메뉴 건너뛰기




Volumn 1632, Issue 1-3, 2003, Pages 80-89

Bezafibrate is a dual ligand for PPARα and PPARβ: Studies using null mice

Author keywords

Bezafibrate; Gene expression; Peroxisome proliferator activated receptor

Indexed keywords

BEZAFIBRATE; LIVER PROTEIN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PIRINIXIC ACID; UNCLASSIFIED DRUG;

EID: 0038694566     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1388-1981(03)00065-9     Document Type: Article
Times cited : (87)

References (94)
  • 1
    • 0025132245 scopus 로고
    • Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
    • Issemann I., Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature. 347:1990;645-650.
    • (1990) Nature , vol.347 , pp. 645-650
    • Issemann, I.1    Green, S.2
  • 4
    • 0027504874 scopus 로고
    • Identification of two mPPAR related receptors and evidence for the existence of five subfamily members
    • Chen F., Law S.W., O'Malley B.W. Identification of two mPPAR related receptors and evidence for the existence of five subfamily members. Biochem. Biophys. Res. Commun. 196:1993;671-677.
    • (1993) Biochem. Biophys. Res. Commun. , vol.196 , pp. 671-677
    • Chen, F.1    Law, S.W.2    O'Malley, B.W.3
  • 5
    • 0027749599 scopus 로고
    • Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver
    • Zhu Y., Alvares K., Huang Q., Rao M.S., Reddy J.K. Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver. J. Biol. Chem. 268:1993;26817-26820.
    • (1993) J. Biol. Chem. , vol.268 , pp. 26817-26820
    • Zhu, Y.1    Alvares, K.2    Huang, Q.3    Rao, M.S.4    Reddy, J.K.5
  • 6
    • 0027191040 scopus 로고
    • CDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor
    • Sher T., Yi H.F., McBride O.W., Gonzalez F.J. cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor. Biochemistry. 32:1993;5598-5604.
    • (1993) Biochemistry , vol.32 , pp. 5598-5604
    • Sher, T.1    Yi, H.F.2    McBride, O.W.3    Gonzalez, F.J.4
  • 7
    • 0026785388 scopus 로고
    • Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids
    • Schmidt A., Endo N., Rutledge S.J., Vogel R., Shinar D., Rodan G.A. Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids. Mol. Endocrinol. 6:1992;1634-1641.
    • (1992) Mol. Endocrinol. , vol.6 , pp. 1634-1641
    • Schmidt, A.1    Endo, N.2    Rutledge, S.J.3    Vogel, R.4    Shinar, D.5    Rodan, G.A.6
  • 8
    • 0029977518 scopus 로고    scopus 로고
    • A human peroxisome-proliferator-activated receptor-gamma is activated by inducers of adipogenesis, including thiazolidinedione drugs
    • Lambe K.G., Tugwood J.D. A human peroxisome-proliferator-activated receptor-gamma is activated by inducers of adipogenesis, including thiazolidinedione drugs. Eur. J. Biochem. 239:1996;1-7.
    • (1996) Eur. J. Biochem. , vol.239 , pp. 1-7
    • Lambe, K.G.1    Tugwood, J.D.2
  • 9
    • 0026100678 scopus 로고
    • Peroxisome proliferation and nongenotoxic carcinogenesis: Commentary on a symposium
    • Moody D.E., Reddy J.K., Lake B.G., Popp J.A., Reese D.H. Peroxisome proliferation and nongenotoxic carcinogenesis: commentary on a symposium. Fundam. Appl. Toxicol. 16:1991;233-248.
    • (1991) Fundam. Appl. Toxicol. , vol.16 , pp. 233-248
    • Moody, D.E.1    Reddy, J.K.2    Lake, B.G.3    Popp, J.A.4    Reese, D.H.5
  • 10
    • 0033739281 scopus 로고    scopus 로고
    • Pristanic acid and phytanic acid. Naturally occurring ligands for the nuclear receptor peroxisome proliferator-activated receptor alpha
    • Zomer A.W., van Der Burg B., Jansen G.A., Wanders R.J., Poll-The B.T., van Der Saag P.T. Pristanic acid and phytanic acid. Naturally occurring ligands for the nuclear receptor peroxisome proliferator-activated receptor alpha. J. Lipid Res. 41:2000;1801-1807.
    • (2000) J. Lipid Res. , vol.41 , pp. 1801-1807
    • Zomer, A.W.1    Van Der Burg, B.2    Jansen, G.A.3    Wanders, R.J.4    Poll-The, B.T.5    Van Der Saag, P.T.6
  • 12
    • 0033613869 scopus 로고    scopus 로고
    • Phytanic acid activates the peroxisome proliferator-activated receptor alpha (PPARalpha) in sterol carrier protein 2-/sterol carrier protein x-deficient mice
    • Ellinghaus P., Wolfrum C., Assmann G., Spener F., Seedorf U. Phytanic acid activates the peroxisome proliferator-activated receptor alpha (PPARalpha) in sterol carrier protein 2-/sterol carrier protein x-deficient mice. J. Biol. Chem. 274:1999;2766-2772.
    • (1999) J. Biol. Chem. , vol.274 , pp. 2766-2772
    • Ellinghaus, P.1    Wolfrum, C.2    Assmann, G.3    Spener, F.4    Seedorf, U.5
  • 13
    • 0030952937 scopus 로고    scopus 로고
    • Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta
    • Forman B.M., Chen J., Evans R.M. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta. Proc. Natl. Acad. Sci. U. S. A. 94:1997;4312-4317.
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 4312-4317
    • Forman, B.M.1    Chen, J.2    Evans, R.M.3
  • 15
    • 0031013395 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs
    • Lehmann J.M., Lenhard J.M., Oliver B.B., Ringold G.M., Kliewer S.A. Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J. Biol. Chem. 272:1997;3406-3410.
    • (1997) J. Biol. Chem. , vol.272 , pp. 3406-3410
    • Lehmann, J.M.1    Lenhard, J.M.2    Oliver, B.B.3    Ringold, G.M.4    Kliewer, S.A.5
  • 17
    • 0033544955 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor {beta} regulates acyl-CoA synthetase 2 in reaggregated rat brain cell cultures
    • Basu-Modak S., Braissant O., Escher P., Desvergne B., Honegger P., Wahli W. Peroxisome proliferator-activated receptor {beta} regulates acyl-CoA synthetase 2 in reaggregated rat brain cell cultures. J. Biol. Chem. 274:1999;35881-35888.
    • (1999) J. Biol. Chem. , vol.274 , pp. 35881-35888
    • Basu-Modak, S.1    Braissant, O.2    Escher, P.3    Desvergne, B.4    Honegger, P.5    Wahli, W.6
  • 18
    • 0030985318 scopus 로고    scopus 로고
    • Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay
    • Krey G., Braissant O., L'Horset F., Kalkhoven E., Perroud M., Parker M.G., Wahli W. Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay. Mol. Endocrinol. 11:1997;779-791.
    • (1997) Mol. Endocrinol. , vol.11 , pp. 779-791
    • Krey, G.1    Braissant, O.2    L'Horset, F.3    Kalkhoven, E.4    Perroud, M.5    Parker, M.G.6    Wahli, W.7
  • 19
    • 0033521702 scopus 로고    scopus 로고
    • Conjugated linoleic acid activates peroxisome proliferator-activated receptor alpha and beta subtypes but does not induce hepatic peroxisome proliferation in Sprague-Dawley rats
    • Moya-Camarena S.Y., Van den Heuvel J.P., Belury M.A. Conjugated linoleic acid activates peroxisome proliferator-activated receptor alpha and beta subtypes but does not induce hepatic peroxisome proliferation in Sprague-Dawley rats. Biochim. Biophys. Acta. 1436:1999;331-342.
    • (1999) Biochim. Biophys. Acta , vol.1436 , pp. 331-342
    • Moya-Camarena, S.Y.1    Van den Heuvel, J.P.2    Belury, M.A.3
  • 20
    • 0028997684 scopus 로고
    • Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators
    • Lee S.S., Pineau T., Drago J., Lee E.J., Owens J.W., Kroetz D.L., Fernandez-Salguero P.M., Westphal H., Gonzalez F.J. Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol. Cell. Biol. 15:1995;3012-3022.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 3012-3022
    • Lee, S.S.1    Pineau, T.2    Drago, J.3    Lee, E.J.4    Owens, J.W.5    Kroetz, D.L.6    Fernandez-Salguero, P.M.7    Westphal, H.8    Gonzalez, F.J.9
  • 21
    • 0032733651 scopus 로고    scopus 로고
    • Hepatic expression of acute-phase protein genes during carcinogenesis induced by peroxisome proliferators
    • Anderson S.P., Cattley R.C., Corton J.C. Hepatic expression of acute-phase protein genes during carcinogenesis induced by peroxisome proliferators. Mol. Carcinog. 26:1999;226-238.
    • (1999) Mol. Carcinog. , vol.26 , pp. 226-238
    • Anderson, S.P.1    Cattley, R.C.2    Corton, J.C.3
  • 22
    • 0032489437 scopus 로고    scopus 로고
    • Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARa)
    • Aoyama A., Peters J.M., Iritani N., Nasu-Nakajima T., Furihata K., Hashimoto T., Gonzalez F.J. Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARa). J. Biol. Chem. 273:1998;5678-5684.
    • (1998) J. Biol. Chem. , vol.273 , pp. 5678-5684
    • Aoyama, A.1    Peters, J.M.2    Iritani, N.3    Nasu-Nakajima, T.4    Furihata, K.5    Hashimoto, T.6    Gonzalez, F.J.7
  • 23
    • 0032806042 scopus 로고    scopus 로고
    • Modulation of cytochrome P-450 gene expression in endotoxemic mice is tissue specific and peroxisome proliferator-activated receptor-alpha dependent
    • Barclay T.B., Peters J.M., Sewer M.B., Ferrari L., Gonzalez F.J., Morgan E.T. Modulation of cytochrome P-450 gene expression in endotoxemic mice is tissue specific and peroxisome proliferator-activated receptor-alpha dependent. J. Pharmacol. Exp. Ther. 290:1999;1250-1257.
    • (1999) J. Pharmacol. Exp. Ther. , vol.290 , pp. 1250-1257
    • Barclay, T.B.1    Peters, J.M.2    Sewer, M.B.3    Ferrari, L.4    Gonzalez, F.J.5    Morgan, E.T.6
  • 24
    • 0032135723 scopus 로고    scopus 로고
    • Comparison of dose-response relationships for induction of lipid metabolizing and growth regulatory genes by peroxisome proliferators in rat liver
    • Belury M.A., Moya-Camarena S.Y., Sun H., Snyder E., Davis J.W., Cunningham M.L., Vanden Heuvel J.P. Comparison of dose-response relationships for induction of lipid metabolizing and growth regulatory genes by peroxisome proliferators in rat liver. Toxicol. Appl. Pharmacol. 151:1998;254-261.
    • (1998) Toxicol. Appl. Pharmacol. , vol.151 , pp. 254-261
    • Belury, M.A.1    Moya-Camarena, S.Y.2    Sun, H.3    Snyder, E.4    Davis, J.W.5    Cunningham, M.L.6    Vanden Heuvel, J.P.7
  • 25
    • 0032508696 scopus 로고    scopus 로고
    • Fatty acids activate transcription of the muscle carnitine palmitoyltransferase I gene in cardiac myocytes via the peroxisome proliferator-activated receptor alpha
    • Brandt J.M., Djouadi F., Kelly D.P. Fatty acids activate transcription of the muscle carnitine palmitoyltransferase I gene in cardiac myocytes via the peroxisome proliferator-activated receptor alpha. J. Biol. Chem. 273:1998;23786-23792.
    • (1998) J. Biol. Chem. , vol.273 , pp. 23786-23792
    • Brandt, J.M.1    Djouadi, F.2    Kelly, D.P.3
  • 26
    • 0031715770 scopus 로고    scopus 로고
    • Down-regulation of cytochrome P450 2C family members and positive acute-phase response gene expression by peroxisome proliferator chemicals
    • Corton J.C., Fan L.Q., Brown S., Anderson S.P., Bocos C., Cattley R.C., Mode A., Gustafsson J.A. Down-regulation of cytochrome P450 2C family members and positive acute-phase response gene expression by peroxisome proliferator chemicals. Mol. Pharmacol. 54:1998;463-473.
    • (1998) Mol. Pharmacol. , vol.54 , pp. 463-473
    • Corton, J.C.1    Fan, L.Q.2    Brown, S.3    Anderson, S.P.4    Bocos, C.5    Cattley, R.C.6    Mode, A.7    Gustafsson, J.A.8
  • 27
    • 0033527569 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kappaB and AP-1
    • Delerive P., De Bosscher K., Besnard S., Vanden Berghe W., Peters J.M., Gonzalez F.J., Fruchart J.C., Tedgui A., Haegeman G., Staels B. Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kappaB and AP-1. J. Biol. Chem. 274:1999;32048-32054.
    • (1999) J. Biol. Chem. , vol.274 , pp. 32048-32054
    • Delerive, P.1    De Bosscher, K.2    Besnard, S.3    Vanden Berghe, W.4    Peters, J.M.5    Gonzalez, F.J.6    Fruchart, J.C.7    Tedgui, A.8    Haegeman, G.9    Staels, B.10
  • 29
    • 0032530765 scopus 로고    scopus 로고
    • A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator-activated receptor alpha-deficient mice
    • Djouadi F., Weinheimer C.J., Saffitz J.E., Pitchford C., Bastin J., Gonzalez F.J., Kelly D.P. A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator-activated receptor alpha-deficient mice. J. Clin. Invest. 102:1998;1083-1091.
    • (1998) J. Clin. Invest. , vol.102 , pp. 1083-1091
    • Djouadi, F.1    Weinheimer, C.J.2    Saffitz, J.E.3    Pitchford, C.4    Bastin, J.5    Gonzalez, F.J.6    Kelly, D.P.7
  • 31
    • 0031825729 scopus 로고    scopus 로고
    • Tissue-specific induction of 17 beta-hydroxysteroid dehydrogenase type IV by peroxisome proliferator chemicals is dependent on the peroxisome proliferator-activated receptor alpha
    • Fan L.Q., Cattley R.C., Corton J.C. Tissue-specific induction of 17 beta-hydroxysteroid dehydrogenase type IV by peroxisome proliferator chemicals is dependent on the peroxisome proliferator-activated receptor alpha. J. Endocrinol. 158:1998;237-246.
    • (1998) J. Endocrinol. , vol.158 , pp. 237-246
    • Fan, L.Q.1    Cattley, R.C.2    Corton, J.C.3
  • 33
    • 0034024333 scopus 로고    scopus 로고
    • Involvement of the peroxisome proliferator-activated receptor alpha in regulating long-chain acyl-CoA thioesterases
    • Hunt M.C., Lindquist P.J., Peters J.M., Gonzalez F.J., Diczfalusy U., Alexson S.E. Involvement of the peroxisome proliferator-activated receptor alpha in regulating long-chain acyl-CoA thioesterases. J. Lipid Res. 41:2000;814-823.
    • (2000) J. Lipid Res. , vol.41 , pp. 814-823
    • Hunt, M.C.1    Lindquist, P.J.2    Peters, J.M.3    Gonzalez, F.J.4    Diczfalusy, U.5    Alexson, S.E.6
  • 34
    • 0033134791 scopus 로고    scopus 로고
    • Fibrates suppress fibrinogen gene expression in rodents via activation of the peroxisome proliferator-activated receptor-alpha
    • Kockx M., Gervois P.P., Poulain P., Derudas B., Peters J.M., Gonzalez F.J., Princen H.M., Kooistra T., Staels B. Fibrates suppress fibrinogen gene expression in rodents via activation of the peroxisome proliferator-activated receptor-alpha. Blood. 93:1999;2991-2998.
    • (1999) Blood , vol.93 , pp. 2991-2998
    • Kockx, M.1    Gervois, P.P.2    Poulain, P.3    Derudas, B.4    Peters, J.M.5    Gonzalez, F.J.6    Princen, H.M.7    Kooistra, T.8    Staels, B.9
  • 35
    • 0033594980 scopus 로고    scopus 로고
    • A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: The PPARalpha-null mouse as a model of fatty acid oxidation disorders
    • Leone T.C., Weinheimer C.J., Kelly D.P. A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders. Proc. Natl. Acad. Sci. U. S. A. 96:1999;7473-7478.
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 7473-7478
    • Leone, T.C.1    Weinheimer, C.J.2    Kelly, D.P.3
  • 36
    • 0034054536 scopus 로고    scopus 로고
    • Sex-dependent regulation of hepatic peroxisome proliferation in mice by trichloroethylene via peroxisome proliferator-activated receptor alpha (PPARalpha)
    • Nakajima T., Kamijo Y., Usuda N., Liang Y., Fukushima Y., Kametani K., Gonzalez F.J., Aoyama T. Sex-dependent regulation of hepatic peroxisome proliferation in mice by trichloroethylene via peroxisome proliferator-activated receptor alpha (PPARalpha). Carcinogenesis. 21:2000;677-682.
    • (2000) Carcinogenesis , vol.21 , pp. 677-682
    • Nakajima, T.1    Kamijo, Y.2    Usuda, N.3    Liang, Y.4    Fukushima, Y.5    Kametani, K.6    Gonzalez, F.J.7    Aoyama, T.8
  • 37
    • 0031418657 scopus 로고    scopus 로고
    • Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643
    • Peters J.M., Cattley R.C., Gonzalez F.J. Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643. Carcinogenesis. 18:1997;2029-2033.
    • (1997) Carcinogenesis , vol.18 , pp. 2029-2033
    • Peters, J.M.1    Cattley, R.C.2    Gonzalez, F.J.3
  • 38
    • 0031781381 scopus 로고    scopus 로고
    • Role of peroxisome proliferator-activated receptor alpha in altered cell cycle regulation in mouse liver
    • Peters J.M., Aoyama T., Cattley R.C., Nobumitsu U., Hashimoto T., Gonzalez F.J. Role of peroxisome proliferator-activated receptor alpha in altered cell cycle regulation in mouse liver. Carcinogenesis. 19:1998;1989-1994.
    • (1998) Carcinogenesis , vol.19 , pp. 1989-1994
    • Peters, J.M.1    Aoyama, T.2    Cattley, R.C.3    Nobumitsu, U.4    Hashimoto, T.5    Gonzalez, F.J.6
  • 39
    • 0032484123 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha activation modulates cellular redox status, represses nuclear factor-kappaB signaling, and reduces inflammatory cytokine production in aging
    • Poynter M.E., Daynes R.A. Peroxisome proliferator-activated receptor alpha activation modulates cellular redox status, represses nuclear factor-kappaB signaling, and reduces inflammatory cytokine production in aging. J. Biol. Chem. 273:1998;32833-32841.
    • (1998) J. Biol. Chem. , vol.273 , pp. 32833-32841
    • Poynter, M.E.1    Daynes, R.A.2
  • 40
    • 0034737322 scopus 로고    scopus 로고
    • Influence of peroxisome proliferator-activated receptor alpha on ubiquinone biosynthesis
    • Turunen M., Peters J.M., Gonzalez F.J., Schedin S., Dallner G. Influence of peroxisome proliferator-activated receptor alpha on ubiquinone biosynthesis. J. Mol. Biol. 297:2000;607-614.
    • (2000) J. Mol. Biol. , vol.297 , pp. 607-614
    • Turunen, M.1    Peters, J.M.2    Gonzalez, F.J.3    Schedin, S.4    Dallner, G.5
  • 41
    • 0031969263 scopus 로고    scopus 로고
    • Receptor and nonreceptor-mediated organ-specific toxicity of di(2-ethylhexyl)phthalate (DEHP) in peroxisome proliferator-activated receptor alpha-null mice
    • Ward J.M., Peters J.M., Perella C.M., Gonzalez F.J. Receptor and nonreceptor-mediated organ-specific toxicity of di(2-ethylhexyl)phthalate (DEHP) in peroxisome proliferator-activated receptor alpha-null mice. Toxicol. Pathol. 26:1998;240-246.
    • (1998) Toxicol. Pathol. , vol.26 , pp. 240-246
    • Ward, J.M.1    Peters, J.M.2    Perella, C.M.3    Gonzalez, F.J.4
  • 42
    • 0031793057 scopus 로고    scopus 로고
    • Identification of a novel peroxisome proliferator responsive cDNA isolated from rat hepatocytes as the zinc-finger protein ZFP-37
    • Vanden Heuvel J.P., Holden P., Tugwood J., Ingle C., Yen W., Galjart N., Greenlee W.F. Identification of a novel peroxisome proliferator responsive cDNA isolated from rat hepatocytes as the zinc-finger protein ZFP-37. Toxicol. Appl. Pharmacol. 152:1998;107-118.
    • (1998) Toxicol. Appl. Pharmacol. , vol.152 , pp. 107-118
    • Vanden Heuvel, J.P.1    Holden, P.2    Tugwood, J.3    Ingle, C.4    Yen, W.5    Galjart, N.6    Greenlee, W.F.7
  • 44
    • 0034666132 scopus 로고    scopus 로고
    • Defect in peroxisome proliferator-activated receptor alpha-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting
    • Hashimoto T., Cook W.S., Qi C., Yeldandi A.V., Reddy J.K., Rao M.S. Defect in peroxisome proliferator-activated receptor alpha-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting. J. Biol. Chem. 275:2000;28918-28928.
    • (2000) J. Biol. Chem. , vol.275 , pp. 28918-28928
    • Hashimoto, T.1    Cook, W.S.2    Qi, C.3    Yeldandi, A.V.4    Reddy, J.K.5    Rao, M.S.6
  • 45
  • 48
    • 0035929170 scopus 로고    scopus 로고
    • Adaptive increase in pyruvate dehydrogenase kinase 4 during starvation is mediated by peroxisome proliferator-activated receptor alpha
    • Wu P., Peters J.M., Harris R.A. Adaptive increase in pyruvate dehydrogenase kinase 4 during starvation is mediated by peroxisome proliferator-activated receptor alpha. Biochem. Biophys. Res. Commun. 287:2001;391-396.
    • (2001) Biochem. Biophys. Res. Commun. , vol.287 , pp. 391-396
    • Wu, P.1    Peters, J.M.2    Harris, R.A.3
  • 49
    • 0035727679 scopus 로고    scopus 로고
    • Responses of insulin-like growth factor (IGF)-I and IGF-binding proteins to nutritional status in peroxisome proliferator-activated receptor-alpha knockout mice
    • Lewitt M.S., Brismar K., Wang J., Wivall-Helleryd I.L., Sindelar P., Gonzalez F.J., Bergman T., Bobek G.A. Responses of insulin-like growth factor (IGF)-I and IGF-binding proteins to nutritional status in peroxisome proliferator-activated receptor-alpha knockout mice. Growth Horm. IGF Res. 11:2001;303-313.
    • (2001) Growth Horm. IGF Res. , vol.11 , pp. 303-313
    • Lewitt, M.S.1    Brismar, K.2    Wang, J.3    Wivall-Helleryd, I.L.4    Sindelar, P.5    Gonzalez, F.J.6    Bergman, T.7    Bobek, G.A.8
  • 50
    • 0037040203 scopus 로고    scopus 로고
    • A role for peroxisome proliferator-activated receptor alpha (PPARalpha) in the control of cardiac malonyl-CoA levels: Reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARalpha are associated with higher concentrations of malonyl-CoA and reduced expression of malonyl-CoA decarboxylase
    • Campbell F.M., Kozak R., Wagner A., Altarejos J.Y., Dyck J.R., Belke D.D., Severson D.L., Kelly D.P., Lopaschuk G.D. A role for peroxisome proliferator-activated receptor alpha (PPARalpha) in the control of cardiac malonyl-CoA levels: reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARalpha are associated with higher concentrations of malonyl-CoA and reduced expression of malonyl-CoA decarboxylase. J. Biol. Chem. 277:2002;4098-4103.
    • (2002) J. Biol. Chem. , vol.277 , pp. 4098-4103
    • Campbell, F.M.1    Kozak, R.2    Wagner, A.3    Altarejos, J.Y.4    Dyck, J.R.5    Belke, D.D.6    Severson, D.L.7    Kelly, D.P.8    Lopaschuk, G.D.9
  • 51
    • 0035914298 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-alpha regulates lipid homeostasis, but is not associated with obesity: Studies with congenic mouse lines
    • Akiyama T.E., Nicol C.J., Fievet C., Staels B., Ward J.M., Auwerx J., Lee S.S., Gonzalez F.J., Peters J.M. Peroxisome proliferator-activated receptor-alpha regulates lipid homeostasis, but is not associated with obesity: studies with congenic mouse lines. J. Biol. Chem. 276:2001;39088-39093.
    • (2001) J. Biol. Chem. , vol.276 , pp. 39088-39093
    • Akiyama, T.E.1    Nicol, C.J.2    Fievet, C.3    Staels, B.4    Ward, J.M.5    Auwerx, J.6    Lee, S.S.7    Gonzalez, F.J.8    Peters, J.M.9
  • 55
    • 0036205326 scopus 로고    scopus 로고
    • Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux
    • Akiyama T.E., Sakai S., Lambert G., Nicol C.J., Matsusue K., Pimprale S., Lee Y.H., Ricote M., Glass C.K., Brewer H.B. Jr., Gonzalez F.J. Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux. Mol. Cell. Biol. 22:2002;2607-2619.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 2607-2619
    • Akiyama, T.E.1    Sakai, S.2    Lambert, G.3    Nicol, C.J.4    Matsusue, K.5    Pimprale, S.6    Lee, Y.H.7    Ricote, M.8    Glass, C.K.9    Brewer H.B., Jr.10    Gonzalez, F.J.11
  • 56
    • 0033625677 scopus 로고    scopus 로고
    • Growth, adipose, brain and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor β(δ)
    • Peters J.M., Lee S.S.T., Li W., Ward J.M., Gavrilova O., Everett C., Reitman M.L., Hudson L.D., Gonzalez F.J. Growth, adipose, brain and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor β(δ). Mol. Cell. Biol. 20:2000;5119-5128.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 5119-5128
    • Peters, J.M.1    Lee, S.S.T.2    Li, W.3    Ward, J.M.4    Gavrilova, O.5    Everett, C.6    Reitman, M.L.7    Hudson, L.D.8    Gonzalez, F.J.9
  • 58
    • 0035432604 scopus 로고    scopus 로고
    • Bezafibrate reduces mRNA levels of adipocyte markers and increases fatty acid oxidation in primary culture of adipocytes
    • Cabrero A., Alegret M., Sanchez R.M., Adzet T., Laguna J.C., Vazquez M. Bezafibrate reduces mRNA levels of adipocyte markers and increases fatty acid oxidation in primary culture of adipocytes. Diabetes. 50:2001;1883-1890.
    • (2001) Diabetes , vol.50 , pp. 1883-1890
    • Cabrero, A.1    Alegret, M.2    Sanchez, R.M.3    Adzet, T.4    Laguna, J.C.5    Vazquez, M.6
  • 59
    • 0035871002 scopus 로고    scopus 로고
    • Differential involvement of peroxisome-proliferator-activated receptors alpha and delta in fibrate and fatty-acid-mediated inductions of the gene encoding liver fatty-acid-binding protein in the liver and the small intestine
    • Poirier H., Niot I., Monnot M.C., Braissant O., Meunier-Durmort C., Costet P., Pineau T., Wahli W., Willson T.M., Besnard P. Differential involvement of peroxisome-proliferator-activated receptors alpha and delta in fibrate and fatty-acid-mediated inductions of the gene encoding liver fatty-acid-binding protein in the liver and the small intestine. Biochem. J. 355:2001;481-488.
    • (2001) Biochem. J. , vol.355 , pp. 481-488
    • Poirier, H.1    Niot, I.2    Monnot, M.C.3    Braissant, O.4    Meunier-Durmort, C.5    Costet, P.6    Pineau, T.7    Wahli, W.8    Willson, T.M.9    Besnard, P.10
  • 61
    • 0029823995 scopus 로고    scopus 로고
    • Peroxisome proliferators induce mouse liver stearoyl-CoA desaturase 1 gene expression
    • Miller C.W., Ntambi J.M. Peroxisome proliferators induce mouse liver stearoyl-CoA desaturase 1 gene expression. Proc. Natl. Acad. Sci. U. S. A. 93:1996;9443-9448.
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 9443-9448
    • Miller, C.W.1    Ntambi, J.M.2
  • 63
    • 0029941669 scopus 로고    scopus 로고
    • Differentiation-dependent expression of the brown adipocyte uncoupling protein gene: Regulation by peroxisome proliferator-activated receptor gamma
    • Sears I.B., MacGinnitie M.A., Kovacs L.G., Graves R.A. Differentiation-dependent expression of the brown adipocyte uncoupling protein gene: regulation by peroxisome proliferator-activated receptor gamma. Mol. Cell. Biol. 16:1996;3410-3419.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 3410-3419
    • Sears, I.B.1    MacGinnitie, M.A.2    Kovacs, L.G.3    Graves, R.A.4
  • 64
    • 0033595591 scopus 로고    scopus 로고
    • PPARalpha activation by Wy 14643 induces transactivation of the rat UCP-1 promoter without increasing UCP-1 mRNA levels and attenuates PPARgamma-mediated increases in UCP-1 mRNA levels induced by rosiglitazone in fetal rat brown adipocytes
    • Teruel T., Clapham J.C., Smith S.A. PPARalpha activation by Wy 14643 induces transactivation of the rat UCP-1 promoter without increasing UCP-1 mRNA levels and attenuates PPARgamma-mediated increases in UCP-1 mRNA levels induced by rosiglitazone in fetal rat brown adipocytes. Biochem. Biophys. Res. Commun. 264:1999;311-315.
    • (1999) Biochem. Biophys. Res. Commun. , vol.264 , pp. 311-315
    • Teruel, T.1    Clapham, J.C.2    Smith, S.A.3
  • 65
    • 0034663347 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha (PPARalpha) activators, bezafibrate and Wy-14,643, increase uncoupling protein-3 mRNA levels without modifying the mitochondrial membrane potential in primary culture of rat preadipocytes
    • Cabrero A., Alegret M., Sanchez R., Adzet T., Laguna J.C., Vazquez M. Peroxisome proliferator-activated receptor alpha (PPARalpha) activators, bezafibrate and Wy-14,643, increase uncoupling protein-3 mRNA levels without modifying the mitochondrial membrane potential in primary culture of rat preadipocytes. Arch. Biochem. Biophys. 380:2000;353-359.
    • (2000) Arch. Biochem. Biophys. , vol.380 , pp. 353-359
    • Cabrero, A.1    Alegret, M.2    Sanchez, R.3    Adzet, T.4    Laguna, J.C.5    Vazquez, M.6
  • 67
    • 0035847001 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell
    • Barbera M.J., Schluter A., Pedraza N., Iglesias R., Villarroya F., Giralt M. Peroxisome proliferator-activated receptor alpha activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell. J. Biol. Chem. 276:2001;1486-1493.
    • (2001) J. Biol. Chem. , vol.276 , pp. 1486-1493
    • Barbera, M.J.1    Schluter, A.2    Pedraza, N.3    Iglesias, R.4    Villarroya, F.5    Giralt, M.6
  • 68
    • 0034052579 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha is restricted to hepatic parenchymal cells, not Kupffer cells: Implications for the mechanism of action of peroxisome proliferators in hepatocarcinogenesis
    • Peters J.M., Rusyn I., Rose M.L., Gonzalez F.J., Thurman R.G. Peroxisome proliferator-activated receptor alpha is restricted to hepatic parenchymal cells, not Kupffer cells: implications for the mechanism of action of peroxisome proliferators in hepatocarcinogenesis. Carcinogenesis. 21:2000;823-826.
    • (2000) Carcinogenesis , vol.21 , pp. 823-826
    • Peters, J.M.1    Rusyn, I.2    Rose, M.L.3    Gonzalez, F.J.4    Thurman, R.G.5
  • 72
    • 0034801882 scopus 로고    scopus 로고
    • Rat PPARs: Quantitative analysis in adult rat tissues and regulation in fasting and refeeding
    • Escher P., Braissant O., Basu-Modak S., Michalik L., Wahli W., Desvergne B. Rat PPARs: quantitative analysis in adult rat tissues and regulation in fasting and refeeding. Endocrinology. 142:2001;4195-4202.
    • (2001) Endocrinology , vol.142 , pp. 4195-4202
    • Escher, P.1    Braissant, O.2    Basu-Modak, S.3    Michalik, L.4    Wahli, W.5    Desvergne, B.6
  • 73
    • 0030047806 scopus 로고    scopus 로고
    • Differential expression of peroxisome proliferator-activated receptors (PPARs): Tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat
    • Braissant O., Foufelle F., Scotto C., Dauca M., Wahli W. Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat. Endocrinology. 137:1996;354-366.
    • (1996) Endocrinology , vol.137 , pp. 354-366
    • Braissant, O.1    Foufelle, F.2    Scotto, C.3    Dauca, M.4    Wahli, W.5
  • 75
    • 0030658022 scopus 로고    scopus 로고
    • Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARalpha and PPARgamma activators
    • Martin G., Schoonjans K., Lefebvre A.M., Staels B., Auwerx J. Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARalpha and PPARgamma activators. J. Biol. Chem. 272:1997;28210-28217.
    • (1997) J. Biol. Chem. , vol.272 , pp. 28210-28217
    • Martin, G.1    Schoonjans, K.2    Lefebvre, A.M.3    Staels, B.4    Auwerx, J.5
  • 76
    • 0024467463 scopus 로고
    • Molecular cloning and nucleotide sequence of cDNAs encoding the precursors of rat long chain acyl-coenzyme A, short chain acyl-coenzyme A, and isovaleryl-coenzyme A dehydrogenases. Sequence homology of four enzymes of the acyl-CoA dehydrogenase family
    • Matsubara Y., Indo Y., Naito E., Ozasa H., Glassberg R., Vockley J., Ikeda Y., Kraus J., Tanaka K. Molecular cloning and nucleotide sequence of cDNAs encoding the precursors of rat long chain acyl-coenzyme A, short chain acyl-coenzyme A, and isovaleryl-coenzyme A dehydrogenases. Sequence homology of four enzymes of the acyl-CoA dehydrogenase family. J. Biol. Chem. 264:1989;16321-16331.
    • (1989) J. Biol. Chem. , vol.264 , pp. 16321-16331
    • Matsubara, Y.1    Indo, Y.2    Naito, E.3    Ozasa, H.4    Glassberg, R.5    Vockley, J.6    Ikeda, Y.7    Kraus, J.8    Tanaka, K.9
  • 77
    • 0028229531 scopus 로고
    • Rat very-long-chain acyl-CoA dehydrogenase, a novel mitochondrial acyl-CoA dehydrogenase gene product, is a rate-limiting enzyme in long-chain fatty acid beta-oxidation system. cDNA and deduced amino acid sequence and distinct specificities of the cDNA-expressed protein
    • Aoyama T., Ueno I., Kamijo T., Hashimoto T. Rat very-long-chain acyl-CoA dehydrogenase, a novel mitochondrial acyl-CoA dehydrogenase gene product, is a rate-limiting enzyme in long-chain fatty acid beta-oxidation system. cDNA and deduced amino acid sequence and distinct specificities of the cDNA-expressed protein. J. Biol. Chem. 269:1994;19088-19094.
    • (1994) J. Biol. Chem. , vol.269 , pp. 19088-19094
    • Aoyama, T.1    Ueno, I.2    Kamijo, T.3    Hashimoto, T.4
  • 78
    • 0024427057 scopus 로고
    • Differentiation-induced gene expression in 3T3-L1 preadipocytes. A second differentially expressed gene encoding stearoyl-CoA desaturase
    • Kaestner K.H., Ntambi J.M., Kelly T.J. Jr., Lane M.D. Differentiation-induced gene expression in 3T3-L1 preadipocytes. A second differentially expressed gene encoding stearoyl-CoA desaturase. J. Biol. Chem. 264:1989;14755-14761.
    • (1989) J. Biol. Chem. , vol.264 , pp. 14755-14761
    • Kaestner, K.H.1    Ntambi, J.M.2    Kelly T.J., Jr.3    Lane, M.D.4
  • 80
    • 0025150029 scopus 로고
    • Alterations in thyroid status modulate apolipoprotein, hepatic triglyceride lipase, and low density lipoprotein receptor in rats
    • Staels B., Van Tol A., Chan L., Will H., Verhoeven G., Auwerx J. Alterations in thyroid status modulate apolipoprotein, hepatic triglyceride lipase, and low density lipoprotein receptor in rats. Endocrinology. 127:1990;1144-1152.
    • (1990) Endocrinology , vol.127 , pp. 1144-1152
    • Staels, B.1    Van Tol, A.2    Chan, L.3    Will, H.4    Verhoeven, G.5    Auwerx, J.6
  • 82
    • 0028817459 scopus 로고
    • Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates
    • Staels B., Vu-Dac N., Kosykh V.A., Saladin R., Fruchart J.C., Dallongeville J., Auwerx J. Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates. J. Clin. Invest. 95:1995;705-712.
    • (1995) J. Clin. Invest. , vol.95 , pp. 705-712
    • Staels, B.1    Vu-Dac, N.2    Kosykh, V.A.3    Saladin, R.4    Fruchart, J.C.5    Dallongeville, J.6    Auwerx, J.7
  • 83
    • 0030849408 scopus 로고    scopus 로고
    • A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a and Cyp4b, but not of CYP4F, genes in mouse and humans
    • Heng Y.M., Kuo C.S., Jones P.S., Savory R., Schulz R.M., Tomlinson S.R., Gray T.J., Bell D.R. A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a and Cyp4b, but not of CYP4F, genes in mouse and humans. Biochem. J. 325(Pt 3):1997;741-749.
    • (1997) Biochem. J. , vol.325 , Issue.PART 3 , pp. 741-749
    • Heng, Y.M.1    Kuo, C.S.2    Jones, P.S.3    Savory, R.4    Schulz, R.M.5    Tomlinson, S.R.6    Gray, T.J.7    Bell, D.R.8
  • 85
    • 0030766476 scopus 로고    scopus 로고
    • Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alpha-deficient mice
    • Peters J.M., Hennuyer N., Staels B., Fruchart J.C., Fievet C., Gonzalez F.J., Auwerx J. Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alpha-deficient mice. J. Biol. Chem. 272:1997;27307-27312.
    • (1997) J. Biol. Chem. , vol.272 , pp. 27307-27312
    • Peters, J.M.1    Hennuyer, N.2    Staels, B.3    Fruchart, J.C.4    Fievet, C.5    Gonzalez, F.J.6    Auwerx, J.7
  • 86
    • 0028998129 scopus 로고
    • Mode of action of peroxisome proliferators as hypolipidemic drugs. Suppression of apolipoprotein C-III
    • Hertz R., Bishara-Shieban J., Bar-Tana J. Mode of action of peroxisome proliferators as hypolipidemic drugs. Suppression of apolipoprotein C-III. J. Biol. Chem. 270:1995;13470-13475.
    • (1995) J. Biol. Chem. , vol.270 , pp. 13470-13475
    • Hertz, R.1    Bishara-Shieban, J.2    Bar-Tana, J.3
  • 87
    • 0037013201 scopus 로고    scopus 로고
    • Dual promoter structure of mouse and human fatty acid translocase/CD36 genes and unique transcriptional activation by peroxisome proliferator-activated receptor alpha and gamma ligands
    • Sato O., Kuriki C., Fukui Y., Motojima K. Dual promoter structure of mouse and human fatty acid translocase/CD36 genes and unique transcriptional activation by peroxisome proliferator-activated receptor alpha and gamma ligands. J. Biol. Chem. 277:2002;15703-15711.
    • (2002) J. Biol. Chem. , vol.277 , pp. 15703-15711
    • Sato, O.1    Kuriki, C.2    Fukui, Y.3    Motojima, K.4
  • 88
    • 0032479423 scopus 로고    scopus 로고
    • Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner
    • Motojima K., Passilly P., Peters J.M., Gonzalez F.J., Latruffe N. Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner. J. Biol. Chem. 273:1998;16710-16714.
    • (1998) J. Biol. Chem. , vol.273 , pp. 16710-16714
    • Motojima, K.1    Passilly, P.2    Peters, J.M.3    Gonzalez, F.J.4    Latruffe, N.5
  • 91
    • 0037088649 scopus 로고    scopus 로고
    • Mechanism for peroxisome proliferator-activated receptor-alpha activator-induced up-regulation of UCP2 mRNA in rodent hepatocytes
    • Nakatani T., Tsuboyama-Kasaoka N., Takahashi M., Miura S., Ezaki O. Mechanism for peroxisome proliferator-activated receptor-alpha activator-induced up-regulation of UCP2 mRNA in rodent hepatocytes. J. Biol. Chem. 277:2002;9562-9569.
    • (2002) J. Biol. Chem. , vol.277 , pp. 9562-9569
    • Nakatani, T.1    Tsuboyama-Kasaoka, N.2    Takahashi, M.3    Miura, S.4    Ezaki, O.5
  • 92
    • 0035658771 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids stimulate hepatic UCP-2 expression via a PPARalpha-mediated pathway
    • Armstrong M.B., Towle H.C. Polyunsaturated fatty acids stimulate hepatic UCP-2 expression via a PPARalpha-mediated pathway. Am. J. Physiol.: Endocrinol. Metab. 281:2001;E1197-E1204.
    • (2001) Am. J. Physiol.: Endocrinol. Metab. , vol.281
    • Armstrong, M.B.1    Towle, H.C.2
  • 93
    • 0032699670 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting
    • Kersten S., Seydoux J., Peters J.M., Gonzalez F.J., Desvergne B., Wahli W. Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J. Clin. Invest. 103:1999;1489-1498.
    • (1999) J. Clin. Invest. , vol.103 , pp. 1489-1498
    • Kersten, S.1    Seydoux, J.2    Peters, J.M.3    Gonzalez, F.J.4    Desvergne, B.5    Wahli, W.6
  • 94
    • 0037022592 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling
    • Shi Y., Hon M., Evans R.M. The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling. Proc. Natl. Acad. Sci. U. S. A. 99:2002;2613-2618.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 2613-2618
    • Shi, Y.1    Hon, M.2    Evans, R.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.