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DNA Photocleavage by phenanathrene diimine complexes of rhodium(III): Shape-selective recognition and reaction
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Solution structure of a metallointercalator bound site specifically to DNA
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Hudson B.P., Barton J.K. Solution structure of a metallointercalator bound site specifically to DNA. J Am Chem Soc. 120:1998;6877-6888.
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0033952705
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Structure of a photoactive rhodium complex intercalated into DNA
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The first high-resolution crystal structure of a metallointercalator site-specifically bound within a DNA octamer is described. The structure reveals the deep stacking of the intercalated ligand within the base-pair stack.
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Kielkopf C.L., Erkkila K.E., Hudson B.P., Barton J.K., Rees D.C. Structure of a photoactive rhodium complex intercalated into DNA. Nat Struct Biol. 7:2000;117-121. The first high-resolution crystal structure of a metallointercalator site-specifically bound within a DNA octamer is described. The structure reveals the deep stacking of the intercalated ligand within the base-pair stack.
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Kielkopf, C.L.1
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Distance-dependent electron transfer in DNA hairpins
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Long-range photoinduced electron transfer through a DNA helix
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Murphy C.J., Arkin M.R., Jenkins Y., Ghatlia N.D., Turro N.J., Barton J.K. Long-range photoinduced electron transfer through a DNA helix. Science. 262:1993;1025-1029.
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Photoinduced electron transfer in ethidium-modified DNA duplexes: Dependence on distance and stacking
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Kelley S.O., Holmlin R.E., Stemp E.D.A., Barton J.K. Photoinduced electron transfer in ethidium-modified DNA duplexes: dependence on distance and stacking. J Am Chem Soc. 119:1997;9861-9870.
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DNA-mediated electron transfer from a modified base to ethidium: Π-stacking as a modulator of activity
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Kelley S.O., Barton J.K. DNA-mediated electron transfer from a modified base to ethidium: π-stacking as a modulator of activity. Chem Biol. 5:1998;413-425.
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0033065078
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Femtosecond dynamics of DNA-mediated electron transfer
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The direct observation of ultrafast electron-transfer between ethidium and 7-deazaguanine through DNA was observed with femtosecond resolution. The electron transfer, which is independent of donor-acceptor distances between 10 and 17 Å, occurs with time constants of 5 ps and 75 ps, where the 5 ps component is attributed to direct electron-transfer and the 75 ps component requires the reorientation of the ethidium intercalator.
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Wan C., Fiebig T., Kelley S.O., Treadway C.R., Barton J.K., Zewail A.H. Femtosecond dynamics of DNA-mediated electron transfer. Proc Natl Acad Sci USA. 96:1999;6014-6019. The direct observation of ultrafast electron-transfer between ethidium and 7-deazaguanine through DNA was observed with femtosecond resolution. The electron transfer, which is independent of donor-acceptor distances between 10 and 17 Å, occurs with time constants of 5 ps and 75 ps, where the 5 ps component is attributed to direct electron-transfer and the 75 ps component requires the reorientation of the ethidium intercalator.
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Wan, C.1
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Electron transfer between bases in double helical DNA
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Long-range triplet energy transfer between metallointercalators tethered to DNA: Importance of intercalation, stacking, and distance
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Holmlin R.E., Tong R.T., Barton J.K. Long-range triplet energy transfer between metallointercalators tethered to DNA: importance of intercalation, stacking, and distance. J Am Chem Soc. 120:1998;9724-9725.
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Synthesis of metallointercalator-DNA conjugates on a solid support
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Holmlin R.E., Dandliker P.J., Barton J.K. Synthesis of metallointercalator-DNA conjugates on a solid support. Bioconj Chem. 10:1999;1122-1127.
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Metal-containing oligonucleotides: Solid-phase synthesis and luminescence properties
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Long-range electron transfer through DNA films
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This paper describes the application of electrochemistry on DNA-modified gold surfaces to examine electron transfer through DNA and the sensitivity of the reaction to a single base mismatch.
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Kelley S.O., Jackson N.M., Hill M.G., Barton J.K. Long-range electron transfer through DNA films. Angew Chem Int Ed. 38:1999;941-945. This paper describes the application of electrochemistry on DNA-modified gold surfaces to examine electron transfer through DNA and the sensitivity of the reaction to a single base mismatch.
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Angew Chem Int Ed
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Kelley, S.O.1
Jackson, N.M.2
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29544444893
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Photoinduced DNA cleavage via electron transfer-demonstration that guanine residues located 5′ to guanine are the most electron-donating sites
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Saito I., Takayama M., Sugiyama H., Nakatani K., Tsuchida A., Yamamoto M. Photoinduced DNA cleavage via electron transfer-demonstration that guanine residues located 5′ to guanine are the most electron-donating sites. J Am Chem Soc. 117:1995;6406-6407.
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Long-range oxidative damage to DNA: Effects of distance and sequence
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Covalently-tethered photoexited Rh(III) and Ru(III) oxidants were shown to oxidize guanine over a distance of 200 Å through the DNA base stack. This long-range oxidation is sensitive to the sequence and stacking of the intervening bases.
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Núñez M.E., Hall D.B., Barton J.K. Long-range oxidative damage to DNA: effects of distance and sequence. Chem Biol. 6:1999;85-97. Covalently-tethered photoexited Rh(III) and Ru(III) oxidants were shown to oxidize guanine over a distance of 200 Å through the DNA base stack. This long-range oxidation is sensitive to the sequence and stacking of the intervening bases.
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Chem Biol
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Núñez, M.E.1
Hall, D.B.2
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0031593021
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Intramolecular photoinduced electron transfer to anthraquinones linked to duplex DNA: The effect of gaps and traps on long-range radical cation migration
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Gasper S.M., Schuster G.B. Intramolecular photoinduced electron transfer to anthraquinones linked to duplex DNA: the effect of gaps and traps on long-range radical cation migration. J Am Chem Soc. 119:1997;12762-12771.
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0033587765
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Long distance charge transport in duplex DNA: The phonon-assisted polaron-like hopping mechanism
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Along with experiments demonstrating charge transfer at long range through the DNA helix from guanine to a tethered anthraquinone, Schuster and co-workers here describe the phonon-assisted polaron hopping mechanism of charge migration through the DNA base stack.
-
Henderson P.T., Jones D., Hampikian G., Kan Y., Schuster G.B. Long distance charge transport in duplex DNA: the phonon-assisted polaron-like hopping mechanism. Proc Natl Acad Sci USA. 96:1999;8353-8358. Along with experiments demonstrating charge transfer at long range through the DNA helix from guanine to a tethered anthraquinone, Schuster and co-workers here describe the phonon-assisted polaron hopping mechanism of charge migration through the DNA base stack.
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Proc Natl Acad Sci USA
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Henderson, P.T.1
Jones, D.2
Hampikian, G.3
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Schuster, G.B.5
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39
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0032506174
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Long-range and short-range oxidative damage to DNA: Photoinduced damage to guanines in ethidium-DNA assemblies
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Hall D.B., Kelley S.O., Barton J.K. Long-range and short-range oxidative damage to DNA: photoinduced damage to guanines in ethidium-DNA assemblies. Biochemistry. 37:1998;15933-15940.
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Biochemistry
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Hall, D.B.1
Kelley, S.O.2
Barton, J.K.3
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0031005140
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Sensitivity of DNA-mediated electron transfer to the intervening pi-stack: A probe for the integrity of the DNA base stack
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Hall D.B., Barton J.K. Sensitivity of DNA-mediated electron transfer to the intervening pi-stack: a probe for the integrity of the DNA base stack. J Am Chem Soc. 119:1997;5045-5046.
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J Am Chem Soc
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Hall, D.B.1
Barton, J.K.2
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41
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1842330888
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Oxidative thymine dimer repair in the DNA helix
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Dandliker P.J., Holmlin R.E., Barton J.K. Oxidative thymine dimer repair in the DNA helix. Science. 275:1997;1465-1468.
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Science
, vol.275
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Dandliker, P.J.1
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42
-
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0345627975
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Oxidative charge transfer to repair thymine dimers and damage guanine bases in DNA assemblies containing tethered metallointercalators
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Photoexcited Rh(III) intercalators were shown both to oxidize guanine and to repair thymine-dimer lesions. In DNA assemblies containing both guanine doublets and thymine-dimer lesions, some guanine oxidation and some thymine-dimer repair is observed, although the yield of both reactions is diminished compared with duplexes containing only one of the oxidizable sites.
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Dandliker P.J., Núñez M.E., Barton J.K. Oxidative charge transfer to repair thymine dimers and damage guanine bases in DNA assemblies containing tethered metallointercalators. Biochemistry. 37:1998;6491-6502. Photoexcited Rh(III) intercalators were shown both to oxidize guanine and to repair thymine-dimer lesions. In DNA assemblies containing both guanine doublets and thymine-dimer lesions, some guanine oxidation and some thymine-dimer repair is observed, although the yield of both reactions is diminished compared with duplexes containing only one of the oxidizable sites.
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(1998)
Biochemistry
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Dandliker, P.J.1
Núñez, M.E.2
Barton, J.K.3
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43
-
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0032717327
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Long-range charge hopping in DNA
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Jortner and co-workers propose, based upon experiments performed by Giese and co-workers, that charges move through DNA according to a mechanism wherein electronic holes hop along the DNA duplex from guanine to guanine in a multistep process.
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Bixon M., Giese B., Wessely S., Langenbacher T., Michel-Beyerle M.E., Jortner J. Long-range charge hopping in DNA. Proc Natl Acad Soc USA. 96:1999;11713-11716. Jortner and co-workers propose, based upon experiments performed by Giese and co-workers, that charges move through DNA according to a mechanism wherein electronic holes hop along the DNA duplex from guanine to guanine in a multistep process.
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Proc Natl Acad Soc USA
, vol.96
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-
Bixon, M.1
Giese, B.2
Wessely, S.3
Langenbacher, T.4
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Jortner, J.6
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0032539233
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Sequence dependent long range hole transport in DNA
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Giese, B.3
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On the mechanism of long-range electron transfer through DNA
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Giese B., Wessely S., Spormann M., Lindemann U., Meggers E., Michel-Beyerle M.E. On the mechanism of long-range electron transfer through DNA. Angew Chem Int Ed. 38:1999;996-998.
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Wessely, S.2
Spormann, M.3
Lindemann, U.4
Meggers, E.5
Michel-Beyerle, M.E.6
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0031027125
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How easily oxidizable is DNA - One electron reduction potentials of adenosine and guanosine radicals in aqueous solution
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Jovanovic, S.V.2
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Purine bases, nucleosides, and nucleotides: Aqueous solution redox chemistry and transformation reactions of their radical cations and e- And OH adducts
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0346053694
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Evidence of electron transfer from peptides to DNA: Oxidation of DNA-bound tryptophan using the flash-quench technique
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Wagenknecht H.-A., Stemp E.D.A., Barton J.K. Evidence of electron transfer from peptides to DNA: oxidation of DNA-bound tryptophan using the flash-quench technique. J Am Chem Soc. 122:2000;1-7.
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J Am Chem Soc
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Wagenknecht, H.-A.1
Stemp, E.D.A.2
Barton, J.K.3
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49
-
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0033575095
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Protein-modulated DNA electron transfer
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Long-range guanine oxidation through oligonucleotides was diminished by the binding of a 'base-flipping' protein, HhaI methylase, to the intervening sequence because the protein binding disrupts the continuity of the π stack. Binding of a mutant Trp-containing methylase restores the π stacking and the long-range guanine oxidation.
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Rajski S.R., Kumar S., Roberts R.J., Barton J.K. Protein-modulated DNA electron transfer. J Am Chem Soc. 121:1999;5615-5616. Long-range guanine oxidation through oligonucleotides was diminished by the binding of a 'base-flipping' protein, HhaI methylase, to the intervening sequence because the protein binding disrupts the continuity of the π stack. Binding of a mutant Trp-containing methylase restores the π stacking and the long-range guanine oxidation.
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(1999)
J Am Chem Soc
, vol.121
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-
Rajski, S.R.1
Kumar, S.2
Roberts, R.J.3
Barton, J.K.4
|