N-methyl-D-aspartate but not glutamate induces the release of hydroxyl radicals in the neonatal rat: Modulation by group I metabotropic glutamate receptors

Journal of Neuroscience Research

Volumn 62, Issue 1, 2000, Pages 84-90

  Mei, Xun ^a   Sweatt, Andrew J ^a   Hammarback, James A ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Hypoxicischemic diseases; Metabotropic receptors; Neonates; NMDA receptors; Oxidative stress

Indexed keywords

3,5 DIHYDROXYPHENYLGLYCINE; GLUTAMIC ACID; HYDROXYL RADICAL; IBOTENIC ACID; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR AGONIST; N METHYL DEXTRO ASPARTIC ACID; NEUROPROTECTIVE AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HYPOXIA; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN PROTECTION; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MICRODIALYSIS; NEUROPATHOLOGY; NEUROPROTECTION; NEUROTOXICITY; NEWBORN; NEWBORN HYPOXIA; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION;

ANIMAL; ANIMALS, NEWBORN; CORPUS STRIATUM; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; GLYCINE; HYDROXYBENZOIC ACIDS; HYDROXYL RADICAL; HYPOXIA-ISCHEMIA, BRAIN; IBOTENIC ACID; INDANS; MICRODIALYSIS; N-METHYLASPARTATE; RATS; RATS, WISTAR; RECEPTORS, METABOTROPIC GLUTAMATE; RECEPTORS, N-METHYL-D-ASPARTATE; RESORCINOLS;

EID: 0033778130     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-4547(20001001)62:1<84::AID-JNR9>3.0.CO;2-U     Document Type: Article

References (48)

1. Developmental regulation of the recovery process following glutamate-induced calcium rise in rodent primary neuronal cultures
2. Modulation of N-methyl-D-aspartate receptors by hydroxyl radicals in rat cortical neurons in vitro
3. Reactive oxygen species mediate activity-dependent neuron-glia signaling in output fibers of the hippocampus
4. Formation of free radicals in hypoxic ischemic brain damage in the neonatal rat, assessed by an endogenous spin trap and lipid peroxidation
5. Pathophysiology of perinatal brain damage
6. Group I metabotropic glutamate receptors: Implications for brain diseases
7. New structures able to prevent the inhibition by hydroxyl radicals of glutamate transport in cultured astrocytes
8. Recurrent glutamate stimulations potentiate the hydroxyl radicals response to a low glutamate concentration
9. Lack of correlation between the effects of transient exposure to glutamate and those of hypoxia/reoxygenation in immature neurons in vitro
10. Oxygen, antioxidants and brain dysfunction
11. Regulation of N-methyl-D-aspartate-induced toxicity in the neostriatum: A role for metabotropic glutamate receptors?
12. Direct effects of metabotropic glutamate receptor compounds on native and recombinant N-methyl-D-aspartate receptors
13. Mechanisms of cerebral injury in perinatal asphyxia and strategies for prevention
14. In vitro neuroprotection against glutamate toxicity provided by novel non-competitive NMDA antagonists
15. Neuronal vacuolization and necrosis induced by the noncompetitive N-methyl-D-aspartate (NMDA) antagonist MK(+)801 (dizocilpine maleate): A light and electron microscopic evaluation of the rat retrosplenial cortex
16. Hypoxic-ischemic injury in the neonatal rat brain: Effects of pre- and post-treatment with the glutamate release inhibitor BW1003C87
17. Glutamate release and free radical production following brain injury: Effects of posttraumatic hypothermia
18. Effects of perinatal stroke on striatal amino acid efflux in rats studied with in vivo microdialysis
19. Intracerebral NMDA injection stimulates production of interleukin 1β in perinatal rat brain
20. Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain
21. Heightened resistance of the neonatal brain to ischemia-reperfusion involves a lack of mitochondrial damage in the nerve terminal
22. Excitotoxicity and neuroprotection
23. A microdialysis study investigating the mechanisms of hydroxyl radical formation in rat striatum exposed to glutamate
24. The novel non-competitive NMDA antagonist gacyclidine blocks the glutamate-induced hydroxyl radicals release in the striatum when dizocilpine don't. A microdialysis study in rats
25. Age-dependent effects of glutamate toxicity in the hippocampus
26. Opposing effects of excitatory amino acids on chick embryo spinal cord motoneurons: Excitotoxic degeneration or prevention of programmed cell death
27. Differential plasma membrane distribution of metabotropic glutamate receptors mGluR1 alpha, mGluR2 and mGluR5, relative to neurotransmitter release sites
28. Effect of ibotenate on brain development: An excitotoxic mouse model of micro gyria and posthypoxic-like lesions
29. Arrest of neuronal migration by excitatory amino acids in hamster developing brain
30. The physiology of excitatory amino acids in the vertebrate central nervous system
31. Metabotropic glutamate receptors: A new target for the therapy of neurodegenerative disorders?
32. Group-I metabotropic glutamate receptors: Hypotheses to explain their dual role in neurotoxicity and neuroprotection
33. NMDA antagonist neurotoxicity: Mechanism and prevention
34. Protection with metabotropic glutamate 1 receptor antagonists in models of ischemic neuronal death: Time-course and mechanisms
35. Glutamate receptor activity is required for normal development of tectal cell dendrites in vivo
36. Long-term evolution of excitotoxic cortical dysgenesis induced in the developing rat brain
37. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate
38. The activation of metabotropic glutamate receptors protects nerve cells from oxidative stress
39. Protective effect of group I metabotropic glutamate receptor activation against hypoxic/hypoglycemic injury in rat hippocampal slices: Timing and involvement of protein kinase C
40. DifFerential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus
41. Effects of hypoxia-ischemia and MK-801 treatment on the binding of a phencyclidine analogue in the developing rat brain
42. Sustained hypoxia-ischemia results in reactive initrogen and oxygen species production and injury in the premature fetal rabbit brain
43. Regulation of NMDA receptor phosphorylation by alternative splicing of the C-terminal domain
44. Brain damage due to cerebral hypoxia/ischemia in the neonate: Pathology and pharmacological modification
45. Potentiation of NMDA and AMPA responses by the specific mGluR5 agonist CHPG in spinal cord motoneurons
46. Neurgdegeneration induced by reversed microdialysis of NMDA; a quantitative model for excitotoxicity in vivo
47. CSF glutamate during hypoxia-ischemia in the immature rat
48. Reactive oxygen species inhibit high-affinity glutamate uptake: Molecular mechanism and neuropathological implications