Opsonization of apoptotic cells and its effect on macrophage and T cell immune responses

Annals of the New York Academy of Sciences

Volumn 987, Issue , 2003, Pages 68-78

  Kim, Sun Jung ^a   Gershov, Debra ^a   Ma, Xiaojing ^a   Brot, Nathan ^a   Elkon, Keith B ^b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Antibody; Apoptosis; Autoimmunity; Complement; Lupus

Indexed keywords

IMMUNOGLOBULIN M; INTERLEUKIN 12; PROTEIN P40; SERUM AMYLOID P;

ABSORPTION; ANTIGEN BINDING; ANTIGEN RECOGNITION; APOPTOSIS; AUTOIMMUNITY; CELL SURFACE; CELLULAR IMMUNITY; COMPLEMENT SYSTEM; CONFERENCE PAPER; CYTOKINE PRODUCTION; IMMUNE RESPONSE; LUPUS ERYTHEMATOSUS; MACROPHAGE; NONHUMAN; OPSONIZATION; PHAGOCYTOSIS; PROTEIN BINDING; PROTEIN SYNTHESIS; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 0038579717     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2003.tb06034.x     Document Type: Conference Paper

References (32)

1. HORVITZ, H., S. SHAHAM & M. HENGARTNER. 1994. The genetics of programmed cell death in the nematode Caenorhabditis elegans. Cold Spring Harbor Symp. Quant. Biol. 59: 377-385.
2. HENGARTNER, M.O. 2001. Apoptosis: corralling the corpses. Cell 104: 325-328.
3. SAVILL, J. & V. FADOK. 2000. Corpse clearance defines the meaning of cell death. Nature 407: 784-788.
4. NAPIREI, M., H. KARSUNKY, B. ZEVNIK, et al. 2000. Features of systemic lupus erythematosus in DNAse1-deficient mice. Nat. Genet. 25: 177-181.
5. YASUTOMO, K., T. HORIUCHI, S. KAGAMI, et al. 2001. Mutation of DNAse1 in people with systemic lupus erythematosus. Nat. Genet. 28: 313-314.
6. SCOTT, R.S., E.J. MCMAHON, S.M. POP, et al. 2001. Phagocytosis and clearance of apoptotic cells is mediated by mer. Nature 411: 207-211.
7. LU, Q. & G. LEMKE. 2001. Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family. Science 293: 306-311.
8. MEDZHITOV, R. & C.A. JANEWAY. 1997. Innate immunity: the virtues of a nonclonal system of recognition. Cell 91: 295-298.
9. MEVORACH, D., J. MASCARENHAS, D.A. GERSHOV, et al. 1998. Complement-dependent clearance of apoptotic cells by human macrophages. J. Exp. Med. 188: 2313-2320.
10. KORB, L.C. & J.M. AHEARN. 1997. C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes. J. Immunol. 158: 4525-4528.
11. BOTTO, M., C. DELL'AGNOLA, A.E. BYGRAVE, et al. 1998. Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies. Nature Gen. 19: 56-59.
12. BALTZ, M.L., F.C. DE BEER, A. FEINSTEIN, et al. 1982. Phylogenetic aspects of C-reactive protein and related proteins. Ann. N.Y. Acad. Sci. 389: 49-75.
13. TILETT, W.S. & T. FRANCIS. 1930. Serological reactions in pneumonia with a non-protein fraction of pneumococcus. J. Exp. Med. 52: 561-571.
14. THOMPSON, D., M.B. PEPYS & S.P. WOOD. 1999. The physiological structure of human C-reactive protein and its complex with phosphocholine. Structure 7: 169-177.
15. KUSHNER, I., L. RAKITA & M.H. KAPLAN. 1963. Studies of acute-phase protein. II. Localization of Cx-reactive protein in heart in induced myocardial infarction in rabbits. J. Clin. Invest. 42: 286-292.
16. VOLANAKIS, J.E. & K.W.A. WIRTZ. 1979. Interaction of C-reactive protein with artificial phosphatidylcholine bilayers. Nature 281: 155-157.
17. ROBEY, F.A., K.D. JONES, T. TANAKA, et al. 1984. Binding of C-reactive protein to chromatin and nucleosome core particles. J. Biol. Chem. 259: 7311-7316.
18. DUCLOS, T.W. 1989. C-reactive protein reacts with the U1 small nuclear ribonucleoprotein. J. Immunol. 143: 2553-2559.
19. GERSHOV, D., S. KIM, N. BROT, et al. 2000. C-reactive protein binds to apoptotic cells, protects the cells from assembly of the terminal complement components, and sustains an antiinflammatory innate immune response: implications for systemic autoimmunity. J. Exp. Med. 192: 1353-1364.
20. VIK, D.P., P. MUNOZ-CANOVES, D.D. CHAPLIN, et al. 1990. Factor H. Curr. Top. Microbiol. Immunol. 153: 147-162.
21. BOES, M. 2000. Role of natural and immune IgM antibodies in immune responses. Mol. Immunol. 37: 1141-1149.
22. EHRENSTEIN, M.R., H.T. COOK & M.S. NEUBERGER. 2000. Deficiency in serum immunoglobulin (Ig)M predisposes to development of IgG autoantibodies. J. Exp. Med. 191: 1253-1258.
23. KIM, S., D. GERSHOV, X. MA, et al. 2002. I-PLA2 activation during apoptosis promotes the exposure of membrane lysophosphatidylcholine leading to binding by natural IgM antibodies and complement activation. J. Exp. Med. 196: 655-665.
24. 2+-independent phospholipase A2 but not cytosolic phospholipase A2, which undergoes proteolytic inactivation. J. Biol. Chem. 273: 13870-13877.
25. SHARMA, A., D.A. ISENBERG & B. DIAMOND. 2001. Crossreactivity of human anti-ds-DNA antibodies to phosphorylcholine: clues to their origin. J. Autoimmun. 16: 479-484.
26. STEINMAN et al. 2003. Dendritic cell function in vivo during the steady state: a role in peripheral tolerance. Ann. N.Y. Acad. Sci. 987: this volume.
27. EGGLETON, P., K.B. REID, U. KISHORE, et al. 1997. Clinical relevance of calreticulin in systemic lupus erythematosus. Lupus 6: 564-571.
28. FADOK, V.A., D.L. BRATTON, A. KONOWAL, et al. 1998. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. J. Clin. Invest. 101: 890-898.
29. STERN, M., J. SAVILL & C. HASLETT. 1996. Human monocyte derived macrophage phagocytosis of senescent eosinophils undergoing apoptosis. Am. J. Pathol. 149: 911-921.
30. SAVILL, J., N. HOGG, Y. REN, et al. 1992. Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis. J. Clin. Invest. 90: 1513-1522.
31. GREGORY, C.D. 2000. CD14-dependent clearance of apoptotic cells: relevance to the immune system. Curr. Opin. Immunol. 12: 27-34.
32. OGDEN, C.A., A. DE CATHELINEAU, P.R. HOFFMAN, et al. 2002. C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells. J. Exp. Med. 194: 781-795.