Remington, T. Jacks, D.E. Brash, Sunbum and p53 in the onset of skin cancer, Nature 372 (1994) 773-776.
76. D.E. Brash, J.A. Rudolph, J.A. Simon, A. Lin, G.J. McKenna, H.P. Baden, A.J. Halperin, J. Ponten, A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma, Proc. Natl. Acad. Sci. USA 88 (1991) 10124-10128.
77. A. Ziegler, D.J. Leffell, S. Kunala, H.W. Shanna, M. Gailani, J.A. Simon, A.J. Halperin, H.P. Baden, P.E. Shapiro, A.E. Bale, D.E. Brash, Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers, Proc. Natl. Acad. Sci. USA 90 (1993) 4216-4220.
78. P. Rady, F. Scinicariello, R.F. Wagner, S.K. Tyring, p53 mutations in basal cell carcinomas, Cancer Res. 52 (1992) 3804-3806.
79. W.E. Pierceall, T. Mukhopadhyay, L.H. Goldberg, H.N. Ananthaswamy, Mutations in p53 tumor suppressor gene in human cutaneous squamous cell carcinomas, Mol. Carcinog. 4 (1991) 445-449.
80. J.P. Moles, C. Moyret, B. Guillot, P. Jeanteur, J.J. Guilhou, C. Theillet, N. Basset-Seguin, p53 gene mutations in human epithelial skin cancers, Oncogene 8 (1993) 583-588.
81. A.J. Nataraj, J.C. Trent, H.N. Ananthaswamy, p53 gene mutations and photocarcinogenesis, Photochem. Photobiol. 62 (1995) 218-230.
82. N. Dumaz, C. Drougard, A. Sarasin, L. Daya-Grosjean, Specific UV-induced mutation spectrum in the p53 gene of skin tumors in DNA repair deficient xeroderma pigmentosum patients, Proc. Natl. Acad. Sci. USA 90 (1993) 10 529-10 533.
83. M. Sato, C. Nishigori, M. Zghal, T. Yagi, H. Takebe, Ultraviolet-specific mutations in the p53 gene in skin tumors in xeroderma pigmentosum patients, Cancer Res. 53 (1993) 2944-2946.
84. S. Kress, S.C. Sutter, P.T. Strickland, H. Mukhtar, J. Schweizer, M. Schwartz, Carcinogen-specific mutational pattern in the p53 gene in ultraviolet B radiation-induced squamous cell carcinomas of mouse skin, Cancer Res. 52 (1992) 6400-6403.
85. S. Kanjilal, W.F. Pierceall, K.K. Cummings, M.L. Kripke, H.N. Ananthaswamy, High frequency of p53 mutations in ultraviolet radiation-induced murine skin tumors: Evidence for strand bias and tumor heterogeneity, Cancer Res. 53 (1993) 2961-2964.
86. C. Campbell, A.G. Quinn, Y.S. Ro, B. Angus, J.L. Rees, p53 mutations are common and early events that precede tumor invasion in squamous cell neoplasia of the skin, J. Invest. Dermatol. 100 (1993) 746-748.
87. H. Nakazawa, D. English, P.L. Randell, K. Nakazawa, N. Martel, B.K. Armstrong, H. Yamasaki, UV and skin cancer: Specific p53 gene mutation in normal skin as a biologically relevant exposure measurement, Proc. Natl. Acad. Sci. USA 91 (1994) 360-364.
88. M.A. Nelson, J.G. Einspahr, D.S. Alberts, C.A. Balfour, J.A. Wymer, K.L. Welch, S.J. Salasche, J.L Bangert, T.M. Grogan, P.O. Bozzo, Analysis of p53 gene in human precancerous actinic keratosis lesions and squamous cell cancers. Cancer Lett. 85 (1994) 23-29.
89. S. Kanjilal, S. Strom, G. Clayman, R. Weber, A. El-Naggar, K.K. Cummings, L.A. Hill, V. Kapur, M. Spitz, M.L. Kripke, H.N. Ananthaswamy, p53 mutations in nomnelanoma skin cancer of the head and neck: Molecular evidence for field cancerization, Cancer Res. 55 (1995) 3604-3609.
90. R.J.W. Berg, H.J. van Kranen, H.G. Rebel, A. deVries, W.A. van Vloten, C.F. van Kreijl, J.C. van der Leun, F.R. de Gruijl, Early p53 alterations in mouse skin carcinogenesis by UVB radiation: Immunohistochemical detection of mutant p53 protein in clusters of preneoplastic epidermal cells, Proc. Natl. Acad. Sci. USA 93 (1996) 274-278.
91. C. Campbell, A.G. Quinn, B. Angus, J.L. Rees, The relation between p53 mutation and p53 immunostaining in non-melanoma skin cancer, Br. J. Dermatol. 129 (1993) 235-241.
92. Y. Kubo, Y. Urano, K. Yoshimoto, H. Iwahana, K. Fukuhara, S. Arase, M. Itakura, p53 gene mutations in human skin cancers and precancemus lesions: Comparision with immunohistochemical analysis, J. Invest. Dermatol. 102 (1994) 440-444.
93. L.J. Kinlen, A.G.R. Sheil, J. Peto, R. Doll, Collaborative United Kingdom-Australasian study of cancer patients treated with immunosuppressive drugs, Br. Med. J. 2 (1979) 1461-1466.
94. M.L. Kripke, Antigenicity of murine skin tumors induced by ultraviolet light, J. Natl. Cancer Inst. 53 (1974) 1333-1336.
95. Y. Sontag, J. Garssen, H. van Loveren, J.C. van der Leun, W.A. van Vloten, F.R. de Gruijl, Time and dose dependence of acceptance of UV-induced syngeneic tumor implants in chronically UV-exposed hairless mice, submitted.
96. J.W. Streilein, J.R. Taylor, T. Yoshikawa, I. Kurimoto, Immunology of human skin and its relationship to skin cancers, Cancer Bull. 45 (1993) 225-231.
97. M.S. Fisher, M.L. Kripke, Suppressor T lymphocytes control the development of primary skin cancers in ultraviolet-irradiated mice, Science 216 (1982) 1133-1134.
98. M.L. Kripke, Ultraviolet radiation and immunity: Something new under the sun-Presidential address, Cancer Res. 54 (1994) 6102-6105.
99. T. Yoshikawa, V. Rae, W. Bruins-Slot, J.W. vand-den-Berg, J.R. Taylor, J.W. Streilein, Susceptibility to effects of UVB radiation on induction of contact hypersensitivity as a risk factor for skin cancer in humans, J. Invest. Dermatol. 95 (1990) 530-536.
100. E.C. de Fabo, F.B. Noonan, Mechanisms of immune suppression by ultraviolet irradiation in vivo. I. Evidence for the existence of a unique photoreceptor in skin and its role in photoimmunology, J. Exp. Med. 158 (1983) 84-98.
101. I. Kurimoto, J.W. Streilein, Cis-urocanic acid suppression of contact hypersensitivity induction is mediated via tumor necrosis factor-α, J. Immunol. 148 (1992) 3072-3078.
102. F.P. Noonan, E.C. deFabo, Immunosuppression by ultraviolet: Initiation by urocanic acid, Immunol. Today 13 (1992) 250-254.
103. M. Norval, N.K. Gibbs, J. Gilmour, The role of urocanic acid in UV-induced immunosuppression: Recent advances (1992-1994), Photochem. Photobiol. 62 (1995) 209-217.
104. A.A. El-Ghorr, M. Norval. A monoclonal antibody to cis-urocanic acid prevents the UV-induced changes in Langerhans cells and DTH responses in mice, although not preventing dendritic cell accumulation in lymph nodes draining the site of irradiation and contact hypersensitivity responses, J. Invest. Dermatol. 105 (1995) 264-268.
105. S. Kondo, D.N. Sauder, R.C. McKenzie, H. Fujisawa, G.M. Shivji, A. El-Ghorr, M. Norval, The role of cis-urocanic acid in UVB-induced suppression of contact hypersensitivity, Immunol. Lett. 48 (1995) 181-186.
106. N.K. Gibbs, M. Norval, N.A. Traynor, M. Wolf, B.E. Johnson, J. Crosby, Action spectra for the trans to cis photoisomerisation of urocanic acid in vitro and in mouse skin, Photochem. Photobiol. 57 (1993) 584-590.
107. V.E. Reeve, G.E. Greenoak, P.J. Canfield, C. Boehm-Wilcox, C.H. Gallagher, Topical urocanic acid enhances UV-induced tumour yield and malignancy in the hairless mouse, Photochem. Photobiol. 49 (1989) 459-464.
108. L.A. Applegate, R.D. Ley, J. Alcalay, M.L. Kripke, Identification of the molecular target for the suppression of contact hypersensitivity by UV radiation, J. Exp. Med. 170 (1989) 1117-1131.
109. M.L. Kripke, P.A. Cox, L.G. Alas, D.B. Yarosh, Pyrimidine dimers in DNA initiate systemic immunosuppression in UV-irradiated mice, Proc. Natl. Acad. Sci. USA 89 (1992) 7516-7520.
110. A.A. Vink, F.M. Strickland, C. Bucana, P.A. Cox, L. Roza, D.B. Yarosh, M.L. Kripke, Localization of DNA damage and its role in altered antigen-presenting cell function in ultraviolet-irradiated mice, J. Exp. Med. 183 (1996) 1491-1500.
111. A. O'Conner, C. Nishigori, D. Yarosh, L. Alas, J. Kibitel, L. Burley, P. Cox, C. Bucana, S. Ullrich, M. Kripke, DNA double strand breaks in epidermal cells cause immune suppression in vivo and cytokine production in vitro, J. Immunol. 157 (1996) 271-278.
112. S.E. Ullrich, The role of epidermal cytokines in the generation of cutaneous immune reactions and ultraviolet radiation induced immune suppression, Photochem. Photobiol. 62 (1995) 389-401.
113. H.M.H. Hurks, C. Out-Luiting, B.J. Vermeer, F.H.J. Claas, A.M. Mommaas, The action spectra for UV-Induced suppression of MLR and MECLR show that immunosuppression is mediated by DNA damage, Photochem. Photobiol. 62 (1995) 449-453.
114. M.M. Simon, Y. Aragane, A. Schwarz, T.A. Luger, T. Schwarz, UVB light induces a nuclear factor κB (NFκB) activity independently from chromosomal DNA damage in cell-free cytosolic extracts, J. Invest. Dermatol. 102 (1994) 422-427.
115. Y. Devary, C. Rosette, J.A. DiDonato, M. Karin, NF-κB activation by ultraviolet light is not dependent on a nuclear signal, Science 261 (1993) 1442-1445.
116. G.F. Vile, A. Tanew-Iliiltschew, R.M. Tyrrell, Activation of NF-κB in human skin fibroblasts by the oxidative stress generated by UVA radiation, Photochem. Photobiol. 62 (1995) 463-468.
117. G.B. Toews, P.R. Bergstresser, J W. Strellein, Epidermal Langerhans cell density determines whether contact hypersensitivity or unresponsiveness follows skin painting with DNFB, J. Immunol. 124 (1980) 445-449.
118. J.C. Weiss, A.C. Renkl, R.W. Denfeld, R. de Roche, M. Spitzlei, E. Schopf, J.C. Simon, Low-dose UVB radiation perturbs the functional expression of B7.1 and B7.2 co-stimulatory molecules on human Langerhans cells, Eur. J. Immunol. 25 (1995) 2858-2862.
119. A. Tang, M.C. Udey, Inhibition of epidermal Langerhans cell function by low dose ultraviolet radiation: UVB radiation selectively modulates ICAM-1 expression by murine Langerhans cells, J. Immunol. 146 (1991) 3347-3356.
120. + epidermal macrophage induction, and Langerhans cell depletion, Proc. Natl. Acad. Sci. USA 89 (1992) 8497-8501.
121. P.D. Cruz, R.E. Tigelaar, P.R. Bergstresser, Langerhans cells that migrate to skin after intervenous infusion regulate the induction of contact hypersensitivity, J. Immunol. 144 (1990) 2486-2492.
122. C. Bucana, J.-M. Tang, K. Dunner, F.M. Strickland, M.L. Kripke, Phenotypic and ultrastructural properties of antigen presenting cells involved in contact sensitization of normal and UV-irradiated mice, J. Invest. Dermatol. 102 (1994) 928-933.
123. I. Kurimoto, M. Arana, J.W. Streilein, Role of dermal cells from normal and ultraviolet B-damaged skin in induction of contact hypersensitivity and tolerance, J. Immunol. 152 (1994) 3317-3323.
124. bright monocytic/macrophagic cells, J. Immunol. 153 (1994) 4914-4924.
125. I. Kurimoto, J.W. Streilein, Characterization of the immunologic basis of ultraviolet-B light effects on contact hypersensitivity induction, Immunology 81 (1994) 353-358.
126. R. Dai, J.W. Strellein, Sensitizing capacity of Langerhans cells obtained from ultraviolet-B-exposed murine skin, Immunology 86 (1996) 661-667.
127. A.H. Enk, V. Angeloni, M.C. Udey, S.I. Katz, Inhibition of Langerhans cell antigen-presenting function by IL-10: A role for IL-10 in induction of tolerance, J. Immunol. 151 (1993) 2390-2398.
128. M. Vermeer, J.W. Streilein, Ultraviolet-B-light induced alterations in epidermal Langerhans cells are mediated by tumor necrosis-alpha, Photodermatol. Photoimmunol. Photomed. 7 (1990) 258-265.
129. + macrophages that infiltrate human epidermis after in vivo Ultraviolet exposure potently produce IL-10 and represent the major secretory source of epidermal IL-10, J.Immunol. 153 (1994) 5256-5264.
130. S. de Kossodo, P.D. Cruz, I. Dougherty, P. Thompson, M. Silva-Valdez, B. Beutler, Expression of the tumor necrosis factor gene by dermal fibroblasts in response to ultraviolet irradiation or lipopolysaccharide, J. Invest. Dermatol. 104 (1995) 318-322.
131. H.-T Chung, D.K. Burnham, B. Robertson, L.K. Roberts, R.A. Daynes, Involvement of Prostaglandins in the immune alterations caused by the exposure of mice to ultraviolet radiation, J. Immunol. 137 (1986) 2478-2484.
132. T. Yoshikawa, J.W. Streilein, Tumor necrosis factor-alpha and ultraviolet light have similar effects on contact hypersensitivity in mice, Regional Immunol. 3 (1990) 139-144.
133. J.M. Rivas, S.E. Ullrich, The role of IL-4, IL-10, and TNF-α in the immune suppression induced by Ultraviolet radiation, J. Leukoc. Biol. 56 (1994) 769-775.
134. S. Grabbe, R.S. Bhardwaj, K. Mahnke, M.M. Simon, T. Schwarz, T.A. Luger, α-Melanocyte-stimulating hormone induces hapten-specific tolerance in mice, J. Immunol. 156 (1996) 473-478.
135. T.A. Luger, E. Schauer, F. Trautinger, J. Krutmann, J. Ansel, A. Schwarz, T. Schwarz, Production of immunosuppressing melanotropins by human keratinocytes, Annals N. Y. Acad. Sci. 680 (1993) 567-570.
136. E.L. Brown, J.M. Rivas, S.E. Ullrich, C.R. Young, S.J. Norris, M.L. Kripke, Modulation of immunity to Borrelia burgdorferi by ultraviolet irradiation: Differential effect on Th1- and Th2 type immune responses, Eur. J. Immunol. 25 (1995) 3017-3022.
137. J.M. Rivas, S.E. Ullrich, Systemic suppression of DTH by supernatants from UV-irradiated keratinocytes: An essential role for interleukin 10, J. Immunol. 149 (1992) 3865-3871.
138. S.E. Ullrich, Mechanism involved in the systemic suppression of antigen-presenting cell function by UV irradiation: Keratinocyte-derived IL-10 modulates antigen-presenting cell function of splenic adherent cells, J. Immunol. 152 (1994) 3410-3416.
139. P.H. Hart, C.A. Jones, K.L. Jones, C.J. Watson, I. Santucci, L.K. Spencer, J J. Finlay-Jones, cis-urocanic acid stimulates human peripheral blood monocyte prostaglandin E-2 production and suppresses indirectly tumor necrosis factor-alpha levels, J. Immunol. 150 (1993) 4514-4523.
140. C.T.M. Tineke, K. van der Pouw, L.C.M. Boeije, R.J.T. Smeenk, J. Wijdenes, L.A. Aarden, Prostaglandin-E2 is a potent inhibitor of human Interleukin-12 production, J. Exp. Med. 181 (1995) 775-779.
141. G. Strassmann, V. Patil-Koota, F. Finkelman, M. Fong, T. Kambayashi, Evidence for the involvement of IL-10 in the differential deactivation of murine peritoneal macrophages by prostaglandin E2, J. Exp. Med. 180 (1994) 2365-2370.
142. A. Ayala, D.L. Lehman, C.D. Herdon, I.H. Chaudry, Mechanism of enhanced susceptibility to sepsis following hemorrhage: IL-10 suppression of T cell response is mediated by eicosanoid-induced IL-4 release, Arch. Surg. 129 (1994) 1172-1178.
143. J. Davidson, A.S. Milton, D. Rotondo, Alpha-melanocyte-stimulating hormone suppresses fever and increases plasma levels of prostaglandin E2 in the rabbit, J. Physiol. (Lond) 451 (1992) 491-502.
144. J. Krutmann, Regulatory interactions between epidermal cell adhesion molecules and cytokines, in: T.A. Luger, T. Schwarz (eds.), Epidermal growth factors and cytokines, Marcel Dekker, Inc., New York, 1994, pp. 415-431.
145. G. Schuhmachers, K. Ariizumi, T. Kitajima, D. Edelbaum, S. Xu, R.K. Shadduck, G.L. Gilmore, P.R. Bergstresser, A. Takashima, UVB radiation interrupts cytokine-mediated support of an epidermal-derived dendritic cell line (XS52) by a dual mechanism, J. Invest. Dermatol. 106 (1996) 1023-1029.
146. A. Takashima, H. Matsue, P.R. Bergstresser, K. Ariizumi, Interleukin-7-dependent interaction of dendritic epidermal T cells with keratinocytes, J. Invest. Dermatol. 105(1 Suppl) (1995) 50S-53S.
147. A. Blauvelt, H. Asada, V. Klaus-Kovtum, D.J. Altman, D.R. Lucey, S.I. Katz, Interleukin-15 mRNA is expressed by human keratinocytes, Langerhans cells, and blood-derived dendritic cells and is downregulated by ultraviolet B radiation, J. Invest. Dermatol. 106 (1996) 1047-1052.
148. M. Mohamadzadeh, A. Takashima, I. Dougherty, J. Knop, P.R. Bergstresser, P.D. Cruz, Ultraviolet B radiation up-regulates the expression of IL-15 in human skin, J. Immunol. 155 (1995) 4492-4496.
149. + T cells, Immunol. Rev. 123 (1991) 209-229.
150. S. Romagnani, G. Del Prente, P. Parronchi, M. De Carli, D. Macchia, S. Sampognaro, M.-P. Piccinni, M.-G. Giudizi, R. Blagiotti, F. Almerigogna, Human Th1 and Th2 subsets, Int. Arch. Allergy Immunol. 99 (1993) 242-245.
151. B. Araneo, T. Dowell, H.B. Moon, R.A. Daynes, Regulation of murine lymphocyte production in vivo. UV radiation exposure depresses IL-2 and enhances IL-4 production by T cells through an IL-1 dependent mechanism, J. Immunol. 143 (1989) 1737-1744.
152. + T helper 1 cells, J. Immunol. 146 (1991) 485-491.
153. + cells of the T helper 2 subset, J. Immunol. 145 (1990) 2087-2091.
154. + T cells through IL-12 produced by Listeria-induced macrophages. Science 260 (1993) 547-549.
155. A.J. McKnight, G.J. Zimmer, I. Fogelman, S.F. Wolf, A.K. Abbas, Effects of IL-12 on helper cell-dependent immune responses in vivo, J. Immunol. 152 (1994) 2172-2179.
156. D.A. Schmitt, L. Owen-Schaub, S.E. Ullrich, Effect of IL-12 on immune suppression and suppressor cell induction by ultraviolet radiation, J. Immunol. 154 (1995) 5114-5420.
157. A.M. Moodycliffe, S.E. Ullrich, in preparation.
158. R.M. Tyrrell, UVA (320-380 nm) radiation as an oxidative stress, in: H. Sies (ed.), Oxidative Stress: Oxidants and Antiooxidants, Academic Press, London, 1991, pp. 559-583.
159. H.S. Black, The defensive role of antioxidants in skin carcinogenesis, in: J. Fuchs, L. Packer (eds.), Oxidative Stress in Dermatology, Marcel Dekker, New York, 1993, pp. 243-269.
160. R.B. Setlow, F.M. Faulcon, J.D. Regan, Defective repair of gamma-ray-induced DNA damage in xeroderma pigmentosum cells, Int. J. Rad. Biol. 29 (1976) 125-136.
161. M.J. Peak, J.G. Peak, B.A. Carnes, Induction of direct and indirect single-strand breaks in human cell DNA by far- and near-ultraviolet radiations: action spectrum and mechanisms, Photochem. Photobiol. 45 (1987) 381-387.
162. R.M. Tyrrell, M. Pidoux, Singlet oxygen involvement in the inactivation of cultured human fibroblasts by UVA (334 nm, 365 nm) and near-visible (405 nm) radiations, Photochem. Photobiol. 49 (1989) 409-412.
163. M.J. Peak, J.S. Johnson, R.W. Tuveson, J.G. Peak, Inactivation by monochromatic near-UV radiation of an Escherichia coli hemA8 mutant grown with and without δ-aminolevulinic acid: the role of DNA vs. membrane damage, Photochem. Photobiol. 45 (1987) 473-478.
164. C. Carraro, M.A. Pathak, Studies on the nature of in vitro and in vivo photosensitization reactions by psoralens and porphyrins, J. Invest Dermatol. 90 (1988) 267-275.
165. J.A. Imlay, S. Linn, DNA damage and oxygen radical toxicity, Science 240 (1988) 1302-1309.
166. R.A. Floyd, M.S. West, K.L. Eneff, W.E. Hogsett, D.T. Tingey, Hydroxy free radical mediated formation of 8-hydroxyguanine in isolated DNA, Arch. Biochem. Biophys. 262 (1988) 266-272.
167. B. Halliwell, O.I. Aruoma, DNA damage by oxygen-derived species: Its mechanism and measurement using chromatographic methods, in: J.G. Scandalios (ed.), Molecular Biology of Free Radical Scavenging Systems, Cold Spring Harbor Laboratory Press, New York, 1992, pp. 47-67.
168. J. Cadet, M. Berger, Radiation-induced decomposition of the purine bases within DNA and related model compounds, Int. J. Radiat. Biol. 47 (1985) 127-143.
169. L. Roza, G.P. van der Schans, P.H.M. Lohman, The induction and repair of DNA damage and its influence on cell death in primary human fibroblasts exposed to UV-A or UV-C irradiation, Mutat. Res. 146 (1985) 89-98.
170. D.L. Bisset, R. Chatterjee, D.P. Hannon, Chronic ultraviolet radiation-induced increase in skin iron and the photoprotective effect of topically applied iron chelators, Photochem. Photobiol. 54 (1991) 215-223.
171. M. Aubailly, R. Santus, S. Salmon, Ferrous ion release from ferritin by ultraviolet-A radiations, Photochem. Photobiol. 54 (1991) 769-773.
172. D.C. Borg, K.M. Schaich, Iron and hydroxyl radicals in lipid oxidation: Fenton reactions in lipid and nucleic acids co-oxidized with lipid, in: P.A. Cerutti, I. Fridovich, J.M. McCord (eds.) Oxy-Radicals in Molecular Biology and Pathology, Alan R. Liss, New York, 1988, pp. 427-441.
173. B.A. Jurkiewicz, G.R. Buettner, Ultraviolet light induced free radical formation in skin: An electron paramagnetic resonance study, Photochem. Photobiol. 59 (1994) 1-4.
174. B.A. Jurkiewicz, D.L. Bissett, G.R. Buettner, Effect of topically applied tocopherol on ultraviolet radiation-mediated free radical damage in skin, J. Invest. Dermatol. 104 (1995) 484-458.
175. L.A. Applegate A. Noel, G. Vile, E. Frenk, R.M. Tyrrell, Two genes contribute to different extents to the heme oxygenase enzyme activity measured in cultured fibroblasts and keratinocytes: Implication for protection against oxidative stress, Photochem. Photobiol. 61 (1995) 285-291.
176. T.M. Reid, L.A. Loeb, Tandem double CC→TT mutations are produced by reactive oxygen species, Proc. Natl. Acad. Sci. USA 90 (1993) 3904-3907.
177. H.S. Black, J.T. Chan, Suppression of ultraviolet light induced tumor formation by dietary antioxidants, J. Invest. Dermatol. 65 (1975) 412-414.
178. J.H. Epstein, Effects of beta-carotene on ultraviolet induced cancer formation in the hairless mouse skin, Photochem. Photobiol. 25 (1977) 211-213.
179. H.S. Black, J.T. Chan, G.E. Brown, Effects of dietary constituents on ultraviolet light-mediated carcinogenesis, Cancer Res. 38 (1978) 1384-1387.
180. M.M. Mathews-Roth, Antitumor activity of β-carotene, canthaxanthin, and phytoene, Oncology 39 (1982) 33-37.
181. W.B. Dunham, E. Zuckerkandl, R. Reynolds, R. Willoughby, R. Marcuson, R. Barth, L. Pauling, Effects of intake of L-ascorbic acid on the incidence of dermal neoplasms induced in mice by ultraviolet light, Proc. Natl. Acad. Sci. USA 79 (1982) 7532-7536.
182. Z.Y. Wang, R. Agarwal, D.R. Bickers, H. Muktar, Protection against ultraviolet B radiation-induced photocarcinogenesis in hairless mice by green tea polyphenols, Carcinogenesis 12 (1991) 1527-1530.
183. K.E. Gerrish, H.L. Gensler, Prevention of photocarcinogenesis by dietary vitamin E, Nutr. Cancer 19 (1993) 125-133.
184. H. Meffert, W. Diezel, N. Sonnichsen, Stable lipid peroxidation products in human skin: Detection, ultraviolet light-induced increase, pathogenic importance, Experientia 32 (1976) 1397-1398.
185. C.A. Baumann, H.P. Rusch, Effect of diet on tumors induced by ultraviolet light, Amer. J. Cancer 35 (1939) 213-221.
186. H.S. Black, W. Lenger, A.W. Phelps, J.I. Thornby, Influence of dietary lipid upon ultraviolet-light carcinogenesis, Nutr. Cancer 5 (1983) 59-68.
187. H.S. Black, W.A. Lenger, J. Gerguis, J.I. Thornby, Relation of antioxidants and level of dietary lipid to epidermal lipid peroxidation and ultraviolet carcinogenesis, Cancer Res. 45 (1985) 6254-6259.
188. V.E. Reeve, M. Matheson, G.E. Greenoak, P.J. Canfield, C. Boehm-Wilcox, C.H. Gallagher, Effect of dietary lipid on UV light carcinogenesis in the hairless mouse, Photochem. Photobiol. 48 (1988) 689-696.
189. H.S. Black, J.I. Thornby, J. Gerguis, W. Lenger, Influence of dietary omega-6, -3 fatty acid sources on the initiation and promotion stages of photocarcinogenesis, Photochem. Photobiol. 56 (1992) 195-199.
190. H.S. Black, J.A. Herd, L.H. Goldberg, J.E. Wolf, J.I. Thornby, T. Rosen, S. Bruce, J.A. Tschen, J.P. Foreyt, L.W. Scott, S. Jaax, K. Andrews, Effect of a low-fat diet on the incidence of actinic keratosis, N. Engl. J. Med. 330 (1994) 1272-1275.
191. H.S. Black, J.I. Thornby, J.E. Wolf, L.H. Goldberg, J.A. Herd, T. Rosen, S. Bruce, J.A. Tschen, L.W. Scott, S. Jaax, J.P. Foreyt, B. Reusser, Evidence that a low-fat diet reduces the occurrence of non-melanoma skin cancer, Int. J. Cancer 62 (1995) 165-169.
192. J.J. Vitale, S.A. Broitman, Lipids and immune function, Cancer Res. 41 (1981) 3706-3710.
193. P.T. Strickland, D. Creasia, M.L. Kripke, Enhancement of two-stage skin carcinogenesis by exposure of distant skin to UV radiation, J. Natl. Cancer Inst. 74 (1985) 1129-1134.
194. H.S. Black, G. Okotie-Eboh, J. Gerguis, J.I. Urban, J.I. Thornby, Dietary fat modulates immunoresponsiveness in UV-irradiated mice, Photochem. Photobiol. 62 (1995) 964-969.