Sulphur-containing amino acids are agonists for group 1 metabotropic receptors expressed in clonal RGT cell lines

Neuropharmacology

Volumn 37, Issue 3, 1998, Pages 277-287

  Kingston, A E ^a   Lowndes, J ^a   Evans, N ^a   Clark, B ^a   Tomlinson, R ^a   Burnett, J P ^a   Mayne, N G ^a   Cockerham, S L ^a   Lodge, D ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

AV12 664 cells; Clonedd mGluRs; Human metabotropic glutamate receptors (hmGluRs); Phosphoinositide hydrolysis; Sulphur amino acids

Indexed keywords

ALANINE AMINOTRANSFERASE; AMINO ACID; COMPLEMENTARY DNA; CYSTEIC ACID; CYSTEINE SULFINIC ACID; HOMOCYSTEINE SULFINIC ACID; METABOTROPIC RECEPTOR; NEUROTRANSMITTER; NEUROTRANSMITTER RECEPTOR; PHOSPHATIDYLINOSITIDE; SERINE SULFATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; DNA LIBRARY; DRUG EFFECT; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; HYDROLYSIS; MOLECULAR CLONING; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SYRIAN HAMSTER; TUMOR CELL LINE;

EID: 0032029102     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(98)00018-5     Document Type: Article

References (50)

1. 2+ signal transduction. J. Biol. Chem. 267:1992;13361-13368.
2. Aramori I., Nakanishi S. Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluR1, in transfected CHO cells. Neuron. 8:1992;757-765.
3. Arrizza J.L., Fairman W.A., Wadiche J.I., Murdoch G.H., Kavanaugh M.P., Amara S.G. Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex. J. Neurosci. 14:1994;5559-5569.
4. Baba A. Neurochemical characterisation of cysteine sulphinic acid, an excitatory amino acid in the hippocampus. Japn. J. Pharmacol. 43:1987;1-7.
5. Berg D., Mc Clure D., Grinnell B. High level expression of secreted proteins from cells adapted to serum-free suspension culture. Biotechniques. 14:1993;972-978.
6. Boyd E.A., Alexander S.P.H., Kendall D.A., Loh V.M. DHPMP: A novel group 1 specific metabotropic glutamate receptor agonist. Biorg. Med. Chem. Lett. 6:1996;2137-2140.
7. Conn P.J., Pin J.-P. Pharmacology and function of metabotropic glutamate receptors. Annu. Rev. Pharmacol. Toxicol. 37:1997;205-237.
8. Curtis D.R., Watkins J.C. The excitation and depression of spinal neurones by structurally related amino acids. J. Neurochem. 6:1960;117-141.
9. Curtis D.R., Watkins J.C. Acidic amino acids with strong excitatory actions on mammalian neurones. J. Physiol. Lond. 166:1963;1-4.
10. Desai M., Burnett J.P., Mayne N.G., Schoepp D.D. Cloning and expression of human mGluR1α: Enhanced coupling upon co-transfection with a glutamate transporter. Mol. Pharmacol. 48:1995;648-657.
11. Do K.Q., Mattenberger M., Streit P., Cuenod M. In vitro release of endogenous excitatory sulphur containing amino acids from various rat brain regions. J. Neurochem. 46:1986;779-786.
12. Do K.Q., Grandes P., Hansel C. et al. Sulphur containig excitatory amino acids; release, activity and localisation. Mol. Neuropharmacol. 2:1992;39-42.
13. Duvoisin R.M., Zhang C., Ramonell K. A novel metabotropic glutamate receptor expressed in the retina and olfactory bulb. J. Neurosci. 15:1995;3075-3083.
14. 3H]L-2-amino-4-phosphonobutyrate labels a metabotropic glutamate receptor, mGluR4a. Br. J. Pharmacol. 116:1995;3279-3287.
15. Graham F.L., Van Der Eb A.J. A new technique for the measurement of infectivity of adenovirus 5 DNA. Virology. 52:1973;456-467.
16. Griffiths R., Grieve A., Dunlop J., Damgaard I., Fosmark H., Schousboe A. Inhibition by excitatory sulphur amino acids of the high affinity L-glutamate transporter in synaptosomes and in primary cultures of cortical astrocytes and cerebellar neurons. Neurochem. Res. 14:1989;339-343.
17. Griffiths R. Cysteine sulphinate (CSA) as an excitatory amino acid transmitter candidate in the mammalian central nervous system. Prog. Neurobiol. 35:1990;313-323.
18. Harvey J., Wedley S., Findlay J.D., Sidell M.R., Pullar I.A. Agatoxin IVA identifies a single calcium channel subtype which contributes to the potassium-induced release of acetylcholine, 5-hydroxytryptamine, dopamine, γ-aminobutyric acid and glutamate from rat brain slices. Neuropharmacology. 35:1996;385-392.
19. Hollman M., Heinenmann S. Cloned glutamate receptors. Ann. Rev. Neurosci. 17:1994;31-103.
20. Houamed K.M., Kuijper J.L., Gilbert T.L. et al. Cloning, expression and gene structure of a G-protein coupled glutamate receptor from rat brain. Science. 252:1991;1318-1321.
21. Iwata H., Yamagami S., Mizuo H., Baba A. Cysteine sulphinic acid in the CNS-uptake and release of cysteine sulphinic acid by a rat brain preparation. J. Neurochem. 38:1982;1268-1274.
22. Kilpatrick I.C., Mozley L.S. An initial analysis of the regional distribution of excitatory sulphur containing amino acids in the rat brain. Neurosci. Lett. 72:1986;189-193.
23. Klockner U., Storck T., Conradt M., Stoffel W. Functional properties and substrate specificity of the cloned L-glutamate/L-aspartate transporter GLAST for rat brain expressed in Xenopus oocytes. J. Neurosci. 14:1994;5759-5765.
24. Lowry O.H., Rosebrough M.J., Farr A.L., Randall R.J. Protein measurement with the folin phenol reagent. J. Biol. Chem. 199:1951;265-275.
25. Maslanski J.A., Busa W.B. A sensitive and specific mass assay for myo-inositol and inositol phosphates. Irvine R.F. Methods in Inositide Research. 1990;113-126 Raven Press, New York.
26. Masu M., Tanabe Y., Tsuchida K., Shigemoto R., Nakanishi S. Sequence and expression of a metabotropic glutamate receptor. Nature. 49:1991;760-765.
27. Mc Pherson G.A. EBDA. In: Kinetic, EBDA, LIGAND, Lowry. McPherson G.A. A Collection of Radioligand Binding Analysis Programs. 1985;14-58 Elsevier-Biosofot, Cambridge.
28. Mewett K.N., Oakes D.J., Olverman H.J., Smith D.A.S., Watkins J.C. Pharmacology of the Excitatory Actions of Sulphonic and Sulphinic Amino Acids. Mandel P., DeFeudis F.V. CNS Receptors - From Molecular Pharmacology to Behaviour. 1983;Raven Press, New York.
29. Miller S., Bridges R.J., Chamberlin A.R., Cotman C.W. Pharmacological dissociation of glutamatergic metabotropic signal transduction pathways in cortical astrocytes. Eur. J. Pharmacol. Mol. Pharmacol. Sect. 269:1994;235-241.
30. Minakami R., Katsuki F., Sugiyama H. A variant of metabotropic glutamate receptor subtype 5: An evolutionally conserved insertion with no termination codon. Biochem. Biophys. Res. Commun. 194:1993;622-627.
31. Munson P.J., Rodbard D. LIGAND: A versatile computerized approach for the characterisation of ligand binding systems. Anal. Biochem. 107:1980;220-239.
32. Nakajima Y., Iwakabe H., Akazawa C. et al. Molecular characterisation of a novel retinal metabotropic glutamate receptor mGluR6 with high agonist selectivity for L-2-amino-4-phosphonobutyrate. J. Biol. Chem. 268:1993;11868-11873.
33. Nakanishi S. Molecular diversity of glutamate receptors and implications for brain function. Science. 258:1992;597-603.
34. Nicoletti F., Meek J.L., Iardorola M.J., Chuang D.M., Roth B.L., Costa E. Coupling of inositol phospholipid metabolism with excitatory amino acid recognition sites in rat hippocampus. J. Neurochem. 46:1986;40-46.
35. Okamoto N., Hori S., Akazawa C. et al. Molecular characterisation of new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction. J. Biol. Chem. 269:1994;1231-1236.
36. Pin J.-P., Waeber C., Prezeau L., Bockaert J., Heinemann S.F. Alternative splicing generates metabotropic glutamate receptors inducing different patterns of calcium release in Xenopus oocytes. Proc. Natl. Acad. Sci. USA. 89:1992;10331-10335.
37. Pin J.-P., Duvoisin R. The metabotropic glutamate receptors: structure and function. Neuropharmacology. 34:1995;1-26.
38. Porter R.H.P., Roberts P.J. Glutamate metabotropic receptor activation in neonatal rat cerebral cortex by sulphur containing excitatory amino acids. Neurosci. Lett. 154:1993;78-80.
39. Pullan L.M., Olney J.W., Price M.T. et al. Excitatory amino acid receptor potency and subclass specificity of sulphur containing amino acids. J. Neurochem. 49:1987;1301-1307.
40. Recasens M., Saadain F., Maitre M. et al. CNS Receptors. Mandel P., DeFeudis F.V. From Molecular Pharmacology to Behaviour. 1983;Raven Press, New York.
41. 3H]-glutamate release from rat brain slices. Neurochem. Int. 6:1984;325-332.
42. Saugstad J.A., Kinzie J.M., Mulvihill E.R., Segerson T.P., Westbrook G.L. Cloning and expression of a new member of the L-2-amino-4-phosphonobutyric acid sensitive class of metabotropic glutamate receptors. Mol. Pharmacol. 45:1994;467-472.
43. Schoepp D., Conn P.J. Metabotropic glutamate receptors in brain function and pathology. Trends Pharm. Sci. 14:1993;13-25.
44. Schoepp D.D., Goldsworthy J., Johnson B.G., Salhoff C.R., Baker S.R. 3,5, Dihyroxyphenylglycine is a highly selective agonist for phosphoinositide-linked metabotropic glutamate receptors in the rat hippocampus. J. Neurochem. 63:1994;769-772.
45. Sladeczek F., Pin J.-P., Reacasen M., Bockaert J., Weiss S. Glutamate stimulates inositol phosphate formation in striatal neurones. Nature. 317:1985;717-719.
46. Sugiyama H., Ito I., Hirono C. A new type of glutamate receptor linked to phospholipid metabolism. Nature. 325:1987;531-533.
47. +-dependent glutamate/aspartate transporter of rat brain. Proc. Natl. Acad. Sci. 89:1992;10955-10959.
48. Tanabe Y., Masu M., Ishii T., Shigemoto R., Nakanishi S. A family of metabotropic glutamate receptors. Neuron. 8:1992;169-179.
49. Thomsen C., Mulvihill E.R., Haldeman B., Pickering D.S., Hampson D.R., Suzdak P.D. A pharmacological characterisation of the mGluR1α subtype of the metabotropic glutamate receptor expressed in a cloned baby hamster kidney cell line. Brain Res. 619:1993;22-28.
50. Thomsen C., Hansen L., Suzdak P.D. L-Glutamate uptake inhibitors may stimulate phosphoinositide hydrolysis in baby hamster kidney cells expressing mGluR1α via heteroexchange with L-glutamate without direct activation of mGluR1α J. Neurochem. 63:1994;2038-2047.