Rates of DNA-mediated electron transfer between metallointercalators

Science

Volumn 273, Issue 5274, 1996, Pages 475-480

  Arkin, M R ^a   Stemp, E D A ^a   Holmlin, R E ^a   Barton, J K ^a   Hormann A ^b   Olson, E J C ^b   Barbara, P F ^b  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^b University of Minnesota   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DNA B; DOUBLE STRANDED DNA; METAL COMPLEX; RHODIUM;

ABSORPTION SPECTROSCOPY; ARTICLE; DNA BINDING; DNA CLEAVAGE; DNA HELIX; ELECTRON TRANSPORT; FLAME PHOTOMETRY; INTERCALATION COMPLEX; LUMINESCENCE; NUCLEAR MAGNETIC RESONANCE; OXIDATION; PRIORITY JOURNAL; TRANSPORT KINETICS;

EID: 0029846245     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.273.5274.475     Document Type: Article

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89. Several authors have determined thermodynamic parameters for the DNA bases, but no: consensus has yet emerged. See S. Steenken, J. P. Telo, H. M. Novais, L. P. Candeias, J. Am. Chem. Soc. 114, 4701 (1992); N. S. Hush and A. S. Cheung, Chem. Phys. Lett. 34, 11 (1975); M. Faraggi and M. H. Klapper, J. Chim. Phys. 91, 1054 (1994); S. V. Jovanovic and M. G. Simic, J. Phys. Chem. 90, 974 (1986); L. Kittler, G. Löber, F. A. Gollnick, H. Berg, J. Electroanal. Chem. 116 , 503 (1980).
90. Several authors have determined thermodynamic parameters for the DNA bases, but no: consensus has yet emerged. See S. Steenken, J. P. Telo, H. M. Novais, L. P. Candeias, J. Am. Chem. Soc. 114, 4701 (1992); N. S. Hush and A. S. Cheung, Chem. Phys. Lett. 34, 11 (1975); M. Faraggi and M. H. Klapper, J. Chim. Phys. 91, 1054 (1994); S. V. Jovanovic and M. G. Simic, J. Phys. Chem. 90, 974 (1986); L. Kittler, G. Löber, F. A. Gollnick, H. Berg, J. Electroanal. Chem. 116 , 503 (1980).
91. Several authors have determined thermodynamic parameters for the DNA bases, but no: consensus has yet emerged. See S. Steenken, J. P. Telo, H. M. Novais, L. P. Candeias, J. Am. Chem. Soc. 114, 4701 (1992); N. S. Hush and A. S. Cheung, Chem. Phys. Lett. 34, 11 (1975); M. Faraggi and M. H. Klapper, J. Chim. Phys. 91, 1054 (1994); S. V. Jovanovic and M. G. Simic, J. Phys. Chem. 90, 974 (1986); L. Kittler, G. Löber, F. A. Gollnick, H. Berg, J. Electroanal. Chem. 116 , 503 (1980).
92. Several authors have determined thermodynamic parameters for the DNA bases, but no: consensus has yet emerged. See S. Steenken, J. P. Telo, H. M. Novais, L. P. Candeias, J. Am. Chem. Soc. 114, 4701 (1992); N. S. Hush and A. S. Cheung, Chem. Phys. Lett. 34, 11 (1975); M. Faraggi and M. H. Klapper, J. Chim. Phys. 91, 1054 (1994); S. V. Jovanovic and M. G. Simic, J. Phys. Chem. 90, 974 (1986); L. Kittler, G. Löber, F. A. Gollnick, H. Berg, J. Electroanal. Chem. 116 , 503 (1980).
93. L. A. Lipscomb et al., Biochemistry 35, 2818 (1996).
94. Transient absorption data on the nanosecond time scale were obtained with instrumentation described by M. Bacharach [thesis, California Institute of Technology (1995)] at concentrations of 67 μmM Ru and 3.4 mM DNA bp.
95. We are grateful to NIH (GM49216 to J.K.B.) and NSF (CHE-9304373 to P.F.B.) for financial support. We also thank NSF for predoctoral support of M.RA and R.E.H., and the American Cancer Society for postdoctoral support of E.D.A.S. We are also grateful to N. J. Turro for helpful discussions and to the reviewers for thoughtful comments.