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Volumn 492, Issue 1-2, 2001, Pages 29-38

Mutagens that are not carcinogens: Faulty theory or faulty tests?

Author keywords

Ames test; Carcinogenicity; False positive; Mutagenicity; Non carcinogen; Salmonella

Indexed keywords

2,2' [(4 METHYLAMINO 3 NITROPHENYL)IMINO]BIS(ETHANOL); 2,2' [[4 (2 HYDROXYETHYLAMINO) 3 NITROPHENYL]IMINO]BIS(ETHANOL); 2,4 DIAMINOTOLUENE; 2,5 DIAMINOTOLUENE; 2,6 DIAMINOTOLUENE; BENZENE DERIVATIVE; BENZENEAMINE DERIVATIVE; BROMOFORM; CARBAMIC ACID DERIVATIVE; CARCINOGEN; CHLOROFORM; HC YELLOW 4; IODOFORM; LEAD DIMETHYLDITHIOCABAMATE; MUTAGENIC AGENT; PHENYLENEDIAMINE DERIVATIVE; PROPYLENE; PROPYLENE OXIDE; TOLUIDINE DERIVATIVE; UNCLASSIFIED DRUG; ZIRAM;

EID: 0035978873     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(01)00153-X     Document Type: Article
Times cited : (69)

References (43)
  • 1
    • 0020533372 scopus 로고
    • Revised methods for the Salmonella mutagenicity test
    • Maron D.M., Ames B.N. Revised methods for the Salmonella mutagenicity test. Mutat. Res. 113:1983;173-215.
    • (1983) Mutat. Res. , vol.113 , pp. 173-215
    • Maron, D.M.1    Ames, B.N.2
  • 2
    • 0001406666 scopus 로고
    • Detection of carcinogens in the Salmonella/microsome test: Assay of 300 chemicals
    • McCann J., Yamasaki E., Ames B.N. Detection of carcinogens in the Salmonella/microsome test: assay of 300 chemicals. Proc. Natl. Acad. Sci. U.S.A. 72:1975;5135-5139.
    • (1975) Proc. Natl. Acad. Sci. U.S.A. , vol.72 , pp. 5135-5139
    • McCann, J.1    Yamasaki, E.2    Ames, B.N.3
  • 6
    • 0032465960 scopus 로고    scopus 로고
    • Identification of rodent carcinogens and non-carcinogens using genetic toxicity tests: Premises, promises, and performance
    • Zeiger E. Identification of rodent carcinogens and non-carcinogens using genetic toxicity tests: premises, promises, and performance. Regul. Toxicol. Pharmacol. 28:1998;85-95.
    • (1998) Regul. Toxicol. Pharmacol. , vol.28 , pp. 85-95
    • Zeiger, E.1
  • 7
    • 0021741621 scopus 로고
    • Chemicals showing no evidence of carcinogenicity in long-term, two-species rodent studies: The need for short-term test data
    • Shelby M.D., Stasiewicz S. Chemicals showing no evidence of carcinogenicity in long-term, two-species rodent studies: the need for short-term test data. Environ. Mutagen. 6:1984;871-878.
    • (1984) Environ. Mutagen. , vol.6 , pp. 871-878
    • Shelby, M.D.1    Stasiewicz, S.2
  • 8
    • 0022380306 scopus 로고
    • Significance of the genotoxic activities observed in vitro for 35 of 70 NTP non-carcinogens
    • Ashby J., Purchase I.F.H. Significance of the genotoxic activities observed in vitro for 35 of 70 NTP non-carcinogens. Environ. Mutagen. 7:1985;747-758.
    • (1985) Environ. Mutagen. , vol.7 , pp. 747-758
    • Ashby, J.1    Purchase, I.F.H.2
  • 9
    • 0024424569 scopus 로고
    • Re-evaluation of the mutagenicity and carcinogenicity of chemicals previously identified as false-positives in the Salmonella typhimurium mutagenicity assay
    • Prival M.J., Dunkel V.C. Re-evaluation of the mutagenicity and carcinogenicity of chemicals previously identified as false-positives in the Salmonella typhimurium mutagenicity assay. Environ. Mol. Mutagen. 13:1989;1-24.
    • (1989) Environ. Mol. Mutagen. , vol.13 , pp. 1-24
    • Prival, M.J.1    Dunkel, V.C.2
  • 10
    • 0001903876 scopus 로고
    • Compendium of abstracts from long-term cancer studies reported by the National Toxicology Program from 1976 to 1992
    • Selkirk J.K., Soward S.M. Compendium of abstracts from long-term cancer studies reported by the National Toxicology Program from 1976 to 1992. Environ. Health Perspect. 101(Suppl. 1):1993;3-281.
    • (1993) Environ. Health Perspect. , vol.101 , Issue.SUPPL. 1 , pp. 3-281
    • Selkirk, J.K.1    Soward, S.M.2
  • 11
    • 0342847731 scopus 로고    scopus 로고
    • EHIS (Environmental Health Information Service), Toxicology and Carcinogenesis Studies
    • EHIS (Environmental Health Information Service), NTP Reports, Toxicology and Carcinogenesis Studies, 2000, http://ehis.niehs.nih.gov/ntp/docs/ntp.htmltech .
    • (2000) NTP Reports
  • 12
  • 13
    • 0023704076 scopus 로고
    • Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals
    • Zeiger E., Anderson B., Haworth S., Lawlor T., Mortelmans K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals. Environ. Mol. Mutagen. 11(Suppl. 12):1988;1-157.
    • (1988) Environ. Mol. Mutagen. , vol.11 , Issue.SUPPL. 12 , pp. 1-157
    • Zeiger, E.1    Anderson, B.2    Haworth, S.3    Lawlor, T.4    Mortelmans, K.5
  • 14
    • 0025004154 scopus 로고
    • An overview of pre-chronic and chronic toxicity/carcinogenicity experimental designs and criteria used by the National Toxicology Program
    • Chhabra R.S., Huff J.E., Schwetz B.S., Selkirk J. An overview of pre-chronic and chronic toxicity/carcinogenicity experimental designs and criteria used by the National Toxicology Program. Environ. Health Perspect. 86:1990;313-321.
    • (1990) Environ. Health Perspect. , vol.86 , pp. 313-321
    • Chhabra, R.S.1    Huff, J.E.2    Schwetz, B.S.3    Selkirk, J.4
  • 15
    • 0342412784 scopus 로고
    • The National Toxicology Program toxicology data evaluation techniques, and long-term carcinogenesis studies
    • in: W.E. Lloyd (Ed.), Hemisphere, Washington, DC
    • J.E. Huff, J.K. Haseman, E.E. McConnell, J.A. Moore, The National Toxicology Program toxicology data evaluation techniques, and long-term carcinogenesis studies, in: W.E. Lloyd (Ed.), Safety Evaluation of Drugs and Chemicals, Hemisphere, Washington, DC, 1986, pp. 411-446.
    • (1986) Safety Evaluation of Drugs and Chemicals , pp. 411-446
    • Huff, J.E.1    Haseman, J.K.2    McConnell, E.E.3    Moore, J.A.4
  • 16
    • 0032512899 scopus 로고    scopus 로고
    • Chemicals mutagenic in Salmonella typhimurium strain TA1535 but not in TA100
    • Prival M.J., Zeiger E. Chemicals mutagenic in Salmonella typhimurium strain TA1535 but not in TA100. Mutat. Res. 412:1998;251-260.
    • (1998) Mutat. Res. , vol.412 , pp. 251-260
    • Prival, M.J.1    Zeiger, E.2
  • 17
    • 0022400101 scopus 로고
    • Fundamental structural alerts to potential carcinogenicity or non-carcinogenicity
    • Ashby J. Fundamental structural alerts to potential carcinogenicity or non-carcinogenicity. Environ. Mutagen. 7:1985;919-921.
    • (1985) Environ. Mutagen. , vol.7 , pp. 919-921
    • Ashby, J.1
  • 18
    • 0000973407 scopus 로고
    • Definitive relationships among chemical structure, carcinogenicity, and mutagenicity for 301 chemicals tested by the US NTP
    • Ashby J., Tennant R.W. Definitive relationships among chemical structure, carcinogenicity, and mutagenicity for 301 chemicals tested by the US NTP. Mutat. Res. 257:1991;229-306.
    • (1991) Mutat. Res. , vol.257 , pp. 229-306
    • Ashby, J.1    Tennant, R.W.2
  • 19
    • 0018675933 scopus 로고
    • Studies on the mutagenicity of p-phenylenediamine in Salmonella typhimurium. Presence of PCB's in rat-liver microsomal fraction induced by Aroclor
    • Shahin M.M., Andrillon P., Goetz N., Bore P., Bugaut A., Kalopissis G. Studies on the mutagenicity of p-phenylenediamine in Salmonella typhimurium. Presence of PCB's in rat-liver microsomal fraction induced by Aroclor. Mutat. Res. 68:1979;327-336.
    • (1979) Mutat. Res. , vol.68 , pp. 327-336
    • Shahin, M.M.1    Andrillon, P.2    Goetz, N.3    Bore, P.4    Bugaut, A.5    Kalopissis, G.6
  • 20
    • 0020038851 scopus 로고
    • The effect of dimethylsulfoxide on the mutagenicity of the hair dye p-phenylenediamine
    • Burnett C., Fuchs C., Corbett J., Menkart J. The effect of dimethylsulfoxide on the mutagenicity of the hair dye p-phenylenediamine. Mutat. Res. 133:1982;1-4.
    • (1982) Mutat. Res. , vol.133 , pp. 1-4
    • Burnett, C.1    Fuchs, C.2    Corbett, J.3    Menkart, J.4
  • 21
    • 0022330775 scopus 로고
    • Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and non-carcinogens in Salmonella typhimurium and Escherichia coli
    • Dunkel V.C., Zeiger E., Brusick D., McCoy E., McGregor D., Mortelmans K., Rosenkranz H.S., Simmon V.F. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and non-carcinogens in Salmonella typhimurium and Escherichia coli. Environ. Mutagen. 7(Suppl. 5):1985;1-248.
    • (1985) Environ. Mutagen. , vol.7 , Issue.SUPPL. 5 , pp. 1-248
    • Dunkel, V.C.1    Zeiger, E.2    Brusick, D.3    McCoy, E.4    McGregor, D.5    Mortelmans, K.6    Rosenkranz, H.S.7    Simmon, V.F.8
  • 22
    • 0019459449 scopus 로고
    • Carcinogenicity of substituted-benzenediamines (phenylenediamines) in rats and mice
    • Sontag J.M. Carcinogenicity of substituted-benzenediamines (phenylenediamines) in rats and mice. J. Nat. Cancer Inst. 66:1981;591-602.
    • (1981) J. Nat. Cancer Inst. , vol.66 , pp. 591-602
    • Sontag, J.M.1
  • 23
    • 0023202828 scopus 로고
    • Failure of short-term in vitro mutagenicity tests to predict the animal carcinogenicity of hair dyes
    • Burnett C.M., Corbett J.F. Failure of short-term in vitro mutagenicity tests to predict the animal carcinogenicity of hair dyes. Fd. Chem. Toxicol. 25:1987;703-707.
    • (1987) Fd. Chem. Toxicol. , vol.25 , pp. 703-707
    • Burnett, C.M.1    Corbett, J.F.2
  • 24
    • 0018900847 scopus 로고
    • Structure-activity relationship within a series of m-diaminobenzene derivatives
    • Shahin M.M., Bugaut A., Kalopissis G. Structure-activity relationship within a series of m-diaminobenzene derivatives. Mutat. Res. 78:1980;25-31.
    • (1980) Mutat. Res. , vol.78 , pp. 25-31
    • Shahin, M.M.1    Bugaut, A.2    Kalopissis, G.3
  • 26
    • 0024845303 scopus 로고
    • Metabolism, disposition, and mutagenicity of 2,6-diaminotoluene, a mutagenic non-carcinogen
    • Cunningham M.L., Burka L.T., Matthews H.B. Metabolism, disposition, and mutagenicity of 2,6-diaminotoluene, a mutagenic non-carcinogen. Drug Metab. Dispos. 17:1989;612-617.
    • (1989) Drug Metab. Dispos. , vol.17 , pp. 612-617
    • Cunningham, M.L.1    Burka, L.T.2    Matthews, H.B.3
  • 27
    • 0026073504 scopus 로고
    • Correlation of hepatocellular proliferation with hepatocarcinogenicity induced by the mutagenic non-carcinogen:carcinogen pair-2,6- And 2,4-diaminotoluene
    • Cunningham M.L., Foley J., Maronpot R.R., Matthews H.B. Correlation of hepatocellular proliferation with hepatocarcinogenicity induced by the mutagenic non-carcinogen:carcinogen pair-2,6- and 2,4-diaminotoluene. Toxicol. Appl. Pharmacol. 107:1991;562-567.
    • (1991) Toxicol. Appl. Pharmacol. , vol.107 , pp. 562-567
    • Cunningham, M.L.1    Foley, J.2    Maronpot, R.R.3    Matthews, H.B.4
  • 28
    • 0029991783 scopus 로고    scopus 로고
    • Distinction of mutagenic carcinogens from a mutagenic non-carcinogen in the Big Blue transgenic mouse
    • Cunningham M.L., Hayward J.J., Shane B.S., Tindall K.R. Distinction of mutagenic carcinogens from a mutagenic non-carcinogen in the Big Blue transgenic mouse. Environ. Health Perspect. 104(Suppl. 3):1996;683-686.
    • (1996) Environ. Health Perspect. , vol.104 , Issue.SUPPL. 3 , pp. 683-686
    • Cunningham, M.L.1    Hayward, J.J.2    Shane, B.S.3    Tindall, K.R.4
  • 29
    • 0028786875 scopus 로고
    • Differential in vivo mutagenicity of the carcinogen/non-carcinogen pair 2,4- And 2,6-diaminotoluene
    • Hayward J.J., Shane B.S., Tindall K.R., Cunningham M.L. Differential in vivo mutagenicity of the carcinogen/non-carcinogen pair 2,4- and 2,6-diaminotoluene. Carcinogenesis. 16:1995;2429-2433.
    • (1995) Carcinogenesis , vol.16 , pp. 2429-2433
    • Hayward, J.J.1    Shane, B.S.2    Tindall, K.R.3    Cunningham, M.L.4
  • 30
    • 0025785978 scopus 로고
    • Isolation of the mutagenic and DNA adduct-inducing components from a commercial preparation of HC Blue 1 using Salmonella (TA98) bioassay-directed HPLC fractionation
    • Abu Shakra A., Johnson L., Earley K., Jameson C.W., Kari F.W., Gupta R., Langenbach R. Isolation of the mutagenic and DNA adduct-inducing components from a commercial preparation of HC Blue 1 using Salmonella (TA98) bioassay-directed HPLC fractionation. Mutat. Res. 260:1991;377-385.
    • (1991) Mutat. Res. , vol.260 , pp. 377-385
    • Abu Shakra, A.1    Johnson, L.2    Earley, K.3    Jameson, C.W.4    Kari, F.W.5    Gupta, R.6    Langenbach, R.7
  • 32
    • 0024401672 scopus 로고
    • Chromosome aberration and sister-chromatid exchange tests in Chinese hamster ovary cells in vitro. III. Results with 27 chemicals
    • Gulati D.K., Witt K., Anderson B., Zeiger E., Shelby M.D. Chromosome aberration and sister-chromatid exchange tests in Chinese hamster ovary cells in vitro. III. Results with 27 chemicals. Environ. Mol. Mutagen. 13:1989;133-193.
    • (1989) Environ. Mol. Mutagen. , vol.13 , pp. 133-193
    • Gulati, D.K.1    Witt, K.2    Anderson, B.3    Zeiger, E.4    Shelby, M.D.5
  • 35
    • 80053096855 scopus 로고    scopus 로고
    • IARC Monographs on the Evaluation of Carcinogenic Risk to Humans
    • IARC, International Agency for Research on Cancer, Lyon
    • IARC, IARC Monographs on the Evaluation of Carcinogenic Risk to Humans, Some Chemicals that Cause Tumours of the Kidney or Urinary Bladder in Rodents and Some Other Substances, Vol. 73, International Agency for Research on Cancer, Lyon, 1999, pp. 132-182.
    • (1999) Some Chemicals That Cause Tumours of the Kidney or Urinary Bladder in Rodents and Some Other Substances , vol.73 , pp. 132-182
  • 36
    • 0025184162 scopus 로고
    • Evaluation of four in vitro genetic toxicity tests for predicting rodent carcinogenicity: Confirmation of earlier results with 41 additional chemicals
    • Zeiger E., Haseman J.K., Shelby M.D., Margolin B.H., Tennant R.W. Evaluation of four in vitro genetic toxicity tests for predicting rodent carcinogenicity: confirmation of earlier results with 41 additional chemicals. Environ. Mol. Mutagen. 16(Suppl. 18):1990;1-14.
    • (1990) Environ. Mol. Mutagen. , vol.16 , Issue.SUPPL. 18 , pp. 1-14
    • Zeiger, E.1    Haseman, J.K.2    Shelby, M.D.3    Margolin, B.H.4    Tennant, R.W.5
  • 37
    • 0024993374 scopus 로고
    • Mutagenicity of 42 chemicals in Salmonella
    • Zeiger E. Mutagenicity of 42 chemicals in Salmonella. Environ. Mol. Mutagen. 16(Suppl. 18):1990;32-54.
    • (1990) Environ. Mol. Mutagen. , vol.16 , Issue.SUPPL. 18 , pp. 32-54
    • Zeiger, E.1
  • 38
    • 0034040057 scopus 로고    scopus 로고
    • 3 metabolism and toxicokinetics in rodent strains differently susceptible to chloroform-induced carcinogenicity
    • 3 metabolism and toxicokinetics in rodent strains differently susceptible to chloroform-induced carcinogenicity. Environ. Toxicol. Pharmacol. 8:2000;103-110.
    • (2000) Environ. Toxicol. Pharmacol. , vol.8 , pp. 103-110
    • Vittozzi, L.1    Gemma, S.2    Sbraccia, M.3    Testai, E.4
  • 39
    • 0342847730 scopus 로고
    • IARC Monographs on the Evaluation of Carcinogenic Risk to Humans
    • IARC, International Agency for Research on Cancer, Lyon
    • IARC, IARC Monographs on the Evaluation of Carcinogenic Risk to Humans, Some Pharmaceutical Drugs, Vol. 50, International Agency for Research on Cancer, Lyon, 1990, pp. 265-273.
    • (1990) Some Pharmaceutical Drugs , vol.50 , pp. 265-273
  • 41
    • 0024378718 scopus 로고
    • Analysis of the National Toxicology Program data on in vitro genetic toxicity tests using multivariate statistical methods
    • Benigni R. Analysis of the National Toxicology Program data on in vitro genetic toxicity tests using multivariate statistical methods. Mutagenesis. 4:1989;412-419.
    • (1989) Mutagenesis , vol.4 , pp. 412-419
    • Benigni, R.1
  • 42
    • 0027230528 scopus 로고
    • Predictive strategies for selecting 379 NCI chemicals evaluated for carcinogenic potential: Scientific and public health impact
    • Fung V.A., Huff J., Weisburger E.K., Hoel D.G. Predictive strategies for selecting 379 NCI chemicals evaluated for carcinogenic potential: scientific and public health impact. Fundam. Appl. Toxicol. 20:1993;413-436.
    • (1993) Fundam. Appl. Toxicol. , vol.20 , pp. 413-436
    • Fung, V.A.1    Huff, J.2    Weisburger, E.K.3    Hoel, D.G.4
  • 43
    • 0002948521 scopus 로고
    • Measuring intra-assay agreement for the Ames Salmonella assay
    • in: L. Hothorn (Ed.), Statistical Methods in Toxicology, Springer, Heidelberg
    • W.W. Piegorsch, E. Zeiger, Measuring intra-assay agreement for the Ames Salmonella assay, in: L. Hothorn (Ed.), Statistical Methods in Toxicology, Lecture Notes in Medical Informatics, Vol. 43, Springer, Heidelberg, 1991, pp. 35-41.
    • (1991) Lecture Notes in Medical Informatics , vol.43 , pp. 35-41
    • Piegorsch, W.W.1    Zeiger, E.2


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